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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMA3-NDUFS8 (FusionGDB2 ID:43638)

Fusion Gene Summary for LAMA3-NDUFS8

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMA3-NDUFS8
Fusion gene ID: 43638
HgeneTgene
Gene symbol

LAMA3

NDUFS8

Gene ID

3910

4728

Gene namelaminin subunit alpha 4NADH:ubiquinone oxidoreductase core subunit S8
SynonymsCMD1JJ|LAMA3|LAMA4*-1CI-23k|CI23KD|MC1DN2|TYKY
Cytomap

6q21

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-4laminin alpha 4 chainlaminin, alpha 4NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 23 kDa subunitcomplex I 23kDa subunitcomplex I-23kD
Modification date2020031320200313
UniProtAcc

Q16787

O00217

Ensembl transtripts involved in fusion geneENST00000313654, ENST00000399516, 
ENST00000269217, ENST00000587184, 
ENST00000588770, 		ENST00000313468, 
ENST00000528492, ENST00000526542, 
Fusion gene scores* DoF score28 X 24 X 10=67203 X 3 X 3=27
# samples 333
** MAII scorelog2(33/6720*10)=-4.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LAMA3 [Title/Abstract] AND NDUFS8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMA3(21364121)-NDUFS8(67800390), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNDUFS8

GO:0006979

response to oxidative stress

12857734


check buttonFusion gene breakpoints across LAMA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NDUFS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8297-01ALAMA3chr18

21364121

+NDUFS8chr11

67800390

+
ChimerDB4STADTCGA-BR-8297-01ALAMA3chr18

21364121

+NDUFS8chr11

67800390

+


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Fusion Gene ORF analysis for LAMA3-NDUFS8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000313654ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000313654ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000313654ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
In-frameENST00000399516ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000399516ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
5CDS-intronENST00000399516ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-3CDSENST00000269217ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000269217ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000269217ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-3CDSENST00000587184ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000587184ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000587184ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-3CDSENST00000588770ENST00000313468LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000588770ENST00000528492LAMA3chr18

21364121

+NDUFS8chr11

67800390

+
intron-intronENST00000588770ENST00000526542LAMA3chr18

21364121

+NDUFS8chr11

67800390

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313654LAMA3chr1821364121+ENST00000313468NDUFS8chr1167800390+241918442412367708
ENST00000399516LAMA3chr1821364121+ENST00000313468NDUFS8chr1167800390+2178160302126708

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313654ENST00000313468LAMA3chr1821364121+NDUFS8chr1167800390+0.0054955650.9945044
ENST00000399516ENST00000313468LAMA3chr1821364121+NDUFS8chr1167800390+0.0047327630.9952673

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Fusion Genomic Features for LAMA3-NDUFS8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LAMA3chr1821364121+NDUFS8chr1167800389+7.14E-060.99999285
LAMA3chr1821364121+NDUFS8chr1167800389+7.14E-060.99999285

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMA3-NDUFS8


check button Go to

FGviewer for the breakpoints of chr18:21364121-chr11:67800390

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA3

Q16787

NDUFS8

O00217

FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; FUNCTION: Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:22499348). Essential for the catalytic activity and assembly of complex I (PubMed:22499348). {ECO:0000269|PubMed:22499348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275299_355534.33333333333343334.0DomainLaminin EGF-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275356_425534.33333333333343334.0DomainLaminin EGF-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275426_469534.33333333333343334.0DomainLaminin EGF-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+127543_298534.33333333333343334.0DomainLaminin N-terminal
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275491_535534.33333333333343334.0DomainLaminin EGF-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274299_355534.33333333333343278.0DomainLaminin EGF-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274356_425534.33333333333343278.0DomainLaminin EGF-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274426_469534.33333333333343278.0DomainLaminin EGF-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+127443_298534.33333333333343278.0DomainLaminin N-terminal
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274491_535534.33333333333343278.0DomainLaminin EGF-like 4
TgeneNDUFS8chr18:21364121chr11:67800390ENST0000031346827102_13136.333333333333336211.0Domain4Fe-4S ferredoxin-type 1
TgeneNDUFS8chr18:21364121chr11:67800390ENST0000031346827141_17036.333333333333336211.0Domain4Fe-4S ferredoxin-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751852_1941534.33333333333343334.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751987_2169534.33333333333343334.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752322_2388534.33333333333343334.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741852_1941534.33333333333343278.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741987_2169534.33333333333343278.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742322_2388534.33333333333343278.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371852_19410.01669.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371987_21690.01669.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372322_23880.01669.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751266_1311534.33333333333343334.0DomainLaminin EGF-like 9
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751312_1355534.33333333333343334.0DomainLaminin EGF-like 10
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751356_1404534.33333333333343334.0DomainLaminin EGF-like 11
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751405_1455534.33333333333343334.0DomainLaminin EGF-like 12
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751476_1653534.33333333333343334.0DomainLaminin IV type A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751687_1733534.33333333333343334.0DomainLaminin EGF-like 13
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751734_1786534.33333333333343334.0DomainLaminin EGF-like 14
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751787_1821534.33333333333343334.0DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752390_2591534.33333333333343334.0DomainLaminin G-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752598_2760534.33333333333343334.0DomainLaminin G-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752767_2927534.33333333333343334.0DomainLaminin G-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752986_3150534.33333333333343334.0DomainLaminin G-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12753157_3330534.33333333333343334.0DomainLaminin G-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275536_588534.33333333333343334.0DomainLaminin EGF-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275590_630534.33333333333343334.0DomainLaminin EGF-like 6
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275631_683534.33333333333343334.0DomainLaminin EGF-like 7
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275684_728534.33333333333343334.0DomainLaminin EGF-like 8
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741266_1311534.33333333333343278.0DomainLaminin EGF-like 9
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741312_1355534.33333333333343278.0DomainLaminin EGF-like 10
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741356_1404534.33333333333343278.0DomainLaminin EGF-like 11
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741405_1455534.33333333333343278.0DomainLaminin EGF-like 12
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741476_1653534.33333333333343278.0DomainLaminin IV type A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741687_1733534.33333333333343278.0DomainLaminin EGF-like 13
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741734_1786534.33333333333343278.0DomainLaminin EGF-like 14
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741787_1821534.33333333333343278.0DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742390_2591534.33333333333343278.0DomainLaminin G-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742598_2760534.33333333333343278.0DomainLaminin G-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742767_2927534.33333333333343278.0DomainLaminin G-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742986_3150534.33333333333343278.0DomainLaminin G-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12743157_3330534.33333333333343278.0DomainLaminin G-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274536_588534.33333333333343278.0DomainLaminin EGF-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274590_630534.33333333333343278.0DomainLaminin EGF-like 6
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274631_683534.33333333333343278.0DomainLaminin EGF-like 7
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274684_728534.33333333333343278.0DomainLaminin EGF-like 8
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371266_13110.01669.0DomainLaminin EGF-like 9
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371312_13550.01669.0DomainLaminin EGF-like 10
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371356_14040.01669.0DomainLaminin EGF-like 11
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371405_14550.01669.0DomainLaminin EGF-like 12
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371476_16530.01669.0DomainLaminin IV type A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371687_17330.01669.0DomainLaminin EGF-like 13
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371734_17860.01669.0DomainLaminin EGF-like 14
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371787_18210.01669.0DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372390_25910.01669.0DomainLaminin G-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372598_27600.01669.0DomainLaminin G-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372767_29270.01669.0DomainLaminin G-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372986_31500.01669.0DomainLaminin G-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137299_3550.01669.0DomainLaminin EGF-like 1
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1373157_33300.01669.0DomainLaminin G-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137356_4250.01669.0DomainLaminin EGF-like 2
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137426_4690.01669.0DomainLaminin EGF-like 3
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+13743_2980.01669.0DomainLaminin N-terminal
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137491_5350.01669.0DomainLaminin EGF-like 4
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137536_5880.01669.0DomainLaminin EGF-like 5
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137590_6300.01669.0DomainLaminin EGF-like 6
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137631_6830.01669.0DomainLaminin EGF-like 7
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137684_7280.01669.0DomainLaminin EGF-like 8
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12752278_2280534.33333333333343334.0MotifCell attachment site
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12742278_2280534.33333333333343278.0MotifCell attachment site
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1372278_22800.01669.0MotifCell attachment site
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751266_1465534.33333333333343334.0RegionNote=Domain III B
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751654_1821534.33333333333343334.0RegionNote=Domain III A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+12751822_2389534.33333333333343334.0RegionNote=Domain II and I
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275298_728534.33333333333343334.0RegionNote=Domain V
HgeneLAMA3chr18:21364121chr11:67800390ENST00000313654+1275796_1265534.33333333333343334.0RegionNote=Domain IV 1 (domain IV B)
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741266_1465534.33333333333343278.0RegionNote=Domain III B
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741654_1821534.33333333333343278.0RegionNote=Domain III A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+12741822_2389534.33333333333343278.0RegionNote=Domain II and I
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274298_728534.33333333333343278.0RegionNote=Domain V
HgeneLAMA3chr18:21364121chr11:67800390ENST00000399516+1274796_1265534.33333333333343278.0RegionNote=Domain IV 1 (domain IV B)
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371266_14650.01669.0RegionNote=Domain III B
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371654_18210.01669.0RegionNote=Domain III A
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+1371822_23890.01669.0RegionNote=Domain II and I
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137298_7280.01669.0RegionNote=Domain V
HgeneLAMA3chr18:21364121chr11:67800390ENST00000587184+137796_12650.01669.0RegionNote=Domain IV 1 (domain IV B)


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Fusion Gene Sequence for LAMA3-NDUFS8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000313654_ENST00000313468_TCGA-BR-8297-01A_LAMA3_chr18_21364121_+_NDUFS8_chr11_67800390_length(transcript)=2419nt_BP=1844nt
GAGCGCTGTCAGTTCCTGATCCGGCTGGTGCCCGCTCCAGCCGCGGCAGGTTCCAGAGCTGAGAGGCCACCCCCACGCCGCGGGCTTCCA
GCGCGTGGAGCAAGGGGAGCGGCCCCGGCGCCGCCCATATCCCCGGCTGCGCTAGTCCTGGCGCTGCAGGTCCGGGAGGCGCAGGCGGAG
AGCGGCGGTGCCCCCGAGCCCCTCTGCGGACGGCTCAGGCGGGAGGACCCCGCGCGGCTGGATGGCGGCGGCCGCGCGGCCTCGGGGTCG
GGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGCTGGTACTGCGGGTGCTGCCAGCCTGCGGGGCGACCGCTCGGGATCCCGG
GGCCGCGGCCGGGCTCAGCCTTCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATTTGGGCCACCGCCACCTGCGGGGAGAGGGG
ACCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCCCCAGGCAGCGGCCACACCATCCAGGGCCA
GTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCACCAATGCCATCGATGGATCTGAACGTTGGTGGCAAAGCCC
TCCCCTGTCCTCAGGCACACAGTACAACAGAGTCAACCTCACCTTGGATCTGGGGCAGCTCTTCCATGTGGCCTATATTTTAATCAAATT
TGCAAATTCTCCTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACCTACTCACCATGGCAATATTTTGCTCATTC
TAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGATGATGTACTTTGTGTTACTGAATATTCCCG
TATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGATAAACGGTCGTCCAGGTGCAAAAAATTTTACTTTCTCTCACACCCTGAG
GGAGTTTACCAAGGCAACAAACATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGACACCTCATCTCCAAAGCCCAGCGAGATCC
AACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTTTGCAATGGCCATGCTGAAGTGTGCAATAT
AAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGGGGAGACGTGTGATCGCTGCTGCACAGGGTACAATCAGAG
GCGCTGGCGGCCCGCCGCTTGGGAGCAGAGCCACGAGTGTGAAGCATGCAACTGCCACGGCCATGCCAGCAACTGTTACTATGATCCAGA
TGTTGAGCGGCAGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGCATTAACTGTCAGCACAACACAGCTGGAGT
AAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCTGATGGCTGCATCCCCTGCAGCTGTGACCC
TGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTCACTGCAAGCCAAATTTCCACGGAGACAACTGTGAGAAGTGTGCAATTGG
ATACTACAATTTCCCATTTTGCTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCAGAAGATCCAGTAGCTGGAGATATAAAAGG
GTGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTGTGCCGCCCTGGGGTTGAGGGCCCTCGATG
TGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGAGTATGTGAACATGCAGGATCCCGAGATGGACATGAAGTCAGTGAC
TGACCGGGCAGCCCGCACCCTGCTGTGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTGAGCTACCTGTTCCGGGAACCGGCCACCAT
CAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCGCTGCGCCGGTACCCATCCGGGGAGGAGCGTTGCAT
TGCCTGCAAGCTCTGCGAGGCCATCTGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCAAGAGCTGATGGCAGCCGCCGGACCACCCG
CTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGTCCCGTGGATGCCATCGTCGAGGGCCCCAACTTTGA
GTTCTCCACGGAGACCCATGAGGAGCTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGGGACAAGTGGGAGGCCGAGATCGCCGCCAA

>In-frame_ENST00000313654_ENST00000313468_TCGA-BR-8297-01A_LAMA3_chr18_21364121_+_NDUFS8_chr11_67800390_length(amino acids)=708AA_start in transcript=241_stop in transcript=2367
MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTA
PGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGST
YSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLG
HLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHG
HASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFH
GDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQEYVNMQ
DPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEP

--------------------------------------------------------------
>In-frame_ENST00000399516_ENST00000313468_TCGA-BR-8297-01A_LAMA3_chr18_21364121_+_NDUFS8_chr11_67800390_length(transcript)=2178nt_BP=1603nt
ATGGCGGCGGCCGCGCGGCCTCGGGGTCGGGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGCTGGTACTGCGGGTGCTGCCA
GCCTGCGGGGCGACCGCTCGGGATCCCGGGGCCGCGGCCGGGCTCAGCCTTCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATT
TGGGCCACCGCCACCTGCGGGGAGAGGGGACCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCC
CCAGGCAGCGGCCACACCATCCAGGGCCAGTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCACCAATGCCATC
GATGGATCTGAACGTTGGTGGCAAAGCCCTCCCCTGTCCTCAGGCACACAGTACAACAGAGTCAACCTCACCTTGGATCTGGGGCAGCTC
TTCCATGTGGCCTATATTTTAATCAAATTTGCAAATTCTCCTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACC
TACTCACCATGGCAATATTTTGCTCATTCTAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGAT
GATGTACTTTGTGTTACTGAATATTCCCGTATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGATAAACGGTCGTCCAGGTGCA
AAAAATTTTACTTTCTCTCACACCCTGAGGGAGTTTACCAAGGCAACAAACATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGA
CACCTCATCTCCAAAGCCCAGCGAGATCCAACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTT
TGCAATGGCCATGCTGAAGTGTGCAATATAAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGGGGAGACGTGT
GATCGCTGCTGCACAGGGTACAATCAGAGGCGCTGGCGGCCCGCCGCTTGGGAGCAGAGCCACGAGTGTGAAGCATGCAACTGCCACGGC
CATGCCAGCAACTGTTACTATGATCCAGATGTTGAGCGGCAGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGC
ATTAACTGTCAGCACAACACAGCTGGAGTAAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCT
GATGGCTGCATCCCCTGCAGCTGTGACCCTGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTCACTGCAAGCCAAATTTCCAC
GGAGACAACTGTGAGAAGTGTGCAATTGGATACTACAATTTCCCATTTTGCTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCA
GAAGATCCAGTAGCTGGAGATATAAAAGGGTGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTG
TGCCGCCCTGGGGTTGAGGGCCCTCGATGTGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGAGTATGTGAACATGCAG
GATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTGTGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTG
AGCTACCTGTTCCGGGAACCGGCCACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCGCTGCGC
CGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATCTGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCA
AGAGCTGATGGCAGCCGCCGGACCACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGTCCCGTG
GATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAGCTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGG
GACAAGTGGGAGGCCGAGATCGCCGCCAACATCCAGGCTGACTACTTGTATCGGTGACGCCCCACCGGCCCGCAGCCCCTGCTGCCCAAT

>In-frame_ENST00000399516_ENST00000313468_TCGA-BR-8297-01A_LAMA3_chr18_21364121_+_NDUFS8_chr11_67800390_length(amino acids)=708AA_start in transcript=0_stop in transcript=2126
MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTA
PGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGST
YSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLG
HLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHG
HASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFH
GDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQEYVNMQ
DPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LAMA3-NDUFS8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMA3-NDUFS8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNDUFS8O00217DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for LAMA3-NDUFS8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMA3C1328355Laryngoonychocutaneous syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLAMA3C0079683Herlitz Disease4CTD_human;GENOMICS_ENGLAND
HgeneLAMA3C0079301Junctional Epidermolysis Bullosa3CTD_human;GENOMICS_ENGLAND
HgeneLAMA3C0268374Adult junctional epidermolysis bullosa (disorder)3CTD_human;GENOMICS_ENGLAND
HgeneLAMA3C0027339Nail Diseases1CTD_human
HgeneLAMA3C0037299Skin Ulcer1CTD_human
HgeneLAMA3C0079297Epidermolysis Bullosa Progressiva1CTD_human
HgeneLAMA3C0399367Amelogenesis imperfecta local hypoplastic form1GENOMICS_ENGLAND
TgeneNDUFS8C0023264Leigh Disease10CLINGEN;GENOMICS_ENGLAND
TgeneNDUFS8C1838951LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY10CLINGEN;GENOMICS_ENGLAND
TgeneNDUFS8C1850597Leigh Syndrome Due To Mitochondrial Complex II Deficiency9CLINGEN
TgeneNDUFS8C1850598Leigh Syndrome due to Mitochondrial Complex III Deficiency9CLINGEN
TgeneNDUFS8C1850599Leigh Syndrome due to Mitochondrial Complex IV Deficiency9CLINGEN
TgeneNDUFS8C1850600Leigh Syndrome due to Mitochondrial Complex V Deficiency9CLINGEN
TgeneNDUFS8C2931891Necrotizing encephalopathy, infantile subacute, of Leigh9CLINGEN
TgeneNDUFS8C4748737MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 23GENOMICS_ENGLAND;UNIPROT
TgeneNDUFS8C1838979MITOCHONDRIAL COMPLEX I DEFICIENCY2GENOMICS_ENGLAND;ORPHANET
TgeneNDUFS8C0029408Degenerative polyarthritis1CTD_human
TgeneNDUFS8C0086743Osteoarthrosis Deformans1CTD_human
TgeneNDUFS8C0751651Mitochondrial Diseases1GENOMICS_ENGLAND