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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2C-IRF5 (FusionGDB2 ID:43015)

Fusion Gene Summary for KMT2C-IRF5

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C-IRF5
Fusion gene ID: 43015
HgeneTgene
Gene symbol

KMT2C

IRF5

Gene ID

58508

3663

Gene namelysine methyltransferase 2Cinterferon regulatory factor 5
SynonymsHALR|KLEFS2|MLL3SLEB10
Cytomap

7q36.1

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage leinterferon regulatory factor 5
Modification date2020032020200315
UniProtAcc

Q8NEZ4

Q13568

Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485655, ENST00000485241, 
ENST00000477535, ENST00000357234, 
ENST00000402030, ENST00000249375, 
ENST00000473745, 
Fusion gene scores* DoF score26 X 23 X 12=71761 X 2 X 1=2
# samples 321
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: KMT2C [Title/Abstract] AND IRF5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2C(151980068)-IRF5(128582125), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722

TgeneIRF5

GO:0032494

response to peptidoglycan

22412986

TgeneIRF5

GO:0032495

response to muramyl dipeptide

22412986

TgeneIRF5

GO:0045944

positive regulation of transcription by RNA polymerase II

12600985|22412986


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IRF5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3C3-06AKMT2Cchr7

151980068

-IRF5chr7

128582125

+
ChimerDB4SKCMTCGA-D3-A3C3-06AKMT2Cchr7

151980068

-IRF5chr7

128582125

+
ChimerDB4SKCMTCGA-D3-A3C3-06AKMT2Cchr7

152007051

-IRF5chr7

128582125

+
ChimerDB4SKCMTCGA-D3-A3C3-06AKMT2Cchr7

152007051

-IRF5chr7

128585899

+


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Fusion Gene ORF analysis for KMT2C-IRF5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000262189ENST00000477535KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000262189ENST00000357234KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000262189ENST00000402030KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000262189ENST00000249375KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000262189ENST00000473745KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000355193ENST00000477535KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000355193ENST00000357234KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000355193ENST00000402030KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000355193ENST00000249375KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000355193ENST00000473745KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000477535KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000357234KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000402030KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000249375KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000473745KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000477535KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000357234KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000402030KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000249375KMT2Cchr7

151980068

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000473745KMT2Cchr7

151980068

-IRF5chr7

128582125

+
5CDS-5UTRENST00000262189ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000262189ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000262189ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000262189ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000262189ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000355193ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000355193ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000355193ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000355193ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128582125

+
5CDS-5UTRENST00000355193ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485655ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128582125

+
intron-5UTRENST00000485241ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128582125

+
In-frameENST00000262189ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000262189ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000262189ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000262189ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000262189ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000355193ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000355193ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000355193ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000355193ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128585899

+
In-frameENST00000355193ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485655ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485655ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485655ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485655ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485655ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485241ENST00000477535KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485241ENST00000357234KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485241ENST00000402030KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485241ENST00000249375KMT2Cchr7

152007051

-IRF5chr7

128585899

+
intron-3CDSENST00000485241ENST00000473745KMT2Cchr7

152007051

-IRF5chr7

128585899

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262189KMT2Cchr7152007051-ENST00000477535IRF5chr7128585899+212610682072111634
ENST00000262189KMT2Cchr7152007051-ENST00000357234IRF5chr7128585899+243210682072417736
ENST00000262189KMT2Cchr7152007051-ENST00000402030IRF5chr7128585899+358710682072369720
ENST00000262189KMT2Cchr7152007051-ENST00000249375IRF5chr7128585899+358210682072369720
ENST00000262189KMT2Cchr7152007051-ENST00000473745IRF5chr7128585899+294010682072369720
ENST00000355193KMT2Cchr7152007051-ENST00000477535IRF5chr7128585899+212610682072111634
ENST00000355193KMT2Cchr7152007051-ENST00000357234IRF5chr7128585899+243210682072417736
ENST00000355193KMT2Cchr7152007051-ENST00000402030IRF5chr7128585899+358710682072369720
ENST00000355193KMT2Cchr7152007051-ENST00000249375IRF5chr7128585899+358210682072369720
ENST00000355193KMT2Cchr7152007051-ENST00000473745IRF5chr7128585899+294010682072369720

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000477535KMT2Cchr7152007051-IRF5chr7128585899+0.0084010120.99159896
ENST00000262189ENST00000357234KMT2Cchr7152007051-IRF5chr7128585899+0.0117020620.988298
ENST00000262189ENST00000402030KMT2Cchr7152007051-IRF5chr7128585899+0.0042377850.9957623
ENST00000262189ENST00000249375KMT2Cchr7152007051-IRF5chr7128585899+0.0043107310.9956892
ENST00000262189ENST00000473745KMT2Cchr7152007051-IRF5chr7128585899+0.0073686260.99263144
ENST00000355193ENST00000477535KMT2Cchr7152007051-IRF5chr7128585899+0.0084010120.99159896
ENST00000355193ENST00000357234KMT2Cchr7152007051-IRF5chr7128585899+0.0117020620.988298
ENST00000355193ENST00000402030KMT2Cchr7152007051-IRF5chr7128585899+0.0042377850.9957623
ENST00000355193ENST00000249375KMT2Cchr7152007051-IRF5chr7128585899+0.0043107310.9956892
ENST00000355193ENST00000473745KMT2Cchr7152007051-IRF5chr7128585899+0.0073686260.99263144

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Fusion Genomic Features for KMT2C-IRF5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KMT2Cchr7152007050-IRF5chr7128582124+0.0011041460.9988959
KMT2Cchr7152007050-IRF5chr7128585898+1.07E-060.9999989
KMT2Cchr7152007050-IRF5chr7128582124+0.0011041460.9988959
KMT2Cchr7152007050-IRF5chr7128585898+1.07E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KMT2C-IRF5


check button Go to

FGviewer for the breakpoints of chr7:152007051-chr7:128585899

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

IRF5

Q13568

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-65992_112283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-66092_112283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-65934_46283.04912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-66034_46283.04969.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659227_262283.04912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660227_262283.04969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneIRF5chr7:152007051chr7:128585899ENST0000024937519142_14965.0499.0Compositional biasNote=Poly-Glu
TgeneIRF5chr7:152007051chr7:128585899ENST0000035723419142_14965.0515.0Compositional biasNote=Poly-Glu
TgeneIRF5chr7:152007051chr7:128585899ENST0000040203019142_14965.0499.0Compositional biasNote=Poly-Glu
TgeneIRF5chr7:152007051chr7:128585899ENST0000047374519142_14965.0499.0Compositional biasNote=Poly-Glu
TgeneIRF5chr7:152007051chr7:128585899ENST0000047753518142_14965.0413.0Compositional biasNote=Poly-Glu
TgeneIRF5chr7:152007051chr7:128585899ENST0000024937519150_16065.0499.0MotifNuclear export signal
TgeneIRF5chr7:152007051chr7:128585899ENST0000035723419150_16065.0515.0MotifNuclear export signal
TgeneIRF5chr7:152007051chr7:128585899ENST0000040203019150_16065.0499.0MotifNuclear export signal
TgeneIRF5chr7:152007051chr7:128585899ENST0000047374519150_16065.0499.0MotifNuclear export signal
TgeneIRF5chr7:152007051chr7:128585899ENST0000047753518150_16065.0413.0MotifNuclear export signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6591338_1366283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6591754_1787283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6593054_3081283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6593173_3272283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6593391_3433283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659644_672283.04912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6601338_1366283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6601754_1787283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6603054_3081283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6603173_3272283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6603391_3433283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660644_672283.04969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6591719_1796283.04912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6591834_2281283.04912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6592412_2630283.04912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6592690_2786283.04912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6593012_3509283.04912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6593277_3381283.04912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6601719_1796283.04969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6601834_2281283.04969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6602412_2630283.04969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6602690_2786283.04969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6603012_3509283.04969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6603277_3381283.04969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659436_489283.04912.0DomainDHHC
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594545_4605283.04912.0DomainFYR N-terminal
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594606_4691283.04912.0DomainFYR C-terminal
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594771_4887283.04912.0DomainSET
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594895_4911283.04912.0DomainPost-SET
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660436_489283.04969.0DomainDHHC
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604545_4605283.04969.0DomainFYR N-terminal
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604606_4691283.04969.0DomainFYR C-terminal
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604771_4887283.04969.0DomainSET
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604895_4911283.04969.0DomainPost-SET
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594848_4849283.04912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604848_4849283.04969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6591007_1057283.04912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6591084_1139283.04912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659283_331283.04912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659341_391283.04912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659344_389283.04912.0Zinc fingerRING-type
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659388_438283.04912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594399_4439283.04912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-6594460_4507283.04912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659464_520283.04912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000262189-659957_1010283.04912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6601007_1057283.04969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6601084_1139283.04969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660283_331283.04969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660341_391283.04969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660344_389283.04969.0Zinc fingerRING-type
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660388_438283.04969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604399_4439283.04969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-6604460_4507283.04969.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660464_520283.04969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152007051chr7:128585899ENST00000355193-660957_1010283.04969.0Zinc fingerPHD-type 5
TgeneIRF5chr7:152007051chr7:128585899ENST000002493751914_12265.0499.0DNA bindingIRF tryptophan pentad repeat
TgeneIRF5chr7:152007051chr7:128585899ENST000003572341914_12265.0515.0DNA bindingIRF tryptophan pentad repeat
TgeneIRF5chr7:152007051chr7:128585899ENST000004020301914_12265.0499.0DNA bindingIRF tryptophan pentad repeat
TgeneIRF5chr7:152007051chr7:128585899ENST000004737451914_12265.0499.0DNA bindingIRF tryptophan pentad repeat
TgeneIRF5chr7:152007051chr7:128585899ENST000004775351814_12265.0413.0DNA bindingIRF tryptophan pentad repeat
TgeneIRF5chr7:152007051chr7:128585899ENST000002493751912_1865.0499.0MotifNuclear localization signal
TgeneIRF5chr7:152007051chr7:128585899ENST000003572341912_1865.0515.0MotifNuclear localization signal
TgeneIRF5chr7:152007051chr7:128585899ENST000004020301912_1865.0499.0MotifNuclear localization signal
TgeneIRF5chr7:152007051chr7:128585899ENST000004737451912_1865.0499.0MotifNuclear localization signal
TgeneIRF5chr7:152007051chr7:128585899ENST000004775351812_1865.0413.0MotifNuclear localization signal


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Fusion Gene Sequence for KMT2C-IRF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262189_ENST00000477535_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=2126nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGTGACCGACCTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTC
TACAGCCAGCTGGAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATC
CCCAGTGACAAGCAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTAT
GCCATCCGCCTGTGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTC
AAGACCAAGCTTTTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATC
TTCTTCTGCTTTGGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTG
CTGCTGGAGATGTTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTG
GAGCAATTCAAGGAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTT

>In-frame_ENST00000262189_ENST00000477535_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=634AA_start in transcript=207_stop in transcript=2111
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTVTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYT
NQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWP
DRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHP

--------------------------------------------------------------
>In-frame_ENST00000262189_ENST00000357234_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=2432nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGATGCAGTGCAGTCTGGCCCCCACATGACACCCTATTCTTTACTCAAAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACT
CTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTGCTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCC
CCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAGCCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAG
CTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGACCTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCC
CTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTGGAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGC
CTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAGCAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGC
GGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTGTGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCC
CATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTTTTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAA
AAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTTGGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTC
ATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATGTTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTA
CAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAGGAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCT
GTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCCTGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGA

>In-frame_ENST00000262189_ENST00000357234_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=736AA_start in transcript=207_stop in transcript=2417
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTDAVQSGPHMTPYSLLKEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRE
LLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSP
EDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPP
FEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAG

--------------------------------------------------------------
>In-frame_ENST00000262189_ENST00000402030_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=3587nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTG
CTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAG
CCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGAC
CTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTG
GAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAG
CAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTG
TGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTT
TTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTT
GGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATG
TTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAG
GAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCC
TGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGACGGTGACTGGCCCTGGCTTCCTGGGTGGCGGTGCGGACTGATGTGGAG
ATGTGACAGCCCCGATGAGCACCTGGCTGGCTGCAGGGTCCTACCTCTGGGTTTCCTGGAAGTGGATTTGGGCCAAGAAGGAGAGGGAGA
AAGGCCCGAGCCCCTGCCTTCCCGGGCCTTTCTCTCCTGGGCTGTCTCTGGTCTGGTCAGCCTGGCTCTCGGGAAATTCAGCCATGAGCA
GGGAAAGAACTCTCCCAACCCTGGGGCCTAGCTGTATAGGAGGAATTGCCTAAGGGTGGCCCACTCTTGTGATTGCCCCATTTCCTCTGG
CAACAAAAGCCAGAGTGTTGTGGGCCAAGTCCCCCCACAGGGCCTCTGCAGGGCATGGCCCTGATTTCCCTGGTTTGAGACTCACTTCCT
CATCTCCCTGTCCTCTGAGATAATATGAGTGAGCACTTAGGTATCATATCAGATGCTCAAGGCTGGCAGCTACCCCCTTCTTGAGAGTCC
AAGAACCTGGAGCAGAAATAATTTTTATGTATTTTTGGATTAATGAATGTTAAAAACAGACTCAGCTGTTTCTTTCCTTTTACTACTACC
AGTTGCTCCCATGCTGCTCCACCAGGCCCTGTTTCGGATGCCAACTGGCCCACTCCCCAAGCACTTGCCCCCAGCTTGCGACCATTGGCA
CTGGGAGGGCCTGGCTTCTGGGCTGATGGGTCAGTTGGGCCTTCATAAACACTCACCTGGCTGGCTTTGCCTTCCAGGAGGAAGCTGGCT
GAAGCAAGGGTGTGGAATTTTAAATGTGTGCACAGTCTGGAAAACTGTCAGAATCAGTTTTCCCATAAAAGGGTGGGCTAGCATTGCAGC
TGCATTTGGGACCATTCAAATCTGTCACTCTCTTGTGTATATTCCTGTGCTATTAAATATATCAGGGCAGTGCATGTAAATCATCCTGAT
ATATTTAATATATTTATTATATTGTCCCCCGAGGTGGGGACAGTGAGTGAGTTCTCTTAGTCCCCCCAGAGCTGGTTGTTAAAGAGCCTG
GCACCTACCCGCTCTCACTTCATCTGTGTCATCTCTGCACACTCCAGCCCACTTTCTGCCTTCAGCCATTGAGTGGAAGCTGCCCCAGGC

>In-frame_ENST00000262189_ENST00000402030_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=720AA_start in transcript=207_stop in transcript=2369
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLP
PAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKP
REKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ

--------------------------------------------------------------
>In-frame_ENST00000262189_ENST00000249375_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=3582nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTG
CTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAG
CCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGAC
CTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTG
GAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAG
CAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTG
TGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTT
TTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTT
GGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATG
TTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAG
GAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCC
TGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGACGGTGACTGGCCCTGGCTTCCTGGGTGGCGGTGCGGACTGATGTGGAG
ATGTGACAGCCCCGATGAGCACCTGGCTGGCTGCAGGGTCCTACCTCTGGGTTTCCTGGAAGTGGATTTGGGCCAAGAAGGAGAGGGAGA
AAGGCCCGAGCCCCTGCCTTCCCGGGCCTTTCTCTCCTGGGCTGTCTCTGGTCTGGTCAGCCTGGCTCTCGGGAAATTCAGCCATGAGCA
GGGAAAGAACTCTCCCAACCCTGGGGCCTAGCTGTATAGGAGGAATTGCCTAAGGGTGGCCCACTCTTGTGATTGCCCCATTTCCTCTGG
CAACAAAAGCCAGAGTGTTGTGGGCCAAGTCCCCCCACAGGGCCTCTGCAGGGCATGGCCCTGATTTCCCTGGTTTGAGACTCACTTCCT
CATCTCCCTGTCCTCTGAGATAATATGAGTGAGCACTTAGGTATCATATCAGATGCTCAAGGCTGGCAGCTACCCCCTTCTTGAGAGTCC
AAGAACCTGGAGCAGAAATAATTTTTATGTATTTTTGGATTAATGAATGTTAAAAACAGACTCAGCTGTTTCTTTCCTTTTACTACTACC
AGTTGCTCCCATGCTGCTCCACCAGGCCCTGTTTCGGATGCCAACTGGCCCACTCCCCAAGCACTTGCCCCCAGCTTGCGACCATTGGCA
CTGGGAGGGCCTGGCTTCTGGGCTGATGGGTCAGTTGGGCCTTCATAAACACTCACCTGGCTGGCTTTGCCTTCCAGGAGGAAGCTGGCT
GAAGCAAGGGTGTGGAATTTTAAATGTGTGCACAGTCTGGAAAACTGTCAGAATCAGTTTTCCCATAAAAGGGTGGGCTAGCATTGCAGC
TGCATTTGGGACCATTCAAATCTGTCACTCTCTTGTGTATATTCCTGTGCTATTAAATATATCAGGGCAGTGCATGTAAATCATCCTGAT
ATATTTAATATATTTATTATATTGTCCCCCGAGGTGGGGACAGTGAGTGAGTTCTCTTAGTCCCCCCAGAGCTGGTTGTTAAAGAGCCTG
GCACCTACCCGCTCTCACTTCATCTGTGTCATCTCTGCACACTCCAGCCCACTTTCTGCCTTCAGCCATTGAGTGGAAGCTGCCCCAGGC

>In-frame_ENST00000262189_ENST00000249375_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=720AA_start in transcript=207_stop in transcript=2369
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLP
PAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKP
REKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ

--------------------------------------------------------------
>In-frame_ENST00000262189_ENST00000473745_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=2940nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTG
CTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAG
CCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGAC
CTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTG
GAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAG
CAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTG
TGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTT
TTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTT
GGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATG
TTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAG
GAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCC
TGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGACGGTGACTGGCCCTGGCTTCCTGGGTGGCGGTGCGGACTGATGTGGAG
ATGTGACAGCCCCGATGAGCACCTGGCTGGCTGCAGGGTCCTACCTCTGGGTTTCCTGGAAGTGGATTTGGGCCAAGAAGGAGAGGGAGA
AAGGCCCGAGCCCCTGCCTTCCCGGGCCTTTCTCTCCTGGGCTGTCTCTGGTCTGGTCAGCCTGGCTCTCGGGAAATTCAGCCATGAGCA
GGGAAAGAACTCTCCCAACCCTGGGGCCTAGCTGTATAGGAGGAATTGCCTAAGGGTGGCCCACTCTTGTGATTGCCCCATTTCCTCTGG
CAACAAAAGCCAGAGTGTTGTGGGCCAAGTCCCCCCACAGGGCCTCTGCAGGGCATGGCCCTGATTTCCCTGGTTTGAGACTCACTTCCT
CATCTCCCTGTCCTCTGAGATAATATGAGTGAGCACTTAGGTATCATATCAGATGCTCAAGGCTGGCAGCTACCCCCTTCTTGAGAGTCC

>In-frame_ENST00000262189_ENST00000473745_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=720AA_start in transcript=207_stop in transcript=2369
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLP
PAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKP
REKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ

--------------------------------------------------------------
>In-frame_ENST00000355193_ENST00000477535_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=2126nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGTGACCGACCTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTC
TACAGCCAGCTGGAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATC
CCCAGTGACAAGCAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTAT
GCCATCCGCCTGTGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTC
AAGACCAAGCTTTTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATC
TTCTTCTGCTTTGGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTG
CTGCTGGAGATGTTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTG
GAGCAATTCAAGGAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTT

>In-frame_ENST00000355193_ENST00000477535_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=634AA_start in transcript=207_stop in transcript=2111
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTVTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYT
NQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWP
DRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHP

--------------------------------------------------------------
>In-frame_ENST00000355193_ENST00000357234_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=2432nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGATGCAGTGCAGTCTGGCCCCCACATGACACCCTATTCTTTACTCAAAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACT
CTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTGCTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCC
CCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAGCCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAG
CTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGACCTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCC
CTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTGGAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGC
CTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAGCAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGC
GGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTGTGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCC
CATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTTTTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAA
AAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTTGGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTC
ATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATGTTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTA
CAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAGGAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCT
GTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCCTGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGA

>In-frame_ENST00000355193_ENST00000357234_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=736AA_start in transcript=207_stop in transcript=2417
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTDAVQSGPHMTPYSLLKEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRE
LLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSP
EDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPP
FEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAG

--------------------------------------------------------------
>In-frame_ENST00000355193_ENST00000402030_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=3587nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTG
CTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAG
CCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGAC
CTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTG
GAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAG
CAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTG
TGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTT
TTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTT
GGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATG
TTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAG
GAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCC
TGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGACGGTGACTGGCCCTGGCTTCCTGGGTGGCGGTGCGGACTGATGTGGAG
ATGTGACAGCCCCGATGAGCACCTGGCTGGCTGCAGGGTCCTACCTCTGGGTTTCCTGGAAGTGGATTTGGGCCAAGAAGGAGAGGGAGA
AAGGCCCGAGCCCCTGCCTTCCCGGGCCTTTCTCTCCTGGGCTGTCTCTGGTCTGGTCAGCCTGGCTCTCGGGAAATTCAGCCATGAGCA
GGGAAAGAACTCTCCCAACCCTGGGGCCTAGCTGTATAGGAGGAATTGCCTAAGGGTGGCCCACTCTTGTGATTGCCCCATTTCCTCTGG
CAACAAAAGCCAGAGTGTTGTGGGCCAAGTCCCCCCACAGGGCCTCTGCAGGGCATGGCCCTGATTTCCCTGGTTTGAGACTCACTTCCT
CATCTCCCTGTCCTCTGAGATAATATGAGTGAGCACTTAGGTATCATATCAGATGCTCAAGGCTGGCAGCTACCCCCTTCTTGAGAGTCC
AAGAACCTGGAGCAGAAATAATTTTTATGTATTTTTGGATTAATGAATGTTAAAAACAGACTCAGCTGTTTCTTTCCTTTTACTACTACC
AGTTGCTCCCATGCTGCTCCACCAGGCCCTGTTTCGGATGCCAACTGGCCCACTCCCCAAGCACTTGCCCCCAGCTTGCGACCATTGGCA
CTGGGAGGGCCTGGCTTCTGGGCTGATGGGTCAGTTGGGCCTTCATAAACACTCACCTGGCTGGCTTTGCCTTCCAGGAGGAAGCTGGCT
GAAGCAAGGGTGTGGAATTTTAAATGTGTGCACAGTCTGGAAAACTGTCAGAATCAGTTTTCCCATAAAAGGGTGGGCTAGCATTGCAGC
TGCATTTGGGACCATTCAAATCTGTCACTCTCTTGTGTATATTCCTGTGCTATTAAATATATCAGGGCAGTGCATGTAAATCATCCTGAT
ATATTTAATATATTTATTATATTGTCCCCCGAGGTGGGGACAGTGAGTGAGTTCTCTTAGTCCCCCCAGAGCTGGTTGTTAAAGAGCCTG
GCACCTACCCGCTCTCACTTCATCTGTGTCATCTCTGCACACTCCAGCCCACTTTCTGCCTTCAGCCATTGAGTGGAAGCTGCCCCAGGC

>In-frame_ENST00000355193_ENST00000402030_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=720AA_start in transcript=207_stop in transcript=2369
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLP
PAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKP
REKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ

--------------------------------------------------------------
>In-frame_ENST00000355193_ENST00000249375_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=3582nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTG
CTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAG
CCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGAC
CTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTG
GAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAG
CAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTG
TGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTT
TTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTT
GGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATG
TTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAG
GAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCC
TGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGACGGTGACTGGCCCTGGCTTCCTGGGTGGCGGTGCGGACTGATGTGGAG
ATGTGACAGCCCCGATGAGCACCTGGCTGGCTGCAGGGTCCTACCTCTGGGTTTCCTGGAAGTGGATTTGGGCCAAGAAGGAGAGGGAGA
AAGGCCCGAGCCCCTGCCTTCCCGGGCCTTTCTCTCCTGGGCTGTCTCTGGTCTGGTCAGCCTGGCTCTCGGGAAATTCAGCCATGAGCA
GGGAAAGAACTCTCCCAACCCTGGGGCCTAGCTGTATAGGAGGAATTGCCTAAGGGTGGCCCACTCTTGTGATTGCCCCATTTCCTCTGG
CAACAAAAGCCAGAGTGTTGTGGGCCAAGTCCCCCCACAGGGCCTCTGCAGGGCATGGCCCTGATTTCCCTGGTTTGAGACTCACTTCCT
CATCTCCCTGTCCTCTGAGATAATATGAGTGAGCACTTAGGTATCATATCAGATGCTCAAGGCTGGCAGCTACCCCCTTCTTGAGAGTCC
AAGAACCTGGAGCAGAAATAATTTTTATGTATTTTTGGATTAATGAATGTTAAAAACAGACTCAGCTGTTTCTTTCCTTTTACTACTACC
AGTTGCTCCCATGCTGCTCCACCAGGCCCTGTTTCGGATGCCAACTGGCCCACTCCCCAAGCACTTGCCCCCAGCTTGCGACCATTGGCA
CTGGGAGGGCCTGGCTTCTGGGCTGATGGGTCAGTTGGGCCTTCATAAACACTCACCTGGCTGGCTTTGCCTTCCAGGAGGAAGCTGGCT
GAAGCAAGGGTGTGGAATTTTAAATGTGTGCACAGTCTGGAAAACTGTCAGAATCAGTTTTCCCATAAAAGGGTGGGCTAGCATTGCAGC
TGCATTTGGGACCATTCAAATCTGTCACTCTCTTGTGTATATTCCTGTGCTATTAAATATATCAGGGCAGTGCATGTAAATCATCCTGAT
ATATTTAATATATTTATTATATTGTCCCCCGAGGTGGGGACAGTGAGTGAGTTCTCTTAGTCCCCCCAGAGCTGGTTGTTAAAGAGCCTG
GCACCTACCCGCTCTCACTTCATCTGTGTCATCTCTGCACACTCCAGCCCACTTTCTGCCTTCAGCCATTGAGTGGAAGCTGCCCCAGGC

>In-frame_ENST00000355193_ENST00000249375_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=720AA_start in transcript=207_stop in transcript=2369
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLP
PAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKP
REKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ

--------------------------------------------------------------
>In-frame_ENST00000355193_ENST00000473745_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(transcript)=2940nt_BP=1068nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAAGCCTGGGCCAAG
GAGACAGGGAAATACACCGAAGGCGTGGATGAAGCCGATCCGGCCAAGTGGAAGGCCAACCTGCGCTGTGCCCTTAACAAGAGCCGGGAC
TTCCGCCTCATCTACGACGGGCCCCGGGACATGCCACCTCAGCCCTACAAGATCTACGAGGTCTGCTCCAATGGCCCTGCTCCCACAGAC
TCCCAGCCCCCTGAGGATTACTCTTTTGGTGCAGGAGAGGAGGAGGAAGAAGAGGAAGAGCTGCAGAGGATGTTGCCAAGCCTGAGCCTC
ACAGAGGATGTCAAGTGGCCGCCCACTCTGCAGCCGCCCACTCTGCGGCCGCCTACTCTGCAGCCGCCCACTCTGCAGCCGCCCGTGGTG
CTGGGTCCCCCTGCTCCAGACCCCAGCCCCCTGGCTCCTCCCCCTGGCAACCCTGCTGGCTTCAGGGAGCTTCTCTCTGAGGTCCTGGAG
CCTGGGCCCCTGCCTGCCAGCCTGCCCCCTGCAGGCGAACAGCTCCTGCCAGACCTGCTGATCAGCCCCCACATGCTGCCTCTGACCGAC
CTGGAGATCAAGTTTCAGTACCGGGGGCGGCCACCCCGGGCCCTCACCATCAGCAACCCCCATGGCTGCCGGCTCTTCTACAGCCAGCTG
GAGGCCACCCAGGAGCAGGTGGAACTCTTCGGCCCCATAAGCCTGGAGCAAGTGCGCTTCCCCAGCCCTGAGGACATCCCCAGTGACAAG
CAGCGCTTCTACACGAACCAGCTGCTGGATGTCCTGGACCGCGGGCTCATCCTCCAGCTACAGGGCCAGGACCTTTATGCCATCCGCCTG
TGTCAGTGCAAGGTGTTCTGGAGCGGGCCTTGTGCCTCAGCCCATGACTCATGCCCCAACCCCATCCAGCGGGAGGTCAAGACCAAGCTT
TTCAGCCTGGAGCATTTTCTCAATGAGCTCATCCTGTTCCAAAAGGGCCAGACCAACACCCCACCACCCTTCGAGATCTTCTTCTGCTTT
GGGGAAGAATGGCCTGACCGCAAACCCCGAGAGAAGAAGCTCATTACTGTACAGGTGGTGCCTGTAGCAGCTCGACTGCTGCTGGAGATG
TTCTCAGGGGAGCTATCTTGGTCAGCTGATAGTATCCGGCTACAGATCTCAAACCCAGACCTCAAAGACCGCATGGTGGAGCAATTCAAG
GAGCTCCATCACATCTGGCAGTCCCAGCAGCGGTTGCAGCCTGTGGCCCAGGCCCCTCCTGGAGCAGGCCTTGGTGTTGGCCAGGGGCCC
TGGCCTATGCACCCAGCTGGCATGCAATAACAAGGCTGCAGACGGTGACTGGCCCTGGCTTCCTGGGTGGCGGTGCGGACTGATGTGGAG
ATGTGACAGCCCCGATGAGCACCTGGCTGGCTGCAGGGTCCTACCTCTGGGTTTCCTGGAAGTGGATTTGGGCCAAGAAGGAGAGGGAGA
AAGGCCCGAGCCCCTGCCTTCCCGGGCCTTTCTCTCCTGGGCTGTCTCTGGTCTGGTCAGCCTGGCTCTCGGGAAATTCAGCCATGAGCA
GGGAAAGAACTCTCCCAACCCTGGGGCCTAGCTGTATAGGAGGAATTGCCTAAGGGTGGCCCACTCTTGTGATTGCCCCATTTCCTCTGG
CAACAAAAGCCAGAGTGTTGTGGGCCAAGTCCCCCCACAGGGCCTCTGCAGGGCATGGCCCTGATTTCCCTGGTTTGAGACTCACTTCCT
CATCTCCCTGTCCTCTGAGATAATATGAGTGAGCACTTAGGTATCATATCAGATGCTCAAGGCTGGCAGCTACCCCCTTCTTGAGAGTCC

>In-frame_ENST00000355193_ENST00000473745_TCGA-D3-A3C3-06A_KMT2C_chr7_152007051_-_IRF5_chr7_128585899_length(amino acids)=720AA_start in transcript=207_stop in transcript=2369
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTEAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSF
GAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLP
PAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKP
REKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KMT2C-IRF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2C-IRF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2C-IRF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKMT2CC3714756Intellectual Disability2GENOMICS_ENGLAND
HgeneKMT2CC4540395KLEEFSTRA SYNDROME 22GENOMICS_ENGLAND
HgeneKMT2CC0001418Adenocarcinoma1CTD_human
HgeneKMT2CC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneKMT2CC0005695Bladder Neoplasm1CTD_human
HgeneKMT2CC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKMT2CC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKMT2CC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneKMT2CC0023897Liver Diseases, Parasitic1CTD_human
HgeneKMT2CC0024623Malignant neoplasm of stomach1CTD_human
HgeneKMT2CC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneKMT2CC0033578Prostatic Neoplasms1CTD_human
HgeneKMT2CC0036920Sezary Syndrome1CTD_human
HgeneKMT2CC0038356Stomach Neoplasms1CTD_human
HgeneKMT2CC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneKMT2CC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneKMT2CC0205643Carcinoma, Cribriform1CTD_human
HgeneKMT2CC0205644Carcinoma, Granular Cell1CTD_human
HgeneKMT2CC0205645Adenocarcinoma, Tubular1CTD_human
HgeneKMT2CC0206698Cholangiocarcinoma1CTD_human
HgeneKMT2CC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneKMT2CC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneKMT2CC0376358Malignant neoplasm of prostate1CTD_human
HgeneKMT2CC1535926Neurodevelopmental Disorders1CTD_human
HgeneKMT2CC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneKMT2CC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneKMT2CC2239176Liver carcinoma1CTD_human
HgeneKMT2CC3805278Extrahepatic Cholangiocarcinoma1CTD_human
TgeneIRF5C0024141Lupus Erythematosus, Systemic6CTD_human;ORPHANET
TgeneIRF5C0003873Rheumatoid Arthritis2CTD_human
TgeneIRF5C0242380Libman-Sacks Disease2CTD_human
TgeneIRF5C0009324Ulcerative Colitis1CTD_human;GENOMICS_ENGLAND
TgeneIRF5C0036421Systemic Scleroderma1CTD_human
TgeneIRF5C0206138CREST Syndrome1ORPHANET
TgeneIRF5C0748540Scleroderma, Limited1ORPHANET
TgeneIRF5C1258104Diffuse Scleroderma1ORPHANET