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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LARGE-IRF2BP2 (FusionGDB2 ID:43831)

Fusion Gene Summary for LARGE-IRF2BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: LARGE-IRF2BP2
Fusion gene ID: 43831
HgeneTgene
Gene symbol

LARGE

IRF2BP2

Gene ID

9215

359948

Gene nameLARGE xylosyl- and glucuronyltransferase 1interferon regulatory factor 2 binding protein 2
SynonymsLARGE|MDC1D|MDDGA6|MDDGB6CVID14
Cytomap

22q12.3

1q42.3

Type of geneprotein-codingprotein-coding
DescriptionLARGE xylosyl- and glucuronyltransferase 1acetylglucosaminyltransferase-like 1Aacetylglucosaminyltransferase-like proteinglycosyltransferase-like protein LARGE1interferon regulatory factor 2-binding protein 2IRF-2-binding protein 2
Modification date2020032820200313
UniProtAcc

GYLTL1B,LARGE2

Q7Z5L9

Ensembl transtripts involved in fusion geneENST00000337431, ENST00000354992, 
ENST00000397394, ENST00000402320, 
ENST00000452586, ENST00000437602, 
ENST00000421232, 		ENST00000366610, 
ENST00000366609, ENST00000491430, 
Fusion gene scores* DoF score10 X 9 X 6=5409 X 6 X 4=216
# samples 139
** MAII scorelog2(13/540*10)=-2.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LARGE [Title/Abstract] AND IRF2BP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLARGE(33733631)-IRF2BP2(234743598), # samples:1
Anticipated loss of major functional domain due to fusion event.LARGE-IRF2BP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LARGE-IRF2BP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLARGE

GO:0035269

protein O-linked mannosylation

22223806|25138275|25279697|25279699

TgeneIRF2BP2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799427

TgeneIRF2BP2

GO:0002327

immature B cell differentiation

27016798


check buttonFusion gene breakpoints across LARGE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IRF2BP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-A6RRLARGEchr22

33733631

-IRF2BP2chr1

234743598

-


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Fusion Gene ORF analysis for LARGE-IRF2BP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000337431ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-3CDSENST00000337431ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-5UTRENST00000337431ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
In-frameENST00000354992ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
In-frameENST00000354992ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
5CDS-5UTRENST00000354992ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
In-frameENST00000397394ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
In-frameENST00000397394ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
5CDS-5UTRENST00000397394ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-3CDSENST00000402320ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-3CDSENST00000402320ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-5UTRENST00000402320ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
Frame-shiftENST00000452586ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
Frame-shiftENST00000452586ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
5CDS-5UTRENST00000452586ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
Frame-shiftENST00000437602ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
Frame-shiftENST00000437602ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
5CDS-5UTRENST00000437602ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-3CDSENST00000421232ENST00000366610LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-3CDSENST00000421232ENST00000366609LARGEchr22

33733631

-IRF2BP2chr1

234743598

-
intron-5UTRENST00000421232ENST00000491430LARGEchr22

33733631

-IRF2BP2chr1

234743598

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354992LARGEchr2233733631-ENST00000366610IRF2BP2chr1234743598-544318595421984480
ENST00000354992LARGEchr2233733631-ENST00000366609IRF2BP2chr1234743598-544318595421984480
ENST00000397394LARGEchr2233733631-ENST00000366610IRF2BP2chr1234743598-538718033541928524
ENST00000397394LARGEchr2233733631-ENST00000366609IRF2BP2chr1234743598-538718033541928524

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354992ENST00000366610LARGEchr2233733631-IRF2BP2chr1234743598-0.001282920.99871707
ENST00000354992ENST00000366609LARGEchr2233733631-IRF2BP2chr1234743598-0.001282920.99871707
ENST00000397394ENST00000366610LARGEchr2233733631-IRF2BP2chr1234743598-0.0012279510.9987721
ENST00000397394ENST00000366609LARGEchr2233733631-IRF2BP2chr1234743598-0.0012279510.9987721

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Fusion Genomic Features for LARGE-IRF2BP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LARGE-IRF2BP2


check button Go to

FGviewer for the breakpoints of chr22:33733631-chr1:234743598

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARGE

GYLTL1B,LARGE2

IRF2BP2

Q7Z5L9

721FUNCTION: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARGEchr22:33733631chr1:234743598ENST00000354992-111653_95429.0757.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33733631chr1:234743598ENST00000397394-101553_95429.0757.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33733631chr1:234743598ENST00000354992-1116138_413429.0757.0RegionXylosyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000397394-1015138_413429.0757.0RegionXylosyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000354992-11161_10429.0757.0Topological domainCytoplasmic
HgeneLARGEchr22:33733631chr1:234743598ENST00000397394-10151_10429.0757.0Topological domainCytoplasmic
HgeneLARGEchr22:33733631chr1:234743598ENST00000354992-111611_31429.0757.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33733631chr1:234743598ENST00000397394-101511_31429.0757.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036660902354_361349.3333333333333588.0MotifNuclear localization signal
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036661002354_361333.3333333333333572.0MotifNuclear localization signal
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036660902506_550349.3333333333333588.0RegionNote=Cys-rich
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036661002506_550333.3333333333333572.0RegionNote=Cys-rich
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036660902506_553349.3333333333333588.0Zinc fingerNote=RING-type%3B degenerate
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036661002506_553333.3333333333333572.0Zinc fingerNote=RING-type%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARGEchr22:33733631chr1:234743598ENST00000337431-11553_950705.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33733631chr1:234743598ENST00000402320-11453_950705.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33733631chr1:234743598ENST00000337431-115138_4130705.0RegionXylosyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000337431-115414_7560705.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000354992-1116414_756429.0757.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000397394-1015414_756429.0757.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000402320-114138_4130705.0RegionXylosyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000402320-114414_7560705.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33733631chr1:234743598ENST00000337431-1151_100705.0Topological domainCytoplasmic
HgeneLARGEchr22:33733631chr1:234743598ENST00000337431-11532_7560705.0Topological domainLumenal
HgeneLARGEchr22:33733631chr1:234743598ENST00000354992-111632_756429.0757.0Topological domainLumenal
HgeneLARGEchr22:33733631chr1:234743598ENST00000397394-101532_756429.0757.0Topological domainLumenal
HgeneLARGEchr22:33733631chr1:234743598ENST00000402320-1141_100705.0Topological domainCytoplasmic
HgeneLARGEchr22:33733631chr1:234743598ENST00000402320-11432_7560705.0Topological domainLumenal
HgeneLARGEchr22:33733631chr1:234743598ENST00000337431-11511_310705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33733631chr1:234743598ENST00000402320-11411_310705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036660902104_200349.3333333333333588.0Compositional biasNote=Pro-rich
TgeneIRF2BP2chr22:33733631chr1:234743598ENST0000036661002104_200333.3333333333333572.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for LARGE-IRF2BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000354992_ENST00000366610_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(transcript)=5443nt_BP=1859nt
CGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAGGCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGTCGGCCCC
GGCGGTCGCTCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGGCTCGGAAGAGTCCCCCGGGCCGGGA
GCAGCTCCAGGCAGCGGCCCCGGAGGAAGAGGAAGAAGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTTGGAGCCG
GGGGCAGTCCCGAACTCTGTGCTTGGCACCGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACCCTGACCCGGACCCCCTGCGCCTCGTAG
GCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGTCTCCCTCTGCCTGGCGGCAGTCACGGCCAAGAACCTACATTAAGAAACGCATTC
AGATGCATCAGCCGTTTGTAAAGCACCTGTCGTGAGCCAGAGAGTATTATGAGGGAGGCCGAGGACTTCATGCTCCGGACAGAGAAACGG
CGCTGGGATTAGGGATTGCCACTTCTGAGAGGATGCTGGGAATCTGCAGGGGGAGACGGAAATTCTTGGCTGCCTCGTTGAGTCTTCTCT
GCATCCCAGCCATCACCTGGATTTACCTGTTTTCTGGGAGCTTCGAAGATGGAAAGCCCGTGTCTCTGTCACCGCTGGAGTCCCAGGCAC
ACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGAGCCTGGAGGTGCGCATGCGCGAGGTGGAGGAGGAGAACCGCGCCCTCC
GCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATCGCCGAGGCAACCACTCCAAGACCTACTCCATGGAGGAGGGCACTGGAG
ACAGCGAGAACCTTCGGGCTGGCATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAGCAGCCGGTCGTGGAGAAATGCGAGACAATCCACG
TTGCTATTGTCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAATCCGTCCTGTTCCATAGACGGAACCCTCTGCACT
TCCACCTTATTGCTGACTCCATTGCGGAGCAGATCCTGGCCACGCTCTTCCAGACCTGGATGGTGCCCGCTGTGCGTGTGGACTTCTACA
ATGCAGACGAGCTCAAGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAAGA
CTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGTGTTCCACA
AGTTCAAAGGTCAGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTGGTACCTTGGAAACCTGTGGAAAAATCACCGCCCATGGCCAG
CCCTTGGAAGAGGCTACAACACAGGGGTGATCCTGTTACTTCTGGATAAGCTGCGGAAGATGAAATGGGAGCAGATGTGGAGGCTGACCG
CAGAGAGGGAGCTCATGGGCATGCTCTCTACATCCTTAGCTGACCAGGATATTTTCAATGCCGTCATCAAACAAAACCCCTTCCTTGTGT
ACCAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACACCCGCTCCGAGCAGTGCTACAGAGACGTGTCTGATCTAAAGGTCATTC
ACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTTTCGCAACCTCTACCTGACCTTCCTGGAGTATGACGGCA
ATCTTCTGAGGCGGGAACTGTTTGGCTGCCCCAGTGAGGCTGATGTCAACAGTGAAAACTTGCAAGAACAGCAAGGAAAAGGAAGCCCTC
TCCAGAACCAGAAGGTGAAGTCGGGCCCCCTAAGATCAACGGAGAGGCCCAGCCGTGGCTGTCCACATCCACAGAGGGGCTCAAGATCCC
CATGACTCCTACATCCTCTTTTGTGTCTCCGCCACCACCCACTGCCTCACCTCATTCCAACCGGACCACACCGCCTGAAGCGGCCCAGAA
TGGCCAGTCCCCCATGGCAGCCCTGATCTTAGTAGCAGACAATGCAGGGGGCAGTCATGCCTCAAAAGATGCCAACCAGGTTCACTCCAC
TACCAGGAGGAATAGCAACAGTCCGCCCTCTCCGTCCTCTATGAACCAAAGAAGGCTGGGCCCCAGAGAGGTGGGGGGCCAGGGAGCAGG
CAACACAGGAGGACTGGAGCCAGTGCACCCTGCCAGCCTCCCGGACTCCTCTCTGGCAACCAGTGCCCCGCTGTGCTGCACCCTCTGCCA
CGAGCGGCTGGAGGACACCCATTTTGTGCAGTGCCCGTCCGTCCCTTCGCACAAGTTCTGCTTCCCTTGCTCCAGACAAAGCATCAAACA
GCAGGGAGCTAGTGGAGAGGTCTATTGTCCCAGTGGGGAAAAATGCCCTCTTGTGGGCTCCAATGTCCCCTGGGCCTTTATGCAAGGGGA
AATTGCAACCATCCTTGCTGGAGATGTGAAAGTGAAAAAAGAGAGAGACTCGTGACTTTTCCGGTTTCAGAAAAACCCAATGATTACCCT
TAATTAAAACTGCTTGAATTGTATATATATCTCCATATATATATATATCCAAGACAAGGGAAATGTAGACTTCATAAACATGGCTGTATA
ATTTTGATTTTTTTTGAATACATTGTGTTTCTATATTTTTTTTGACGACAAAAGGTATGTACTTATAAAGACATTTTTTTCTTTTGTTAA
CGTTATTAGCATATCTTTGTGCTTTATTATCCTGGTGACAGTTACCGTTCTATGTAGGCTGTGACTTGCGCTGCTTTTTTAGAGCACTTG
GCAAATCAGAAATGCTTCTAGCTGTATTTGTATGCACTTATTTTAAAAAGAAAAAAAAAGCCAAATACATTTTCTGACATTGTAAGATTG
CCTTACTGTCTGTCATTCCTTATTGCTGGCCCCTTTCTCAGGCCGGAGGCCAAGTGGTGGAGAAGGAAAGGAAATGATCGAACGGGCATG
TTGTCAAGTGGGCATGCCACTGGGAAATACCACCAGTTTACCCTGAAACATTGTCCTCAGAGGAGTAGGAAAGTGGATTTTGAATCTCTA
TTTTGCTCAAAAGTTCAGTTCCTGAGATACTGATGACTGAGAGTGCTGCTGGGAAATTTTCAGGATTGTGTGGTCTTTTGGGGTTTTTTG
TTTTTTTTTTTTTAAGACAAAGTTGACCGCTGTTCACTGTCCACGTGATCAGTTGTAAGATTACAATGCTGCATGCTAGTTGGTTACATA
AGATACAATTCCAGTGATGGAAGGCGGTTATAATGGATGGTGGTGTGTACAAGATGGCACTGCCATCTTTGAGCAGAGCCCAGCTCTGCA
GCGCCACTTCATCTTTTTAAACACCCTAGAGGTCTGTTTGTTGTTGCTGTTGTCCTTTATTTTGAAAGAGTTGCAAGAGAAGTTACAGTC
CAGGTGAACTTGGAGATTGTGGGATTGGTTTTGTTTCTGTTTTGTTTTGTTTATCATTTACCTGTAGTGCTATTGCTGTTGATACTATCA
CCTATACCCTGTTTCTAGTGAGTGCTGAATACAGTATGGTACAATGACAGTAACAGCCGCGTGGTGCTGCCAGGACTGCCCTTGGGCATA
TCAGTGACAGCCCAAATGTGGGTGGAGGAAACCTGTAATTTCCTTCTTAACATGTGTTTGAAATACCAAGTGAATAATACTGTTCTGGAA
AAAAATGATAAACTAGTGGAAATTAAAGAAATTAAGGGTTTTATATAATAGACAGGCCCCACCTCTCAAAATATTTTTAGAAGTCTTTTT
GTAAACTAATTTCTTTTGATCACTATTTTGCATCAGTAAAATGATTTTTTTAAAACCAATAAATCATCAATTATTAGAAATAGTTGTCTC
ACAGTGATACTGGTTTTTCTTTTGTGCTGTTATGATTTAACATTGACAGGAACACTATTTTAAATCCTTACGTTCAGGTGTTTGTAACTT
GGCCTTATAATTAGGCTGAATTATGGCTTCAAGGTCTACAATTTATGTGTATGGTTCACAGCCTAGCTTCTATTTACATTTGAAAATACA
GATTTTTACCAACTTTGGATTCTTTTTTAGTTATATGTTTGTCTTTCCTTTTTAAATTGTTCAAAACTATTTTTTAATGGTCAAGTTACT
AACACTTGAAAATCAGATACTGCACCAAATACAGTGTTTTTCCGTAGTGTTTTTAATGAGTGCACCTATTACTACTGTGCGAGAATTCAT
GTTTTACCAGTCATTGTTATATTACAAACAGACTTGCATGATTAACCAGTTGTTACACTTACTTTTTCAAGTTGGAGTATATATGACTCA
GTGCAGACTGGTCTCTCTTATGTGAATGCACACATGCAGAAATGCAGAGTCAATTTTACATGCCCATAAAGACATTTGTAAAGAATTCAG
CTCTTATGGTCTGTTGTATAAATGTGTATCTAGGCACTTTGGAATTTGACCTCACAGATGTTACAACTTGATCAGTCGTTTGACCTAATT
TGTGGTAGCTATCTGTATGTTTTGCAATCTTAATACAGACATGCTTTCCAAAAAGATTAATACAGAACCATCCTGCCGTTTTGGATAAGT
CTATCCAGCTGTGGAAAGGGCAACCTGTGGTTTCTCTGTACTGGTGTTTAATGGGGGAAGAATATGAACAGCTTTAAAGAGCTGTGTATT
GTGGTTACTACTATTAAAAAATAAGATCTGCACGAGTCTGACTGGCCTTTGGGTGGCCTTTGTGGACGGCTCGTAGCTGGAAAGTGTTGA
TCTGGGTTTTCTGGCATTCTTTTAAGTTAAAAAGTTAACATCGGGACATGGGTTTGATCTTTTGTTGTACCTGATGACAGTGCAGAGATT
CTCCACAGCTGGATAAAAATGTCACAAAGCTACTTACTGTACATGGGCAGTATCAGATTTCAAATCCTAATATTTCAGCTGTGCTTTTAA
TACTCAAAATATTAGGGGATGGGGTGTTGAAGCTTTCCCTTTTTTGCTTTTAACAATTTATAGAATTTAACAGATGTACTGTCTTTCATG
TGGCCTCACATTTAAAGTTATGAGAACATACACATGGTTTACAACTTTTACTATATACCTTTCCTTGGCCACCAAGTATTTTAAAAGTGT
GCCACCTTTTAACCTTTACTTTTTTTAAGTTGAAGGTGATACTTTTTCTATATATGATGAAACTCATGTCAACTGAAGTGAGTGTAATCT
CAGATACCAACATTATTATATTTTAAAATCACGCTATGGAAATATCACCTGAATTCTGTCATTTGTCAGATTTACAGTACCTTTTTTTCT

>In-frame_ENST00000354992_ENST00000366610_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(amino acids)=480AA_start in transcript=542_stop in transcript=1984
MGLGIATSERMLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALR
RQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHF
HLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHK
FKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVY
QLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQEQQGKGSPL

--------------------------------------------------------------
>In-frame_ENST00000354992_ENST00000366609_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(transcript)=5443nt_BP=1859nt
CGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAGGCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGTCGGCCCC
GGCGGTCGCTCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGGCTCGGAAGAGTCCCCCGGGCCGGGA
GCAGCTCCAGGCAGCGGCCCCGGAGGAAGAGGAAGAAGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTTGGAGCCG
GGGGCAGTCCCGAACTCTGTGCTTGGCACCGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACCCTGACCCGGACCCCCTGCGCCTCGTAG
GCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGTCTCCCTCTGCCTGGCGGCAGTCACGGCCAAGAACCTACATTAAGAAACGCATTC
AGATGCATCAGCCGTTTGTAAAGCACCTGTCGTGAGCCAGAGAGTATTATGAGGGAGGCCGAGGACTTCATGCTCCGGACAGAGAAACGG
CGCTGGGATTAGGGATTGCCACTTCTGAGAGGATGCTGGGAATCTGCAGGGGGAGACGGAAATTCTTGGCTGCCTCGTTGAGTCTTCTCT
GCATCCCAGCCATCACCTGGATTTACCTGTTTTCTGGGAGCTTCGAAGATGGAAAGCCCGTGTCTCTGTCACCGCTGGAGTCCCAGGCAC
ACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGAGCCTGGAGGTGCGCATGCGCGAGGTGGAGGAGGAGAACCGCGCCCTCC
GCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATCGCCGAGGCAACCACTCCAAGACCTACTCCATGGAGGAGGGCACTGGAG
ACAGCGAGAACCTTCGGGCTGGCATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAGCAGCCGGTCGTGGAGAAATGCGAGACAATCCACG
TTGCTATTGTCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAATCCGTCCTGTTCCATAGACGGAACCCTCTGCACT
TCCACCTTATTGCTGACTCCATTGCGGAGCAGATCCTGGCCACGCTCTTCCAGACCTGGATGGTGCCCGCTGTGCGTGTGGACTTCTACA
ATGCAGACGAGCTCAAGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAAGA
CTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGTGTTCCACA
AGTTCAAAGGTCAGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTGGTACCTTGGAAACCTGTGGAAAAATCACCGCCCATGGCCAG
CCCTTGGAAGAGGCTACAACACAGGGGTGATCCTGTTACTTCTGGATAAGCTGCGGAAGATGAAATGGGAGCAGATGTGGAGGCTGACCG
CAGAGAGGGAGCTCATGGGCATGCTCTCTACATCCTTAGCTGACCAGGATATTTTCAATGCCGTCATCAAACAAAACCCCTTCCTTGTGT
ACCAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACACCCGCTCCGAGCAGTGCTACAGAGACGTGTCTGATCTAAAGGTCATTC
ACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTTTCGCAACCTCTACCTGACCTTCCTGGAGTATGACGGCA
ATCTTCTGAGGCGGGAACTGTTTGGCTGCCCCAGTGAGGCTGATGTCAACAGTGAAAACTTGCAAGAACAGCAAGGAAAAGGAAGCCCTC
TCCAGAACCAGAAGGTGAAGTCGGGCCCCCTAAGATCAACGGAGAGGCCCAGCCGTGGCTGTCCACATCCACAGAGGGGCTCAAGATCCC
CATGACTCCTACATCCTCTTTTGTGTCTCCGCCACCACCCACTGCCTCACCTCATTCCAACCGGACCACACCGCCTGAAGCGGCCCAGAA
TGGCCAGTCCCCCATGGCAGCCCTGATCTTAGTAGCAGACAATGCAGGGGGCAGTCATGCCTCAAAAGATGCCAACCAGGTTCACTCCAC
TACCAGGAGGAATAGCAACAGTCCGCCCTCTCCGTCCTCTATGAACCAAAGAAGGCTGGGCCCCAGAGAGGTGGGGGGCCAGGGAGCAGG
CAACACAGGAGGACTGGAGCCAGTGCACCCTGCCAGCCTCCCGGACTCCTCTCTGGCAACCAGTGCCCCGCTGTGCTGCACCCTCTGCCA
CGAGCGGCTGGAGGACACCCATTTTGTGCAGTGCCCGTCCGTCCCTTCGCACAAGTTCTGCTTCCCTTGCTCCAGACAAAGCATCAAACA
GCAGGGAGCTAGTGGAGAGGTCTATTGTCCCAGTGGGGAAAAATGCCCTCTTGTGGGCTCCAATGTCCCCTGGGCCTTTATGCAAGGGGA
AATTGCAACCATCCTTGCTGGAGATGTGAAAGTGAAAAAAGAGAGAGACTCGTGACTTTTCCGGTTTCAGAAAAACCCAATGATTACCCT
TAATTAAAACTGCTTGAATTGTATATATATCTCCATATATATATATATCCAAGACAAGGGAAATGTAGACTTCATAAACATGGCTGTATA
ATTTTGATTTTTTTTGAATACATTGTGTTTCTATATTTTTTTTGACGACAAAAGGTATGTACTTATAAAGACATTTTTTTCTTTTGTTAA
CGTTATTAGCATATCTTTGTGCTTTATTATCCTGGTGACAGTTACCGTTCTATGTAGGCTGTGACTTGCGCTGCTTTTTTAGAGCACTTG
GCAAATCAGAAATGCTTCTAGCTGTATTTGTATGCACTTATTTTAAAAAGAAAAAAAAAGCCAAATACATTTTCTGACATTGTAAGATTG
CCTTACTGTCTGTCATTCCTTATTGCTGGCCCCTTTCTCAGGCCGGAGGCCAAGTGGTGGAGAAGGAAAGGAAATGATCGAACGGGCATG
TTGTCAAGTGGGCATGCCACTGGGAAATACCACCAGTTTACCCTGAAACATTGTCCTCAGAGGAGTAGGAAAGTGGATTTTGAATCTCTA
TTTTGCTCAAAAGTTCAGTTCCTGAGATACTGATGACTGAGAGTGCTGCTGGGAAATTTTCAGGATTGTGTGGTCTTTTGGGGTTTTTTG
TTTTTTTTTTTTTAAGACAAAGTTGACCGCTGTTCACTGTCCACGTGATCAGTTGTAAGATTACAATGCTGCATGCTAGTTGGTTACATA
AGATACAATTCCAGTGATGGAAGGCGGTTATAATGGATGGTGGTGTGTACAAGATGGCACTGCCATCTTTGAGCAGAGCCCAGCTCTGCA
GCGCCACTTCATCTTTTTAAACACCCTAGAGGTCTGTTTGTTGTTGCTGTTGTCCTTTATTTTGAAAGAGTTGCAAGAGAAGTTACAGTC
CAGGTGAACTTGGAGATTGTGGGATTGGTTTTGTTTCTGTTTTGTTTTGTTTATCATTTACCTGTAGTGCTATTGCTGTTGATACTATCA
CCTATACCCTGTTTCTAGTGAGTGCTGAATACAGTATGGTACAATGACAGTAACAGCCGCGTGGTGCTGCCAGGACTGCCCTTGGGCATA
TCAGTGACAGCCCAAATGTGGGTGGAGGAAACCTGTAATTTCCTTCTTAACATGTGTTTGAAATACCAAGTGAATAATACTGTTCTGGAA
AAAAATGATAAACTAGTGGAAATTAAAGAAATTAAGGGTTTTATATAATAGACAGGCCCCACCTCTCAAAATATTTTTAGAAGTCTTTTT
GTAAACTAATTTCTTTTGATCACTATTTTGCATCAGTAAAATGATTTTTTTAAAACCAATAAATCATCAATTATTAGAAATAGTTGTCTC
ACAGTGATACTGGTTTTTCTTTTGTGCTGTTATGATTTAACATTGACAGGAACACTATTTTAAATCCTTACGTTCAGGTGTTTGTAACTT
GGCCTTATAATTAGGCTGAATTATGGCTTCAAGGTCTACAATTTATGTGTATGGTTCACAGCCTAGCTTCTATTTACATTTGAAAATACA
GATTTTTACCAACTTTGGATTCTTTTTTAGTTATATGTTTGTCTTTCCTTTTTAAATTGTTCAAAACTATTTTTTAATGGTCAAGTTACT
AACACTTGAAAATCAGATACTGCACCAAATACAGTGTTTTTCCGTAGTGTTTTTAATGAGTGCACCTATTACTACTGTGCGAGAATTCAT
GTTTTACCAGTCATTGTTATATTACAAACAGACTTGCATGATTAACCAGTTGTTACACTTACTTTTTCAAGTTGGAGTATATATGACTCA
GTGCAGACTGGTCTCTCTTATGTGAATGCACACATGCAGAAATGCAGAGTCAATTTTACATGCCCATAAAGACATTTGTAAAGAATTCAG
CTCTTATGGTCTGTTGTATAAATGTGTATCTAGGCACTTTGGAATTTGACCTCACAGATGTTACAACTTGATCAGTCGTTTGACCTAATT
TGTGGTAGCTATCTGTATGTTTTGCAATCTTAATACAGACATGCTTTCCAAAAAGATTAATACAGAACCATCCTGCCGTTTTGGATAAGT
CTATCCAGCTGTGGAAAGGGCAACCTGTGGTTTCTCTGTACTGGTGTTTAATGGGGGAAGAATATGAACAGCTTTAAAGAGCTGTGTATT
GTGGTTACTACTATTAAAAAATAAGATCTGCACGAGTCTGACTGGCCTTTGGGTGGCCTTTGTGGACGGCTCGTAGCTGGAAAGTGTTGA
TCTGGGTTTTCTGGCATTCTTTTAAGTTAAAAAGTTAACATCGGGACATGGGTTTGATCTTTTGTTGTACCTGATGACAGTGCAGAGATT
CTCCACAGCTGGATAAAAATGTCACAAAGCTACTTACTGTACATGGGCAGTATCAGATTTCAAATCCTAATATTTCAGCTGTGCTTTTAA
TACTCAAAATATTAGGGGATGGGGTGTTGAAGCTTTCCCTTTTTTGCTTTTAACAATTTATAGAATTTAACAGATGTACTGTCTTTCATG
TGGCCTCACATTTAAAGTTATGAGAACATACACATGGTTTACAACTTTTACTATATACCTTTCCTTGGCCACCAAGTATTTTAAAAGTGT
GCCACCTTTTAACCTTTACTTTTTTTAAGTTGAAGGTGATACTTTTTCTATATATGATGAAACTCATGTCAACTGAAGTGAGTGTAATCT
CAGATACCAACATTATTATATTTTAAAATCACGCTATGGAAATATCACCTGAATTCTGTCATTTGTCAGATTTACAGTACCTTTTTTTCT

>In-frame_ENST00000354992_ENST00000366609_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(amino acids)=480AA_start in transcript=542_stop in transcript=1984
MGLGIATSERMLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALR
RQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHF
HLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHK
FKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVY
QLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQEQQGKGSPL

--------------------------------------------------------------
>In-frame_ENST00000397394_ENST00000366610_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(transcript)=5387nt_BP=1803nt
GGGGGCGCGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAGGCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGT
CGGCCCCGGCGGTCGCTCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGGCTCGGAAGAGTCCCCCGG
GCCGGGAGCAGCTCCAGGCAGCGGCCCCGGAGGAAGAGGAAGAAGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTT
GGAGCCGGGGGCAGTCCCGAACTCTGTGCTTGGCACCGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACCCTGACCCGGACCCCCTGCGC
CTCGTAGGCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGTCTCCCTCTGCCTGGCGGCAGTCACGGCCAAGAGAGTATTATGAGGGA
GGCCGAGGACTTCATGCTCCGGACAGAGAAACGGCGCTGGGATTAGGGATTGCCACTTCTGAGAGGATGCTGGGAATCTGCAGGGGGAGA
CGGAAATTCTTGGCTGCCTCGTTGAGTCTTCTCTGCATCCCAGCCATCACCTGGATTTACCTGTTTTCTGGGAGCTTCGAAGATGGAAAG
CCCGTGTCTCTGTCACCGCTGGAGTCCCAGGCACACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGAGCCTGGAGGTGCGC
ATGCGCGAGGTGGAGGAGGAGAACCGCGCCCTCCGCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATCGCCGAGGCAACCAC
TCCAAGACCTACTCCATGGAGGAGGGCACTGGAGACAGCGAGAACCTTCGGGCTGGCATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAG
CAGCCGGTCGTGGAGAAATGCGAGACAATCCACGTTGCTATTGTCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAA
TCCGTCCTGTTCCATAGACGGAACCCTCTGCACTTCCACCTTATTGCTGACTCCATTGCGGAGCAGATCCTGGCCACGCTCTTCCAGACC
TGGATGGTGCCCGCTGTGCGTGTGGACTTCTACAATGCAGACGAGCTCAAGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGG
ATTTATGGTCTGATGAAGCTTGTCCTGACCAAGACTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCC
ACTGACATTGCAGAGCTGTGGGCTGTGTTCCACAAGTTCAAAGGTCAGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTGGTACCTT
GGAAACCTGTGGAAAAATCACCGCCCATGGCCAGCCCTTGGAAGAGGCTACAACACAGGGGTGATCCTGTTACTTCTGGATAAGCTGCGG
AAGATGAAATGGGAGCAGATGTGGAGGCTGACCGCAGAGAGGGAGCTCATGGGCATGCTCTCTACATCCTTAGCTGACCAGGATATTTTC
AATGCCGTCATCAAACAAAACCCCTTCCTTGTGTACCAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACACCCGCTCCGAGCAG
TGCTACAGAGACGTGTCTGATCTAAAGGTCATTCACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTTTCGC
AACCTCTACCTGACCTTCCTGGAGTATGACGGCAATCTTCTGAGGCGGGAACTGTTTGGCTGCCCCAGTGAGGCTGATGTCAACAGTGAA
AACTTGCAAGAACAGCAAGGAAAAGGAAGCCCTCTCCAGAACCAGAAGGTGAAGTCGGGCCCCCTAAGATCAACGGAGAGGCCCAGCCGT
GGCTGTCCACATCCACAGAGGGGCTCAAGATCCCCATGACTCCTACATCCTCTTTTGTGTCTCCGCCACCACCCACTGCCTCACCTCATT
CCAACCGGACCACACCGCCTGAAGCGGCCCAGAATGGCCAGTCCCCCATGGCAGCCCTGATCTTAGTAGCAGACAATGCAGGGGGCAGTC
ATGCCTCAAAAGATGCCAACCAGGTTCACTCCACTACCAGGAGGAATAGCAACAGTCCGCCCTCTCCGTCCTCTATGAACCAAAGAAGGC
TGGGCCCCAGAGAGGTGGGGGGCCAGGGAGCAGGCAACACAGGAGGACTGGAGCCAGTGCACCCTGCCAGCCTCCCGGACTCCTCTCTGG
CAACCAGTGCCCCGCTGTGCTGCACCCTCTGCCACGAGCGGCTGGAGGACACCCATTTTGTGCAGTGCCCGTCCGTCCCTTCGCACAAGT
TCTGCTTCCCTTGCTCCAGACAAAGCATCAAACAGCAGGGAGCTAGTGGAGAGGTCTATTGTCCCAGTGGGGAAAAATGCCCTCTTGTGG
GCTCCAATGTCCCCTGGGCCTTTATGCAAGGGGAAATTGCAACCATCCTTGCTGGAGATGTGAAAGTGAAAAAAGAGAGAGACTCGTGAC
TTTTCCGGTTTCAGAAAAACCCAATGATTACCCTTAATTAAAACTGCTTGAATTGTATATATATCTCCATATATATATATATCCAAGACA
AGGGAAATGTAGACTTCATAAACATGGCTGTATAATTTTGATTTTTTTTGAATACATTGTGTTTCTATATTTTTTTTGACGACAAAAGGT
ATGTACTTATAAAGACATTTTTTTCTTTTGTTAACGTTATTAGCATATCTTTGTGCTTTATTATCCTGGTGACAGTTACCGTTCTATGTA
GGCTGTGACTTGCGCTGCTTTTTTAGAGCACTTGGCAAATCAGAAATGCTTCTAGCTGTATTTGTATGCACTTATTTTAAAAAGAAAAAA
AAAGCCAAATACATTTTCTGACATTGTAAGATTGCCTTACTGTCTGTCATTCCTTATTGCTGGCCCCTTTCTCAGGCCGGAGGCCAAGTG
GTGGAGAAGGAAAGGAAATGATCGAACGGGCATGTTGTCAAGTGGGCATGCCACTGGGAAATACCACCAGTTTACCCTGAAACATTGTCC
TCAGAGGAGTAGGAAAGTGGATTTTGAATCTCTATTTTGCTCAAAAGTTCAGTTCCTGAGATACTGATGACTGAGAGTGCTGCTGGGAAA
TTTTCAGGATTGTGTGGTCTTTTGGGGTTTTTTGTTTTTTTTTTTTTAAGACAAAGTTGACCGCTGTTCACTGTCCACGTGATCAGTTGT
AAGATTACAATGCTGCATGCTAGTTGGTTACATAAGATACAATTCCAGTGATGGAAGGCGGTTATAATGGATGGTGGTGTGTACAAGATG
GCACTGCCATCTTTGAGCAGAGCCCAGCTCTGCAGCGCCACTTCATCTTTTTAAACACCCTAGAGGTCTGTTTGTTGTTGCTGTTGTCCT
TTATTTTGAAAGAGTTGCAAGAGAAGTTACAGTCCAGGTGAACTTGGAGATTGTGGGATTGGTTTTGTTTCTGTTTTGTTTTGTTTATCA
TTTACCTGTAGTGCTATTGCTGTTGATACTATCACCTATACCCTGTTTCTAGTGAGTGCTGAATACAGTATGGTACAATGACAGTAACAG
CCGCGTGGTGCTGCCAGGACTGCCCTTGGGCATATCAGTGACAGCCCAAATGTGGGTGGAGGAAACCTGTAATTTCCTTCTTAACATGTG
TTTGAAATACCAAGTGAATAATACTGTTCTGGAAAAAAATGATAAACTAGTGGAAATTAAAGAAATTAAGGGTTTTATATAATAGACAGG
CCCCACCTCTCAAAATATTTTTAGAAGTCTTTTTGTAAACTAATTTCTTTTGATCACTATTTTGCATCAGTAAAATGATTTTTTTAAAAC
CAATAAATCATCAATTATTAGAAATAGTTGTCTCACAGTGATACTGGTTTTTCTTTTGTGCTGTTATGATTTAACATTGACAGGAACACT
ATTTTAAATCCTTACGTTCAGGTGTTTGTAACTTGGCCTTATAATTAGGCTGAATTATGGCTTCAAGGTCTACAATTTATGTGTATGGTT
CACAGCCTAGCTTCTATTTACATTTGAAAATACAGATTTTTACCAACTTTGGATTCTTTTTTAGTTATATGTTTGTCTTTCCTTTTTAAA
TTGTTCAAAACTATTTTTTAATGGTCAAGTTACTAACACTTGAAAATCAGATACTGCACCAAATACAGTGTTTTTCCGTAGTGTTTTTAA
TGAGTGCACCTATTACTACTGTGCGAGAATTCATGTTTTACCAGTCATTGTTATATTACAAACAGACTTGCATGATTAACCAGTTGTTAC
ACTTACTTTTTCAAGTTGGAGTATATATGACTCAGTGCAGACTGGTCTCTCTTATGTGAATGCACACATGCAGAAATGCAGAGTCAATTT
TACATGCCCATAAAGACATTTGTAAAGAATTCAGCTCTTATGGTCTGTTGTATAAATGTGTATCTAGGCACTTTGGAATTTGACCTCACA
GATGTTACAACTTGATCAGTCGTTTGACCTAATTTGTGGTAGCTATCTGTATGTTTTGCAATCTTAATACAGACATGCTTTCCAAAAAGA
TTAATACAGAACCATCCTGCCGTTTTGGATAAGTCTATCCAGCTGTGGAAAGGGCAACCTGTGGTTTCTCTGTACTGGTGTTTAATGGGG
GAAGAATATGAACAGCTTTAAAGAGCTGTGTATTGTGGTTACTACTATTAAAAAATAAGATCTGCACGAGTCTGACTGGCCTTTGGGTGG
CCTTTGTGGACGGCTCGTAGCTGGAAAGTGTTGATCTGGGTTTTCTGGCATTCTTTTAAGTTAAAAAGTTAACATCGGGACATGGGTTTG
ATCTTTTGTTGTACCTGATGACAGTGCAGAGATTCTCCACAGCTGGATAAAAATGTCACAAAGCTACTTACTGTACATGGGCAGTATCAG
ATTTCAAATCCTAATATTTCAGCTGTGCTTTTAATACTCAAAATATTAGGGGATGGGGTGTTGAAGCTTTCCCTTTTTTGCTTTTAACAA
TTTATAGAATTTAACAGATGTACTGTCTTTCATGTGGCCTCACATTTAAAGTTATGAGAACATACACATGGTTTACAACTTTTACTATAT
ACCTTTCCTTGGCCACCAAGTATTTTAAAAGTGTGCCACCTTTTAACCTTTACTTTTTTTAAGTTGAAGGTGATACTTTTTCTATATATG
ATGAAACTCATGTCAACTGAAGTGAGTGTAATCTCAGATACCAACATTATTATATTTTAAAATCACGCTATGGAAATATCACCTGAATTC

>In-frame_ENST00000397394_ENST00000366610_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(amino acids)=524AA_start in transcript=354_stop in transcript=1928
MRLVGGGAAAPPCSSVSPSAWRQSRPREYYEGGRGLHAPDRETALGLGIATSERMLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFED
GKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSEC
GQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHY
SGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDK
LRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEF

--------------------------------------------------------------
>In-frame_ENST00000397394_ENST00000366609_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(transcript)=5387nt_BP=1803nt
GGGGGCGCGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAGGCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGT
CGGCCCCGGCGGTCGCTCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGGCTCGGAAGAGTCCCCCGG
GCCGGGAGCAGCTCCAGGCAGCGGCCCCGGAGGAAGAGGAAGAAGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTT
GGAGCCGGGGGCAGTCCCGAACTCTGTGCTTGGCACCGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACCCTGACCCGGACCCCCTGCGC
CTCGTAGGCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGTCTCCCTCTGCCTGGCGGCAGTCACGGCCAAGAGAGTATTATGAGGGA
GGCCGAGGACTTCATGCTCCGGACAGAGAAACGGCGCTGGGATTAGGGATTGCCACTTCTGAGAGGATGCTGGGAATCTGCAGGGGGAGA
CGGAAATTCTTGGCTGCCTCGTTGAGTCTTCTCTGCATCCCAGCCATCACCTGGATTTACCTGTTTTCTGGGAGCTTCGAAGATGGAAAG
CCCGTGTCTCTGTCACCGCTGGAGTCCCAGGCACACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGAGCCTGGAGGTGCGC
ATGCGCGAGGTGGAGGAGGAGAACCGCGCCCTCCGCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATCGCCGAGGCAACCAC
TCCAAGACCTACTCCATGGAGGAGGGCACTGGAGACAGCGAGAACCTTCGGGCTGGCATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAG
CAGCCGGTCGTGGAGAAATGCGAGACAATCCACGTTGCTATTGTCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAA
TCCGTCCTGTTCCATAGACGGAACCCTCTGCACTTCCACCTTATTGCTGACTCCATTGCGGAGCAGATCCTGGCCACGCTCTTCCAGACC
TGGATGGTGCCCGCTGTGCGTGTGGACTTCTACAATGCAGACGAGCTCAAGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGG
ATTTATGGTCTGATGAAGCTTGTCCTGACCAAGACTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCC
ACTGACATTGCAGAGCTGTGGGCTGTGTTCCACAAGTTCAAAGGTCAGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTGGTACCTT
GGAAACCTGTGGAAAAATCACCGCCCATGGCCAGCCCTTGGAAGAGGCTACAACACAGGGGTGATCCTGTTACTTCTGGATAAGCTGCGG
AAGATGAAATGGGAGCAGATGTGGAGGCTGACCGCAGAGAGGGAGCTCATGGGCATGCTCTCTACATCCTTAGCTGACCAGGATATTTTC
AATGCCGTCATCAAACAAAACCCCTTCCTTGTGTACCAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACACCCGCTCCGAGCAG
TGCTACAGAGACGTGTCTGATCTAAAGGTCATTCACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTTTCGC
AACCTCTACCTGACCTTCCTGGAGTATGACGGCAATCTTCTGAGGCGGGAACTGTTTGGCTGCCCCAGTGAGGCTGATGTCAACAGTGAA
AACTTGCAAGAACAGCAAGGAAAAGGAAGCCCTCTCCAGAACCAGAAGGTGAAGTCGGGCCCCCTAAGATCAACGGAGAGGCCCAGCCGT
GGCTGTCCACATCCACAGAGGGGCTCAAGATCCCCATGACTCCTACATCCTCTTTTGTGTCTCCGCCACCACCCACTGCCTCACCTCATT
CCAACCGGACCACACCGCCTGAAGCGGCCCAGAATGGCCAGTCCCCCATGGCAGCCCTGATCTTAGTAGCAGACAATGCAGGGGGCAGTC
ATGCCTCAAAAGATGCCAACCAGGTTCACTCCACTACCAGGAGGAATAGCAACAGTCCGCCCTCTCCGTCCTCTATGAACCAAAGAAGGC
TGGGCCCCAGAGAGGTGGGGGGCCAGGGAGCAGGCAACACAGGAGGACTGGAGCCAGTGCACCCTGCCAGCCTCCCGGACTCCTCTCTGG
CAACCAGTGCCCCGCTGTGCTGCACCCTCTGCCACGAGCGGCTGGAGGACACCCATTTTGTGCAGTGCCCGTCCGTCCCTTCGCACAAGT
TCTGCTTCCCTTGCTCCAGACAAAGCATCAAACAGCAGGGAGCTAGTGGAGAGGTCTATTGTCCCAGTGGGGAAAAATGCCCTCTTGTGG
GCTCCAATGTCCCCTGGGCCTTTATGCAAGGGGAAATTGCAACCATCCTTGCTGGAGATGTGAAAGTGAAAAAAGAGAGAGACTCGTGAC
TTTTCCGGTTTCAGAAAAACCCAATGATTACCCTTAATTAAAACTGCTTGAATTGTATATATATCTCCATATATATATATATCCAAGACA
AGGGAAATGTAGACTTCATAAACATGGCTGTATAATTTTGATTTTTTTTGAATACATTGTGTTTCTATATTTTTTTTGACGACAAAAGGT
ATGTACTTATAAAGACATTTTTTTCTTTTGTTAACGTTATTAGCATATCTTTGTGCTTTATTATCCTGGTGACAGTTACCGTTCTATGTA
GGCTGTGACTTGCGCTGCTTTTTTAGAGCACTTGGCAAATCAGAAATGCTTCTAGCTGTATTTGTATGCACTTATTTTAAAAAGAAAAAA
AAAGCCAAATACATTTTCTGACATTGTAAGATTGCCTTACTGTCTGTCATTCCTTATTGCTGGCCCCTTTCTCAGGCCGGAGGCCAAGTG
GTGGAGAAGGAAAGGAAATGATCGAACGGGCATGTTGTCAAGTGGGCATGCCACTGGGAAATACCACCAGTTTACCCTGAAACATTGTCC
TCAGAGGAGTAGGAAAGTGGATTTTGAATCTCTATTTTGCTCAAAAGTTCAGTTCCTGAGATACTGATGACTGAGAGTGCTGCTGGGAAA
TTTTCAGGATTGTGTGGTCTTTTGGGGTTTTTTGTTTTTTTTTTTTTAAGACAAAGTTGACCGCTGTTCACTGTCCACGTGATCAGTTGT
AAGATTACAATGCTGCATGCTAGTTGGTTACATAAGATACAATTCCAGTGATGGAAGGCGGTTATAATGGATGGTGGTGTGTACAAGATG
GCACTGCCATCTTTGAGCAGAGCCCAGCTCTGCAGCGCCACTTCATCTTTTTAAACACCCTAGAGGTCTGTTTGTTGTTGCTGTTGTCCT
TTATTTTGAAAGAGTTGCAAGAGAAGTTACAGTCCAGGTGAACTTGGAGATTGTGGGATTGGTTTTGTTTCTGTTTTGTTTTGTTTATCA
TTTACCTGTAGTGCTATTGCTGTTGATACTATCACCTATACCCTGTTTCTAGTGAGTGCTGAATACAGTATGGTACAATGACAGTAACAG
CCGCGTGGTGCTGCCAGGACTGCCCTTGGGCATATCAGTGACAGCCCAAATGTGGGTGGAGGAAACCTGTAATTTCCTTCTTAACATGTG
TTTGAAATACCAAGTGAATAATACTGTTCTGGAAAAAAATGATAAACTAGTGGAAATTAAAGAAATTAAGGGTTTTATATAATAGACAGG
CCCCACCTCTCAAAATATTTTTAGAAGTCTTTTTGTAAACTAATTTCTTTTGATCACTATTTTGCATCAGTAAAATGATTTTTTTAAAAC
CAATAAATCATCAATTATTAGAAATAGTTGTCTCACAGTGATACTGGTTTTTCTTTTGTGCTGTTATGATTTAACATTGACAGGAACACT
ATTTTAAATCCTTACGTTCAGGTGTTTGTAACTTGGCCTTATAATTAGGCTGAATTATGGCTTCAAGGTCTACAATTTATGTGTATGGTT
CACAGCCTAGCTTCTATTTACATTTGAAAATACAGATTTTTACCAACTTTGGATTCTTTTTTAGTTATATGTTTGTCTTTCCTTTTTAAA
TTGTTCAAAACTATTTTTTAATGGTCAAGTTACTAACACTTGAAAATCAGATACTGCACCAAATACAGTGTTTTTCCGTAGTGTTTTTAA
TGAGTGCACCTATTACTACTGTGCGAGAATTCATGTTTTACCAGTCATTGTTATATTACAAACAGACTTGCATGATTAACCAGTTGTTAC
ACTTACTTTTTCAAGTTGGAGTATATATGACTCAGTGCAGACTGGTCTCTCTTATGTGAATGCACACATGCAGAAATGCAGAGTCAATTT
TACATGCCCATAAAGACATTTGTAAAGAATTCAGCTCTTATGGTCTGTTGTATAAATGTGTATCTAGGCACTTTGGAATTTGACCTCACA
GATGTTACAACTTGATCAGTCGTTTGACCTAATTTGTGGTAGCTATCTGTATGTTTTGCAATCTTAATACAGACATGCTTTCCAAAAAGA
TTAATACAGAACCATCCTGCCGTTTTGGATAAGTCTATCCAGCTGTGGAAAGGGCAACCTGTGGTTTCTCTGTACTGGTGTTTAATGGGG
GAAGAATATGAACAGCTTTAAAGAGCTGTGTATTGTGGTTACTACTATTAAAAAATAAGATCTGCACGAGTCTGACTGGCCTTTGGGTGG
CCTTTGTGGACGGCTCGTAGCTGGAAAGTGTTGATCTGGGTTTTCTGGCATTCTTTTAAGTTAAAAAGTTAACATCGGGACATGGGTTTG
ATCTTTTGTTGTACCTGATGACAGTGCAGAGATTCTCCACAGCTGGATAAAAATGTCACAAAGCTACTTACTGTACATGGGCAGTATCAG
ATTTCAAATCCTAATATTTCAGCTGTGCTTTTAATACTCAAAATATTAGGGGATGGGGTGTTGAAGCTTTCCCTTTTTTGCTTTTAACAA
TTTATAGAATTTAACAGATGTACTGTCTTTCATGTGGCCTCACATTTAAAGTTATGAGAACATACACATGGTTTACAACTTTTACTATAT
ACCTTTCCTTGGCCACCAAGTATTTTAAAAGTGTGCCACCTTTTAACCTTTACTTTTTTTAAGTTGAAGGTGATACTTTTTCTATATATG
ATGAAACTCATGTCAACTGAAGTGAGTGTAATCTCAGATACCAACATTATTATATTTTAAAATCACGCTATGGAAATATCACCTGAATTC

>In-frame_ENST00000397394_ENST00000366609_TCGA-IN-A6RR_LARGE_chr22_33733631_-_IRF2BP2_chr1_234743598_length(amino acids)=524AA_start in transcript=354_stop in transcript=1928
MRLVGGGAAAPPCSSVSPSAWRQSRPREYYEGGRGLHAPDRETALGLGIATSERMLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFED
GKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSEC
GQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHY
SGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDK
LRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEF

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Fusion Gene PPI Analysis for LARGE-IRF2BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LARGE-IRF2BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LARGE-IRF2BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIRF2BP2C0023487Acute Promyelocytic Leukemia2CTD_human;ORPHANET
TgeneIRF2BP2C0009447Common Variable Immunodeficiency1GENOMICS_ENGLAND
TgeneIRF2BP2C4540380IMMUNODEFICIENCY, COMMON VARIABLE, 141UNIPROT