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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LEMD3-XPOT (FusionGDB2 ID:44201)

Fusion Gene Summary for LEMD3-XPOT

check button Fusion gene summary
Fusion gene informationFusion gene name: LEMD3-XPOT
Fusion gene ID: 44201
HgeneTgene
Gene symbol

LEMD3

XPOT

Gene ID

23592

11260

Gene nameLEM domain containing 3exportin for tRNA
SynonymsMAN1XPO3
Cytomap

12q14.3

12q14.2

Type of geneprotein-codingprotein-coding
Descriptioninner nuclear membrane protein Man1LEM domain-containing protein 3LEMD3/MKX fusionintegral inner nuclear membrane proteinexportin-Texportin(tRNA)exportin, tRNA (nuclear export receptor for tRNAs)tRNA exportin
Modification date2020031320200313
UniProtAcc

Q9Y2U8

.
Ensembl transtripts involved in fusion geneENST00000308330, ENST00000541171, 
ENST00000332707, 
Fusion gene scores* DoF score13 X 8 X 6=62410 X 11 X 6=660
# samples 1412
** MAII scorelog2(14/624*10)=-2.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LEMD3 [Title/Abstract] AND XPOT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLEMD3(65612399)-XPOT(64833024), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLEMD3

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

15647271

HgeneLEMD3

GO:0030514

negative regulation of BMP signaling pathway

15647271

HgeneLEMD3

GO:0032926

negative regulation of activin receptor signaling pathway

15647271

TgeneXPOT

GO:0006409

tRNA export from nucleus

9660920


check buttonFusion gene breakpoints across LEMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across XPOT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HN-01ALEMD3chr12

65612399

+XPOTchr12

64833024

+
ChimerDB4BRCATCGA-C8-A1HNLEMD3chr12

65612399

+XPOTchr12

64833023

+
ChimerDB4BRCATCGA-C8-A1HN-01ALEMD3chr12

65612399

+XPOTchr12

64833024

+
ChimerDB4BRCATCGA-C8-A1HN-01ALEMD3chr12

65612399

+XPOTchr12

64838855

+
ChimerDB4BRCATCGA-C8-A1HN-01ALEMD3chr12

65612399

-XPOTchr12

64833024

+


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Fusion Gene ORF analysis for LEMD3-XPOT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000308330ENST00000332707LEMD3chr12

65612399

+XPOTchr12

64833024

+
intron-3CDSENST00000541171ENST00000332707LEMD3chr12

65612399

+XPOTchr12

64833024

+
In-frameENST00000308330ENST00000332707LEMD3chr12

65612399

+XPOTchr12

64833023

+
intron-3CDSENST00000541171ENST00000332707LEMD3chr12

65612399

+XPOTchr12

64833023

+
In-frameENST00000308330ENST00000332707LEMD3chr12

65612399

+XPOTchr12

64838855

+
intron-3CDSENST00000541171ENST00000332707LEMD3chr12

65612399

+XPOTchr12

64838855

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308330LEMD3chr1265612399+ENST00000332707XPOTchr1264833024+48731721261876616
ENST00000308330LEMD3chr1265612399+ENST00000332707XPOTchr1264833023+48731721261876616
ENST00000308330LEMD3chr1265612399+ENST00000332707XPOTchr1264838855+48011721261804592

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308330ENST00000332707LEMD3chr1265612399+XPOTchr1264833024+0.0004650890.99953496
ENST00000308330ENST00000332707LEMD3chr1265612399+XPOTchr1264833023+0.0004650890.99953496
ENST00000308330ENST00000332707LEMD3chr1265612399+XPOTchr1264838855+0.0004434750.9995565

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Fusion Genomic Features for LEMD3-XPOT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LEMD3chr1265612399+XPOTchr1264833023+2.24E-060.99999774
LEMD3chr1265612399+XPOTchr1264833023+2.24E-060.99999774
LEMD3chr1265612399+XPOTchr1264838854+2.44E-121
LEMD3chr1265612399+XPOTchr1264833023+2.24E-060.99999774
LEMD3chr1265612399+XPOTchr1264833023+2.24E-060.99999774
LEMD3chr1265612399+XPOTchr1264838854+2.44E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LEMD3-XPOT


check button Go to

FGviewer for the breakpoints of chr12:65612399-chr12:64833024

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LEMD3

Q9Y2U8

.
FUNCTION: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413155_158565.0912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413265_268565.0912.0Compositional biasNote=Poly-Asp
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413312_315565.0912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413322_325565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413337_340565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+41365_70565.0912.0Compositional biasNote=Poly-Asn
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+41372_87565.0912.0Compositional biasNote=Ala-rich
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+41382_87565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413155_158565.0912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413265_268565.0912.0Compositional biasNote=Poly-Asp
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413312_315565.0912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413322_325565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413337_340565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+41365_70565.0912.0Compositional biasNote=Poly-Asn
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+41372_87565.0912.0Compositional biasNote=Ala-rich
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+41382_87565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413155_158565.0912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413265_268565.0912.0Compositional biasNote=Poly-Asp
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413312_315565.0912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413322_325565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413337_340565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+41365_70565.0912.0Compositional biasNote=Poly-Asn
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+41372_87565.0912.0Compositional biasNote=Ala-rich
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+41382_87565.0912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+4136_50565.0912.0DomainLEM
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+4136_50565.0912.0DomainLEM
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+4136_50565.0912.0DomainLEM
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413475_495565.0912.0TransmembraneHelical
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413475_495565.0912.0TransmembraneHelical
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413475_495565.0912.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413635_640565.0912.0Compositional biasNote=Poly-Leu
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413659_662565.0912.0Compositional biasNote=Poly-Glu
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413635_640565.0912.0Compositional biasNote=Poly-Leu
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413659_662565.0912.0Compositional biasNote=Poly-Glu
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413635_640565.0912.0Compositional biasNote=Poly-Leu
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413659_662565.0912.0Compositional biasNote=Poly-Glu
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413707_726565.0912.0DNA binding.
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413707_726565.0912.0DNA binding.
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413707_726565.0912.0DNA binding.
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413628_648565.0912.0TransmembraneHelical
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413628_648565.0912.0TransmembraneHelical
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413628_648565.0912.0TransmembraneHelical
TgeneXPOTchr12:65612399chr12:64833023ENST000003327072125443_962911.0963.0RegionNote=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export
TgeneXPOTchr12:65612399chr12:64833024ENST000003327072125443_962911.0963.0RegionNote=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export
TgeneXPOTchr12:65612399chr12:64838855ENST000003327072225443_962935.0963.0RegionNote=Necessary for tRNA-binding%2C cytoplasmic localization and nuclear export


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Fusion Gene Sequence for LEMD3-XPOT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000308330_ENST00000332707_TCGA-C8-A1HN-01A_LEMD3_chr12_65612399_+_XPOT_chr12_64833024_length(transcript)=4873nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAAGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTT
GTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCC
CTGTGCCTACTTCATGATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTT
GAGCTTATTGCAGTATATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTG
CATGCCGGTCCAAATTGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTA
AGTCAAGTCCTTTATAAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTAT
GTGTGAAGACACAAAGTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCA
ATATGTATTCTACAAAAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAA
TCTTCCAAGTCTTTTCTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACA
AATATGAGTGTGTGGATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTT
TAATGTACTGGAAAAAGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACT
TTGGGAGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC
AACAGCCAGGTGTGATGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTG
CAGTGAGCTGAGATTGTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCA
ATTTATTTTCTAACTCTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACT
GACATTTAATTATTAGAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTAT
CAGTAGTGTCACTGGAAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATT
GAGATGTTCAGGGAGGGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTC
TATTCTAAATTTTGTACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAA
CTAAATTGACAGTTATAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGT
GTTTCTTTGATAGGTTCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCA
TAGCATAGTGGGTAAGAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGA
ACCTTGGGCAAGTTAAAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAA
TTCAATGAGTTAAACTTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCA
TATATGGAATTAATAGTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTG
GTGACATCATAGCTCACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCA
CCACACCCAGCTACATTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCC
CACTGGCCTCACAATGTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCC
CTTTCAGAGCTCTTTAAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAA
AATTAAACTCTTCATGTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCC
ATCATGAATTACCTTATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGG
GATTTGTTTGACTTGACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGT
TAATTGCTTCCCAGTTGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTT
AATCACTCCCACAACTTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGA
AATTAGTTGGAATTGTAAGCAGTGAATAGATGTGTTGTTAGAATGATTCCATCACTTATACATTGTTTAAAATGCTAATAAAGTAACTTG

>In-frame_ENST00000308330_ENST00000332707_TCGA-C8-A1HN-01A_LEMD3_chr12_65612399_+_XPOT_chr12_64833024_length(amino acids)=616AA_start in transcript=26_stop in transcript=1876
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ

--------------------------------------------------------------
>In-frame_ENST00000308330_ENST00000332707_TCGA-C8-A1HN_LEMD3_chr12_65612399_+_XPOT_chr12_64833023_length(transcript)=4873nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAAGGCCCAGAATGTGTTCAGTATCTTCAACAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTT
GTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGCCCTGAGGACTGGATTTCC
CTGTGCCTACTTCATGATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGGTCTTTTTCACATTGTTTT
GAGCTTATTGCAGTATATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAACAACAAAAGAAGTTGCCTG
CATGCCGGTCCAAATTGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCTTTTTTATTTGAAATTTTA
AGTCAAGTCCTTTATAAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATCTTTGAAAATTTTCTTTAT
GTGTGAAGACACAAAGTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTTTAAACTGTTTCAACGCCA
ATATGTATTCTACAAAAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAATAAACTTTACGTAGTGAAA
TCTTCCAAGTCTTTTCTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTTCCCATTTAAAGGTTTACA
AATATGAGTGTGTGGATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTATATGAGAGTCTTTTTCTT
TAATGTACTGGAAAAAGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCACGACTGTAATCCCAGAACT
TTGGGAGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC
AACAGCCAGGTGTGATGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTG
CAGTGAGCTGAGATTGTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAAAAAGAATTTAAAATCCCA
ATTTATTTTCTAACTCTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTATGTTTGTAAATGGTAACT
GACATTTAATTATTAGAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAAGGAAAAAATAATAGTTAT
CAGTAGTGTCACTGGAAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTAAATTCTAAAAGCCCAATT
GAGATGTTCAGGGAGGGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTTATAAACTCTGTAAAATTC
TATTCTAAATTTTGTACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCATATAATAAAAATACTTAA
CTAAATTGACAGTTATAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATAGATAAGTGAAAGCTGAGT
GTTTCTTTGATAGGTTCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAATGGATACTAATGAATAGCA
TAGCATAGTGGGTAAGAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTGCCAGTAACTGGTTTTAGA
ACCTTGGGCAAGTTAAAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTACCTCAAACCTCATTACGAA
TTCAATGAGTTAAACTTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGATGCTATCTCATATTAGCA
TATATGGAATTAATAGTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCACCCAGGCTGGAGTGCAGTG
GTGACATCATAGCTCACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGTGATTACAGGTGTGCACCA
CCACACCCAGCTACATTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCCGGCCTCAAGCAATCCTCC
CACTGGCCTCACAATGTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATATATGGAAAGGTGTTTTCC
CTTTCAGAGCTCTTTAAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGAAATTGAGTGTGTAATAAA
AATTAAACTCTTCATGTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCATCACAGCTAGGAAGCTTCC
ATCATGAATTACCTTATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTACAAGCTGAAATATTTGGG
GATTTGTTTGACTTGACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTTAAATCTTAATGCTAATGT
TAATTGCTTCCCAGTTGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATGAAGGCCTGTGGCTCAGTT
AATCACTCCCACAACTTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCATTAGATATCAAAGAACTGA
AATTAGTTGGAATTGTAAGCAGTGAATAGATGTGTTGTTAGAATGATTCCATCACTTATACATTGTTTAAAATGCTAATAAAGTAACTTG

>In-frame_ENST00000308330_ENST00000332707_TCGA-C8-A1HN_LEMD3_chr12_65612399_+_XPOT_chr12_64833023_length(amino acids)=616AA_start in transcript=26_stop in transcript=1876
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ

--------------------------------------------------------------
>In-frame_ENST00000308330_ENST00000332707_TCGA-C8-A1HN-01A_LEMD3_chr12_65612399_+_XPOT_chr12_64838855_length(transcript)=4801nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAAGAGTTTTGTCAAGCGCTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCAAAGC
CCTGAGGACTGGATTTCCCTGTGCCTACTTCATGATCATGAATTCCAGTTAATTTATAAAGAGGCGATTTTTGTGTGCCATTCACACTGG
TCTTTTTCACATTGTTTTGAGCTTATTGCAGTATATGTTTTGGGATTTTTCTGTAAAATGGGTGTAATTTTCCTAATACAGGTATGTAAC
AACAAAAGAAGTTGCCTGCATGCCGGTCCAAATTGTTCTGTATAAAGATGCTCTTAAAAGACACAAGAGTTATCCTAGAACCTTAATTCT
TTTTTATTTGAAATTTTAAGTCAAGTCCTTTATAAAGACCATAGCAGTGGAAAACAGTGTACTTTTTAAAAAATTGCTGAATATAAAATC
TTTGAAAATTTTCTTTATGTGTGAAGACACAAAGTATGGGGGAAGACAGCAATCAAAACTAACTTTTTGTAGATAGCCATTTCATTTCTT
TAAACTGTTTCAACGCCAATATGTATTCTACAAAAGAGAATGGTTTTAGGCTCCAGTGTTATACTTTTTTTTATATATATATATAAAAAT
AAACTTTACGTAGTGAAATCTTCCAAGTCTTTTCTGGAATTATTATAAATACTTTAGTTTTATTTTCTCATCTTAATCTCTCCATAATTT
CCCATTTAAAGGTTTACAAATATGAGTGTGTGGATGCTTTAATTCATTTAACCTCACTCCTCAAAGGTAACATGCAACTTAGTTCTGTTA
TATGAGAGTCTTTTTCTTTAATGTACTGGAAAAAGCCTATGTGAATCTGTTGATAGAATTTAAAATTCCAGGCCGGGCGTGGTGGCTCAC
GACTGTAATCCCAGAACTTTGGGAGGCCAAGGCAGGTGGATCACTTGAGGTCAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACCC
CATCTCTACTAAAAATACAACAGCCAGGTGTGATGGTGCACGCTCGTAATCCCGGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAA
CCCGGAAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACGCCAGCCTGGGCAAGAGAGTAAGACTCTCTCTCAAAAAAAAAAAA
AAAGAATTTAAAATCCCAATTTATTTTCTAACTCTTTTATTGGATGTATTTAGAACACAGTATACCTATAGTATACCTATGTGTTTATTA
TGTTTGTAAATGGTAACTGACATTTAATTATTAGAAGTACTTACCCCTGCCTTCCTCCATTTTTATTCATGGCTACTTGAGAAAGCAAAA
GGAAAAAATAATAGTTATCAGTAGTGTCACTGGAAAGAAGAGAGGAGGGACAAAACTGAGCAGCAGAATTCGTATAGACATTTACGTTTA
AATTCTAAAAGCCCAATTGAGATGTTCAGGGAGGGTTTGTTTTGCCCTTTGGCCTCATGAATGGGTTTCATGAATGGGCTTCAGTGGCTT
ATAAACTCTGTAAAATTCTATTCTAAATTTTGTACATTTATTTTGTTCCGGTTAATTCCAGAAGACATTTCAAACATTTTTCTTACACCA
TATAATAAAAATACTTAACTAAATTGACAGTTATAAAAATAAATCAGTGAAATGTACCTTATACTTTAATAAAAAATGTTTTCAGAAATA
GATAAGTGAAAGCTGAGTGTTTCTTTGATAGGTTCCCCTGTACTATAGGAGTGATAATTGCAGCTATTGCAATAGTAGTAATTGTTAAAT
GGATACTAATGAATAGCATAGCATAGTGGGTAAGAGTTTATATAGCACAGGCTCTAGAATCAGATTAAGTAGGTTCAAATACCAGTTCTG
CCAGTAACTGGTTTTAGAACCTTGGGCAAGTTAAAGAATGTCTCCCAGCCTCAGTTTCCCTATTTGTAAAATGGAAATAATGGTAGCTAC
CTCAAACCTCATTACGAATTCAATGAGTTAAACTTGAAAAGACTTATTACAGTAGCTGGCACATAAAGACTTGATAGTAGTTTATATGGA
TGCTATCTCATATTAGCATATATGGAATTAATAGTGTATCACTATACTTTTTTTTTCTTTTTTTTTTTTGAATAGAGATCAGTCTATCAC
CCAGGCTGGAGTGCAGTGGTGACATCATAGCTCACTGTAACTTCTCCCATACTCTACCAATCCTCCTGCCTCAGCATCCAGACTAGCTGT
GATTACAGGTGTGCACCACCACACCCAGCTACATTTTTTTTTGGTAGAGACAGGGTCTCACTATGTTACCCAGTCTGGTCTCAAACTCCC
GGCCTCAAGCAATCCTCCCACTGGCCTCACAATGTTGGGATTACAGGTATAAGCCACTGCACACGGCCTTACTATGCTATCAATTCCATA
TATGGAAAGGTGTTTTCCCTTTCAGAGCTCTTTAAAGCTCTGCAGAAGATTTACATGTGTTTATAGAGCTAAGAGAAATCAGGGCATGGA
AATTGAGTGTGTAATAAAAATTAAACTCTTCATGTTATATAATCATGCATAACTTCTATCTTCATTCTCTGAAGTTGCCTAGAGCACCAT
CACAGCTAGGAAGCTTCCATCATGAATTACCTTATTTCCAAAAGCAAGTACTCAAATAATTGTCTCAAGAGAGGAAGGACAAAACTGTTA
CAAGCTGAAATATTTGGGGATTTGTTTGACTTGACTAGGGAACCACAAGTTTTCATATAATGCCTGATTTAGCCCTGTGCCTAACAGTTT
AAATCTTAATGCTAATGTTAATTGCTTCCCAGTTGGTTGACCTTATAAGAAAACACTGTGTGGTATTTTAATGTGGTAAACATGTGAATG
AAGGCCTGTGGCTCAGTTAATCACTCCCACAACTTTGAGCTGTGAGTTTTACTGGTGGAAGGAACTTTAACAGGTCTTCGCTCTTGTCAT
TAGATATCAAAGAACTGAAATTAGTTGGAATTGTAAGCAGTGAATAGATGTGTTGTTAGAATGATTCCATCACTTATACATTGTTTAAAA

>In-frame_ENST00000308330_ENST00000332707_TCGA-C8-A1HN-01A_LEMD3_chr12_65612399_+_XPOT_chr12_64838855_length(amino acids)=592AA_start in transcript=26_stop in transcript=1804
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LEMD3-XPOT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLEMD3chr12:65612399chr12:64833023ENST00000308330+413699_911565.0912.0SMAD1%2C SMAD2%2C SMAD3 and SMAD5
HgeneLEMD3chr12:65612399chr12:64833024ENST00000308330+413699_911565.0912.0SMAD1%2C SMAD2%2C SMAD3 and SMAD5
HgeneLEMD3chr12:65612399chr12:64838855ENST00000308330+413699_911565.0912.0SMAD1%2C SMAD2%2C SMAD3 and SMAD5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LEMD3-XPOT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LEMD3-XPOT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLEMD3C0265514Dermatofibrosis lenticularis disseminata2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLEMD3C2931505Mixed sclerosing bone dystrophy2ORPHANET
HgeneLEMD3C3149631MELORHEOSTOSIS, ISOLATED2GENOMICS_ENGLAND
HgeneLEMD3C3149695Melorheostosis with Osteopoikilosis2ORPHANET
HgeneLEMD3C0029455Osteopoikilosis (disorder)1ORPHANET
HgeneLEMD3C0152423Congenital small ears1GENOMICS_ENGLAND
HgeneLEMD3C1833699Osteopoikilosis, Isolated1ORPHANET
HgeneLEMD3C430514012q14 microdeletion syndrome1ORPHANET