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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMTOR1-UVRAG (FusionGDB2 ID:43766)

Fusion Gene Summary for LAMTOR1-UVRAG

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMTOR1-UVRAG
Fusion gene ID: 43766
HgeneTgene
Gene symbol

LAMTOR1

UVRAG

Gene ID

55004

7405

Gene namelate endosomal/lysosomal adaptor, MAPK and MTOR activator 1UV radiation resistance associated
SynonymsC11orf59|PDRO|Ragulator1|p18|p27RF-RhoDHTX|VPS38|p63
Cytomap

11q13.4

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionragulator complex protein LAMTOR1RhoA activator C11orf59late endosomal/lysosomal adaptor and MAPK and MTOR activator 1lipid raft adaptor protein p18p27Kip1-releasing factor from RhoAp27kip1 releasing factor from RhoAprotein associated with DRMs and UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
Modification date2020032720200313
UniProtAcc

Q6IAA8

.
Ensembl transtripts involved in fusion geneENST00000545249, ENST00000535107, 
ENST00000278671, ENST00000538404, 
ENST00000539797, 		ENST00000356136, 
ENST00000528420, ENST00000533454, 
ENST00000531818, ENST00000532130, 
ENST00000539288, ENST00000525872, 
ENST00000538870, 
Fusion gene scores* DoF score4 X 4 X 4=6428 X 21 X 11=6468
# samples 436
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6468*10)=-4.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMTOR1 [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMTOR1(71809335)-UVRAG(75562928), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

TgeneUVRAG

GO:0097352

autophagosome maturation

28306502

TgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check buttonFusion gene breakpoints across LAMTOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UVRAG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-UF-A7JV-01ALAMTOR1chr11

71809335

-UVRAGchr11

75562928

+


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Fusion Gene ORF analysis for LAMTOR1-UVRAG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000545249ENST00000356136LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-5UTRENST00000545249ENST00000528420LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000545249ENST00000533454LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000545249ENST00000531818LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000545249ENST00000532130LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000545249ENST00000539288LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000545249ENST00000525872LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000545249ENST00000538870LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-3CDSENST00000535107ENST00000356136LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-5UTRENST00000535107ENST00000528420LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000535107ENST00000533454LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000535107ENST00000531818LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000535107ENST00000532130LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000535107ENST00000539288LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000535107ENST00000525872LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000535107ENST00000538870LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
In-frameENST00000278671ENST00000356136LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-5UTRENST00000278671ENST00000528420LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000278671ENST00000533454LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000278671ENST00000531818LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000278671ENST00000532130LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000278671ENST00000539288LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000278671ENST00000525872LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5CDS-intronENST00000278671ENST00000538870LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-3CDSENST00000538404ENST00000356136LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-5UTRENST00000538404ENST00000528420LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000538404ENST00000533454LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000538404ENST00000531818LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000538404ENST00000532130LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000538404ENST00000539288LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000538404ENST00000525872LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
intron-intronENST00000538404ENST00000538870LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-3CDSENST00000539797ENST00000356136LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-5UTRENST00000539797ENST00000528420LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-intronENST00000539797ENST00000533454LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-intronENST00000539797ENST00000531818LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-intronENST00000539797ENST00000532130LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-intronENST00000539797ENST00000539288LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-intronENST00000539797ENST00000525872LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+
5UTR-intronENST00000539797ENST00000538870LAMTOR1chr11

71809335

-UVRAGchr11

75562928

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545249LAMTOR1chr1171809335-ENST00000356136UVRAGchr1175562928+4180415222397791
ENST00000278671LAMTOR1chr1171809335-ENST00000356136UVRAGchr1175562928+43215561632538791

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545249ENST00000356136LAMTOR1chr1171809335-UVRAGchr1175562928+0.0022807870.9977192
ENST00000278671ENST00000356136LAMTOR1chr1171809335-UVRAGchr1175562928+0.0023108540.9976891

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Fusion Genomic Features for LAMTOR1-UVRAG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LAMTOR1chr1171809334-UVRAGchr1175562927+2.17E-060.99999785
LAMTOR1chr1171809334-UVRAGchr1175562927+2.17E-060.99999785

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMTOR1-UVRAG


check button Go to

FGviewer for the breakpoints of chr11:71809335-chr11:75562928

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMTOR1

Q6IAA8

.
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUVRAGchr11:71809335chr11:75562928ENST00000356136015224_30539.0700.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUVRAGchr11:71809335chr11:75562928ENST0000035613601523_14939.0700.0DomainC2


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Fusion Gene Sequence for LAMTOR1-UVRAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000545249_ENST00000356136_TCGA-UF-A7JV-01A_LAMTOR1_chr11_71809335_-_UVRAG_chr11_75562928_length(transcript)=4180nt_BP=415nt
AGCGCCCGGCCCGACCCCGGCCATGGGGTGCTGCTACAGCAGCGAGAACGAGGACTCGGACCAGGACCGAGAGGAGCGGAAGCTGCTGCT
GGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCT
GCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGA
CCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAG
CCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCG
GAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTA
TAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTC
TTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTT
GGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTA
TTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAG
AGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAA
TGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGA
GGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGA
ATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTT
ACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGA
CTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCC
CCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCC
ACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGG
ACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACAC
CTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAA
AGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGT
GACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAA
CAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGG
GCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTC
AGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGC
ATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTA
TGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGA
AGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAA
AAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGC
CTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCC
TTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATG
GTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGA
AGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCC
CCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCT
TCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGG
GACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCA
GGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAG
GTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCT
AGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGAT
TTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCAT
GTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGACCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCC
ATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCATGTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATA
TAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCACATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTAT
TTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGCTACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAA
ATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATCTGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTA
GAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTTTGGAGTCAGTGTGGGTGGAGACAGCATCGTGGATATGCACGTGCTGCGG

>In-frame_ENST00000545249_ENST00000356136_TCGA-UF-A7JV-01A_LAMTOR1_chr11_71809335_-_UVRAG_chr11_75562928_length(amino acids)=791AA_start in transcript=22_stop in transcript=2397
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYST
RLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKN
SLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTI
LLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQ
QIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDG
SIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLR
QTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMG
ETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCT

--------------------------------------------------------------
>In-frame_ENST00000278671_ENST00000356136_TCGA-UF-A7JV-01A_LAMTOR1_chr11_71809335_-_UVRAG_chr11_75562928_length(transcript)=4321nt_BP=556nt
GGGGTATTGACTGAGGCGGCCAAGCGGCTCCGGGACAGGGGGTACGGGGGGTGGGGGCGGGTGGTTGCCTGCGGGAGGCCGCCGCGGGTC
ATGTGACCGGAAGGGCTCCTCACGGACGCCGTCCCTCCTCGGCGCGGCCTGAGCGCCCGGCCCGACCCCGGCCATGGGGTGCTGCTACAG
CAGCGAGAACGAGGACTCGGACCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGC
CGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCAT
TGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAG
CAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTT
CTCTGATTTGCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATAC
CTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTG
GCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACAT
CTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAAT
TTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCA
GAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCA
GAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAAT
TTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGA
CAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAG
AGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAA
TGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCT
TGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAAC
AATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTA
TGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCT
GAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCAT
ATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACT
TCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGAT
AACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGG
AGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGA
GCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGA
AATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGA
GTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCG
CAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCT
TTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATT
GTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAG
AGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAA
TAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAG
GTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTC
CCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAG
GACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCT
TAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCA
TCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACA
AAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGG
GTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTC
ATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGAC
ATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCC
GACCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCC
ATGTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGC
CACATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATA
GCTACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGA
TCTGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCAT
TTTGGAGTCAGTGTGGGTGGAGACAGCATCGTGGATATGCACGTGCTGCGGGGCCCTCCAGGGAAGTAACATTTACCAAAAAAAAAGAAA

>In-frame_ENST00000278671_ENST00000356136_TCGA-UF-A7JV-01A_LAMTOR1_chr11_71809335_-_UVRAG_chr11_75562928_length(amino acids)=791AA_start in transcript=163_stop in transcript=2538
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYST
RLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKN
SLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTI
LLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQ
QIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDG
SIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLR
QTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMG
ETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCT

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Fusion Gene PPI Analysis for LAMTOR1-UVRAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLAMTOR1chr11:71809335chr11:75562928ENST00000278671-45121_161131.0162.0LAMTOR2 and LAMTOR3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMTOR1-UVRAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMTOR1-UVRAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource