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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:LAMA2-NUP107 (FusionGDB2 ID:43618) |
Fusion Gene Summary for LAMA2-NUP107 |
Fusion gene summary |
Fusion gene information | Fusion gene name: LAMA2-NUP107 | Fusion gene ID: 43618 | Hgene | Tgene | Gene symbol | LAMA2 | NUP107 | Gene ID | 3908 | 57122 |
Gene name | laminin subunit alpha 2 | nucleoporin 107 | |
Synonyms | LAMM|MDC1A | NPHS11|NUP84|ODG6|ODG6; GAMOS7 | |
Cytomap | 6q22.33 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | laminin subunit alpha-2laminin M chainlaminin, alpha 2laminin-12 subunit alphalaminin-2 subunit alphalaminin-4 subunit alphamerosin heavy chainmutant laminin subunit alpha 2 | nuclear pore complex protein Nup107nucleoporin 107kDa | |
Modification date | 20200328 | 20200313 | |
UniProtAcc | P24043 | P57740 | |
Ensembl transtripts involved in fusion gene | ENST00000421865, ENST00000498257, | ENST00000229179, ENST00000378905, ENST00000539906, ENST00000401003, | |
Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 27 X 22 X 9=5346 |
# samples | 9 | 37 | |
** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/5346*10)=-3.85286266172677 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LAMA2 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | LAMA2(129641800)-NUP107(69135593), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NUP107 | GO:0006406 | mRNA export from nucleus | 11684705 |
Fusion gene breakpoints across LAMA2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across NUP107 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-3B-A9HS-01A | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
ChimerDB4 | SARC | TCGA-3B-A9HS-01A | LAMA2 | chr6 | 129641800 | - | NUP107 | chr12 | 69135593 | + |
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Fusion Gene ORF analysis for LAMA2-NUP107 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000421865 | ENST00000229179 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
In-frame | ENST00000421865 | ENST00000378905 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
In-frame | ENST00000421865 | ENST00000539906 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
5CDS-intron | ENST00000421865 | ENST00000401003 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
intron-3CDS | ENST00000498257 | ENST00000229179 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
intron-3CDS | ENST00000498257 | ENST00000378905 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
intron-3CDS | ENST00000498257 | ENST00000539906 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
intron-intron | ENST00000498257 | ENST00000401003 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000421865 | LAMA2 | chr6 | 129641800 | + | ENST00000229179 | NUP107 | chr12 | 69135593 | + | 5044 | 4225 | 49 | 4500 | 1483 |
ENST00000421865 | LAMA2 | chr6 | 129641800 | + | ENST00000378905 | NUP107 | chr12 | 69135593 | + | 4722 | 4225 | 49 | 4500 | 1483 |
ENST00000421865 | LAMA2 | chr6 | 129641800 | + | ENST00000539906 | NUP107 | chr12 | 69135593 | + | 4570 | 4225 | 49 | 4500 | 1483 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000421865 | ENST00000229179 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + | 0.000163705 | 0.9998363 |
ENST00000421865 | ENST00000378905 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + | 0.000219675 | 0.99978036 |
ENST00000421865 | ENST00000539906 | LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135593 | + | 0.000273111 | 0.99972683 |
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Fusion Genomic Features for LAMA2-NUP107 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135592 | + | 2.99E-05 | 0.9999702 |
LAMA2 | chr6 | 129641800 | + | NUP107 | chr12 | 69135592 | + | 2.99E-05 | 0.9999702 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LAMA2-NUP107 |
Go to FGviewer for the breakpoints of chr6:129641800-chr12:69135593 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LAMA2 | NUP107 |
FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1014_1059 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 11 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1060_1105 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 12 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1106_1165 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 13 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1166_1175 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 14%3B first part |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1176_1379 | 1392.0 | 3123.0 | Domain | Laminin IV type A 2 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 287_343 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 1 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 344_413 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 2 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 35_286 | 1392.0 | 3123.0 | Domain | Laminin N-terminal |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 414_468 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 3 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 469_517 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 4 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 518_527 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 5%3B first part |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 531_723 | 1392.0 | 3123.0 | Domain | Laminin IV type A 1 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 724_756 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 5%3B second part |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 757_806 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 6 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 807_864 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 7 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 865_917 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 8 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 918_966 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 9 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 967_1013 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 10 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1630_2150 | 1392.0 | 3123.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1380_1419 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 14%3B second part |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1420_1468 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 15 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1469_1526 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 16 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1527_1573 | 1392.0 | 3123.0 | Domain | Laminin EGF-like 17 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 2145_2328 | 1392.0 | 3123.0 | Domain | Laminin G-like 1 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 2340_2521 | 1392.0 | 3123.0 | Domain | Laminin G-like 2 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 2526_2710 | 1392.0 | 3123.0 | Domain | Laminin G-like 3 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 2763_2934 | 1392.0 | 3123.0 | Domain | Laminin G-like 4 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 2939_3110 | 1392.0 | 3123.0 | Domain | Laminin G-like 5 |
Hgene | LAMA2 | chr6:129641800 | chr12:69135593 | ENST00000421865 | + | 28 | 65 | 1574_2144 | 1392.0 | 3123.0 | Region | Note=Domain II and I |
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Fusion Gene Sequence for LAMA2-NUP107 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000421865_ENST00000229179_TCGA-3B-A9HS-01A_LAMA2_chr6_129641800_+_NUP107_chr12_69135593_length(transcript)=5044nt_BP=4225nt CAGCGACTCCTCTGGCTCCCGAGAAGTGGATCCGGTCGCGGCCACTACGATGCCGGGAGCCGCCGGGGTCCTCCTCCTTCTGCTGCTCTC CGGAGGCCTCGGGGGCGTACAGGCGCAGCGGCCGCAGCAGCAGCGGCAGTCACAGGCACATCAGCAAAGAGGTTTATTCCCTGCTGTCCT GAATCTTGCTTCTAATGCTCTTATCACGACCAATGCAACATGTGGAGAAAAAGGACCTGAAATGTACTGCAAATTGGTAGAACATGTCCC TGGGCAGCCTGTGAGGAACCCGCAGTGTCGAATCTGCAATCAAAACAGCAGCAATCCAAACCAGAGACACCCGATTACAAATGCTATTGA TGGAAAGAACACTTGGTGGCAGAGTCCCAGTATTAAGAATGGAATCGAATACCATTATGTGACAATTACCCTGGATTTACAGCAGGTGTT CCAGATCGCGTATGTGATTGTGAAGGCAGCTAACTCCCCCCGGCCTGGAAACTGGATTTTGGAACGCTCTCTTGATGATGTTGAATACAA GCCCTGGCAGTATCATGCTGTGACAGACACGGAGTGCCTAACGCTTTACAATATTTATCCCCGCACTGGGCCACCGTCATATGCCAAAGA TGATGAGGTCATCTGCACTTCATTTTACTCCAAGATACACCCCTTAGAAAATGGAGAGATTCACATCTCTTTAATCAATGGGAGACCAAG TGCCGATGATCCTTCTCCAGAACTGCTAGAATTTACCTCCGCTCGCTATATTCGCCTGAGATTTCAGAGGATCCGCACACTGAATGCTGA CTTGATGATGTTTGCTCACAAAGACCCAAGAGAAATTGACCCCATTGTCACCAGAAGATATTACTACTCGGTCAAGGATATTTCAGTTGG AGGGATGTGCATCTGCTATGGTCATGCCAGGGCTTGTCCACTTGATCCAGCGACAAATAAATCTCGCTGTGAGTGTGAGCATAACACATG TGGCGATAGCTGTGATCAGTGCTGTCCAGGATTCCATCAGAAACCCTGGAGAGCTGGAACTTTTCTAACTAAAACTGAATGTGAAGCATG CAATTGTCATGGAAAAGCTGAAGAATGCTATTATGATGAAAATGTTGCCAGAAGAAATCTGAGTTTGAATATACGTGGAAAGTACATTGG AGGGGGTGTCTGCATTAATTGTACCCAAAACACTGCTGGTATAAACTGCGAGACATGTACTGATGGCTTCTTCAGACCCAAAGGGGTATC TCCAAATTATCCAAGGCCATGCCAGCCATGTCATTGCGATCCAATTGGTTCCTTAAATGAAGTCTGTGTCAAGGATGAGAAACATGCTCG ACGAGGTTTGGCACCTGGATCCTGTCATTGCAAAACTGGTTTTGGAGGTGTGAGCTGTGATCGGTGTGCCAGGGGCTACACTGGCTACCC GGACTGCAAAGCCTGTAACTGCAGTGGGTTAGGGAGCAAAAATGAGGATCCTTGTTTTGGCCCCTGTATCTGCAAGGAAAATGTTGAAGG AGGAGACTGTAGTCGTTGCAAATCCGGCTTCTTCAATTTGCAAGAGGATAATTGGAAAGGCTGCGATGAGTGTTTCTGTTCAGGGGTTTC AAACAGATGTCAGAGTTCCTACTGGACCTATGGCAAAATACAAGATATGAGTGGCTGGTATCTGACTGACCTTCCTGGCCGCATTCGAGT GGCTCCCCAGCAGGACGACTTGGACTCACCTCAGCAGATCAGCATCAGTAACGCGGAGGCCCGGCAAGCCCTGCCGCACAGCTACTACTG GAGCGCGCCGGCTCCCTATCTGGGAAACAAACTCCCAGCAGTAGGAGGACAGTTGACATTTACCATATCATATGACCTTGAAGAAGAGGA AGAAGATACAGAACGTGTTCTCCAGCTTATGATTATCTTAGAGGGTAATGACTTGAGCATCAGCACAGCCCAAGATGAGGTGTACCTGCA CCCATCTGAAGAACATACTAATGTATTGTTACTTAAAGAAGAATCATTTACCATACATGGCACACATTTTCCAGTCCGTAGAAAGGAATT TATGACAGTGCTTGCGAATTTGAAGAGAGTCCTCCTACAAATCACATACAGCTTTGGGATGGATGCCATCTTCAGGTTGAGCTCTGTTAA CCTTGAATCCGCTGTCTCCTATCCTACTGATGGAAGCATTGCAGCAGCTGTAGAAGTGTGTCAGTGCCCACCAGGGTATACTGGCTCCTC TTGTGAATCTTGTTGGCCTAGGCACAGGCGAGTTAACGGCACTATTTTTGGTGGCATCTGTGAGCCATGTCAGTGCTTTGGTCATGCGGA GTCCTGTGATGACGTCACTGGAGAATGCCTGAACTGTAAGGATCACACAGGTGGCCCATATTGTGATAAATGTCTTCCTGGTTTCTATGG CGAGCCTACTAAAGGAACCTCTGAAGACTGTCAACCCTGTGCCTGTCCACTCAATATCCCATCCAATAACTTTAGCCCAACGTGCCATTT AGACCGGAGTCTTGGATTGATCTGTGATGGATGCCCTGTCGGGTACACAGGACCACGCTGTGAGAGGTGTGCAGAAGGCTATTTTGGACA ACCCTCTGTACCTGGAGGATCATGTCAGCCATGCCAATGCAATGACAACCTTGACTTCTCCATCCCTGGCAGCTGTGACAGCTTGTCTGG CTCCTGTCTGATATGTAAACCAGGTACAACAGGCCGGTACTGTGAGCTCTGTGCTGATGGATATTTTGGAGATGCAGTTGATGCGAAGAA CTGTCAGCCCTGTCGCTGTAATGCCGGTGGCTCTTTCTCTGAGGTTTGCCACAGTCAAACTGGACAGTGTGAGTGCAGAGCCAACGTTCA GGGTCAGAGATGTGACAAATGCAAGGCTGGGACCTTTGGCCTACAATCAGCAAGGGGCTGTGTTCCCTGCAACTGCAATTCTTTTGGGTC TAAGTCATTCGACTGTGAAGAGAGTGGACAATGTTGGTGCCAACCTGGAGTCACAGGGAAGAAATGTGACCGCTGTGCCCACGGCTATTT CAACTTCCAAGAAGGAGGCTGCACAGCTTGTGAATGTTCTCATCTGGGTAATAATTGTGACCCAAAGACTGGGCGATGCATTTGCCCTCC CAATACCATTGGAGAGAAATGTTCTAAATGTGCACCCAATACCTGGGGCCACAGCATTACCACTGGTTGTAAGGCTTGTAACTGCAGCAC AGTGGGATCCTTGGATTTCCAATGCAATGTAAATACAGGCCAATGCAACTGTCATCCAAAATTCTCTGGTGCAAAATGTACAGAGTGCAG TCGAGGTCACTGGAACTACCCTCGCTGCAATCTCTGTGACTGCTTCCTCCCTGGGACAGATGCCACAACCTGTGATTCAGAGACTAAAAA ATGCTCCTGTAGTGATCAAACTGGGCAGTGCACTTGTAAGGTGAATGTGGAAGGCATCCACTGTGACAGATGCCGGCCTGGCAAATTCGG ACTCGATGCCAAGAATCCACTTGGCTGCAGCAGCTGCTATTGCTTCGGCACTACTACCCAGTGCTCTGAAGCAAAAGGACTGATCCGGAC GTGGGTGACTCTGAAGGCTGAGCAGACCATTCTACCCCTGGTAGATGAGGCTCTGCAGCACACGACCACCAAGGGCATTGTTTTTCAACA TCCAGAGATTGTTGCCCACATGGACCTGATGAGAGAAGATCTCCATTTGGAACCTTTTTATTGGAAACTTCCAGAACAATTTGAAGGAAA GAAGTTGATGGCCTATGGGGGCAAACTCAAGTATGCAATCTATTTCGAGGCTCGGGAAGAAACAGGTTTCTCTACATATAATCCTCAAGT GATCATTCGAGGTGGGACACCTACTCATGCTAGAATTATCGTCAGGCATATGGCTGCTCCTCTGATTGGCCAATTGACAAGGCATGAAAT TGAAATGACAGAGAAAGAATGGAAATATTATGGGGATGATCCTCGAGTCCATAGAACTGTGACCCGAGAAGACTTCTTGGATATACTATA TGATATTCATTACATTCTTATCAAAGCTACTTATGGAAATTTCATGCGACAAAGCAGGATTTCTGAAATCTCAATGGAGGTAGCTGAACA AGGACGTGGAACAACAATGACTCCTCCAGCTGACTTGATTGAAAAATGTGATTGTCCCCTGGGCTATTCTGGCCTGTCCTGTGAGGATGC CAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCA CAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGA GCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATA GTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTAC CATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTG CTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTT TCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTAC GTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCT ATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAGCAAACTTCCTATCAAAATAAGAGCATATAAAGACTTAGCG >In-frame_ENST00000421865_ENST00000229179_TCGA-3B-A9HS-01A_LAMA2_chr6_129641800_+_NUP107_chr12_69135593_length(amino acids)=1483AA_start in transcript=49_stop in transcript=4500 MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNS SNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIV TRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGG VSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGN DLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACP LNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPG VTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFG TTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMR QSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVS -------------------------------------------------------------- >In-frame_ENST00000421865_ENST00000378905_TCGA-3B-A9HS-01A_LAMA2_chr6_129641800_+_NUP107_chr12_69135593_length(transcript)=4722nt_BP=4225nt CAGCGACTCCTCTGGCTCCCGAGAAGTGGATCCGGTCGCGGCCACTACGATGCCGGGAGCCGCCGGGGTCCTCCTCCTTCTGCTGCTCTC CGGAGGCCTCGGGGGCGTACAGGCGCAGCGGCCGCAGCAGCAGCGGCAGTCACAGGCACATCAGCAAAGAGGTTTATTCCCTGCTGTCCT GAATCTTGCTTCTAATGCTCTTATCACGACCAATGCAACATGTGGAGAAAAAGGACCTGAAATGTACTGCAAATTGGTAGAACATGTCCC TGGGCAGCCTGTGAGGAACCCGCAGTGTCGAATCTGCAATCAAAACAGCAGCAATCCAAACCAGAGACACCCGATTACAAATGCTATTGA TGGAAAGAACACTTGGTGGCAGAGTCCCAGTATTAAGAATGGAATCGAATACCATTATGTGACAATTACCCTGGATTTACAGCAGGTGTT CCAGATCGCGTATGTGATTGTGAAGGCAGCTAACTCCCCCCGGCCTGGAAACTGGATTTTGGAACGCTCTCTTGATGATGTTGAATACAA GCCCTGGCAGTATCATGCTGTGACAGACACGGAGTGCCTAACGCTTTACAATATTTATCCCCGCACTGGGCCACCGTCATATGCCAAAGA TGATGAGGTCATCTGCACTTCATTTTACTCCAAGATACACCCCTTAGAAAATGGAGAGATTCACATCTCTTTAATCAATGGGAGACCAAG TGCCGATGATCCTTCTCCAGAACTGCTAGAATTTACCTCCGCTCGCTATATTCGCCTGAGATTTCAGAGGATCCGCACACTGAATGCTGA CTTGATGATGTTTGCTCACAAAGACCCAAGAGAAATTGACCCCATTGTCACCAGAAGATATTACTACTCGGTCAAGGATATTTCAGTTGG AGGGATGTGCATCTGCTATGGTCATGCCAGGGCTTGTCCACTTGATCCAGCGACAAATAAATCTCGCTGTGAGTGTGAGCATAACACATG TGGCGATAGCTGTGATCAGTGCTGTCCAGGATTCCATCAGAAACCCTGGAGAGCTGGAACTTTTCTAACTAAAACTGAATGTGAAGCATG CAATTGTCATGGAAAAGCTGAAGAATGCTATTATGATGAAAATGTTGCCAGAAGAAATCTGAGTTTGAATATACGTGGAAAGTACATTGG AGGGGGTGTCTGCATTAATTGTACCCAAAACACTGCTGGTATAAACTGCGAGACATGTACTGATGGCTTCTTCAGACCCAAAGGGGTATC TCCAAATTATCCAAGGCCATGCCAGCCATGTCATTGCGATCCAATTGGTTCCTTAAATGAAGTCTGTGTCAAGGATGAGAAACATGCTCG ACGAGGTTTGGCACCTGGATCCTGTCATTGCAAAACTGGTTTTGGAGGTGTGAGCTGTGATCGGTGTGCCAGGGGCTACACTGGCTACCC GGACTGCAAAGCCTGTAACTGCAGTGGGTTAGGGAGCAAAAATGAGGATCCTTGTTTTGGCCCCTGTATCTGCAAGGAAAATGTTGAAGG AGGAGACTGTAGTCGTTGCAAATCCGGCTTCTTCAATTTGCAAGAGGATAATTGGAAAGGCTGCGATGAGTGTTTCTGTTCAGGGGTTTC AAACAGATGTCAGAGTTCCTACTGGACCTATGGCAAAATACAAGATATGAGTGGCTGGTATCTGACTGACCTTCCTGGCCGCATTCGAGT GGCTCCCCAGCAGGACGACTTGGACTCACCTCAGCAGATCAGCATCAGTAACGCGGAGGCCCGGCAAGCCCTGCCGCACAGCTACTACTG GAGCGCGCCGGCTCCCTATCTGGGAAACAAACTCCCAGCAGTAGGAGGACAGTTGACATTTACCATATCATATGACCTTGAAGAAGAGGA AGAAGATACAGAACGTGTTCTCCAGCTTATGATTATCTTAGAGGGTAATGACTTGAGCATCAGCACAGCCCAAGATGAGGTGTACCTGCA CCCATCTGAAGAACATACTAATGTATTGTTACTTAAAGAAGAATCATTTACCATACATGGCACACATTTTCCAGTCCGTAGAAAGGAATT TATGACAGTGCTTGCGAATTTGAAGAGAGTCCTCCTACAAATCACATACAGCTTTGGGATGGATGCCATCTTCAGGTTGAGCTCTGTTAA CCTTGAATCCGCTGTCTCCTATCCTACTGATGGAAGCATTGCAGCAGCTGTAGAAGTGTGTCAGTGCCCACCAGGGTATACTGGCTCCTC TTGTGAATCTTGTTGGCCTAGGCACAGGCGAGTTAACGGCACTATTTTTGGTGGCATCTGTGAGCCATGTCAGTGCTTTGGTCATGCGGA GTCCTGTGATGACGTCACTGGAGAATGCCTGAACTGTAAGGATCACACAGGTGGCCCATATTGTGATAAATGTCTTCCTGGTTTCTATGG CGAGCCTACTAAAGGAACCTCTGAAGACTGTCAACCCTGTGCCTGTCCACTCAATATCCCATCCAATAACTTTAGCCCAACGTGCCATTT AGACCGGAGTCTTGGATTGATCTGTGATGGATGCCCTGTCGGGTACACAGGACCACGCTGTGAGAGGTGTGCAGAAGGCTATTTTGGACA ACCCTCTGTACCTGGAGGATCATGTCAGCCATGCCAATGCAATGACAACCTTGACTTCTCCATCCCTGGCAGCTGTGACAGCTTGTCTGG CTCCTGTCTGATATGTAAACCAGGTACAACAGGCCGGTACTGTGAGCTCTGTGCTGATGGATATTTTGGAGATGCAGTTGATGCGAAGAA CTGTCAGCCCTGTCGCTGTAATGCCGGTGGCTCTTTCTCTGAGGTTTGCCACAGTCAAACTGGACAGTGTGAGTGCAGAGCCAACGTTCA GGGTCAGAGATGTGACAAATGCAAGGCTGGGACCTTTGGCCTACAATCAGCAAGGGGCTGTGTTCCCTGCAACTGCAATTCTTTTGGGTC TAAGTCATTCGACTGTGAAGAGAGTGGACAATGTTGGTGCCAACCTGGAGTCACAGGGAAGAAATGTGACCGCTGTGCCCACGGCTATTT CAACTTCCAAGAAGGAGGCTGCACAGCTTGTGAATGTTCTCATCTGGGTAATAATTGTGACCCAAAGACTGGGCGATGCATTTGCCCTCC CAATACCATTGGAGAGAAATGTTCTAAATGTGCACCCAATACCTGGGGCCACAGCATTACCACTGGTTGTAAGGCTTGTAACTGCAGCAC AGTGGGATCCTTGGATTTCCAATGCAATGTAAATACAGGCCAATGCAACTGTCATCCAAAATTCTCTGGTGCAAAATGTACAGAGTGCAG TCGAGGTCACTGGAACTACCCTCGCTGCAATCTCTGTGACTGCTTCCTCCCTGGGACAGATGCCACAACCTGTGATTCAGAGACTAAAAA ATGCTCCTGTAGTGATCAAACTGGGCAGTGCACTTGTAAGGTGAATGTGGAAGGCATCCACTGTGACAGATGCCGGCCTGGCAAATTCGG ACTCGATGCCAAGAATCCACTTGGCTGCAGCAGCTGCTATTGCTTCGGCACTACTACCCAGTGCTCTGAAGCAAAAGGACTGATCCGGAC GTGGGTGACTCTGAAGGCTGAGCAGACCATTCTACCCCTGGTAGATGAGGCTCTGCAGCACACGACCACCAAGGGCATTGTTTTTCAACA TCCAGAGATTGTTGCCCACATGGACCTGATGAGAGAAGATCTCCATTTGGAACCTTTTTATTGGAAACTTCCAGAACAATTTGAAGGAAA GAAGTTGATGGCCTATGGGGGCAAACTCAAGTATGCAATCTATTTCGAGGCTCGGGAAGAAACAGGTTTCTCTACATATAATCCTCAAGT GATCATTCGAGGTGGGACACCTACTCATGCTAGAATTATCGTCAGGCATATGGCTGCTCCTCTGATTGGCCAATTGACAAGGCATGAAAT TGAAATGACAGAGAAAGAATGGAAATATTATGGGGATGATCCTCGAGTCCATAGAACTGTGACCCGAGAAGACTTCTTGGATATACTATA TGATATTCATTACATTCTTATCAAAGCTACTTATGGAAATTTCATGCGACAAAGCAGGATTTCTGAAATCTCAATGGAGGTAGCTGAACA AGGACGTGGAACAACAATGACTCCTCCAGCTGACTTGATTGAAAAATGTGATTGTCCCCTGGGCTATTCTGGCCTGTCCTGTGAGGATGC CAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCA CAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGA GCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATA GTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTAC CATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTG >In-frame_ENST00000421865_ENST00000378905_TCGA-3B-A9HS-01A_LAMA2_chr6_129641800_+_NUP107_chr12_69135593_length(amino acids)=1483AA_start in transcript=49_stop in transcript=4500 MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNS SNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIV TRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGG VSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGN DLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACP LNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPG VTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFG TTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMR QSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVS -------------------------------------------------------------- >In-frame_ENST00000421865_ENST00000539906_TCGA-3B-A9HS-01A_LAMA2_chr6_129641800_+_NUP107_chr12_69135593_length(transcript)=4570nt_BP=4225nt CAGCGACTCCTCTGGCTCCCGAGAAGTGGATCCGGTCGCGGCCACTACGATGCCGGGAGCCGCCGGGGTCCTCCTCCTTCTGCTGCTCTC CGGAGGCCTCGGGGGCGTACAGGCGCAGCGGCCGCAGCAGCAGCGGCAGTCACAGGCACATCAGCAAAGAGGTTTATTCCCTGCTGTCCT GAATCTTGCTTCTAATGCTCTTATCACGACCAATGCAACATGTGGAGAAAAAGGACCTGAAATGTACTGCAAATTGGTAGAACATGTCCC TGGGCAGCCTGTGAGGAACCCGCAGTGTCGAATCTGCAATCAAAACAGCAGCAATCCAAACCAGAGACACCCGATTACAAATGCTATTGA TGGAAAGAACACTTGGTGGCAGAGTCCCAGTATTAAGAATGGAATCGAATACCATTATGTGACAATTACCCTGGATTTACAGCAGGTGTT CCAGATCGCGTATGTGATTGTGAAGGCAGCTAACTCCCCCCGGCCTGGAAACTGGATTTTGGAACGCTCTCTTGATGATGTTGAATACAA GCCCTGGCAGTATCATGCTGTGACAGACACGGAGTGCCTAACGCTTTACAATATTTATCCCCGCACTGGGCCACCGTCATATGCCAAAGA TGATGAGGTCATCTGCACTTCATTTTACTCCAAGATACACCCCTTAGAAAATGGAGAGATTCACATCTCTTTAATCAATGGGAGACCAAG TGCCGATGATCCTTCTCCAGAACTGCTAGAATTTACCTCCGCTCGCTATATTCGCCTGAGATTTCAGAGGATCCGCACACTGAATGCTGA CTTGATGATGTTTGCTCACAAAGACCCAAGAGAAATTGACCCCATTGTCACCAGAAGATATTACTACTCGGTCAAGGATATTTCAGTTGG AGGGATGTGCATCTGCTATGGTCATGCCAGGGCTTGTCCACTTGATCCAGCGACAAATAAATCTCGCTGTGAGTGTGAGCATAACACATG TGGCGATAGCTGTGATCAGTGCTGTCCAGGATTCCATCAGAAACCCTGGAGAGCTGGAACTTTTCTAACTAAAACTGAATGTGAAGCATG CAATTGTCATGGAAAAGCTGAAGAATGCTATTATGATGAAAATGTTGCCAGAAGAAATCTGAGTTTGAATATACGTGGAAAGTACATTGG AGGGGGTGTCTGCATTAATTGTACCCAAAACACTGCTGGTATAAACTGCGAGACATGTACTGATGGCTTCTTCAGACCCAAAGGGGTATC TCCAAATTATCCAAGGCCATGCCAGCCATGTCATTGCGATCCAATTGGTTCCTTAAATGAAGTCTGTGTCAAGGATGAGAAACATGCTCG ACGAGGTTTGGCACCTGGATCCTGTCATTGCAAAACTGGTTTTGGAGGTGTGAGCTGTGATCGGTGTGCCAGGGGCTACACTGGCTACCC GGACTGCAAAGCCTGTAACTGCAGTGGGTTAGGGAGCAAAAATGAGGATCCTTGTTTTGGCCCCTGTATCTGCAAGGAAAATGTTGAAGG AGGAGACTGTAGTCGTTGCAAATCCGGCTTCTTCAATTTGCAAGAGGATAATTGGAAAGGCTGCGATGAGTGTTTCTGTTCAGGGGTTTC AAACAGATGTCAGAGTTCCTACTGGACCTATGGCAAAATACAAGATATGAGTGGCTGGTATCTGACTGACCTTCCTGGCCGCATTCGAGT GGCTCCCCAGCAGGACGACTTGGACTCACCTCAGCAGATCAGCATCAGTAACGCGGAGGCCCGGCAAGCCCTGCCGCACAGCTACTACTG GAGCGCGCCGGCTCCCTATCTGGGAAACAAACTCCCAGCAGTAGGAGGACAGTTGACATTTACCATATCATATGACCTTGAAGAAGAGGA AGAAGATACAGAACGTGTTCTCCAGCTTATGATTATCTTAGAGGGTAATGACTTGAGCATCAGCACAGCCCAAGATGAGGTGTACCTGCA CCCATCTGAAGAACATACTAATGTATTGTTACTTAAAGAAGAATCATTTACCATACATGGCACACATTTTCCAGTCCGTAGAAAGGAATT TATGACAGTGCTTGCGAATTTGAAGAGAGTCCTCCTACAAATCACATACAGCTTTGGGATGGATGCCATCTTCAGGTTGAGCTCTGTTAA CCTTGAATCCGCTGTCTCCTATCCTACTGATGGAAGCATTGCAGCAGCTGTAGAAGTGTGTCAGTGCCCACCAGGGTATACTGGCTCCTC TTGTGAATCTTGTTGGCCTAGGCACAGGCGAGTTAACGGCACTATTTTTGGTGGCATCTGTGAGCCATGTCAGTGCTTTGGTCATGCGGA GTCCTGTGATGACGTCACTGGAGAATGCCTGAACTGTAAGGATCACACAGGTGGCCCATATTGTGATAAATGTCTTCCTGGTTTCTATGG CGAGCCTACTAAAGGAACCTCTGAAGACTGTCAACCCTGTGCCTGTCCACTCAATATCCCATCCAATAACTTTAGCCCAACGTGCCATTT AGACCGGAGTCTTGGATTGATCTGTGATGGATGCCCTGTCGGGTACACAGGACCACGCTGTGAGAGGTGTGCAGAAGGCTATTTTGGACA ACCCTCTGTACCTGGAGGATCATGTCAGCCATGCCAATGCAATGACAACCTTGACTTCTCCATCCCTGGCAGCTGTGACAGCTTGTCTGG CTCCTGTCTGATATGTAAACCAGGTACAACAGGCCGGTACTGTGAGCTCTGTGCTGATGGATATTTTGGAGATGCAGTTGATGCGAAGAA CTGTCAGCCCTGTCGCTGTAATGCCGGTGGCTCTTTCTCTGAGGTTTGCCACAGTCAAACTGGACAGTGTGAGTGCAGAGCCAACGTTCA GGGTCAGAGATGTGACAAATGCAAGGCTGGGACCTTTGGCCTACAATCAGCAAGGGGCTGTGTTCCCTGCAACTGCAATTCTTTTGGGTC TAAGTCATTCGACTGTGAAGAGAGTGGACAATGTTGGTGCCAACCTGGAGTCACAGGGAAGAAATGTGACCGCTGTGCCCACGGCTATTT CAACTTCCAAGAAGGAGGCTGCACAGCTTGTGAATGTTCTCATCTGGGTAATAATTGTGACCCAAAGACTGGGCGATGCATTTGCCCTCC CAATACCATTGGAGAGAAATGTTCTAAATGTGCACCCAATACCTGGGGCCACAGCATTACCACTGGTTGTAAGGCTTGTAACTGCAGCAC AGTGGGATCCTTGGATTTCCAATGCAATGTAAATACAGGCCAATGCAACTGTCATCCAAAATTCTCTGGTGCAAAATGTACAGAGTGCAG TCGAGGTCACTGGAACTACCCTCGCTGCAATCTCTGTGACTGCTTCCTCCCTGGGACAGATGCCACAACCTGTGATTCAGAGACTAAAAA ATGCTCCTGTAGTGATCAAACTGGGCAGTGCACTTGTAAGGTGAATGTGGAAGGCATCCACTGTGACAGATGCCGGCCTGGCAAATTCGG ACTCGATGCCAAGAATCCACTTGGCTGCAGCAGCTGCTATTGCTTCGGCACTACTACCCAGTGCTCTGAAGCAAAAGGACTGATCCGGAC GTGGGTGACTCTGAAGGCTGAGCAGACCATTCTACCCCTGGTAGATGAGGCTCTGCAGCACACGACCACCAAGGGCATTGTTTTTCAACA TCCAGAGATTGTTGCCCACATGGACCTGATGAGAGAAGATCTCCATTTGGAACCTTTTTATTGGAAACTTCCAGAACAATTTGAAGGAAA GAAGTTGATGGCCTATGGGGGCAAACTCAAGTATGCAATCTATTTCGAGGCTCGGGAAGAAACAGGTTTCTCTACATATAATCCTCAAGT GATCATTCGAGGTGGGACACCTACTCATGCTAGAATTATCGTCAGGCATATGGCTGCTCCTCTGATTGGCCAATTGACAAGGCATGAAAT TGAAATGACAGAGAAAGAATGGAAATATTATGGGGATGATCCTCGAGTCCATAGAACTGTGACCCGAGAAGACTTCTTGGATATACTATA TGATATTCATTACATTCTTATCAAAGCTACTTATGGAAATTTCATGCGACAAAGCAGGATTTCTGAAATCTCAATGGAGGTAGCTGAACA AGGACGTGGAACAACAATGACTCCTCCAGCTGACTTGATTGAAAAATGTGATTGTCCCCTGGGCTATTCTGGCCTGTCCTGTGAGGATGC CAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCA CAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGA GCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATA >In-frame_ENST00000421865_ENST00000539906_TCGA-3B-A9HS-01A_LAMA2_chr6_129641800_+_NUP107_chr12_69135593_length(amino acids)=1483AA_start in transcript=49_stop in transcript=4500 MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNS SNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIV TRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGG VSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGN DLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACP LNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPG VTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFG TTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMR QSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LAMA2-NUP107 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LAMA2-NUP107 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LAMA2-NUP107 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LAMA2 | C1263858 | Muscular dystrophy congenital, merosin negative | 6 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | LAMA2 | C0026850 | Muscular Dystrophy | 2 | CTD_human |
Hgene | LAMA2 | C0036341 | Schizophrenia | 2 | CTD_human |
Hgene | LAMA2 | C4748327 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, AUTOSOMAL RECESSIVE 23 | 2 | UNIPROT |
Hgene | LAMA2 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
Hgene | LAMA2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | LAMA2 | C0027092 | Myopia | 1 | CTD_human |
Tgene | NUP107 | C4225228 | NEPHROTIC SYNDROME, TYPE 11 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | NUP107 | C0018051 | Gonadal Dysgenesis | 1 | GENOMICS_ENGLAND |
Tgene | NUP107 | C0685837 | Pure Gonadal Dysgenesis, 46, XX | 1 | ORPHANET |
Tgene | NUP107 | C0795949 | Galloway Mowat syndrome | 1 | ORPHANET |
Tgene | NUP107 | C0949595 | Gonadal Dysgenesis, 46,XX | 1 | ORPHANET |
Tgene | NUP107 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | ORPHANET |
Tgene | NUP107 | C4748084 | OVARIAN DYSGENESIS 6 | 1 | UNIPROT |