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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KYNU-KYNU (FusionGDB2 ID:43539)

Fusion Gene Summary for KYNU-KYNU

check button Fusion gene summary
Fusion gene informationFusion gene name: KYNU-KYNU
Fusion gene ID: 43539
HgeneTgene
Gene symbol

KYNU

KYNU

Gene ID

8942

8942

Gene namekynureninasekynureninase
SynonymsKYNUU|VCRL2KYNUU|VCRL2
Cytomap

2q22.2

2q22.2

Type of geneprotein-codingprotein-coding
DescriptionkynureninaseL-kynurenine hydrolasekynureninaseL-kynurenine hydrolase
Modification date2020031320200313
UniProtAcc.

CCBL1

Ensembl transtripts involved in fusion geneENST00000264170, ENST00000375773, 
ENST00000409512, ENST00000410015, 
ENST00000264170, ENST00000375773, 
ENST00000409512, ENST00000410015, 
Fusion gene scores* DoF score4 X 5 X 2=407 X 7 X 6=294
# samples 510
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KYNU [Title/Abstract] AND KYNU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKYNU(143743591)-KYNU(143712379), # samples:1
KYNU(143746830)-KYNU(143746729), # samples:1
Anticipated loss of major functional domain due to fusion event.KYNU-KYNU seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KYNU-KYNU seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKYNU

GO:0019805

quinolinate biosynthetic process

9291104

HgeneKYNU

GO:0034341

response to interferon-gamma

9291104

HgeneKYNU

GO:0043420

anthranilate metabolic process

11985583

TgeneKYNU

GO:0019805

quinolinate biosynthetic process

9291104

TgeneKYNU

GO:0034341

response to interferon-gamma

9291104

TgeneKYNU

GO:0043420

anthranilate metabolic process

11985583


check buttonFusion gene breakpoints across KYNU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KYNU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF907726KYNUchr2

143743591

+KYNUchr2

143712379

+
ChiTaRS5.0N/ACB851853KYNUchr2

143746830

-KYNUchr2

143746729

+


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Fusion Gene ORF analysis for KYNU-KYNU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264170ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000264170ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000264170ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
5CDS-intronENST00000264170ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000375773ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000375773ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000375773ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
5CDS-intronENST00000375773ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000409512ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000409512ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000409512ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
5CDS-intronENST00000409512ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-3CDSENST00000410015ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-3CDSENST00000410015ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-3CDSENST00000410015ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-intronENST00000410015ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-intronENST00000264170ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000264170ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000264170ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000264170ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KYNU-KYNU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KYNUchr2143743590+KYNUchr2143712378+0.0042838370.99571615
KYNUchr2143743590+KYNUchr2143712378+0.0042838370.99571615

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KYNU-KYNU


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KYNU

CCBL1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.422

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KYNU-KYNU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KYNU-KYNU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KYNU-KYNU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KYNU-KYNU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKYNUC0268474Hydroxykynureninuria2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneKYNUC0000772Multiple congenital anomalies1GENOMICS_ENGLAND
HgeneKYNUC0021368Inflammation1CTD_human
HgeneKYNUC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneKYNUC0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneKYNUC0524851Neurodegenerative Disorders1CTD_human
HgeneKYNUC0751733Degenerative Diseases, Spinal Cord1CTD_human
HgeneKYNUC1302790Congenital malformation syndrome1GENOMICS_ENGLAND
HgeneKYNUC4540004VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 11ORPHANET
HgeneKYNUC4540014VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 21GENOMICS_ENGLAND;ORPHANET
TgeneKYNUC0268474Hydroxykynureninuria2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneKYNUC0000772Multiple congenital anomalies1GENOMICS_ENGLAND
TgeneKYNUC0021368Inflammation1CTD_human
TgeneKYNUC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneKYNUC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneKYNUC0524851Neurodegenerative Disorders1CTD_human
TgeneKYNUC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneKYNUC1302790Congenital malformation syndrome1GENOMICS_ENGLAND
TgeneKYNUC4540004VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 11ORPHANET
TgeneKYNUC4540014VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 21GENOMICS_ENGLAND;ORPHANET