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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMB1-PUS7 (FusionGDB2 ID:43693)

Fusion Gene Summary for LAMB1-PUS7

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB1-PUS7
Fusion gene ID: 43693
HgeneTgene
Gene symbol

LAMB1

PUS7

Gene ID

3912

54517

Gene namelaminin subunit beta 1pseudouridine synthase 7
SynonymsCLM|LIS5IDDABS
Cytomap

7q31.1

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit beta-1laminin B1 chainlaminin, beta 1pseudouridylate synthase 7 homologpseudouridylate synthase 7 (putative)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000393561, ENST00000222399, 
ENST00000393560, ENST00000474380, 
ENST00000356362, ENST00000469408, 
Fusion gene scores* DoF score11 X 11 X 5=6056 X 6 X 3=108
# samples 137
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMB1 [Title/Abstract] AND PUS7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMB1(107626467)-PUS7(105098373), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLAMB1

GO:0030335

positive regulation of cell migration

16289578

HgeneLAMB1

GO:0031175

neuron projection development

15894315

HgeneLAMB1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

HgeneLAMB1

GO:0042476

odontogenesis

15894315

TgenePUS7

GO:0017148

negative regulation of translation

29628141

TgenePUS7

GO:0031119

tRNA pseudouridine synthesis

29628141


check buttonFusion gene breakpoints across LAMB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PUS7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6868-01BLAMB1chr7

107626467

-PUS7chr7

105098373

-
ChimerDB4HNSCTCGA-BA-6868LAMB1chr7

107626466

-PUS7chr7

105098373

-
ChimerDB4HNSCTCGA-BA-6868LAMB1chr7

107626467

-PUS7chr7

105098373

-
ChimerDB4HNSCTCGA-BA-6868-01BLAMB1chr7

107626467

-PUS7chr7

105098373

-


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Fusion Gene ORF analysis for LAMB1-PUS7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393561ENST00000356362LAMB1chr7

107626467

-PUS7chr7

105098373

-
In-frameENST00000393561ENST00000469408LAMB1chr7

107626467

-PUS7chr7

105098373

-
Frame-shiftENST00000222399ENST00000356362LAMB1chr7

107626467

-PUS7chr7

105098373

-
Frame-shiftENST00000222399ENST00000469408LAMB1chr7

107626467

-PUS7chr7

105098373

-
Frame-shiftENST00000393560ENST00000356362LAMB1chr7

107626467

-PUS7chr7

105098373

-
Frame-shiftENST00000393560ENST00000469408LAMB1chr7

107626467

-PUS7chr7

105098373

-
intron-3CDSENST00000474380ENST00000356362LAMB1chr7

107626467

-PUS7chr7

105098373

-
intron-3CDSENST00000474380ENST00000469408LAMB1chr7

107626467

-PUS7chr7

105098373

-
In-frameENST00000393561ENST00000356362LAMB1chr7

107626466

-PUS7chr7

105098373

-
In-frameENST00000393561ENST00000469408LAMB1chr7

107626466

-PUS7chr7

105098373

-
Frame-shiftENST00000222399ENST00000356362LAMB1chr7

107626466

-PUS7chr7

105098373

-
Frame-shiftENST00000222399ENST00000469408LAMB1chr7

107626466

-PUS7chr7

105098373

-
Frame-shiftENST00000393560ENST00000356362LAMB1chr7

107626466

-PUS7chr7

105098373

-
Frame-shiftENST00000393560ENST00000469408LAMB1chr7

107626466

-PUS7chr7

105098373

-
intron-3CDSENST00000474380ENST00000356362LAMB1chr7

107626466

-PUS7chr7

105098373

-
intron-3CDSENST00000474380ENST00000469408LAMB1chr7

107626466

-PUS7chr7

105098373

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393561LAMB1chr7107626467-ENST00000356362PUS7chr7105098373-2349933561069337
ENST00000393561LAMB1chr7107626467-ENST00000469408PUS7chr7105098373-1201933561069337
ENST00000393561LAMB1chr7107626466-ENST00000356362PUS7chr7105098373-2349933561069337
ENST00000393561LAMB1chr7107626466-ENST00000469408PUS7chr7105098373-1201933561069337

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393561ENST00000356362LAMB1chr7107626467-PUS7chr7105098373-0.0009258150.9990742
ENST00000393561ENST00000469408LAMB1chr7107626467-PUS7chr7105098373-0.0064666080.9935334
ENST00000393561ENST00000356362LAMB1chr7107626466-PUS7chr7105098373-0.0009258150.9990742
ENST00000393561ENST00000469408LAMB1chr7107626466-PUS7chr7105098373-0.0064666080.9935334

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Fusion Genomic Features for LAMB1-PUS7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMB1-PUS7


check button Go to

FGviewer for the breakpoints of chr7:107626467-chr7:105098373

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341216_1315225.333333333333341787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341353_1388225.333333333333341787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341442_1781225.333333333333341787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341216_1315225.333333333333341787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341353_1388225.333333333333341787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341442_1781225.333333333333341787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341028_1083225.333333333333341787.0DomainLaminin EGF-like 11
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341084_1131225.333333333333341787.0DomainLaminin EGF-like 12
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341132_1178225.333333333333341787.0DomainLaminin EGF-like 13
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734271_334225.333333333333341787.0DomainLaminin EGF-like 1
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-73431_270225.333333333333341787.0DomainLaminin N-terminal
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734335_397225.333333333333341787.0DomainLaminin EGF-like 2
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734398_457225.333333333333341787.0DomainLaminin EGF-like 3
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734458_509225.333333333333341787.0DomainLaminin EGF-like 4
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734510_540225.333333333333341787.0DomainLaminin EGF-like 5%3B truncated
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734549_767225.333333333333341787.0DomainLaminin IV type B
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734773_820225.333333333333341787.0DomainLaminin EGF-like 6
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734821_866225.333333333333341787.0DomainLaminin EGF-like 7
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734867_916225.333333333333341787.0DomainLaminin EGF-like 8
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734917_975225.333333333333341787.0DomainLaminin EGF-like 9
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-734976_1027225.333333333333341787.0DomainLaminin EGF-like 10
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341028_1083225.333333333333341787.0DomainLaminin EGF-like 11
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341084_1131225.333333333333341787.0DomainLaminin EGF-like 12
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341132_1178225.333333333333341787.0DomainLaminin EGF-like 13
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734271_334225.333333333333341787.0DomainLaminin EGF-like 1
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-73431_270225.333333333333341787.0DomainLaminin N-terminal
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734335_397225.333333333333341787.0DomainLaminin EGF-like 2
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734398_457225.333333333333341787.0DomainLaminin EGF-like 3
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734458_509225.333333333333341787.0DomainLaminin EGF-like 4
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734510_540225.333333333333341787.0DomainLaminin EGF-like 5%3B truncated
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734549_767225.333333333333341787.0DomainLaminin IV type B
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734773_820225.333333333333341787.0DomainLaminin EGF-like 6
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734821_866225.333333333333341787.0DomainLaminin EGF-like 7
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734867_916225.333333333333341787.0DomainLaminin EGF-like 8
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734917_975225.333333333333341787.0DomainLaminin EGF-like 9
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-734976_1027225.333333333333341787.0DomainLaminin EGF-like 10
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341179_1397225.333333333333341787.0RegionNote=Domain II
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341398_1430225.333333333333341787.0RegionNote=Domain alpha
HgeneLAMB1chr7:107626466chr7:105098373ENST00000222399-7341431_1786225.333333333333341787.0RegionNote=Domain I
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341179_1397225.333333333333341787.0RegionNote=Domain II
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341398_1430225.333333333333341787.0RegionNote=Domain alpha
HgeneLAMB1chr7:107626467chr7:105098373ENST00000222399-7341431_1786225.333333333333341787.0RegionNote=Domain I
TgenePUS7chr7:107626466chr7:105098373ENST000003563621416370_580616.3333333333334662.0DomainTRUD
TgenePUS7chr7:107626466chr7:105098373ENST000004694081416370_580616.3333333333334662.0DomainTRUD
TgenePUS7chr7:107626467chr7:105098373ENST000003563621416370_580616.3333333333334662.0DomainTRUD
TgenePUS7chr7:107626467chr7:105098373ENST000004694081416370_580616.3333333333334662.0DomainTRUD


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Fusion Gene Sequence for LAMB1-PUS7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393561_ENST00000356362_TCGA-BA-6868-01B_LAMB1_chr7_107626467_-_PUS7_chr7_105098373_length(transcript)=2349nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGAAAGGCAAATACAGGGCTCTGAAAATGGATTTTTCTCTACCCCCTTCTACTTACGCCA
CCATGGCCATTCGAGAAGTGCTAAAAATGGATACCAGTATCAAGAACCAGACGCAGCTGAATACAACCTGGCTTCGCTGAGCAGTACCTT
GTCCACAGATTAGAAAACGTACACAAGTGTTTGCTTCCTGGCTCCCTGTGCATTTTTGTCTTAGTTCAGACTCATATATGGATTTCAAAT
CTTTGTAATAAAAATTATTTGTATTTTTAAGTTTTTATTAGCTTAAAGAAATAATTTGCAATATTTGTACATGTACACAAATCCTGAGGT
TCTTAATTTTAGCTCAGAATATAAATTAGTCAAAATACACTTCAGGTGCTTAAATCAGAGTAAAATGTCAGCTTTACAATAATAAAAAAA
GGACTTTGGTTTAAAGTAGCAGGTTTAGGTTTTGCTACATTCTCAAAAGACAGCAGGAGTATTTGACACATCTGTGATGGAGTATACAAC
AATGCATTTTAAGAGCAAATGCAACAAAACAAATCTGGACTATGGATAAATAATTTGAGAGCTGCCACCCACAAATATAAATACAGTACT
CATGCTGACTGAAATAATAAGACATCTACAAATTTATAAACAAAAAGTGATTGTCATTATCCTGCTTATGTACTAGATTCAGGCAAGCAT
TATAGACTTTTTGGTTGCGGTGGCTTTTGCATTTATATTATCAATGCCTTGCAGGAACGTTGCATTGATAGGCCCATTTTATTTTTTTAT
TTTTTTTTTCGAGACAGGATCTCACTCTGTAGCACAGGCTGGATTGCAGTGCAATCCTGCAATTCTCAATCTTGCACTGCAGCCTCGACC
TCCCAGGCTCCAGTGACTCTCCCACCTCAGCCTCCTAAGTAGCTGGGAGTACAGGCGCGCACCACCACGCCTAGCTGATTTTTGTATTTT
TTTGTAGAGACGGGGGTTTGGCCATGTTGCCGAGGCTAACTCCTGGGATTACAGGCATGAGCTGTGCTGGCCGGGTTTTTTTTTCTTGAT
GTAAACGTGTACAGCTGTTTTATTAGTTAAGGTCTAATTTTTACTCTAGGTGCCTTTTATGTTCAGAACTCTTTCCACTGGACTGGTATT
TGCTCAAAAATAAATAATGGTAGAGAAGAAAACTATAAAAATGGACAAGGCTTTCTTCTATCAGTAGCGTTTACCCTTTGTCACCAGTGG
CTTTGGTATTTCCATGTCTGGCATTGCATAAACTTCTCTGGTGTGAAAGGATAAATATGCCTTTCTAAAGTTGTATATCAAAATTGTATC
AATTTTTATTTTCTATGATTTCTAGAAACAAATGTAATAAATATTTTTAAAATCTCCTTTCTACTGGTTATGTAAATAAATCAAATAAAT

>In-frame_ENST00000393561_ENST00000356362_TCGA-BA-6868-01B_LAMB1_chr7_107626467_-_PUS7_chr7_105098373_length(amino acids)=337AA_start in transcript=56_stop in transcript=1069
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG

--------------------------------------------------------------
>In-frame_ENST00000393561_ENST00000469408_TCGA-BA-6868-01B_LAMB1_chr7_107626467_-_PUS7_chr7_105098373_length(transcript)=1201nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGAAAGGCAAATACAGGGCTCTGAAAATGGATTTTTCTCTACCCCCTTCTACTTACGCCA
CCATGGCCATTCGAGAAGTGCTAAAAATGGATACCAGTATCAAGAACCAGACGCAGCTGAATACAACCTGGCTTCGCTGAGCAGTACCTT
GTCCACAGATTAGAAAACGTACACAAGTGTTTGCTTCCTGGCTCCCTGTGCATTTTTGTCTTAGTTCAGACTCATATATGGATTTCAAAT

>In-frame_ENST00000393561_ENST00000469408_TCGA-BA-6868-01B_LAMB1_chr7_107626467_-_PUS7_chr7_105098373_length(amino acids)=337AA_start in transcript=56_stop in transcript=1069
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG

--------------------------------------------------------------
>In-frame_ENST00000393561_ENST00000356362_TCGA-BA-6868_LAMB1_chr7_107626466_-_PUS7_chr7_105098373_length(transcript)=2349nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGAAAGGCAAATACAGGGCTCTGAAAATGGATTTTTCTCTACCCCCTTCTACTTACGCCA
CCATGGCCATTCGAGAAGTGCTAAAAATGGATACCAGTATCAAGAACCAGACGCAGCTGAATACAACCTGGCTTCGCTGAGCAGTACCTT
GTCCACAGATTAGAAAACGTACACAAGTGTTTGCTTCCTGGCTCCCTGTGCATTTTTGTCTTAGTTCAGACTCATATATGGATTTCAAAT
CTTTGTAATAAAAATTATTTGTATTTTTAAGTTTTTATTAGCTTAAAGAAATAATTTGCAATATTTGTACATGTACACAAATCCTGAGGT
TCTTAATTTTAGCTCAGAATATAAATTAGTCAAAATACACTTCAGGTGCTTAAATCAGAGTAAAATGTCAGCTTTACAATAATAAAAAAA
GGACTTTGGTTTAAAGTAGCAGGTTTAGGTTTTGCTACATTCTCAAAAGACAGCAGGAGTATTTGACACATCTGTGATGGAGTATACAAC
AATGCATTTTAAGAGCAAATGCAACAAAACAAATCTGGACTATGGATAAATAATTTGAGAGCTGCCACCCACAAATATAAATACAGTACT
CATGCTGACTGAAATAATAAGACATCTACAAATTTATAAACAAAAAGTGATTGTCATTATCCTGCTTATGTACTAGATTCAGGCAAGCAT
TATAGACTTTTTGGTTGCGGTGGCTTTTGCATTTATATTATCAATGCCTTGCAGGAACGTTGCATTGATAGGCCCATTTTATTTTTTTAT
TTTTTTTTTCGAGACAGGATCTCACTCTGTAGCACAGGCTGGATTGCAGTGCAATCCTGCAATTCTCAATCTTGCACTGCAGCCTCGACC
TCCCAGGCTCCAGTGACTCTCCCACCTCAGCCTCCTAAGTAGCTGGGAGTACAGGCGCGCACCACCACGCCTAGCTGATTTTTGTATTTT
TTTGTAGAGACGGGGGTTTGGCCATGTTGCCGAGGCTAACTCCTGGGATTACAGGCATGAGCTGTGCTGGCCGGGTTTTTTTTTCTTGAT
GTAAACGTGTACAGCTGTTTTATTAGTTAAGGTCTAATTTTTACTCTAGGTGCCTTTTATGTTCAGAACTCTTTCCACTGGACTGGTATT
TGCTCAAAAATAAATAATGGTAGAGAAGAAAACTATAAAAATGGACAAGGCTTTCTTCTATCAGTAGCGTTTACCCTTTGTCACCAGTGG
CTTTGGTATTTCCATGTCTGGCATTGCATAAACTTCTCTGGTGTGAAAGGATAAATATGCCTTTCTAAAGTTGTATATCAAAATTGTATC
AATTTTTATTTTCTATGATTTCTAGAAACAAATGTAATAAATATTTTTAAAATCTCCTTTCTACTGGTTATGTAAATAAATCAAATAAAT

>In-frame_ENST00000393561_ENST00000356362_TCGA-BA-6868_LAMB1_chr7_107626466_-_PUS7_chr7_105098373_length(amino acids)=337AA_start in transcript=56_stop in transcript=1069
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG

--------------------------------------------------------------
>In-frame_ENST00000393561_ENST00000469408_TCGA-BA-6868_LAMB1_chr7_107626466_-_PUS7_chr7_105098373_length(transcript)=1201nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGAAAGGCAAATACAGGGCTCTGAAAATGGATTTTTCTCTACCCCCTTCTACTTACGCCA
CCATGGCCATTCGAGAAGTGCTAAAAATGGATACCAGTATCAAGAACCAGACGCAGCTGAATACAACCTGGCTTCGCTGAGCAGTACCTT
GTCCACAGATTAGAAAACGTACACAAGTGTTTGCTTCCTGGCTCCCTGTGCATTTTTGTCTTAGTTCAGACTCATATATGGATTTCAAAT

>In-frame_ENST00000393561_ENST00000469408_TCGA-BA-6868_LAMB1_chr7_107626466_-_PUS7_chr7_105098373_length(amino acids)=337AA_start in transcript=56_stop in transcript=1069
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LAMB1-PUS7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMB1-PUS7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMB1-PUS7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMB1C3554657LISSENCEPHALY 53CLINGEN;GENOMICS_ENGLAND;ORPHANET
HgeneLAMB1C0004352Autistic Disorder1CTD_human
HgeneLAMB1C0009324Ulcerative Colitis1CTD_human
HgeneLAMB1C0009363Congenital ocular coloboma (disorder)1CTD_human
HgeneLAMB1C0014175Endometriosis1CTD_human
HgeneLAMB1C0034069Pulmonary Fibrosis1CTD_human
HgeneLAMB1C0269102Endometrioma1CTD_human
HgeneLAMB1C4554007Uveoretinal Coloboma1CTD_human
HgeneLAMB1C4721507Alveolitis, Fibrosing1CTD_human
TgenePUS7C0013336Dwarfism1GENOMICS_ENGLAND
TgenePUS7C0025958Microcephaly1GENOMICS_ENGLAND
TgenePUS7C0233514Abnormal behavior1GENOMICS_ENGLAND
TgenePUS7C0349588Short stature1GENOMICS_ENGLAND
TgenePUS7C2919142Short Stature, CTCAE1GENOMICS_ENGLAND
TgenePUS7C3714756Intellectual Disability1GENOMICS_ENGLAND