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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LASP1-STAC2 (FusionGDB2 ID:43953)

Fusion Gene Summary for LASP1-STAC2

check button Fusion gene summary
Fusion gene informationFusion gene name: LASP1-STAC2
Fusion gene ID: 43953
HgeneTgene
Gene symbol

LASP1

STAC2

Gene ID

3927

342667

Gene nameLIM and SH3 protein 1SH3 and cysteine rich domain 2
SynonymsLasp-1|MLN5024b2|24b2/STAC2
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
DescriptionLIM and SH3 domain protein 1metastatic lymph node gene 50 proteinSH3 and cysteine-rich domain-containing protein 2SRC homology 3 and cysteine-rich domain-containing protein 2
Modification date2020031320200313
UniProtAcc

Q14847

.
Ensembl transtripts involved in fusion geneENST00000318008, ENST00000433206, 
ENST00000435347, 		ENST00000333461, 
Fusion gene scores* DoF score18 X 17 X 8=24489 X 6 X 6=324
# samples 2112
** MAII scorelog2(21/2448*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LASP1 [Title/Abstract] AND STAC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLASP1(37046757)-STAC2(37374426), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LASP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across STAC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4T-01ALASP1chr17

37046757

+STAC2chr17

37374426

-


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Fusion Gene ORF analysis for LASP1-STAC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318008ENST00000333461LASP1chr17

37046757

+STAC2chr17

37374426

-
intron-3CDSENST00000433206ENST00000333461LASP1chr17

37046757

+STAC2chr17

37374426

-
In-frameENST00000435347ENST00000333461LASP1chr17

37046757

+STAC2chr17

37374426

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318008LASP1chr1737046757+ENST00000333461STAC2chr1737374426-34825801797298499
ENST00000435347LASP1chr1737046757+ENST00000333461STAC2chr1737374426-3198296151314499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318008ENST00000333461LASP1chr1737046757+STAC2chr1737374426-0.0289216730.97107834
ENST00000435347ENST00000333461LASP1chr1737046757+STAC2chr1737374426-0.0251162760.9748837

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Fusion Genomic Features for LASP1-STAC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LASP1-STAC2


check button Go to

FGviewer for the breakpoints of chr17:37046757-chr17:37374426

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LASP1

Q14847

.
FUNCTION: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLASP1chr17:37046757chr17:37374426ENST00000318008+375_5683.0262.0DomainLIM zinc-binding
HgeneLASP1chr17:37046757chr17:37374426ENST00000435347+385_5683.0708.3333333333334DomainLIM zinc-binding
TgeneSTAC2chr17:37046757chr17:37374426ENST0000033346101170_10130.0412.0Compositional biasNote=Pro-rich
TgeneSTAC2chr17:37046757chr17:37374426ENST00000333461011292_35130.0412.0DomainSH3 1
TgeneSTAC2chr17:37046757chr17:37374426ENST00000333461011354_41130.0412.0DomainSH3 2
TgeneSTAC2chr17:37046757chr17:37374426ENST00000333461011110_16130.0412.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLASP1chr17:37046757chr17:37374426ENST00000318008+37201_20483.0262.0Compositional biasNote=Poly-Gly
HgeneLASP1chr17:37046757chr17:37374426ENST00000435347+38201_20483.0708.3333333333334Compositional biasNote=Poly-Gly
HgeneLASP1chr17:37046757chr17:37374426ENST00000318008+37202_26183.0262.0DomainSH3
HgeneLASP1chr17:37046757chr17:37374426ENST00000435347+38202_26183.0708.3333333333334DomainSH3
HgeneLASP1chr17:37046757chr17:37374426ENST00000318008+3761_9583.0262.0RepeatNote=Nebulin 1
HgeneLASP1chr17:37046757chr17:37374426ENST00000318008+3797_13183.0262.0RepeatNote=Nebulin 2
HgeneLASP1chr17:37046757chr17:37374426ENST00000435347+3861_9583.0708.3333333333334RepeatNote=Nebulin 1
HgeneLASP1chr17:37046757chr17:37374426ENST00000435347+3897_13183.0708.3333333333334RepeatNote=Nebulin 2


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Fusion Gene Sequence for LASP1-STAC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000318008_ENST00000333461_TCGA-ZF-AA4T-01A_LASP1_chr17_37046757_+_STAC2_chr17_37374426_length(transcript)=3482nt_BP=580nt
GCAGTCAGCCTGAGAGCGCTGAGGCGCCAGCACCGCGGGCCCCGCCGTCCCCCCAGGAACCCGCCCCCGCGCAGCCCCACGTCGCCCGGA
GAGCGCGCCTCGCTGCGCGTGCCCTTGCCCGCGCCCGAGGCGCGTGCCCGCCCCAGTGCAGCCCCTCCTCCCCGCTGTGTTTATTAGGGG
AAGGAGGGCGGAGGCGGAGGCCAGTTCCCCAGCTCCAGCCGCCGTCGCTGCTGCCTGTGTAGTTGCAGCCGCGGCCGCCTCCCGCCAGCT
CGCCTCGGGGAACAGGACGCGCGTGAGCTCAGGCGTCCCCGCCCCAGCTTTTCTCGGAACCATGAACCCCAACTGCGCCCGGTGCGGCAA
GATCGTGTATCCCACGGAGAAGGTGAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTGAA
CATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGTCCTTCACCATGGTGGCGGACACCCCGGA
AAACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAGTCAGCTCCAGCGATTCAAGCGCTCCCTCTCCCTCAAGACCATCCTCCGAAGTAA
GAGCTTGGAGAACTTCTTCCTTCGCTCGGGCTCTGAGCTCAAGTGCCCCACCGAGGTGCTGCTGACGCCCCCAACCCCACTGCCCCCTCC
CTCCCCACCACCCACAGCCTCGGACAGGGGCCTGGCTACCCCATCCCCCTCCCCATGCCCAGTCCCACGCCCCCTGGCAGCGCTCAAACC
AGTGAGGCTGCACAGCTTCCAGGAACATGTCTTCAAGCGAGCTAGCCCTTGTGAGCTGTGCCACCAGCTCATCGTAGGAAACTCCAAACA
GGGCTTGCGATGTAAGATGTGCAAAGTCAGCGTCCACCTCTGGTGCTCTGAGGAGATCTCCCACCAGCAATGCCCAGGCAAGACGTCCAC
CTCCTTCCGCCGCAACTTCAGTTCCCCTCTCCTGGTGCATGAGCCGCCACCAGTCTGTGCCACAAGCAAAGAGTCCCCACCCACTGGGGA
CAGTGGGAAGGTGGACCCTGTCTACGAGACCCTGCGCTATGGCACCTCCCTGGCACTGATGAACCGCTCCAGTTTCAGCAGCACCTCTGA
GTCCCCGACAAGGAGCCTGAGTGAGCGGGATGAGCTGACCGAGGATGGGGAAGGCAGCATCCGCAGCTCTGAGGAGGGGCCTGGTGACAG
TGCATCTCCAGTATTCACAGCCCCAGCAGAGAGTGAAGGGCCAGGACCAGAGGAGAAGAGTCCTGGACAGCAGCTCCCCAAAGCCACCCT
GCGGAAGGATGTGGGGCCCATGTACTCCTACGTTGCACTCTACAAGTTTCTGCCCCAGGAGAACAATGATCTGGCTCTGCAGCCTGGAGA
TCGGATCATGCTGGTGGATGACTCTAACGAGGACTGGTGGAAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCA
ACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCA
GATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGC
CCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGC
CCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATT
TTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGG
TAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTC
TCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACC
GTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACC
ATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTT
GAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAG
CTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAG
CCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCA
GAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAA
TCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGT
CAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGG
ACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGA
CAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCT
GCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGC
ACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCA
AGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCAT

>In-frame_ENST00000318008_ENST00000333461_TCGA-ZF-AA4T-01A_LASP1_chr17_37046757_+_STAC2_chr17_37374426_length(amino acids)=499AA_start in transcript=1797_stop in transcript=298
MIPSLARSKVQAWARVSSGFPWLLSDLSQGVDWHQAPLLATADADEAVSILASAHAHADLVLLEAHVTLFLVPGEGLAAAPNILAWPHPL
HKISWEEANPVADLALPPVLVRVIHQHDPISRLQSQIIVLLGQKLVECNVGVHGPHILPQGGFGELLSRTLLLWSWPFTLCWGCEYWRCT
VTRPLLRAADAAFPILGQLIPLTQAPCRGLRGAAETGAVHQCQGGAIAQGLVDRVHLPTVPSGWGLFACGTDWWRLMHQERGTEVAAEGG
GRLAWALLVGDLLRAPEVDADFAHLTSQALFGVSYDELVAQLTRASSLEDMFLEAVQPHWFERCQGAWDWAWGGGWGSQAPVRGCGWWGG
RGQWGWGRQQHLGGALELRARAKEEVLQALTSEDGLEGEGALESLELTLELTLLLEAKVFRGVRHHGEGLLGVVCVAVGLLLVALVVLHV

--------------------------------------------------------------
>In-frame_ENST00000435347_ENST00000333461_TCGA-ZF-AA4T-01A_LASP1_chr17_37046757_+_STAC2_chr17_37374426_length(transcript)=3198nt_BP=296nt
GGACGCGCGTGAGCTCAGGCGTCCCCGCCCCAGCTTTTCTCGGAACCATGAACCCCAACTGCGCCCGGTGCGGCAAGATCGTGTATCCCA
CGGAGAAGGTGAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTGAACATGAAGAACTACA
AGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGTCCTTCACCATGGTGGCGGACACCCCGGAAAACCTTCGCCTCA
AGCAACAGAGTGAGCTCCAGAGTCAGCTCCAGCGATTCAAGCGCTCCCTCTCCCTCAAGACCATCCTCCGAAGTAAGAGCTTGGAGAACT
TCTTCCTTCGCTCGGGCTCTGAGCTCAAGTGCCCCACCGAGGTGCTGCTGACGCCCCCAACCCCACTGCCCCCTCCCTCCCCACCACCCA
CAGCCTCGGACAGGGGCCTGGCTACCCCATCCCCCTCCCCATGCCCAGTCCCACGCCCCCTGGCAGCGCTCAAACCAGTGAGGCTGCACA
GCTTCCAGGAACATGTCTTCAAGCGAGCTAGCCCTTGTGAGCTGTGCCACCAGCTCATCGTAGGAAACTCCAAACAGGGCTTGCGATGTA
AGATGTGCAAAGTCAGCGTCCACCTCTGGTGCTCTGAGGAGATCTCCCACCAGCAATGCCCAGGCAAGACGTCCACCTCCTTCCGCCGCA
ACTTCAGTTCCCCTCTCCTGGTGCATGAGCCGCCACCAGTCTGTGCCACAAGCAAAGAGTCCCCACCCACTGGGGACAGTGGGAAGGTGG
ACCCTGTCTACGAGACCCTGCGCTATGGCACCTCCCTGGCACTGATGAACCGCTCCAGTTTCAGCAGCACCTCTGAGTCCCCGACAAGGA
GCCTGAGTGAGCGGGATGAGCTGACCGAGGATGGGGAAGGCAGCATCCGCAGCTCTGAGGAGGGGCCTGGTGACAGTGCATCTCCAGTAT
TCACAGCCCCAGCAGAGAGTGAAGGGCCAGGACCAGAGGAGAAGAGTCCTGGACAGCAGCTCCCCAAAGCCACCCTGCGGAAGGATGTGG
GGCCCATGTACTCCTACGTTGCACTCTACAAGTTTCTGCCCCAGGAGAACAATGATCTGGCTCTGCAGCCTGGAGATCGGATCATGCTGG
TGGATGACTCTAACGAGGACTGGTGGAAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCCAG
GCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGGCG
TGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAGATCT
GAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGCCCCCTTGTCCACTC
CATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATTTTATTTCTTGGGTG
GGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGGTAGGTCCACCCAAC
GCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTCTCCCAGCCTTCCCC
TGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACCGTGCATCTGCTCCT
TTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACCATAGGAAGGTCCTG
AGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTTGAAACCTGGGCGGA
CAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAGCTGGCCAGGTGTGG
TGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGG
TGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCAGAGGCTGAGGCAAG
AGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGAGCGAGACTCCGTCT
CAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAATCCTGGCCCGTGCT
TGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGTCAGTTCCTGTCCCA
GGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGGACAGGGCAGGTGCT
GCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGACAGACAAGGAAGGT
GGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCTGCTTTTCTCGGTGC
CAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGCACAGTTACACCCTC
CCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCAAGCCACACTGCCCT
GTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCATGATGGGTCTGGGGC

>In-frame_ENST00000435347_ENST00000333461_TCGA-ZF-AA4T-01A_LASP1_chr17_37046757_+_STAC2_chr17_37374426_length(amino acids)=499AA_start in transcript=1513_stop in transcript=14
MIPSLARSKVQAWARVSSGFPWLLSDLSQGVDWHQAPLLATADADEAVSILASAHAHADLVLLEAHVTLFLVPGEGLAAAPNILAWPHPL
HKISWEEANPVADLALPPVLVRVIHQHDPISRLQSQIIVLLGQKLVECNVGVHGPHILPQGGFGELLSRTLLLWSWPFTLCWGCEYWRCT
VTRPLLRAADAAFPILGQLIPLTQAPCRGLRGAAETGAVHQCQGGAIAQGLVDRVHLPTVPSGWGLFACGTDWWRLMHQERGTEVAAEGG
GRLAWALLVGDLLRAPEVDADFAHLTSQALFGVSYDELVAQLTRASSLEDMFLEAVQPHWFERCQGAWDWAWGGGWGSQAPVRGCGWWGG
RGQWGWGRQQHLGGALELRARAKEEVLQALTSEDGLEGEGALESLELTLELTLLLEAKVFRGVRHHGEGLLGVVCVAVGLLLVALVVLHV

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Fusion Gene PPI Analysis for LASP1-STAC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LASP1-STAC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LASP1-STAC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLASP1C0004352Autistic Disorder1CTD_human
HgeneLASP1C0014170Endometrial Neoplasms1CTD_human
HgeneLASP1C0036341Schizophrenia1PSYGENET
HgeneLASP1C0476089Endometrial Carcinoma1CTD_human