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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KSR1-MSI2 (FusionGDB2 ID:43486)

Fusion Gene Summary for KSR1-MSI2

check button Fusion gene summary
Fusion gene informationFusion gene name: KSR1-MSI2
Fusion gene ID: 43486
HgeneTgene
Gene symbol

KSR1

MSI2

Gene ID

8844

124540

Gene namekinase suppressor of ras 1musashi RNA binding protein 2
SynonymsKSR|RSU2MSI2H
Cytomap

17q11.2

17q22

Type of geneprotein-codingprotein-coding
Descriptionkinase suppressor of Ras 1RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2
Modification date2020032720200313
UniProtAcc

Q8IVT5

Q96DH6

Ensembl transtripts involved in fusion geneENST00000509603, ENST00000319524, 
ENST00000268763, ENST00000398988, 
ENST00000581975, ENST00000582410, 
ENST00000578981, 		ENST00000416426, 
ENST00000284073, ENST00000322684, 
ENST00000442934, ENST00000579180, 
ENST00000579505, 
Fusion gene scores* DoF score10 X 9 X 6=54026 X 18 X 10=4680
# samples 1030
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4680*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KSR1 [Title/Abstract] AND MSI2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKSR1(25783900)-MSI2(55478740), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKSR1

GO:0000185

activation of MAPKKK activity

29433126


check buttonFusion gene breakpoints across KSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MSI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14V-01AKSR1chr17

25783900

+MSI2chr17

55478740

+
ChimerDB4BRCATCGA-E2-A14V-01AKSR1chr17

25783900

+MSI2chr17

55478740

+
ChimerDB4BRCATCGA-E2-A14V-01AKSR1chr17

25783900

-MSI2chr17

55478740

+


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Fusion Gene ORF analysis for KSR1-MSI2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000509603ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000509603ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000509603ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000509603ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000509603ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
5CDS-intronENST00000509603ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000319524ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000319524ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000319524ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000319524ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
In-frameENST00000319524ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
5CDS-intronENST00000319524ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000268763ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000268763ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000268763ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000268763ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000268763ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-intronENST00000268763ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000398988ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000398988ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000398988ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000398988ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000398988ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-intronENST00000398988ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000581975ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000581975ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000581975ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000581975ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000581975ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-intronENST00000581975ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000582410ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000582410ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000582410ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000582410ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000582410ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-intronENST00000582410ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000578981ENST00000416426KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000578981ENST00000284073KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000578981ENST00000322684KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000578981ENST00000442934KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-3CDSENST00000578981ENST00000579180KSR1chr17

25783900

+MSI2chr17

55478740

+
intron-intronENST00000578981ENST00000579505KSR1chr17

25783900

+MSI2chr17

55478740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509603KSR1chr1725783900+ENST00000416426MSI2chr1755478740+15642310959319
ENST00000509603KSR1chr1725783900+ENST00000284073MSI2chr1755478740+60742310905301
ENST00000509603KSR1chr1725783900+ENST00000322684MSI2chr1755478740+17562310686228
ENST00000509603KSR1chr1725783900+ENST00000442934MSI2chr1755478740+16862310905301
ENST00000509603KSR1chr1725783900+ENST00000579180MSI2chr1755478740+17612310686228
ENST00000319524KSR1chr1725783900+ENST00000416426MSI2chr1755478740+15642310959319
ENST00000319524KSR1chr1725783900+ENST00000284073MSI2chr1755478740+60742310905301
ENST00000319524KSR1chr1725783900+ENST00000322684MSI2chr1755478740+17562310686228
ENST00000319524KSR1chr1725783900+ENST00000442934MSI2chr1755478740+16862310905301
ENST00000319524KSR1chr1725783900+ENST00000579180MSI2chr1755478740+17612310686228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509603ENST00000416426KSR1chr1725783900+MSI2chr1755478740+0.0012163850.99878365
ENST00000509603ENST00000284073KSR1chr1725783900+MSI2chr1755478740+0.0001627420.9998373
ENST00000509603ENST00000322684KSR1chr1725783900+MSI2chr1755478740+0.001298190.9987018
ENST00000509603ENST00000442934KSR1chr1725783900+MSI2chr1755478740+0.0010129420.998987
ENST00000509603ENST00000579180KSR1chr1725783900+MSI2chr1755478740+0.0012438290.9987562
ENST00000319524ENST00000416426KSR1chr1725783900+MSI2chr1755478740+0.0012163850.99878365
ENST00000319524ENST00000284073KSR1chr1725783900+MSI2chr1755478740+0.0001627420.9998373
ENST00000319524ENST00000322684KSR1chr1725783900+MSI2chr1755478740+0.001298190.9987018
ENST00000319524ENST00000442934KSR1chr1725783900+MSI2chr1755478740+0.0010129420.998987
ENST00000319524ENST00000579180KSR1chr1725783900+MSI2chr1755478740+0.0012438290.9987562

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Fusion Genomic Features for KSR1-MSI2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KSR1chr1725783900+MSI2chr1755478739+1.91E-060.9999981
KSR1chr1725783900+MSI2chr1755478739+1.91E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KSR1-MSI2


check button Go to

FGviewer for the breakpoints of chr17:25783900-chr17:55478740

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KSR1

Q8IVT5

MSI2

Q96DH6

FUNCTION: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMSI2chr17:25783900chr17:55478740ENST00000284073414253_260104.01951.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:25783900chr17:55478740ENST00000322684310253_260100.0252.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:25783900chr17:55478740ENST0000057918007253_2600.0152.0Compositional biasNote=Poly-Ala
TgeneMSI2chr17:25783900chr17:55478740ENST00000284073414110_187104.01951.0DomainRRM 2
TgeneMSI2chr17:25783900chr17:55478740ENST00000322684310110_187100.0252.0DomainRRM 2
TgeneMSI2chr17:25783900chr17:55478740ENST0000057918007110_1870.0152.0DomainRRM 2
TgeneMSI2chr17:25783900chr17:55478740ENST000005791800721_1110.0152.0DomainRRM 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKSR1chr17:25783900chr17:55478740ENST00000268763+12217_210787.0Compositional biasNote=Poly-Gly
HgeneKSR1chr17:25783900chr17:55478740ENST00000268763+122289_2920787.0Compositional biasNote=Poly-Pro
HgeneKSR1chr17:25783900chr17:55478740ENST00000268763+122613_8830787.0DomainProtein kinase
HgeneKSR1chr17:25783900chr17:55478740ENST00000268763+122619_6270787.0Nucleotide bindingATP
HgeneKSR1chr17:25783900chr17:55478740ENST00000268763+1221_1720787.0RegionMediates association with membranes
HgeneKSR1chr17:25783900chr17:55478740ENST00000268763+122347_3910787.0Zinc fingerPhorbol-ester/DAG-type
TgeneMSI2chr17:25783900chr17:55478740ENST0000028407341421_111104.01951.0DomainRRM 1
TgeneMSI2chr17:25783900chr17:55478740ENST0000032268431021_111100.0252.0DomainRRM 1


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Fusion Gene Sequence for KSR1-MSI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000509603_ENST00000416426_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1564nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGTCCTGAATAGC
TACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGGCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCA
GGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGC
TTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGA
GAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGC
CTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACA
ACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCA
TTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAA
CCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGC
TGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAG

>In-frame_ENST00000509603_ENST00000416426_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=319AA_start in transcript=0_stop in transcript=959
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM
DAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSP

--------------------------------------------------------------
>In-frame_ENST00000509603_ENST00000284073_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=6074nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCG
GCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAAT
TACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATAC
CATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTG
TTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACA
TCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTT
TTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCA
GTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTT
GCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAA
TTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAA
GAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCA
ATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTTTTTTTCTGTTGAAAGAGGTGATATTATAAGGTTTTTTGA
AATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTCCATTAACTACATAGAAACTATTAAGAAAGAGAGAATCAAAAATATTTTTG
TGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAGGAGGCGGGAAGGGAACGTTGGCCAAGTCAGTTACTGAGATGAAGATCGCC
CAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTTTAGCTCCTTTGTCTGTGTGATAGACCTAAGAACTGTATTAGTGTTGTACC
AGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTACCGTCTAGTTAGATTTTTATTTAAAATATGAAAAACTGCTTTTCCCAAGA
TGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACATATTTAAAGTTTCAAAGCACACCTGTTTGGCTTGGGTGGGGGTGGGGTGGG
GGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGATCATTTTCTATTGTCCAATCATTTCAGCACCTCCAAAGGTCCCTAGGACAC
TTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCACATCTGGGGGCCCATGGGCCAGGAGTGGATAAGCCTGCATTAATACAACCT
TTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACCTTTTGGTTTATATATATTTTTTTTAATACCTCAGTGCTGCAAGTATCACC
AGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGATGTAAACAGAATTTTAAAAATAAAAAGTATAAACATCACTGCACTGTGAC
TGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTAACATTTGGCTGTTATAATATATGGTCCTCGGTTGGGGAAAGATACTTATG
ATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTGGTAATAGGTCGGCAACAGCAACTATAGAAGTACAACTCAATAGATGGCAT
TAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTTAAAATGTGATATTGACGTTTTATTAATATTTTTTAAATTGTTACGTTTAT
AAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAATGCGACATTTATTATAAAGAGCTGCTGCACTCCTATTTTTATAAATTTTA
CTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTAGGGCAAAAGCATCTTCAAACTAAAGACTCCAAAATGCTAACTCAGAAAGA
AAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAACATTTTTTTTAATTAAAAAAAAAATCATGTTCTTTGTTTTTCTAATAAAA
TGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCCTTTCTTTGTTTCTTTTCTTTTCCCCCAAACAACCAGATTAAATGCTGAGC
GCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAACAAAACATAAGTTTTATTTAAAAAAAAAAAAAGAAAGAAAAAATAGTAAAT
TCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCTATTTTGTCCATGTTGGTGATGTACTGTACTTCCCTTCCTTTTCTCTGCAT
CCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTATGTTAATAATGTATAAAATGGCTATCTTGTAAGCGTGCTGTCCTGGTACT
AGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATATTGATAGGTATAACATAATTAAGGTTTAAAAAAAATTAGACATAGTTATT
CAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTATGAAAAAAAATGCTAATAATTTTGGGGCAGTTTTTTCCTTTAATTATTTT
TTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATGTGGTTTCAACTAACCCAAGGTCTCACCATGTTAAAATGCCGGCGGACTCT
ACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAAGGGGTGCCATACTACCTTAAATGCTAATGCTAGATATGCAAAACTGGATT
TTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATTAAAATGATTTTACTAAGAGAAAAAATATTTTTTTAAGAATGCTCAGAAGA
AATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATACCTTTTGAAGAGACCCAGTAGCCCATAGCACAAATCTTGTGGAAATCCGA
TATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTAGTCCCCCCATTCCATCTAGAAGTCCATTTTGAAAGATTTTTGTAAATTCT
TTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAAGCTCAATGGCGAACATGGGAACCACCTTTCGCCTTCCCTGGGGGAGAAAC
CCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGCCACCGGGTGACTTTCTGGCTTCCAGATCCATCTGCCTGAGACCCCCGAAC
TCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCTCCCGGACCCATTCCCGGTCCTAGCTGGGCATGGGGCTGACGGAGATGACC
AAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGCTCGTGGCCTTCCTTATATCCACTGGGAACAAACAGCCTCGCGCTCTATAC
CAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTGATTCAAACAAAGCCCCAGCAGGCCTTTGCGTTTTTATCCTTCATAACCTT
CATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCATGGCTCTATTGCTGTCAATTTACTGTTTCACTGCACAGCAATCACAGCCA
GTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATCATTGGGTAATTGTTGGTTCTAATGACCTGAAAGGTGTTCAGTTTTTGTTC
TTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTTGCTTGTTGTTCCTTTTCATTTGGGGGTTTTTGGGGAAAAAATTTATTTTT
GGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGTGCAAACGAGGGCTAGGGACTTAGCCTCCTCCACCACCTCCACACTGCTTC
ATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAGCAATATCGTTTACTACATTTTTTATTGAAGGTCAGCCATGCTTTCTGTAT
TATATTGCATATGAAATTGTTTACAAAAGAAACACTAACTCATACTTCTCTTTATTGGTTGCAAGTGGCACGCAGGAACAGAGGGAGAGT
GGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTCTTGAATGTGCTTCGCAAGCCAGGCTATCTTCCAAGGAAGGCAGACAGTGG
GAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAAAGACACTGGCGGGTTTCCCCACCCTCACCCCAAAGCAGAAAACTAGCAGA
CGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAGGAGACGCTGGAAGTTAAGCAATACTTTAATACTGTAATATGTTTGTTTTC
TTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAACTAAAACACAAAAACATATAAATAAAATCCATCCCTCTTGTCGGGGACCT
GCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAATAATCAGAATGTATTGTCTCAGACAGGATTTCAGTTCCGGGAGGCAGGGGC
ATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTCCAGAGCCTCCCTCGAAGGTTCTCTACTACTGTATTCTGTACATAATGTAC
CATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGTGGGCTAGCCAATCTGCCGTTCATGGTGTATTGTAAACTCCGAATTCCATA
TGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAAATGTATCTAAATAAAACTTTCCCTAGCACTGTGGCTGACCTCACCCTTAC
TTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGTGAGTATTTTTTTTATATATATACATATATATGTACTATCTATATATATAT
CTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAAGCCCTGTTGTAAAAAATTACTATGTGGATGGCAGTCTCTCACATCACAGA
TGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAATAAGTTTGTGAAAGGTTTCCATCCTCTACTGTGGTCCAGAAATCAATGTGT

>In-frame_ENST00000509603_ENST00000284073_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=301AA_start in transcript=0_stop in transcript=905
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM
DAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGN

--------------------------------------------------------------
>In-frame_ENST00000509603_ENST00000322684_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1756nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGC
TACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTT
TGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCT
CCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAG
CCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTT
GAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGA
CAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGG
CTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGA
TCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGG
AACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACT
TCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGT
GCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAG

>In-frame_ENST00000509603_ENST00000322684_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=228AA_start in transcript=0_stop in transcript=686
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM

--------------------------------------------------------------
>In-frame_ENST00000509603_ENST00000442934_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1686nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCG
GCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAAT
TACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATAC
CATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTG
TTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACA
TCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTT
TTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCA
GTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTT
GCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAA
TTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAA
GAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCA

>In-frame_ENST00000509603_ENST00000442934_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=301AA_start in transcript=0_stop in transcript=905
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM
DAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGN

--------------------------------------------------------------
>In-frame_ENST00000509603_ENST00000579180_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1761nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGC
TACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTT
TGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCT
CCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAG
CCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTT
GAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGA
CAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGG
CTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGA
TCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGG
AACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACT
TCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGT
GCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAG

>In-frame_ENST00000509603_ENST00000579180_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=228AA_start in transcript=0_stop in transcript=686
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM

--------------------------------------------------------------
>In-frame_ENST00000319524_ENST00000416426_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1564nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGTCCTGAATAGC
TACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGGCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCA
GGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGC
TTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGA
GAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGC
CTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACA
ACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCA
TTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAA
CCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGC
TGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAG

>In-frame_ENST00000319524_ENST00000416426_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=319AA_start in transcript=0_stop in transcript=959
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM
DAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSP

--------------------------------------------------------------
>In-frame_ENST00000319524_ENST00000284073_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=6074nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCG
GCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAAT
TACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATAC
CATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTG
TTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACA
TCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTT
TTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCA
GTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTT
GCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAA
TTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAA
GAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCA
ATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTTTTTTTCTGTTGAAAGAGGTGATATTATAAGGTTTTTTGA
AATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTCCATTAACTACATAGAAACTATTAAGAAAGAGAGAATCAAAAATATTTTTG
TGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAGGAGGCGGGAAGGGAACGTTGGCCAAGTCAGTTACTGAGATGAAGATCGCC
CAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTTTAGCTCCTTTGTCTGTGTGATAGACCTAAGAACTGTATTAGTGTTGTACC
AGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTACCGTCTAGTTAGATTTTTATTTAAAATATGAAAAACTGCTTTTCCCAAGA
TGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACATATTTAAAGTTTCAAAGCACACCTGTTTGGCTTGGGTGGGGGTGGGGTGGG
GGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGATCATTTTCTATTGTCCAATCATTTCAGCACCTCCAAAGGTCCCTAGGACAC
TTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCACATCTGGGGGCCCATGGGCCAGGAGTGGATAAGCCTGCATTAATACAACCT
TTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACCTTTTGGTTTATATATATTTTTTTTAATACCTCAGTGCTGCAAGTATCACC
AGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGATGTAAACAGAATTTTAAAAATAAAAAGTATAAACATCACTGCACTGTGAC
TGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTAACATTTGGCTGTTATAATATATGGTCCTCGGTTGGGGAAAGATACTTATG
ATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTGGTAATAGGTCGGCAACAGCAACTATAGAAGTACAACTCAATAGATGGCAT
TAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTTAAAATGTGATATTGACGTTTTATTAATATTTTTTAAATTGTTACGTTTAT
AAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAATGCGACATTTATTATAAAGAGCTGCTGCACTCCTATTTTTATAAATTTTA
CTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTAGGGCAAAAGCATCTTCAAACTAAAGACTCCAAAATGCTAACTCAGAAAGA
AAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAACATTTTTTTTAATTAAAAAAAAAATCATGTTCTTTGTTTTTCTAATAAAA
TGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCCTTTCTTTGTTTCTTTTCTTTTCCCCCAAACAACCAGATTAAATGCTGAGC
GCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAACAAAACATAAGTTTTATTTAAAAAAAAAAAAAGAAAGAAAAAATAGTAAAT
TCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCTATTTTGTCCATGTTGGTGATGTACTGTACTTCCCTTCCTTTTCTCTGCAT
CCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTATGTTAATAATGTATAAAATGGCTATCTTGTAAGCGTGCTGTCCTGGTACT
AGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATATTGATAGGTATAACATAATTAAGGTTTAAAAAAAATTAGACATAGTTATT
CAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTATGAAAAAAAATGCTAATAATTTTGGGGCAGTTTTTTCCTTTAATTATTTT
TTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATGTGGTTTCAACTAACCCAAGGTCTCACCATGTTAAAATGCCGGCGGACTCT
ACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAAGGGGTGCCATACTACCTTAAATGCTAATGCTAGATATGCAAAACTGGATT
TTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATTAAAATGATTTTACTAAGAGAAAAAATATTTTTTTAAGAATGCTCAGAAGA
AATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATACCTTTTGAAGAGACCCAGTAGCCCATAGCACAAATCTTGTGGAAATCCGA
TATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTAGTCCCCCCATTCCATCTAGAAGTCCATTTTGAAAGATTTTTGTAAATTCT
TTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAAGCTCAATGGCGAACATGGGAACCACCTTTCGCCTTCCCTGGGGGAGAAAC
CCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGCCACCGGGTGACTTTCTGGCTTCCAGATCCATCTGCCTGAGACCCCCGAAC
TCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCTCCCGGACCCATTCCCGGTCCTAGCTGGGCATGGGGCTGACGGAGATGACC
AAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGCTCGTGGCCTTCCTTATATCCACTGGGAACAAACAGCCTCGCGCTCTATAC
CAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTGATTCAAACAAAGCCCCAGCAGGCCTTTGCGTTTTTATCCTTCATAACCTT
CATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCATGGCTCTATTGCTGTCAATTTACTGTTTCACTGCACAGCAATCACAGCCA
GTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATCATTGGGTAATTGTTGGTTCTAATGACCTGAAAGGTGTTCAGTTTTTGTTC
TTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTTGCTTGTTGTTCCTTTTCATTTGGGGGTTTTTGGGGAAAAAATTTATTTTT
GGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGTGCAAACGAGGGCTAGGGACTTAGCCTCCTCCACCACCTCCACACTGCTTC
ATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAGCAATATCGTTTACTACATTTTTTATTGAAGGTCAGCCATGCTTTCTGTAT
TATATTGCATATGAAATTGTTTACAAAAGAAACACTAACTCATACTTCTCTTTATTGGTTGCAAGTGGCACGCAGGAACAGAGGGAGAGT
GGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTCTTGAATGTGCTTCGCAAGCCAGGCTATCTTCCAAGGAAGGCAGACAGTGG
GAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAAAGACACTGGCGGGTTTCCCCACCCTCACCCCAAAGCAGAAAACTAGCAGA
CGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAGGAGACGCTGGAAGTTAAGCAATACTTTAATACTGTAATATGTTTGTTTTC
TTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAACTAAAACACAAAAACATATAAATAAAATCCATCCCTCTTGTCGGGGACCT
GCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAATAATCAGAATGTATTGTCTCAGACAGGATTTCAGTTCCGGGAGGCAGGGGC
ATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTCCAGAGCCTCCCTCGAAGGTTCTCTACTACTGTATTCTGTACATAATGTAC
CATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGTGGGCTAGCCAATCTGCCGTTCATGGTGTATTGTAAACTCCGAATTCCATA
TGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAAATGTATCTAAATAAAACTTTCCCTAGCACTGTGGCTGACCTCACCCTTAC
TTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGTGAGTATTTTTTTTATATATATACATATATATGTACTATCTATATATATAT
CTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAAGCCCTGTTGTAAAAAATTACTATGTGGATGGCAGTCTCTCACATCACAGA
TGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAATAAGTTTGTGAAAGGTTTCCATCCTCTACTGTGGTCCAGAAATCAATGTGT

>In-frame_ENST00000319524_ENST00000284073_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=301AA_start in transcript=0_stop in transcript=905
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM
DAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGN

--------------------------------------------------------------
>In-frame_ENST00000319524_ENST00000322684_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1756nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGC
TACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTT
TGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCT
CCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAG
CCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTT
GAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGA
CAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGG
CTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGA
TCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGG
AACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACT
TCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGT
GCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAG

>In-frame_ENST00000319524_ENST00000322684_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=228AA_start in transcript=0_stop in transcript=686
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM

--------------------------------------------------------------
>In-frame_ENST00000319524_ENST00000442934_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1686nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCG
GCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAAT
TACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATAC
CATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTG
TTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACA
TCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTT
TTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCA
GTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTT
GCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAA
TTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTTGTAGAA
GAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTTTCGGCA

>In-frame_ENST00000319524_ENST00000442934_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=301AA_start in transcript=0_stop in transcript=905
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM
DAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGN

--------------------------------------------------------------
>In-frame_ENST00000319524_ENST00000579180_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(transcript)=1761nt_BP=231nt
ATGGATAGAGCAGCGCTGCGCGCGGCGGCGATGGGAGAGAAGAAGGAGGGCGGTGGCGGGGGGGATGCGGCGGCCGCGGAGGGAGGCGCA
GGGGCCGCGGCCAGCCGGGCGCTGCAGCAGTGCGGGCAGCTCCAGAAGCTCATCGACATCTCCATCGGCAGCCTGCGCGGGCTGCGCACC
AAGTGCGCTGTGTCCAACGACCTCACCCAGCAGGAGATACGGACCCTGGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA
TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACC
AACAGGCACAGAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATCAATAAT
AAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTACACCATG
GACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGCTAT
GGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGGGGTTGC
TACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTGCCTGTT
TGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAGTCCCCT
CCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTCGTAGAG
CCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTGAGCTTT
GAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACACAGAGA
CAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGCCAGTGG
CTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGGCACCGA
TCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGGGGGTGG
AACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGCTTGACT
TCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTTGTCTGT
GCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTCCTTGAG

>In-frame_ENST00000319524_ENST00000579180_TCGA-E2-A14V-01A_KSR1_chr17_25783900_+_MSI2_chr17_55478740_length(amino acids)=228AA_start in transcript=0_stop in transcript=686
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEMVTRTKKIFVGGL
SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KSR1-MSI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KSR1-MSI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KSR1-MSI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource