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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LETM1-RGS12 (FusionGDB2 ID:44247)

Fusion Gene Summary for LETM1-RGS12

check button Fusion gene summary
Fusion gene informationFusion gene name: LETM1-RGS12
Fusion gene ID: 44247
HgeneTgene
Gene symbol

LETM1

RGS12

Gene ID

3954

6002

Gene nameleucine zipper and EF-hand containing transmembrane protein 1regulator of G protein signaling 12
SynonymsSLC55A1-
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial proton/calcium exchanger proteinLETM1 and EF-hand domain-containing protein 1, mitochondrialMdm38 homologleucine zipper-EF-hand containing transmembrane protein 1regulator of G-protein signaling 12regulator of G-protein signalling 12
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000302787, ENST00000512189, 
ENST00000543385, ENST00000336727, 
ENST00000344733, ENST00000382788, 
ENST00000306648, ENST00000338806, 
ENST00000508158, ENST00000538395, 
Fusion gene scores* DoF score10 X 13 X 7=9106 X 8 X 5=240
# samples 128
** MAII scorelog2(12/910*10)=-2.92283213947754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LETM1 [Title/Abstract] AND RGS12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLETM1(1824714)-RGS12(3344663), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLETM1

GO:0006851

mitochondrial calcium ion transmembrane transport

19797662

HgeneLETM1

GO:0051560

mitochondrial calcium ion homeostasis

19797662

HgeneLETM1

GO:0099093

calcium export from the mitochondrion

19797662


check buttonFusion gene breakpoints across LETM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RGS12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A938LETM1chr4

1824714

-RGS12chr4

3344663

+
ChimerDB4ESCATCGA-JY-A938LETM1chr4

1824714

-RGS12chr4

3344663

+


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Fusion Gene ORF analysis for LETM1-RGS12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000302787ENST00000543385LETM1chr4

1824714

-RGS12chr4

3344663

+
In-frameENST00000302787ENST00000336727LETM1chr4

1824714

-RGS12chr4

3344663

+
In-frameENST00000302787ENST00000344733LETM1chr4

1824714

-RGS12chr4

3344663

+
In-frameENST00000302787ENST00000382788LETM1chr4

1824714

-RGS12chr4

3344663

+
In-frameENST00000302787ENST00000306648LETM1chr4

1824714

-RGS12chr4

3344663

+
5CDS-intronENST00000302787ENST00000338806LETM1chr4

1824714

-RGS12chr4

3344663

+
5CDS-intronENST00000302787ENST00000508158LETM1chr4

1824714

-RGS12chr4

3344663

+
5CDS-intronENST00000302787ENST00000538395LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-3CDSENST00000512189ENST00000543385LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-3CDSENST00000512189ENST00000336727LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-3CDSENST00000512189ENST00000344733LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-3CDSENST00000512189ENST00000382788LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-3CDSENST00000512189ENST00000306648LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-intronENST00000512189ENST00000338806LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-intronENST00000512189ENST00000508158LETM1chr4

1824714

-RGS12chr4

3344663

+
intron-intronENST00000512189ENST00000538395LETM1chr4

1824714

-RGS12chr4

3344663

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302787LETM1chr41824714-ENST00000543385RGS12chr43344663+254017732971895532
ENST00000302787LETM1chr41824714-ENST00000336727RGS12chr43344663+5228177329740221241
ENST00000302787LETM1chr41824714-ENST00000344733RGS12chr43344663+4457177329742351312
ENST00000302787LETM1chr41824714-ENST00000382788RGS12chr43344663+5301177329740221241
ENST00000302787LETM1chr41824714-ENST00000306648RGS12chr43344663+3485177329733651022

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302787ENST00000543385LETM1chr41824714-RGS12chr43344663+0.0385931730.9614068
ENST00000302787ENST00000336727LETM1chr41824714-RGS12chr43344663+0.0038772760.99612266
ENST00000302787ENST00000344733LETM1chr41824714-RGS12chr43344663+0.0056840740.9943159
ENST00000302787ENST00000382788LETM1chr41824714-RGS12chr43344663+0.0035164060.99648356
ENST00000302787ENST00000306648LETM1chr41824714-RGS12chr43344663+0.0066744580.9933255

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Fusion Genomic Features for LETM1-RGS12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LETM1chr41824714-RGS12chr43344663+8.38E-101
LETM1chr41824714-RGS12chr43344663+8.38E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LETM1-RGS12


check button Go to

FGviewer for the breakpoints of chr4:1824714-chr4:3344663

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914115_136492.0740.0Coiled coilOntology_term=ECO:0000255
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914462_490492.0740.0Coiled coilOntology_term=ECO:0000255
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-91418_21492.0740.0Compositional biasNote=Poly-Pro
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914116_208492.0740.0Topological domainMitochondrial intermembrane
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914209_229492.0740.0TransmembraneHelical
TgeneRGS12chr4:1824714chr4:3344663ENST000003066480151034_110425.0556.0DomainRBD 2
TgeneRGS12chr4:1824714chr4:3344663ENST000003066480151187_120925.0556.0DomainGoLoco
TgeneRGS12chr4:1824714chr4:3344663ENST00000306648015228_34025.0556.0DomainPID
TgeneRGS12chr4:1824714chr4:3344663ENST0000030664801522_9825.0556.0DomainPDZ
TgeneRGS12chr4:1824714chr4:3344663ENST00000306648015715_83225.0556.0DomainRGS
TgeneRGS12chr4:1824714chr4:3344663ENST00000306648015962_103225.0556.0DomainRBD 1
TgeneRGS12chr4:1824714chr4:3344663ENST000003367271171034_1104627.01377.0DomainRBD 2
TgeneRGS12chr4:1824714chr4:3344663ENST000003367271171187_1209627.01377.0DomainGoLoco
TgeneRGS12chr4:1824714chr4:3344663ENST00000336727117715_832627.01377.0DomainRGS
TgeneRGS12chr4:1824714chr4:3344663ENST00000336727117962_1032627.01377.0DomainRBD 1
TgeneRGS12chr4:1824714chr4:3344663ENST000003388060161034_11040800.0DomainRBD 2
TgeneRGS12chr4:1824714chr4:3344663ENST000003388060161187_12090800.0DomainGoLoco
TgeneRGS12chr4:1824714chr4:3344663ENST00000338806016228_3400800.0DomainPID
TgeneRGS12chr4:1824714chr4:3344663ENST0000033880601622_980800.0DomainPDZ
TgeneRGS12chr4:1824714chr4:3344663ENST00000338806016715_8320800.0DomainRGS
TgeneRGS12chr4:1824714chr4:3344663ENST00000338806016962_10320800.0DomainRBD 1
TgeneRGS12chr4:1824714chr4:3344663ENST000003447331181034_1104627.01448.0DomainRBD 2
TgeneRGS12chr4:1824714chr4:3344663ENST000003447331181187_1209627.01448.0DomainGoLoco
TgeneRGS12chr4:1824714chr4:3344663ENST00000344733118715_832627.01448.0DomainRGS
TgeneRGS12chr4:1824714chr4:3344663ENST00000344733118962_1032627.01448.0DomainRBD 1
TgeneRGS12chr4:1824714chr4:3344663ENST000003827880161034_1104627.01377.0DomainRBD 2
TgeneRGS12chr4:1824714chr4:3344663ENST000003827880161187_1209627.01377.0DomainGoLoco
TgeneRGS12chr4:1824714chr4:3344663ENST00000382788016715_832627.01377.0DomainRGS
TgeneRGS12chr4:1824714chr4:3344663ENST00000382788016962_1032627.01377.0DomainRBD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914676_688492.0740.0Calcium bindingOntology_term=ECO:0000255
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914537_627492.0740.0Coiled coilOntology_term=ECO:0000255
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914708_739492.0740.0Coiled coilOntology_term=ECO:0000255
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914252_537492.0740.0DomainLetm1 RBD
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914663_698492.0740.0DomainEF-hand
HgeneLETM1chr4:1824714chr4:3344663ENST00000302787-914230_739492.0740.0Topological domainMitochondrial matrix
TgeneRGS12chr4:1824714chr4:3344663ENST00000336727117228_340627.01377.0DomainPID
TgeneRGS12chr4:1824714chr4:3344663ENST0000033672711722_98627.01377.0DomainPDZ
TgeneRGS12chr4:1824714chr4:3344663ENST00000344733118228_340627.01448.0DomainPID
TgeneRGS12chr4:1824714chr4:3344663ENST0000034473311822_98627.01448.0DomainPDZ
TgeneRGS12chr4:1824714chr4:3344663ENST00000382788016228_340627.01377.0DomainPID
TgeneRGS12chr4:1824714chr4:3344663ENST0000038278801622_98627.01377.0DomainPDZ


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Fusion Gene Sequence for LETM1-RGS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000302787_ENST00000543385_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(transcript)=2540nt_BP=1773nt
GAACCGGTAGTCCGCGGTGGCGCGGTCCGCCCCTCACCTGGCCAGCGGCGGGCGCTGAGGGGCCCAATGGGAGCCGCGGCCTGGCCGCCC
CGCCCCGCGCCTCCGGACGTCTGTGCCGGGACAAGGCCGCCGCTGGTGCCGGGTCCTTGAGGAGAGCGCCTCCCGTCCGAGGCCAGCCGC
CTCTGTCAGCCGTCCGCGCGGGCCGGGTCTGAAGCGCCGCCGGGACGGCGAAGAGCCGCGGCCGCCGCGGAGAAGGAGGCAGCGCAGGAG
GCCGGAGCGGCCGCCGCGCCCGAGCACATGGCGTCCATCTTACTGAGGAGCTGCCGCGGCCGGGCGCCCGCCCGCCTCCCGCCGCCGCCT
CGGTACACCGTCCCGCGGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCA
TTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGC
ATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCG
CGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTAC
AGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTA
TGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGG
ATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTC
TTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCC
AAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAG
AAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTG
ACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGG
CTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCA
CGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCC
ACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCA
GAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAG
GAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGGGCTCAAAATTTGGGCGGGGAACTGGA
CTCACTCAGCCTTCTCAACGCACGTCTGCTCGGAGATCATTTGGGAGATCCAAGAGATTCAGTATCACTCGCTCCCTTGATGATCTTGAG
AGTTGACGGGCGCCGACCTGAAGGACTGCGTCAGCAACAACAGCCTGAGCAGCAATGCCAGCCTCCCCAGCGTGCAGAGCTGCCGGCGCC
TGCGTGAGAGGAGGGTCGCCAGCTGGGCCGTGTCCTTTGAGCGCCTGCTGCAGGACCCCGTCGGTGTCCGCTACTTCTCTGATTTTCTAA
GGAAAGAATTCAGTGAAGAAAACATTTTATTCTGGCAGGCCTGTGAATATTTTAATCATGTTCCTGCACATGACAAAAAGGAGCTTTCCT
ACAGGGCCCGGGAGATTTTCAGTAAGTTTCTCTGCAGCAAAGCCACCACCCCGGTCAACATCGACAGCCAGGCCCAGCTAGCAGACGACG
TCCTCCGCGCACCTCACCCAGACATGTTCAAGGAGCAGCAGCTGCAGATCTTCAATCTCATGAAGTTTGATAGCTACACTCGCTTTCTGA
AGTCCCCGCTGTACCAGGAATGCATCCTGGCGGAAGTGGAGGGCCGTGCACTCCCGGACTCGCAGCAGGTCCCCAGCAGCCCGGCTTCCA
AGCACAGCCTCGGTTCAGACCACTCCAGTGTGTCCACGCCAAAAAAGTTAAGTGGAAAATCAAAATCCGGCCGATCCCTGAATGAAGAGC

>In-frame_ENST00000302787_ENST00000543385_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(amino acids)=532AA_start in transcript=297_stop in transcript=1895
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTS
TSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV

--------------------------------------------------------------
>In-frame_ENST00000302787_ENST00000336727_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(transcript)=5228nt_BP=1773nt
GAACCGGTAGTCCGCGGTGGCGCGGTCCGCCCCTCACCTGGCCAGCGGCGGGCGCTGAGGGGCCCAATGGGAGCCGCGGCCTGGCCGCCC
CGCCCCGCGCCTCCGGACGTCTGTGCCGGGACAAGGCCGCCGCTGGTGCCGGGTCCTTGAGGAGAGCGCCTCCCGTCCGAGGCCAGCCGC
CTCTGTCAGCCGTCCGCGCGGGCCGGGTCTGAAGCGCCGCCGGGACGGCGAAGAGCCGCGGCCGCCGCGGAGAAGGAGGCAGCGCAGGAG
GCCGGAGCGGCCGCCGCGCCCGAGCACATGGCGTCCATCTTACTGAGGAGCTGCCGCGGCCGGGCGCCCGCCCGCCTCCCGCCGCCGCCT
CGGTACACCGTCCCGCGGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCA
TTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGC
ATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCG
CGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTAC
AGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTA
TGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGG
ATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTC
TTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCC
AAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAG
AAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTG
ACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGG
CTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCA
CGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCC
ACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCA
GAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAG
GAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGGGCTCAAAATTTGGGCGGGGAACTGGA
CTCACTCAGCCTTCTCAACGCACGTCTGCTCGGAGATCATTTGGGAGATCCAAGAGATTCAGTATCACTCGCTCCCTTGATGATCTTGAG
TCTGCAACTGTGTCTGATGGCGAGTTGACGGGCGCCGACCTGAAGGACTGCGTCAGCAACAACAGCCTGAGCAGCAATGCCAGCCTCCCC
AGCGTGCAGAGCTGCCGGCGCCTGCGTGAGAGGAGGGTCGCCAGCTGGGCCGTGTCCTTTGAGCGCCTGCTGCAGGACCCCGTCGGTGTC
CGCTACTTCTCTGATTTTCTAAGGAAAGAATTCAGTGAAGAAAACATTTTATTCTGGCAGGCCTGTGAATATTTTAATCATGTTCCTGCA
CATGACAAAAAGGAGCTTTCCTACAGGGCCCGGGAGATTTTCAGTAAGTTTCTCTGCAGCAAAGCCACCACCCCGGTCAACATCGACAGC
CAGGCCCAGCTAGCAGACGACGTCCTCCGCGCACCTCACCCAGACATGTTCAAGGAGCAGCAGCTGCAGATCTTCAATCTCATGAAGTTT
GATAGCTACACTCGCTTTCTGAAGTCCCCGCTGTACCAGGAATGCATCCTGGCGGAAGTGGAGGGCCGTGCACTCCCGGACTCGCAGCAG
GTCCCCAGCAGCCCGGCTTCCAAGCACAGCCTCGGTTCAGACCACTCCAGTGTGTCCACGCCAAAAAAGTTAAGTGGAAAATCAAAATCC
GGCCGATCCCTGAATGAAGAGCTGGGGGATGAGGACAGCGAGAAGAAGCGGAAAGGCGCGTTTTTCTCGTGGTCGCGGACCAGGAGCACC
GGGAGGTCCCAGAAAAAGAGGGAGCACGGGGACCACGCAGACGACGCCCTGCATGCCAATGGAGGCCTGTGTCGCCGAGAGTCGCAGGGC
TCTGTGTCCTCTGCGGGGAGCCTGGACCTGTCGGAGGCCTGCAGGACTTTGGCACCCGAGAAGGACAAGGCCACCAAGCACTGCTGCATT
CATCTCCCGGATGGGACATCCTGCGTGGTGGCTGTCAAGGCGGGCTTCTCCATCAAAGACATCCTGTCCGGACTCTGTGAGCGGCATGGC
ATCAACGGGGCGGCCGCGGACCTCTTCCTGGTGGGCGGGGACAAGCCTCTGGTGCTGCACCAAGACAGTAGCATCTTGGAGTCAAGGGAC
CTGCGCCTAGAAAAGCGCACCTTGTTTCGGCTGGATCTTGTTCCGATTAACCGGTCAGTGGGACTCAAGGCCAAGCCCACCAAGCCCGTC
ACGGAGGTGCTGCGGCCCGTGGTGGCCAGATACGGCCTGGACCTCAGTGGCCTGCTGGTGAGGCTGAGTGGAGAGAAGGAGCCCCTGGAC
CTTGGCGCCCCTATATCGAGTCTGGACGGACAGCGGGTTGTCTTGGAGGAGAAGGATCCTTCCAGAGGAAAGGCATCCGCAGATAAACAG
AAAGGTGTGCCAGTGAAACAGAACACAGCTGTAAATTCCAGCTCCAGAAACCACTCGGCTACGGGAGAGGAAAGAACACTAGGCAAGTCT
AATTCTATTAAAATAAAAGGAGAAAATGGAAAAAATGCTAGGGATCCCCGGCTTTCAAAGAGAGAAGAATCTATTGCAAAGATTGGGAAA
AAAAAATATCAGAAAATTAATTTGGACGAAGCAGAGGAGTTTTTTGAGCTTATTTCCAAAGCTCAGAGCAACAGAGCAGATGACCAACGT
GGGCTGCTAAGGAAGGAAGACCTGGTGTTGCCAGAGTTCCTCCGTTTACCTCCTGGTTCCACAGAACTCACCCTCCCCACTCCAGCTGCT
GTGGCCAAGGGCTTTAGCAAGAGAAGCGCCACAGGCAACGGCCGGGAGAGCGCCTCCCAGCCTGGCGAGCAGTGGGAGCCAGTCCAGGAG
AGCAGCGACAGCCCGTCCACCAGCCCGGGCTCAGCCTCCAGCCCCCCTGGACCTCCTGGGACGACCCCCCCCGGGCAGAAGTCTCCCAGC
GGGCCCTTCTGCACTCCCCAGTCCCCCGTCTCCCTCGCGCAGGAGGGCACCGCCCAGATCTGGAAGAGGCAGTCTCAGGAAGTGGAGGCC
GGGGGCATCCAGACGGTGGAGGATGAGCACGTGGCCGAGCTGACCCTGATGGGGGAGGGGGACATCAGCAGCCCCAACAGCACCTTGCTG
CCGCCGCCCTCCACCCCCCAGGAAGTGCCAGGACCTTCCAGACCAGGTACCTCCAGGTTCTGATCCCTCCACCTTGGCCCCGTAAGCGTG
GTCTGCTCAGCTTCCAGTCAGAAAGGACAGTGGGCCCCCGGCTGCCACTGTTTGCTGGTGGTCTCCGTGACCCCCTCCTCACCTGCTGGT
TGGGGGCTTCCTTGGCCCTCTTGGAAAGGAGGGGCTCGTGTGGCCCCAGGCCAGTGTCTGTCAGGATGGTCCCCCCGAGGCGCTCTGGGC
AGGCATCCTGGTGTCCTGAGAGGCTCTTGCAGGAATGATACGTGGCAGTGCCTGCAGCGAGGTCTGGGAACACCCTGGGTGAGGCCTGGG
GGTTTCCGAAAATGGAGGCATTCCTTTCCAAATCTGGACAGCGATCGTTTTTAGTGTTTCTGTCTCAAGACTGGAAAACAATAGCATTTG
TCTTGAGTGAGGAAGTGAAGCCCGCTGTGTTCATAGCAGGAGAGGGCTCCCAGACACAGGCCCGTCCTCGGAAGAGCCTTGAGAGTGCAG
CTCGGACCCACCGGCGGCCCCCGTAGCAGGTGGTGTGGGTGCTCGGGAGTGGAGGTGACGTCAGCAGCGCTCTCTGACCGCGGGTGTCAC
GGGCATTTCTCAAAGGAAGCAGGGGATTCAGTGAGTGTGAAGGTGAACAGGATGGCCTGGCAGCAGGGATGTTTCCGTGAGCCACAAATA
CCAGAAACTGAGGCGAGGCTCCCAGCAGCCGGTAGGGAAAGGTGTTTCCAGGGGTCCGAGGGCCGTGGCCTGCGTGGCCATCCCCTGGAG
AGAGGAGCCGCTCAGGGTGCGCGTCATGGAGTGTGCTCAGGGGTGCGTGGACACCTCTGCTGTGGTTTGCTGCTGGGGGCGATGGGAGCG
CCTCTCCGTCCTGTGCCCTGGTCCAGGATGCTGACAGCAGTGAGAGGCCTGCCGTGAGGTTTGGTCTTGTCAGACCTGTAGCCTGGACCT
CGCCGGGGGACCAGGGAGTGCACGTCTGTAGATCTGTACATATCTGGGCCTTTGGAGGCCACGTGTGGCATGGGAGGGGCTACCTGGTCC
CTTTCACAGCCAGGACACGCCTGGATGAGAAAGCCTGAGGTGCCTGGCATGCCCACCGGTGCCACTCTGCAGCCTCCACCCCTGGCCTGA
GTCCCCCTCCATCCGTCTTGGTGGACACCTGTGTGGCTCTCACCTGCGTTTTGAGTCTGTTCTTCCAGGAGTAATAAATTCTGGACATCA

>In-frame_ENST00000302787_ENST00000336727_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(amino acids)=1241AA_start in transcript=297_stop in transcript=4022
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTS
TSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV
KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGEL
TGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYR
AREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKH
SLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLD
LSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLF
RLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNT
AVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLV
LPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSP

--------------------------------------------------------------
>In-frame_ENST00000302787_ENST00000344733_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(transcript)=4457nt_BP=1773nt
GAACCGGTAGTCCGCGGTGGCGCGGTCCGCCCCTCACCTGGCCAGCGGCGGGCGCTGAGGGGCCCAATGGGAGCCGCGGCCTGGCCGCCC
CGCCCCGCGCCTCCGGACGTCTGTGCCGGGACAAGGCCGCCGCTGGTGCCGGGTCCTTGAGGAGAGCGCCTCCCGTCCGAGGCCAGCCGC
CTCTGTCAGCCGTCCGCGCGGGCCGGGTCTGAAGCGCCGCCGGGACGGCGAAGAGCCGCGGCCGCCGCGGAGAAGGAGGCAGCGCAGGAG
GCCGGAGCGGCCGCCGCGCCCGAGCACATGGCGTCCATCTTACTGAGGAGCTGCCGCGGCCGGGCGCCCGCCCGCCTCCCGCCGCCGCCT
CGGTACACCGTCCCGCGGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCA
TTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGC
ATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCG
CGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTAC
AGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTA
TGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGG
ATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTC
TTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCC
AAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAG
AAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTG
ACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGG
CTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCA
CGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCC
ACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCA
GAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAG
GAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGGGCTCAAAATTTGGGCGGGGAACTGGA
CTCACTCAGCCTTCTCAACGCACGTCTGCTCGGAGATCATTTGGGAGATCCAAGAGATTCAGTATCACTCGCTCCCTTGATGATCTTGAG
TCTGCAACTGTGTCTGATGGCGAGTTGACGGGCGCCGACCTGAAGGACTGCGTCAGCAACAACAGCCTGAGCAGCAATGCCAGCCTCCCC
AGCGTGCAGAGCTGCCGGCGCCTGCGTGAGAGGAGGGTCGCCAGCTGGGCCGTGTCCTTTGAGCGCCTGCTGCAGGACCCCGTCGGTGTC
CGCTACTTCTCTGATTTTCTAAGGAAAGAATTCAGTGAAGAAAACATTTTATTCTGGCAGGCCTGTGAATATTTTAATCATGTTCCTGCA
CATGACAAAAAGGAGCTTTCCTACAGGGCCCGGGAGATTTTCAGTAAGTTTCTCTGCAGCAAAGCCACCACCCCGGTCAACATCGACAGC
CAGGCCCAGCTAGCAGACGACGTCCTCCGCGCACCTCACCCAGACATGTTCAAGGAGCAGCAGCTGCAGATCTTCAATCTCATGAAGTTT
GATAGCTACACTCGCTTTCTGAAGTCCCCGCTGTACCAGGAATGCATCCTGGCGGAAGTGGAGGGCCGTGCACTCCCGGACTCGCAGCAG
GTCCCCAGCAGCCCGGCTTCCAAGCACAGCCTCGGTTCAGACCACTCCAGTGTGTCCACGCCAAAAAAGTTAAGTGGAAAATCAAAATCC
GGCCGATCCCTGAATGAAGAGCTGGGGGATGAGGACAGCGAGAAGAAGCGGAAAGGCGCGTTTTTCTCGTGGTCGCGGACCAGGAGCACC
GGGAGGTCCCAGAAAAAGAGGGAGCACGGGGACCACGCAGACGACGCCCTGCATGCCAATGGAGGCCTGTGTCGCCGAGAGTCGCAGGGC
TCTGTGTCCTCTGCGGGGAGCCTGGACCTGTCGGAGGCCTGCAGGACTTTGGCACCCGAGAAGGACAAGGCCACCAAGCACTGCTGCATT
CATCTCCCGGATGGGACATCCTGCGTGGTGGCTGTCAAGGCGGGCTTCTCCATCAAAGACATCCTGTCCGGACTCTGTGAGCGGCATGGC
ATCAACGGGGCGGCCGCGGACCTCTTCCTGGTGGGCGGGGACAAGCCTCTGGTGCTGCACCAAGACAGTAGCATCTTGGAGTCAAGGGAC
CTGCGCCTAGAAAAGCGCACCTTGTTTCGGCTGGATCTTGTTCCGATTAACCGGTCAGTGGGACTCAAGGCCAAGCCCACCAAGCCCGTC
ACGGAGGTGCTGCGGCCCGTGGTGGCCAGATACGGCCTGGACCTCAGTGGCCTGCTGGTGAGGCTGAGTGGAGAGAAGGAGCCCCTGGAC
CTTGGCGCCCCTATATCGAGTCTGGACGGACAGCGGGTTGTCTTGGAGGAGAAGGATCCTTCCAGAGGAAAGGCATCCGCAGATAAACAG
AAAGGTGTGCCAGTGAAACAGAACACAGCTGTAAATTCCAGCTCCAGAAACCACTCGGCTACGGGAGAGGAAAGAACACTAGGCAAGTCT
AATTCTATTAAAATAAAAGGAGAAAATGGAAAAAATGCTAGGGATCCCCGGCTTTCAAAGAGAGAAGAATCTATTGCAAAGATTGGGAAA
AAAAAATATCAGAAAATTAATTTGGACGAAGCAGAGGAGTTTTTTGAGCTTATTTCCAAAGCTCAGAGCAACAGAGCAGATGACCAACGT
GGGCTGCTAAGGAAGGAAGACCTGGTGTTGCCAGAGTTCCTCCGTTTACCTCCTGGTTCCACAGAACTCACCCTCCCCACTCCAGCTGCT
GTGGCCAAGGGCTTTAGCAAGAGAAGCGCCACAGGCAACGGCCGGGAGAGCGCCTCCCAGCCTGGCGAGCAGTGGGAGCCAGTCCAGGAG
AGCAGCGACAGCCCGTCCACCAGCCCGGGCTCAGCCTCCAGCCCCCCTGGACCTCCTGGGACGACCCCCCCCGGGCAGAAGTCTCCCAGC
GGGCCCTTCTGCACTCCCCAGTCCCCCGTCTCCCTCGCGCAGGAGGGCACCGCCCAGATCTGGAAGAGGCAGTCTCAGGAAGTGGAGGCC
GGGGGCATCCAGACGGTGGAGGATGAGCACGTGGCCGAGCTGACCCTGATGGGGGAGGGGGACATCAGCAGCCCCAACAGCACCTTGCTG
CCGCCGCCCTCCACCCCCCAGGAAGTGCCAGGACCTTCCAGACCAGGAAGTGGGACCCATGGCAGCCGAGACCTCCCAGTCAACAGAATC
ATCGATGTGGATCTTGTAACTGGCTCGGCGCCCGGGCGGGATGGTGGCATAGCGGGGGCACAGGCTGGCCCTGGGAGGTCGCAGGCCAGT
GGTGGGCCTCCTACATCAGACCTCCCTGGCTTGGGCCCCGTCCCGGGTGAGCCTGCTAAGCCCAAGACCAGCGCTCACCACGCCACCTTC
GTCTGAGCTGCCCTGGCCTGGCCAACTCTCCTGTGGACATGTCGGGGTGGGGCAGCCCAGGTGGATTCTGTGGGCCTCAGGGGGGCCACC
CTGGCCACCACACCCTCAGGAGCCCAGCCAGGAGGGCAGGGGGTGACCTCGCTGGAGGCACTGGCCCCGGACATTCGCCATGCTGGCCAT

>In-frame_ENST00000302787_ENST00000344733_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(amino acids)=1312AA_start in transcript=297_stop in transcript=4235
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTS
TSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV
KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGEL
TGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYR
AREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKH
SLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLD
LSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLF
RLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNT
AVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLV
LPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSP
VSLAQEGTAQIWKRQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGSRDLPVNRIIDVDLVTGS

--------------------------------------------------------------
>In-frame_ENST00000302787_ENST00000382788_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(transcript)=5301nt_BP=1773nt
GAACCGGTAGTCCGCGGTGGCGCGGTCCGCCCCTCACCTGGCCAGCGGCGGGCGCTGAGGGGCCCAATGGGAGCCGCGGCCTGGCCGCCC
CGCCCCGCGCCTCCGGACGTCTGTGCCGGGACAAGGCCGCCGCTGGTGCCGGGTCCTTGAGGAGAGCGCCTCCCGTCCGAGGCCAGCCGC
CTCTGTCAGCCGTCCGCGCGGGCCGGGTCTGAAGCGCCGCCGGGACGGCGAAGAGCCGCGGCCGCCGCGGAGAAGGAGGCAGCGCAGGAG
GCCGGAGCGGCCGCCGCGCCCGAGCACATGGCGTCCATCTTACTGAGGAGCTGCCGCGGCCGGGCGCCCGCCCGCCTCCCGCCGCCGCCT
CGGTACACCGTCCCGCGGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCA
TTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGC
ATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCG
CGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTAC
AGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTA
TGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGG
ATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTC
TTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCC
AAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAG
AAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTG
ACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGG
CTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCA
CGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCC
ACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCA
GAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAG
GAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGGGCTCAAAATTTGGGCGGGGAACTGGA
CTCACTCAGCCTTCTCAACGCACGTCTGCTCGGAGATCATTTGGGAGATCCAAGAGATTCAGTATCACTCGCTCCCTTGATGATCTTGAG
TCTGCAACTGTGTCTGATGGCGAGTTGACGGGCGCCGACCTGAAGGACTGCGTCAGCAACAACAGCCTGAGCAGCAATGCCAGCCTCCCC
AGCGTGCAGAGCTGCCGGCGCCTGCGTGAGAGGAGGGTCGCCAGCTGGGCCGTGTCCTTTGAGCGCCTGCTGCAGGACCCCGTCGGTGTC
CGCTACTTCTCTGATTTTCTAAGGAAAGAATTCAGTGAAGAAAACATTTTATTCTGGCAGGCCTGTGAATATTTTAATCATGTTCCTGCA
CATGACAAAAAGGAGCTTTCCTACAGGGCCCGGGAGATTTTCAGTAAGTTTCTCTGCAGCAAAGCCACCACCCCGGTCAACATCGACAGC
CAGGCCCAGCTAGCAGACGACGTCCTCCGCGCACCTCACCCAGACATGTTCAAGGAGCAGCAGCTGCAGATCTTCAATCTCATGAAGTTT
GATAGCTACACTCGCTTTCTGAAGTCCCCGCTGTACCAGGAATGCATCCTGGCGGAAGTGGAGGGCCGTGCACTCCCGGACTCGCAGCAG
GTCCCCAGCAGCCCGGCTTCCAAGCACAGCCTCGGTTCAGACCACTCCAGTGTGTCCACGCCAAAAAAGTTAAGTGGAAAATCAAAATCC
GGCCGATCCCTGAATGAAGAGCTGGGGGATGAGGACAGCGAGAAGAAGCGGAAAGGCGCGTTTTTCTCGTGGTCGCGGACCAGGAGCACC
GGGAGGTCCCAGAAAAAGAGGGAGCACGGGGACCACGCAGACGACGCCCTGCATGCCAATGGAGGCCTGTGTCGCCGAGAGTCGCAGGGC
TCTGTGTCCTCTGCGGGGAGCCTGGACCTGTCGGAGGCCTGCAGGACTTTGGCACCCGAGAAGGACAAGGCCACCAAGCACTGCTGCATT
CATCTCCCGGATGGGACATCCTGCGTGGTGGCTGTCAAGGCGGGCTTCTCCATCAAAGACATCCTGTCCGGACTCTGTGAGCGGCATGGC
ATCAACGGGGCGGCCGCGGACCTCTTCCTGGTGGGCGGGGACAAGCCTCTGGTGCTGCACCAAGACAGTAGCATCTTGGAGTCAAGGGAC
CTGCGCCTAGAAAAGCGCACCTTGTTTCGGCTGGATCTTGTTCCGATTAACCGGTCAGTGGGACTCAAGGCCAAGCCCACCAAGCCCGTC
ACGGAGGTGCTGCGGCCCGTGGTGGCCAGATACGGCCTGGACCTCAGTGGCCTGCTGGTGAGGCTGAGTGGAGAGAAGGAGCCCCTGGAC
CTTGGCGCCCCTATATCGAGTCTGGACGGACAGCGGGTTGTCTTGGAGGAGAAGGATCCTTCCAGAGGAAAGGCATCCGCAGATAAACAG
AAAGGTGTGCCAGTGAAACAGAACACAGCTGTAAATTCCAGCTCCAGAAACCACTCGGCTACGGGAGAGGAAAGAACACTAGGCAAGTCT
AATTCTATTAAAATAAAAGGAGAAAATGGAAAAAATGCTAGGGATCCCCGGCTTTCAAAGAGAGAAGAATCTATTGCAAAGATTGGGAAA
AAAAAATATCAGAAAATTAATTTGGACGAAGCAGAGGAGTTTTTTGAGCTTATTTCCAAAGCTCAGAGCAACAGAGCAGATGACCAACGT
GGGCTGCTAAGGAAGGAAGACCTGGTGTTGCCAGAGTTCCTCCGTTTACCTCCTGGTTCCACAGAACTCACCCTCCCCACTCCAGCTGCT
GTGGCCAAGGGCTTTAGCAAGAGAAGCGCCACAGGCAACGGCCGGGAGAGCGCCTCCCAGCCTGGCGAGCAGTGGGAGCCAGTCCAGGAG
AGCAGCGACAGCCCGTCCACCAGCCCGGGCTCAGCCTCCAGCCCCCCTGGACCTCCTGGGACGACCCCCCCCGGGCAGAAGTCTCCCAGC
GGGCCCTTCTGCACTCCCCAGTCCCCCGTCTCCCTCGCGCAGGAGGGCACCGCCCAGATCTGGAAGAGGCAGTCTCAGGAAGTGGAGGCC
GGGGGCATCCAGACGGTGGAGGATGAGCACGTGGCCGAGCTGACCCTGATGGGGGAGGGGGACATCAGCAGCCCCAACAGCACCTTGCTG
CCGCCGCCCTCCACCCCCCAGGAAGTGCCAGGACCTTCCAGACCAGGTACCTCCAGGTTCTGATCCCTCCACCTTGGCCCCGTAAGCGTG
GTCTGCTCAGCTTCCAGTCAGAAAGGACAGTGGGCCCCCGGCTGCCACTGTTTGCTGGTGGTCTCCGTGACCCCCTCCTCACCTGCTGGT
TGGGGGCTTCCTTGGCCCTCTTGGAAAGGAGGGGCTCGTGTGGCCCCAGGCCAGTGTCTGTCAGGATGGTCCCCCCGAGGCGCTCTGGGC
AGGCATCCTGGTGTCCTGAGAGGCTCTTGCAGGAATGATACGTGGCAGTGCCTGCAGCGAGGTCTGGGAACACCCTGGGTGAGGCCTGGG
GGTTTCCGAAAATGGAGGCATTCCTTTCCAAATCTGGACAGCGATCGTTTTTAGTGTTTCTGTCTCAAGACTGGAAAACAATAGCATTTG
TCTTGAGTGAGGAAGTGAAGCCCGCTGTGTTCATAGCAGGAGAGGGCTCCCAGACACAGGCCCGTCCTCGGAAGAGCCTTGAGAGTGCAG
CTCGGACCCACCGGCGGCCCCCGTAGCAGGTGGTGTGGGTGCTCGGGAGTGGAGGTGACGTCAGCAGCGCTCTCTGACCGCGGGTGTCAC
GGGCATTTCTCAAAGGAAGCAGGGGATTCAGTGAGTGTGAAGGTGAACAGGATGGCCTGGCAGCAGGGATGTTTCCGTGAGCCACAAATA
CCAGAAACTGAGGCGAGGCTCCCAGCAGCCGGTAGGGAAAGGTGTTTCCAGGGGTCCGAGGGCCGTGGCCTGCGTGGCCATCCCCTGGAG
AGAGGAGCCGCTCAGGGTGCGCGTCATGGAGTGTGCTCAGGGGTGCGTGGACACCTCTGCTGTGGTTTGCTGCTGGGGGCGATGGGAGCG
CCTCTCCGTCCTGTGCCCTGGTCCAGGATGCTGACAGCAGTGAGAGGCCTGCCGTGAGGTTTGGTCTTGTCAGACCTGTAGCCTGGACCT
CGCCGGGGGACCAGGGAGTGCACGTCTGTAGATCTGTACATATCTGGGCCTTTGGAGGCCACGTGTGGCATGGGAGGGGCTACCTGGTCC
CTTTCACAGCCAGGACACGCCTGGATGAGAAAGCCTGAGGTGCCTGGCATGCCCACCGGTGCCACTCTGCAGCCTCCACCCCTGGCCTGA
GTCCCCCTCCATCCGTCTTGGTGGACACCTGTGTGGCTCTCACCTGCGTTTTGAGTCTGTTCTTCCAGGAGTAATAAATTCTGGACATCA

>In-frame_ENST00000302787_ENST00000382788_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(amino acids)=1241AA_start in transcript=297_stop in transcript=4022
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTS
TSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV
KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGEL
TGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYR
AREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKH
SLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLD
LSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLF
RLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNT
AVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLV
LPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSP

--------------------------------------------------------------
>In-frame_ENST00000302787_ENST00000306648_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(transcript)=3485nt_BP=1773nt
GAACCGGTAGTCCGCGGTGGCGCGGTCCGCCCCTCACCTGGCCAGCGGCGGGCGCTGAGGGGCCCAATGGGAGCCGCGGCCTGGCCGCCC
CGCCCCGCGCCTCCGGACGTCTGTGCCGGGACAAGGCCGCCGCTGGTGCCGGGTCCTTGAGGAGAGCGCCTCCCGTCCGAGGCCAGCCGC
CTCTGTCAGCCGTCCGCGCGGGCCGGGTCTGAAGCGCCGCCGGGACGGCGAAGAGCCGCGGCCGCCGCGGAGAAGGAGGCAGCGCAGGAG
GCCGGAGCGGCCGCCGCGCCCGAGCACATGGCGTCCATCTTACTGAGGAGCTGCCGCGGCCGGGCGCCCGCCCGCCTCCCGCCGCCGCCT
CGGTACACCGTCCCGCGGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCA
TTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGC
ATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCG
CGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTAC
AGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTA
TGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGG
ATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTC
TTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCC
AAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAG
AAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTG
ACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGG
CTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCA
CGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCC
ACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCA
GAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAG
GAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGGGCTCAAAATTTGGGCGGGGAACTGGA
CTCACTCAGCCTTCTCAACGCACGTCTGCTCGGAGATCATTTGGGAGATCCAAGAGATTCAGTATCACTCGCTCCCTTGATGATCTTGAG
TCTGCAACTGTGTCTGATGGCGAGTTGACGGGCGCCGACCTGAAGGACTGCGTCAGCAACAACAGCCTGAGCAGCAATGCCAGCCTCCCC
AGCGTGCAGAGCTGCCGGCGCCTGCGTGAGAGGAGGGTCGCCAGCTGGGCCGTGTCCTTTGAGCGCCTGCTGCAGGACCCCGTCGGTGTC
CGCTACTTCTCTGATTTTCTAAGGAAAGAATTCAGTGAAGAAAACATTTTATTCTGGCAGGCCTGTGAATATTTTAATCATGTTCCTGCA
CATGACAAAAAGGAGCTTTCCTACAGGGCCCGGGAGATTTTCAGTAAGTTTCTCTGCAGCAAAGCCACCACCCCGGTCAACATCGACAGC
CAGGCCCAGCTAGCAGACGACGTCCTCCGCGCACCTCACCCAGACATGTTCAAGGAGCAGCAGCTGCAGATCTTCAATCTCATGAAGTTT
GATAGCTACACTCGCTTTCTGAAGTCCCCGCTGTACCAGGAATGCATCCTGGCGGAAGTGGAGGGCCGTGCACTCCCGGACTCGCAGCAG
GTCCCCAGCAGCCCGGCTTCCAAGCACAGCCTCGGTTCAGACCACTCCAGTGTGTCCACGCCAAAAAAGTTAAGTGGAAAATCAAAATCC
GGCCGATCCCTGAATGAAGAGCTGGGGGATGAGGACAGCGAGAAGAAGCGGAAAGGCGCGTTTTTCTCGTGGTCGCGGACCAGGAGCACC
GGGAGGTCCCAGAAAAAGAGGGAGCACGGGGACCACGCAGACGACGCCCTGCATGCCAATGGAGGCCTGTGTCGCCGAGAGTCGCAGGGC
TCTGTGTCCTCTGCGGGGAGCCTGGACCTGTCGGAGGCCTGCAGGACTTTGGCACCCGAGAAGGACAAGGCCACCAAGCACTGCTGCATT
CATCTCCCGGATGGGACATCCTGCGTGGTGGCTGTCAAGGCGGGCTTCTCCATCAAAGACATCCTGTCCGGACTCTGTGAGCGGCATGGC
ATCAACGGGGCGGCCGCGGACCTCTTCCTGGTGGGCGGGGACAAGCCTCTGGTGCTGCACCAAGACAGTAGCATCTTGGAGTCAAGGGAC
CTGCGCCTAGAAAAGCGCACCTTGTTTCGGCTGGATCTTGTTCCGATTAACCGGTCAGTGGGACTCAAGGCCAAGCCCACCAAGCCCGTC
ACGGAGGTGCTGCGGCCCGTGGTGGCCAGATACGGCCTGGACCTCAGTGGCCTGCTGGTGAGGCTGAGTGGAGAGAAGGAGCCCCTGGAC
CTTGGCGCCCCTATATCGAGTCTGGACGGACAGCGGGTTGTCTTGGAGGAGAAGGATCCTTCCAGAGGAAAGGCATCCGCAGATAAACAG
AAAGGTGTGCCAGTGAAACAGAACACAGCTGTAAATTCCAGCTCCAGAAACCACTCGGCTACGAGTTTTTTGAGCTTATTTCCAAAGCTC
AGAGCAACAGAGCAGATGACCAACGTGGGCTGCTAAGGAAGGAAGACCTGGTGTTGCCAGAGTTCCTCCGTTTACCTCCTGGTTCCACAG

>In-frame_ENST00000302787_ENST00000306648_TCGA-JY-A938_LETM1_chr4_1824714_-_RGS12_chr4_3344663_length(amino acids)=1022AA_start in transcript=297_stop in transcript=3365
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTS
TSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV
KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGEL
TGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYR
AREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKH
SLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLD
LSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLF
RLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNT

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Fusion Gene PPI Analysis for LETM1-RGS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LETM1-RGS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LETM1-RGS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLETM1C0020796Profound Mental Retardation1CTD_human
HgeneLETM1C0022333Jacksonian Seizure1CTD_human
HgeneLETM1C0025363Mental Retardation, Psychosocial1CTD_human
HgeneLETM1C0026825Flaccid Muscle Tone1CTD_human
HgeneLETM1C0026827Muscle hypotonia1CTD_human
HgeneLETM1C0036572Seizures1CTD_human
HgeneLETM1C0149958Complex partial seizures1CTD_human
HgeneLETM1C0234533Generalized seizures1CTD_human
HgeneLETM1C0234535Clonic Seizures1CTD_human
HgeneLETM1C0270824Visual seizure1CTD_human
HgeneLETM1C0270844Tonic Seizures1CTD_human
HgeneLETM1C0270846Epileptic drop attack1CTD_human
HgeneLETM1C0376634Craniofacial Abnormalities1CTD_human
HgeneLETM1C0422850Seizures, Somatosensory1CTD_human
HgeneLETM1C0422852Seizures, Auditory1CTD_human
HgeneLETM1C0422853Olfactory seizure1CTD_human
HgeneLETM1C0422854Gustatory seizure1CTD_human
HgeneLETM1C0422855Vertiginous seizure1CTD_human
HgeneLETM1C0427201Floppy Muscles1CTD_human
HgeneLETM1C0427202Muscle Tone Atonic1CTD_human
HgeneLETM1C0494475Tonic - clonic seizures1CTD_human
HgeneLETM1C0751056Non-epileptic convulsion1CTD_human
HgeneLETM1C0751110Single Seizure1CTD_human
HgeneLETM1C0751123Atonic Absence Seizures1CTD_human
HgeneLETM1C0751330Unilateral Hypotonia1CTD_human
HgeneLETM1C0751494Convulsive Seizures1CTD_human
HgeneLETM1C0751495Seizures, Focal1CTD_human
HgeneLETM1C0751496Seizures, Sensory1CTD_human
HgeneLETM1C0796117Pitt-Rogers-Danks Syndrome1CTD_human
HgeneLETM1C0917816Mental deficiency1CTD_human
HgeneLETM1C1956097Wolf-Hirschhorn Syndrome1CTD_human;ORPHANET
HgeneLETM1C2239176Liver carcinoma1CTD_human
HgeneLETM1C2267233Neonatal Hypotonia1CTD_human
HgeneLETM1C3495874Nonepileptic Seizures1CTD_human
HgeneLETM1C3714756Intellectual Disability1CTD_human
HgeneLETM1C4048158Convulsions1CTD_human
HgeneLETM1C4316903Absence Seizures1CTD_human
HgeneLETM1C4317109Epileptic Seizures1CTD_human
HgeneLETM1C4317123Myoclonic Seizures1CTD_human
HgeneLETM1C4505436Generalized Absence Seizures1CTD_human
TgeneRGS12C0036341Schizophrenia1CTD_human