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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KREMEN1-MAPK1 (FusionGDB2 ID:43215)

Fusion Gene Summary for KREMEN1-MAPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: KREMEN1-MAPK1
Fusion gene ID: 43215
HgeneTgene
Gene symbol

KREMEN1

MAPK1

Gene ID

83999

5594

Gene namekringle containing transmembrane protein 1mitogen-activated protein kinase 1
SynonymsECTD13|KREMEN|KRM1ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK
Cytomap

22q12.1

22q11.22

Type of geneprotein-codingprotein-coding
Descriptionkremen protein 1dickkopf receptorkringle domain-containing transmembrane protein 1kringle-coding gene marking the eye and the nosekringle-containing protein marking the eye and the nosemitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
Modification date2020031320200327
UniProtAcc

Q96MU8

Q8NDC0

Ensembl transtripts involved in fusion geneENST00000400338, ENST00000400335, 
ENST00000327813, ENST00000407188, 
ENST00000479755, 		ENST00000215832, 
ENST00000398822, ENST00000544786, 
ENST00000491588, 
Fusion gene scores* DoF score9 X 8 X 7=50415 X 8 X 9=1080
# samples 1116
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KREMEN1 [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKREMEN1(29469215)-MAPK1(22123609), # samples:2
Anticipated loss of major functional domain due to fusion event.KREMEN1-MAPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KREMEN1-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
KREMEN1-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KREMEN1-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPK1

GO:0006468

protein phosphorylation

23184662

TgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

TgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

TgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

TgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

TgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

TgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

TgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356


check buttonFusion gene breakpoints across KREMEN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A45X-01AKREMEN1chr22

29469215

+MAPK1chr22

22123609

-
ChimerDB4HNSCTCGA-CV-A45XKREMEN1chr22

29469215

+MAPK1chr22

22123609

-


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Fusion Gene ORF analysis for KREMEN1-MAPK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000400338ENST00000215832KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000400338ENST00000398822KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000400338ENST00000544786KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
5CDS-5UTRENST00000400338ENST00000491588KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000400335ENST00000215832KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000400335ENST00000398822KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000400335ENST00000544786KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
5CDS-5UTRENST00000400335ENST00000491588KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000327813ENST00000215832KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000327813ENST00000398822KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000327813ENST00000544786KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
5CDS-5UTRENST00000327813ENST00000491588KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000407188ENST00000215832KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000407188ENST00000398822KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
Frame-shiftENST00000407188ENST00000544786KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
5CDS-5UTRENST00000407188ENST00000491588KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
intron-3CDSENST00000479755ENST00000215832KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
intron-3CDSENST00000479755ENST00000398822KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
intron-3CDSENST00000479755ENST00000544786KREMEN1chr22

29469215

+MAPK1chr22

22123609

-
intron-5UTRENST00000479755ENST00000491588KREMEN1chr22

29469215

+MAPK1chr22

22123609

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KREMEN1-MAPK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KREMEN1-MAPK1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KREMEN1

Q96MU8

MAPK1

Q8NDC0

FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. {ECO:0000250|UniProtKB:Q90Y90, ECO:0000250|UniProtKB:Q99N43}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KREMEN1-MAPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KREMEN1-MAPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KREMEN1-MAPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KREMEN1-MAPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKREMEN1C0036341Schizophrenia1PSYGENET
HgeneKREMEN1C4479322ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMAPK1C0009171Cocaine Abuse2CTD_human
TgeneMAPK1C0020429Hyperalgesia2CTD_human
TgeneMAPK1C0024121Lung Neoplasms2CTD_human
TgeneMAPK1C0236736Cocaine-Related Disorders2CTD_human
TgeneMAPK1C0242379Malignant neoplasm of lung2CTD_human
TgeneMAPK1C0458247Allodynia2CTD_human
TgeneMAPK1C0600427Cocaine Dependence2CTD_human
TgeneMAPK1C0751211Hyperalgesia, Primary2CTD_human
TgeneMAPK1C0751212Hyperalgesia, Secondary2CTD_human
TgeneMAPK1C0751213Tactile Allodynia2CTD_human
TgeneMAPK1C0751214Hyperalgesia, Thermal2CTD_human
TgeneMAPK1C2936719Mechanical Allodynia2CTD_human
TgeneMAPK1C0005398Cholestasis, Extrahepatic1CTD_human
TgeneMAPK1C0005586Bipolar Disorder1PSYGENET
TgeneMAPK1C0007137Squamous cell carcinoma1CTD_human
TgeneMAPK1C0007786Brain Ischemia1CTD_human
TgeneMAPK1C0017639Gliosis1CTD_human
TgeneMAPK1C0018671Head and Neck Neoplasms1CTD_human
TgeneMAPK1C0018675Head Neoplasms1CTD_human
TgeneMAPK1C0019207Hepatoma, Morris1CTD_human
TgeneMAPK1C0019208Hepatoma, Novikoff1CTD_human
TgeneMAPK1C0020564Hypertrophy1CTD_human
TgeneMAPK1C0021361Female infertility1CTD_human
TgeneMAPK1C0022665Kidney Neoplasm1CTD_human
TgeneMAPK1C0023904Liver Neoplasms, Experimental1CTD_human
TgeneMAPK1C0024623Malignant neoplasm of stomach1CTD_human
TgeneMAPK1C0027533Neck Neoplasms1CTD_human
TgeneMAPK1C0027626Neoplasm Invasiveness1CTD_human
TgeneMAPK1C0027627Neoplasm Metastasis1CTD_human
TgeneMAPK1C0027746Nerve Degeneration1CTD_human
TgeneMAPK1C0033141Cardiomyopathies, Primary1CTD_human
TgeneMAPK1C0034189Pyemia1CTD_human
TgeneMAPK1C0036341Schizophrenia1PSYGENET
TgeneMAPK1C0036529Myocardial Diseases, Secondary1CTD_human
TgeneMAPK1C0036690Septicemia1CTD_human
TgeneMAPK1C0036920Sezary Syndrome1CTD_human
TgeneMAPK1C0038279Sterility, Postpartum1CTD_human
TgeneMAPK1C0038356Stomach Neoplasms1CTD_human
TgeneMAPK1C0038587Substance Withdrawal Syndrome1CTD_human
TgeneMAPK1C0040997Trigeminal Neuralgia1CTD_human
TgeneMAPK1C0086189Drug Withdrawal Symptoms1CTD_human
TgeneMAPK1C0086404Experimental Hepatoma1CTD_human
TgeneMAPK1C0087031Juvenile-Onset Still Disease1CTD_human
TgeneMAPK1C0087169Withdrawal Symptoms1CTD_human
TgeneMAPK1C0155862Streptococcal pneumonia1CTD_human
TgeneMAPK1C0178417Anhedonia1PSYGENET
TgeneMAPK1C0243026Sepsis1CTD_human
TgeneMAPK1C0278996Malignant Head and Neck Neoplasm1CTD_human
TgeneMAPK1C0341869Subfertility, Female1CTD_human
TgeneMAPK1C0393786Trigeminal Neuralgia, Idiopathic1CTD_human
TgeneMAPK1C0393787Secondary Trigeminal Neuralgia1CTD_human
TgeneMAPK1C0740457Malignant neoplasm of kidney1CTD_human
TgeneMAPK1C0746787Cancer of Neck1CTD_human
TgeneMAPK1C0751177Cancer of Head1CTD_human
TgeneMAPK1C0878544Cardiomyopathies1CTD_human
TgeneMAPK1C0887900Upper Aerodigestive Tract Neoplasms1CTD_human
TgeneMAPK1C0917730Female sterility1CTD_human
TgeneMAPK1C0917798Cerebral Ischemia1CTD_human
TgeneMAPK1C0919267ovarian neoplasm1CTD_human
TgeneMAPK1C1140680Malignant neoplasm of ovary1CTD_human
TgeneMAPK1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneMAPK1C1719672Severe Sepsis1CTD_human
TgeneMAPK1C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
TgeneMAPK1C3495559Juvenile arthritis1CTD_human
TgeneMAPK1C3714758Juvenile psoriatic arthritis1CTD_human
TgeneMAPK1C3887640Astrocytosis1CTD_human
TgeneMAPK1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneMAPK1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human