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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMB1-KPNA3 (FusionGDB2 ID:43689)

Fusion Gene Summary for LAMB1-KPNA3

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB1-KPNA3
Fusion gene ID: 43689
HgeneTgene
Gene symbol

LAMB1

KPNA3

Gene ID

3912

3839

Gene namelaminin subunit beta 1karyopherin subunit alpha 3
SynonymsCLM|LIS5IPOA4|SRP1|SRP1gamma|SRP4|hSRP1
Cytomap

7q31.1

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit beta-1laminin B1 chainlaminin, beta 1importin subunit alpha-4SRP1-gammaimportin alpha 4importin alpha Q2importin alpha-3importin subunit alpha-3karyopherin alpha 3 (importin alpha 4)qip2
Modification date2020031320200313
UniProtAcc.

O00505

Ensembl transtripts involved in fusion geneENST00000393561, ENST00000222399, 
ENST00000393560, ENST00000474380, 
ENST00000261667, 
Fusion gene scores* DoF score11 X 11 X 5=60511 X 9 X 5=495
# samples 1311
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMB1 [Title/Abstract] AND KPNA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMB1(107569507)-KPNA3(50279920), # samples:1
Anticipated loss of major functional domain due to fusion event.LAMB1-KPNA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLAMB1

GO:0030335

positive regulation of cell migration

16289578

HgeneLAMB1

GO:0031175

neuron projection development

15894315

HgeneLAMB1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

HgeneLAMB1

GO:0042476

odontogenesis

15894315


check buttonFusion gene breakpoints across LAMB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KPNA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACB119417LAMB1chr7

107569507

-KPNA3chr13

50279920

-


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Fusion Gene ORF analysis for LAMB1-KPNA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393561ENST00000261667LAMB1chr7

107569507

-KPNA3chr13

50279920

-
Frame-shiftENST00000222399ENST00000261667LAMB1chr7

107569507

-KPNA3chr13

50279920

-
intron-3CDSENST00000393560ENST00000261667LAMB1chr7

107569507

-KPNA3chr13

50279920

-
intron-3CDSENST00000474380ENST00000261667LAMB1chr7

107569507

-KPNA3chr13

50279920

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393561LAMB1chr7107569507-ENST00000261667KPNA3chr1350279920-799051445655001814

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393561ENST00000261667LAMB1chr7107569507-KPNA3chr1350279920-8.54E-050.9999145

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Fusion Genomic Features for LAMB1-KPNA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMB1-KPNA3


check button Go to

FGviewer for the breakpoints of chr7:107569507-chr13:50279920

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KPNA3

O00505

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341216_13151629.01787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341353_13881629.01787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341028_10831629.01787.0DomainLaminin EGF-like 11
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341084_11311629.01787.0DomainLaminin EGF-like 12
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341132_11781629.01787.0DomainLaminin EGF-like 13
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134271_3341629.01787.0DomainLaminin EGF-like 1
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-313431_2701629.01787.0DomainLaminin N-terminal
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134335_3971629.01787.0DomainLaminin EGF-like 2
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134398_4571629.01787.0DomainLaminin EGF-like 3
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134458_5091629.01787.0DomainLaminin EGF-like 4
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134510_5401629.01787.0DomainLaminin EGF-like 5%3B truncated
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134549_7671629.01787.0DomainLaminin IV type B
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134773_8201629.01787.0DomainLaminin EGF-like 6
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134821_8661629.01787.0DomainLaminin EGF-like 7
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134867_9161629.01787.0DomainLaminin EGF-like 8
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134917_9751629.01787.0DomainLaminin EGF-like 9
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-3134976_10271629.01787.0DomainLaminin EGF-like 10
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341179_13971629.01787.0RegionNote=Domain II
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341398_14301629.01787.0RegionNote=Domain alpha
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317401_443403.0522.0RepeatNote=ARM 9
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317447_485403.0522.0RepeatNote=ARM 10%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341442_17811629.01787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107569507chr13:50279920ENST00000222399-31341431_17861629.01787.0RegionNote=Domain I
TgeneKPNA3chr7:107569507chr13:50279920ENST0000026166713172_58403.0522.0DomainIBB
TgeneKPNA3chr7:107569507chr13:50279920ENST00000261667131743_52403.0522.0MotifNuclear localization signal
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317137_229403.0522.0RegionNLS binding site (major)
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317306_394403.0522.0RegionNLS binding site (minor)
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317107_149403.0522.0RepeatNote=ARM 2
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317150_194403.0522.0RepeatNote=ARM 3
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317195_233403.0522.0RepeatNote=ARM 4
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317234_278403.0522.0RepeatNote=ARM 5
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317279_318403.0522.0RepeatNote=ARM 6
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317319_360403.0522.0RepeatNote=ARM 7
TgeneKPNA3chr7:107569507chr13:50279920ENST000002616671317361_400403.0522.0RepeatNote=ARM 8
TgeneKPNA3chr7:107569507chr13:50279920ENST00000261667131766_106403.0522.0RepeatNote=ARM 1%3B truncated


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Fusion Gene Sequence for LAMB1-KPNA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393561_ENST00000261667_CB119417_LAMB1_chr7_107569507_-_KPNA3_chr13_50279920_length(transcript)=7990nt_BP=5144nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGAATTTATTAAAAATTACCAACTTGAGAATCAAGTTTGTGAAACTGCATACTTTGGGAG
ATAACCTTCTGGATTCCAGGATGGAAATCAGAGAAAAGTATTATTATGCAGTTTATGATATGGTGGTTCGAGGAAATTGCTTCTGCTATG
GTCATGCCAGCGAATGTGCCCCTGTGGATGGATTCAATGAAGAAGTGGAAGGAATGGTTCACGGACACTGCATGTGCAGGCATAACACCA
AGGGCTTAAACTGTGAACTCTGCATGGATTTCTACCATGATTTACCTTGGAGACCTGCTGAAGGCCGAAACAGCAACGCCTGTAAAAAAT
GTAACTGCAATGAACATTCCATCTCTTGTCACTTTGACATGGCTGTTTACCTGGCCACGGGGAACGTCAGCGGAGGCGTGTGTGATGACT
GTCAGCACAACACCATGGGGCGCAACTGTGAGCAGTGCAAGCCGTTTTACTACCAGCACCCAGAGAGGGACATCCGAGATCCTAATTTCT
GTGAACGATGTACGTGTGACCCAGCTGGCTCTCAAAATGAGGGAATTTGTGACAGCTATACTGATTTTTCTACTGGTCTCATTGCTGGCC
AGTGTCGGTGTAAATTAAATGTGGAAGGAGAACATTGTGATGTTTGCAAAGAAGGCTTCTATGATTTAAGCAGTGAAGATCCATTTGGTT
GTAAATCTTGTGCTTGCAATCCTCTGGGAACAATTCCTGGAGGGAATCCTTGTGATTCCGAGACAGGTCACTGCTACTGCAAGCGTCTGG
TGACAGGACAGCATTGTGACCAGTGCCTGCCAGAGCACTGGGGCTTAAGCAATGATTTGGATGGATGTCGACCATGTGACTGTGACCTTG
GGGGAGCCTTAAACAACAGTTGCTTTGCGGAGTCAGGCCAGTGCTCATGCCGGCCTCACATGATTGGACGTCAGTGCAACGAAGTGGAAC
CTGGTTACTACTTTGCCACCCTGGATCACTACCTCTATGAAGCGGAGGAAGCCAACTTGGGGCCTGGGGTTAGCATAGTGGAGCGGCAAT
ATATCCAGGACCGGATTCCCTCCTGGACTGGAGCCGGCTTCGTCCGAGTGCCTGAAGGGGCTTATTTGGAGTTTTTCATTGACAACATAC
CATATTCCATGGAGTACGACATCCTAATTCGCTACGAGCCACAGCTACCCGACCACTGGGAAAAAGCTGTCATCACAGTGCAGCGACCTG
GAAGGATTCCAACCAGCAGCCGATGTGGTAATACCATCCCCGATGATGACAACCAGGTGGTGTCATTATCACCAGGCTCAAGATATGTCG
TCCTTCCTCGGCCGGTGTGCTTTGAGAAGGGAACAAACTACACGGTGAGGTTGGAGCTGCCTCAGTACACCTCCTCTGATAGCGACGTGG
AGAGCCCCTACACGCTGATCGATTCTCTTGTTCTCATGCCATACTGTAAATCACTGGACATCTTCACCGTGGGAGGTTCAGGAGATGGGG
TGGTCACCAACAGTGCCTGGGAAACCTTTCAGAGATACCGATGTCTAGAGAACAGCAGAAGCGTTGTGAAAACACCGATGACAGATGTTT
GCAGAAACATCATCTTTAGCATTTCTGCCCTGTTACACCAGACAGGCCTGGCTTGTGAATGCGACCCTCAGGGTTCGTTAAGTTCCGTGT
GTGATCCCAACGGAGGCCAGTGCCAGTGCCGGCCCAACGTGGTTGGAAGAACCTGCAACAGATGTGCACCTGGAACTTTTGGCTTTGGCC
CCAGTGGATGCAAACCTTGTGAGTGCCATCTGCAAGGATCTGTCAATGCCTTCTGCAATCCCGTCACTGGCCAGTGCCACTGTTTCCAGG
GAGTGTATGCTCGGCAGTGTGATCGGTGCTTACCTGGGCACTGGGGCTTTCCAAGTTGCCAGCCCTGCCAGTGCAATGGCCACGCCGATG
ACTGCGACCCAGTGACTGGGGAGTGCTTGAACTGCCAGGACTACACCATGGGTCATAACTGTGAAAGGTGCTTGGCTGGTTACTATGGCG
ACCCCATCATTGGGTCAGGAGATCACTGCCGCCCTTGCCCTTGCCCAGATGGTCCCGACAGTGGACGCCAGTTTGCCAGGAGCTGCTACC
AAGATCCTGTTACTTTACAGCTTGCCTGTGTTTGTGATCCTGGATACATTGGTTCCAGATGTGACGACTGTGCCTCAGGATACTTTGGCA
ATCCATCAGAAGTTGGGGGGTCGTGTCAGCCTTGCCAGTGTCACAACAACATTGACACGACAGACCCAGAAGCCTGTGACAAGGAGACTG
GGAGGTGTCTCAAGTGCCTGTACCACACGGAAGGGGAACACTGTCAGTTCTGCCGGTTTGGATACTATGGTGATGCCCTCCAGCAGGACT
GTCGAAAGTGTGTCTGTAATTACCTGGGCACCGTGCAAGAGCACTGTAACGGCTCTGACTGCCAGTGCGACAAAGCCACTGGTCAGTGCT
TGTGTCTTCCTAATGTGATCGGGCAGAACTGTGACCGCTGTGCGCCCAATACCTGGCAGCTGGCCAGTGGCACTGGCTGTGACCCATGCA
ACTGCAATGCTGCTCATTCCTTCGGGCCATCTTGCAATGAGTTCACGGGGCAGTGCCAGTGCATGCCTGGGTTTGGAGGCCGCACCTGCA
GCGAGTGCCAGGAACTCTTCTGGGGAGACCCCGACGTGGAGTGCCGAGCCTGTGACTGTGACCCCAGGGGCATTGAGACGCCACAGTGTG
ACCAGTCCACGGGCCAGTGTGTCTGCGTTGAGGGTGTTGAGGGTCCACGCTGTGACAAGTGCACGCGAGGGTACTCGGGGGTCTTCCCTG
ACTGCACACCCTGCCACCAGTGCTTTGCTCTCTGGGATGTGATCATTGCCGAGCTGACCAACAGGACACACAGATTCCTGGAGAAAGCCA
AGGCCTTGAAGATCAGTGGTGTGATCGGGCCTTACCGTGAGACTGTGGACTCGGTGGAGAGGAAAGTCAGCGAGATAAAAGACATCCTGG
CGCAGAGCCCCGCAGCAGAGCCACTGAAAAACATTGGGAATCTCTTTGAGGAAGCAGAGAAACTGATTAAAGATGTTACAGAAATGATGG
CTCAAGTAGAAGTGAAATTATCTGACACAACTTCCCAAAGCAACAGCACAGCCAAAGAACTGGATTCTCTACAGACAGAAGCCGAAAGCC
TAGACAACACTGTGAAAGAACTTGCTGAACAACTGGAATTTATCAAAAACTCAGATATTCGGGGTGCCTTGGATAGCATTACCAAGTATT
TCCAGATGTCTCTTGAGGCAGAGGAGAGGGTGAATGCCTCCACCACAGAACCCAACAGCACTGTGGAGCAGTCAGCCCTCATGAGAGACA
GAGTAGAAGACGTGATGATGGAGCGAGAATCCCAGTTCAAGGAAAAACAAGAGGAGCAGGCTCGCCTCCTTGATGAACTGGCAGGCAAGC
TACAAAGCCTAGACCTTTCAGCCGCTGCCGAAATGACCTGTGGAACACCCCCAGGGGCCTCCTGTTCCGAGACTGAATGTGGCGGGCCAA
ACTGCAGAACTGACGAAGGAGAGAGGAAGTGTGGGGGGCCTGGCTGTGGTGGTCTGGTTACTGTTGCACACAACGCCTGGCAGAAAGCCA
TGGACTTGGACCAAGATGTCCTGAGTGCCCTGGCTGAAGTGGAACAGCTCTCCAAGATGGTCTCTGAAGCAAAACTGAGGGCAGATGAGG
CAAAACAAAGTGCTGAAGACATTCTGTTGAAGACAAATGCTACCAAAGAAAAAATGGACAAGAGCAATGAGGAGCTGAGAAATCTAATCA
AGCAAATCAGAAACTTTTTGACCCAGGATAGTGCTGATTTGGACAGCATTGAAGCAGTTGCTAATGAAGTATTGAAAATGGAGATGCCTA
GCACCCCACAGCAGTTACAGAACTTGACAGAAGATATACGTGAACGAGTTGAAAGCCTTTCTCAAGTAGAGGTTATTCTTCAGCATAGTG
CTGCTGACATTGCCAGAGCTGAGATGTTGTTAGAAGAAGCTAAAAGAGCAAGCAAAAGTGCAACAGATGTTAAAGTCACTGCAGATATGG
TAAAGGAAGCTCTGGAAGAAGCAGAAAAGGCCCAGGTCGCAGCAGAGAAGGCAATTAAACAAGCAGATGAAGACATTCAAGGAACCCAGA
ACCTGTTAACTTCGGTTGAGTACCTTGTACAGCAGAATGTAATACCACCGTTCTGTAATTTACTGTCAGTGAAAGATTCTCAAGTGGTTC
AGGTGGTTCTAGATGGTCTAAAAAACATTCTGATAATGGCCGGTGATGAAGCAAGCACAATAGCTGAAATAATAGAGGAATGTGGAGGTT
TGGAGAAAATTGAAGTTTTACAGCAACATGAAAATGAAGACATATATAAATTAGCATTTGAAATCATAGATCAGTATTTCTCTGGTGATG
ATATTGATGAAGATCCCTGCCTCATTCCTGAAGCAACACAAGGAGGTACCTACAATTTTGATCCAACAGCCAACCTTCAAACAAAAGAAT
TTAATTTTTAAATTCAGTTGAGTGCAGCATCTTTCCCACATTCAATATGAAGCACCACCAGATGGCTACCAAATGATAAGAACAACAGCA
ACAAAAGGCTCCAAAACACACATGCCTCTTTGTTTTGATGCTTCTAAAGCAAGCCATGTCTCAGTCACTTTGCAGTTGCCAAAAGTCACT
ATCACATGGACTGTAAATGCATATGCATGATTTCCTAAACTGTTTTAGAACTCTCCTTAACAATCTCAACTACCCTATTTTTCCCTGTTC
CCTGGTGCCACAGGCTGACAACTGCAGTCTCCAGTTTAGAATAAATATTCCATAGTGGTGACATGTCAGCTGCCCACTGATACTCCTTTG
GAAAATGGTGCGCTGTGGATCAAGACACTTTGGTATGATGCATATACAAGTTGGAAGACTAAAGAGGTGCAGTGTGATCTGAGCCTCCAT
CATTGTCCTCCACAAACATATTTTCATATTCTTTATGTGGAAGAATAGATTTTAAAGTACAAGCCAAATGATTTTCATTGGTGGAACTGA
CACAAAAAAAGTAACTTAAAAACAAGAAACTTGGTTATTGAATAAACAGATAAGTTTAAAAAAAAAAAAAAACTACTTCATCTACCAGTA
ATTGATGTGTTTATTATCTGCCTCAGAAGCCAGGGTTGGAGGAAGAACTTTAGATATGGATATTAATGCTTTTGCCATTATACCTAATTT
TTGAGAACAGCAAGCCCTATTTGACCACTCTCTTCAGCCTGTGTGTTCCTGCTGTTTTGAAGTAATCAAATGCTGTGCATGGTATTTTAC
CTGAGCTGCAACCTGTTATGGACTTGAACTTCTGTTTAAGTTGAAAGCAAGAGTCCCTGAGTATAAAGGAAAAACAGCAAAACAAAAAGC
AAACAAAAAAAAACTGCAAAAGTCTAAAATACCCATTGGTGATGTTTTTTAAAAAAATCTTGCTTTCAGCTTTCAGGAGTTAATATTCTT
TGTTTTAATTTGATAATTGGATATGGTTGATTTATATTGGGTTTAAACTGTGGAGCTTTCATGTTTACTGTAATTTAGTCTTAAAATATT
TTTTACTTAGTAACCAGTGCTTTTGATAATGTGGTTGGCAACAAACCAGCAACTATTTAGAAGTGTCATAAGAGTTCATTCTTTGAGTAT
TGGGAAAGTTAATTCAGATCCTACTCAAAAAGCATCTTCACATATTAAAAGATTCAGACAGGGATCTGTGTAGAGGAGTAATTTGCAGTT
ATTTAACATAAACCTGATTTGCAGTGATCTCTAAGTAATTCTGCAAAATCCGGTATTACTATGTCAAGTTATTGCTTTTGGTAAATTGTC
TGACCCAGTTATTAATGAAAGAATATGGATTTAAAAATTTTTAAACTAAATAATTTGTGCTGTCACAGAAATGGTATTGTTGCTCTTGTT
TACTGGGTATAATTTCCCAATGCATTGATGTGAAGGGATAGAAAATCTAAACTAATTTAGTTATCCATTGGGGGGTGTATTTACTGTGAT
GAAGATGAGACAGATGCCATCAGAGCTTTGTGAATCAGCTGGGGTGTTTTCACTGATAAACAACACATAGCAGGTGTGCATTCATTACAA
ATATATGTATCTGCCAAGGTGGAGCCACTTTAAAGAGTGAGTTTTGTCTTGTATCTAAAGTGGATACAAGCGTATGTTTAAACTGCAAGA
TTTTTACTTGCTAGAGAATCTGTTTTAATATAGTGGTTTGGCCTCTGATTATTTATAGGTTTTATAAATTTTAGAATCAATTTCTCTTTA
AGGTGGCTCAGATTTTTCAACTCTTGTGCACATAAAATTGAGTTGAAGTTCATTGTGCCTTTTTTTCTTTATCCAAATTTTGAGTTAAAG
CTTCATATGGTAACTGCATCCTGTTCGGACACTATAGTCTAAATTTTTGAAACTGTGTGGTGTTCGCTAAAAGTAGGAATAACAACGTAA
AAGCTAATTAAGGTCACAAACTTCGGTGAAACCCTTAAAAGTCCAAATCTTCTTGATATTGTGAACCGTACCCCTTCCAGTTTAGTTTCT
TCTGGACTTTCCTTACTTAACTGACAGTTACCTTTTAAAATTTGCACACATTATGATTAAAATTGGGCCTCTACTGTGATGATTCCTATT
TCCTCTCATGTTTTAAAGTGCAAACTAACATTTAAGTGAACATTAGCATCAAGTAGTGCAGACACTTGTATGCATTTCCTTGATTCAATT
TGTGACCTTACCAGTTTTGAATTGGAATTGCACCATTTCGTAGATAAAGGAAACTAAGTATATTGCTGCACTTTTAAGTTTTCAAAACAG
TGTTTAAAAATTGCATTGTTATTTTTTTTTAAACTCAGTTTAAAAAGACTAAAACGTTCTTTCAAAAGAGGCATCTAAATGTGTTCCTAA

>In-frame_ENST00000393561_ENST00000261667_CB119417_LAMB1_chr7_107569507_-_KPNA3_chr13_50279920_length(amino acids)=1814AA_start in transcript=56_stop in transcript=5500
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHASECAPVDGFNEEVEGM
VHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQ
HPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCD
SETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEAN
LGPGVSIVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTIPDDDNQ
VVSLSPGSRYVVLPRPVCFEKGTNYTVRLELPQYTSSDSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCLENS
RSVVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAFC
NPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGP
DSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFCR
FGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQC
QCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIAEL
TNRTHRFLEKAKALKISGVIGPYRETVDSVERKVSEIKDILAQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTAK
ELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDSITKYFQMSLEAEERVNASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEE
QARLLDELAGKLQSLDLSAAAEMTCGTPPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSALAEVEQLSK
MVSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDSADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVES
LSQVEVILQHSAADIARAEMLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSVEYLVQQNVIPPFC
NLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYN

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Fusion Gene PPI Analysis for LAMB1-KPNA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMB1-KPNA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMB1-KPNA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMB1C3554657LISSENCEPHALY 53CLINGEN;GENOMICS_ENGLAND;ORPHANET
HgeneLAMB1C0004352Autistic Disorder1CTD_human
HgeneLAMB1C0009324Ulcerative Colitis1CTD_human
HgeneLAMB1C0009363Congenital ocular coloboma (disorder)1CTD_human
HgeneLAMB1C0014175Endometriosis1CTD_human
HgeneLAMB1C0034069Pulmonary Fibrosis1CTD_human
HgeneLAMB1C0269102Endometrioma1CTD_human
HgeneLAMB1C4554007Uveoretinal Coloboma1CTD_human
HgeneLAMB1C4721507Alveolitis, Fibrosing1CTD_human
TgeneKPNA3C0036341Schizophrenia3PSYGENET
TgeneKPNA3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneKPNA3C0041696Unipolar Depression1PSYGENET
TgeneKPNA3C1269683Major Depressive Disorder1PSYGENET