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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LIMCH1-CWH43 (FusionGDB2 ID:44451)

Fusion Gene Summary for LIMCH1-CWH43

check button Fusion gene summary
Fusion gene informationFusion gene name: LIMCH1-CWH43
Fusion gene ID: 44451
HgeneTgene
Gene symbol

LIMCH1

CWH43

Gene ID

22998

80157

Gene nameLIM and calponin homology domains 1cell wall biogenesis 43 C-terminal homolog
SynonymsLIMCH1A|LMO7BCWH43-C|PGAP2IP
Cytomap

4p13

4p11

Type of geneprotein-codingprotein-coding
DescriptionLIM and calponin homology domains-containing protein 1PGAP2-interacting proteincell wall biogenesis protein 43 C-terminal homolog
Modification date2020031320200313
UniProtAcc

Q9UPQ0

Q9H720

Ensembl transtripts involved in fusion geneENST00000513024, ENST00000509638, 
ENST00000508501, ENST00000512946, 
ENST00000313860, ENST00000512632, 
ENST00000512820, ENST00000503057, 
ENST00000511496, ENST00000514096, 
ENST00000509277, ENST00000396595, 
ENST00000381753, ENST00000509454, 
ENST00000515785, 		ENST00000226432, 
ENST00000513409, 
Fusion gene scores* DoF score14 X 12 X 9=15123 X 6 X 3=54
# samples 194
** MAII scorelog2(19/1512*10)=-2.99238681589013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/54*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIMCH1 [Title/Abstract] AND CWH43 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIMCH1(41526495)-CWH43(49030646), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LIMCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CWH43 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A5W6-01ALIMCH1chr4

41526495

+CWH43chr4

49030646

+
ChimerDB4BLCATCGA-CU-A5W6-01ALIMCH1chr4

41526495

+CWH43chr4

49030646

+
ChimerDB4BLCATCGA-CU-A5W6-01ALIMCH1chr4

41526495

-CWH43chr4

49030646

+


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Fusion Gene ORF analysis for LIMCH1-CWH43

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000513024ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
5UTR-3CDSENST00000513024ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
5UTR-3CDSENST00000509638ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
5UTR-3CDSENST00000509638ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000508501ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000508501ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000512946ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000512946ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000313860ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000313860ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000512632ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000512632ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000512820ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
In-frameENST00000512820ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000503057ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000503057ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000511496ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000511496ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000514096ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000514096ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000509277ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000509277ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000396595ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000396595ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000381753ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000381753ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000509454ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000509454ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000515785ENST00000226432LIMCH1chr4

41526495

+CWH43chr4

49030646

+
intron-3CDSENST00000515785ENST00000513409LIMCH1chr4

41526495

+CWH43chr4

49030646

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000508501LIMCH1chr441526495+ENST00000226432CWH43chr449030646+1316293321126364
ENST00000508501LIMCH1chr441526495+ENST00000513409CWH43chr449030646+1313293321126364
ENST00000512946LIMCH1chr441526495+ENST00000226432CWH43chr449030646+1316293321126364
ENST00000512946LIMCH1chr441526495+ENST00000513409CWH43chr449030646+1313293321126364
ENST00000313860LIMCH1chr441526495+ENST00000226432CWH43chr449030646+1314291301124364
ENST00000313860LIMCH1chr441526495+ENST00000513409CWH43chr449030646+1311291301124364
ENST00000512632LIMCH1chr441526495+ENST00000226432CWH43chr449030646+1294271101104364
ENST00000512632LIMCH1chr441526495+ENST00000513409CWH43chr449030646+1291271101104364
ENST00000512820LIMCH1chr441526495+ENST00000226432CWH43chr449030646+128626321096364
ENST00000512820LIMCH1chr441526495+ENST00000513409CWH43chr449030646+128326321096364

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000508501ENST00000226432LIMCH1chr441526495+CWH43chr449030646+0.0007835640.99921644
ENST00000508501ENST00000513409LIMCH1chr441526495+CWH43chr449030646+0.0007950560.99920493
ENST00000512946ENST00000226432LIMCH1chr441526495+CWH43chr449030646+0.0007835640.99921644
ENST00000512946ENST00000513409LIMCH1chr441526495+CWH43chr449030646+0.0007950560.99920493
ENST00000313860ENST00000226432LIMCH1chr441526495+CWH43chr449030646+0.0007637890.9992362
ENST00000313860ENST00000513409LIMCH1chr441526495+CWH43chr449030646+0.0007749040.99922514
ENST00000512632ENST00000226432LIMCH1chr441526495+CWH43chr449030646+0.0007524850.99924755
ENST00000512632ENST00000513409LIMCH1chr441526495+CWH43chr449030646+0.0007608880.9992391
ENST00000512820ENST00000226432LIMCH1chr441526495+CWH43chr449030646+0.0007832920.9992167
ENST00000512820ENST00000513409LIMCH1chr441526495+CWH43chr449030646+0.0007928130.9992072

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Fusion Genomic Features for LIMCH1-CWH43


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LIMCH1chr441526495+CWH43chr449030645+4.89E-050.9999511
LIMCH1chr441526495+CWH43chr449030645+4.89E-050.9999511

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LIMCH1-CWH43


check button Go to

FGviewer for the breakpoints of chr4:41526495-chr4:49030646

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIMCH1

Q9UPQ0

CWH43

Q9H720

FUNCTION: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.FUNCTION: Involved in lipid remodeling during GPI-anchor maturation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816607_627422.0700.0RegionRequired for function in lipid remodeling

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000313860+327354_43979.01084.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000313860+327782_82379.01084.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000381753+120354_4390891.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000381753+120782_8230891.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000396595+121354_4390903.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000396595+121782_8230903.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000508501+326354_43979.01057.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000508501+326782_82379.01057.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000511496+123354_4390898.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000511496+123782_8230898.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512820+326354_43979.01070.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512820+326782_82379.01070.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512946+326354_43979.01058.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512946+326782_82379.01058.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000513024+326354_4390911.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000513024+326782_8230911.0Coiled coilOntology_term=ECO:0000255
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000313860+3271011_107779.01084.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000313860+32721_12579.01084.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000381753+1201011_10770891.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000381753+12021_1250891.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000396595+1211011_10770903.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000396595+12121_1250903.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000508501+3261011_107779.01057.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000508501+32621_12579.01057.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000511496+1231011_10770898.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000511496+12321_1250898.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512820+3261011_107779.01070.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512820+32621_12579.01070.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512946+3261011_107779.01058.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000512946+32621_12579.01058.0DomainCalponin-homology (CH)
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000513024+3261011_10770911.0DomainLIM zinc-binding
HgeneLIMCH1chr4:41526495chr4:49030646ENST00000513024+32621_1250911.0DomainCalponin-homology (CH)
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816123_143422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST0000022643281613_33422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816196_216422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816237_257422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816273_293422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816316_336422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816349_369422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST00000226432816390_410422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST0000022643281641_61422.0700.0TransmembraneHelical
TgeneCWH43chr4:41526495chr4:49030646ENST0000022643281693_113422.0700.0TransmembraneHelical


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Fusion Gene Sequence for LIMCH1-CWH43


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000508501_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1316nt_BP=293nt
GGCGACGGCGGCGGCCGTCCTCATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTC
AGCCCCTGCAGCCCGAGCCGCCCCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATA
AAGATTTTCGGACAGGTTTAGAAAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGAT
TGCCTACCCCCATTGCAGGACTGGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGT
CTAGTCTAGAAAGATCAGCTCACCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGG
GGAACAATGACTTAACCATGTGGCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTA
TGGCTTTGTCAAGATACCCAATTGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCG
TTAACATTTCGGGCAAGCTGGTGGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTG
TTTCAAAACTACTGAAAAGTAGCTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCA
CTGAACATGGCAATGTGAAGGATATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTT
ATGCAAGAATCTCCCATGCTGAACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACA
ACCAGAAAGTGGTCATAGACCACAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATG
AAAACAACCATCATTTTCATATGAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAA
AAAAGTATGTAAGATAAAAAGAAGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCA

>In-frame_ENST00000508501_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=32_stop in transcript=1126
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000508501_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1313nt_BP=293nt
GGCGACGGCGGCGGCCGTCCTCATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTC
AGCCCCTGCAGCCCGAGCCGCCCCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATA
AAGATTTTCGGACAGGTTTAGAAAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGAT
TGCCTACCCCCATTGCAGGACTGGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGT
CTAGTCTAGAAAGATCAGCTCACCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGG
GGAACAATGACTTAACCATGTGGCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTA
TGGCTTTGTCAAGATACCCAATTGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCG
TTAACATTTCGGGCAAGCTGGTGGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTG
TTTCAAAACTACTGAAAAGTAGCTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCA
CTGAACATGGCAATGTGAAGGATATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTT
ATGCAAGAATCTCCCATGCTGAACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACA
ACCAGAAAGTGGTCATAGACCACAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATG
AAAACAACCATCATTTTCATATGAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAA
AAAAGTATGTAAGATAAAAAGAAGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCA

>In-frame_ENST00000508501_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=32_stop in transcript=1126
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000512946_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1316nt_BP=293nt
GGCGACGGCGGCGGCCGTCCTCATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTC
AGCCCCTGCAGCCCGAGCCGCCCCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATA
AAGATTTTCGGACAGGTTTAGAAAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGAT
TGCCTACCCCCATTGCAGGACTGGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGT
CTAGTCTAGAAAGATCAGCTCACCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGG
GGAACAATGACTTAACCATGTGGCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTA
TGGCTTTGTCAAGATACCCAATTGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCG
TTAACATTTCGGGCAAGCTGGTGGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTG
TTTCAAAACTACTGAAAAGTAGCTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCA
CTGAACATGGCAATGTGAAGGATATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTT
ATGCAAGAATCTCCCATGCTGAACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACA
ACCAGAAAGTGGTCATAGACCACAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATG
AAAACAACCATCATTTTCATATGAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAA
AAAAGTATGTAAGATAAAAAGAAGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCA

>In-frame_ENST00000512946_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=32_stop in transcript=1126
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000512946_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1313nt_BP=293nt
GGCGACGGCGGCGGCCGTCCTCATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTC
AGCCCCTGCAGCCCGAGCCGCCCCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATA
AAGATTTTCGGACAGGTTTAGAAAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGAT
TGCCTACCCCCATTGCAGGACTGGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGT
CTAGTCTAGAAAGATCAGCTCACCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGG
GGAACAATGACTTAACCATGTGGCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTA
TGGCTTTGTCAAGATACCCAATTGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCG
TTAACATTTCGGGCAAGCTGGTGGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTG
TTTCAAAACTACTGAAAAGTAGCTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCA
CTGAACATGGCAATGTGAAGGATATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTT
ATGCAAGAATCTCCCATGCTGAACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACA
ACCAGAAAGTGGTCATAGACCACAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATG
AAAACAACCATCATTTTCATATGAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAA
AAAAGTATGTAAGATAAAAAGAAGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCA

>In-frame_ENST00000512946_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=32_stop in transcript=1126
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000313860_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1314nt_BP=291nt
CGACGGCGGCGGCCGTCCTCATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTCAG
CCCCTGCAGCCCGAGCCGCCCCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATAAA
GATTTTCGGACAGGTTTAGAAAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGATTG
CCTACCCCCATTGCAGGACTGGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGTCT
AGTCTAGAAAGATCAGCTCACCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGGGG
AACAATGACTTAACCATGTGGCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTATG
GCTTTGTCAAGATACCCAATTGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCGTT
AACATTTCGGGCAAGCTGGTGGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTGTT
TCAAAACTACTGAAAAGTAGCTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCACT
GAACATGGCAATGTGAAGGATATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTTAT
GCAAGAATCTCCCATGCTGAACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACAAC
CAGAAAGTGGTCATAGACCACAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATGAA
AACAACCATCATTTTCATATGAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAAAA
AAGTATGTAAGATAAAAAGAAGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCAGT

>In-frame_ENST00000313860_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=30_stop in transcript=1124
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000313860_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1311nt_BP=291nt
CGACGGCGGCGGCCGTCCTCATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTCAG
CCCCTGCAGCCCGAGCCGCCCCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATAAA
GATTTTCGGACAGGTTTAGAAAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGATTG
CCTACCCCCATTGCAGGACTGGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGTCT
AGTCTAGAAAGATCAGCTCACCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGGGG
AACAATGACTTAACCATGTGGCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTATG
GCTTTGTCAAGATACCCAATTGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCGTT
AACATTTCGGGCAAGCTGGTGGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTGTT
TCAAAACTACTGAAAAGTAGCTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCACT
GAACATGGCAATGTGAAGGATATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTTAT
GCAAGAATCTCCCATGCTGAACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACAAC
CAGAAAGTGGTCATAGACCACAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATGAA
AACAACCATCATTTTCATATGAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAAAA
AAGTATGTAAGATAAAAAGAAGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCAGT

>In-frame_ENST00000313860_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=30_stop in transcript=1124
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000512632_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1294nt_BP=271nt
ATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTCAGCCCCTGCAGCCCGAGCCGCC
CCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATAAAGATTTTCGGACAGGTTTAGA
AAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGATTGCCTACCCCCATTGCAGGACT
GGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGTCTAGTCTAGAAAGATCAGCTCA
CCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGGGGAACAATGACTTAACCATGTG
GCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTATGGCTTTGTCAAGATACCCAAT
TGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCGTTAACATTTCGGGCAAGCTGGT
GGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTGTTTCAAAACTACTGAAAAGTAG
CTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCACTGAACATGGCAATGTGAAGGA
TATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTTATGCAAGAATCTCCCATGCTGA
ACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACAACCAGAAAGTGGTCATAGACCA
CAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATGAAAACAACCATCATTTTCATAT
GAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAAAAAAGTATGTAAGATAAAAAGA
AGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCAGTGGGAAATTACCTCCATTTGT

>In-frame_ENST00000512632_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=10_stop in transcript=1104
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000512632_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1291nt_BP=271nt
ATCCCGGCGCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTCAGCCCCTGCAGCCCGAGCCGCC
CCCCGAGCCCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATAAAGATTTTCGGACAGGTTTAGA
AAATGGAATCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGATTGCCTACCCCCATTGCAGGACT
GGCACCAACCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGTCTAGTCTAGAAAGATCAGCTCA
CCTGCTCAATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGGGGAACAATGACTTAACCATGTG
GCTAGGGGAAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTATGGCTTTGTCAAGATACCCAAT
TGTGAAATCTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCGTTAACATTTCGGGCAAGCTGGT
GGATTTTGTCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTGTTTCAAAACTACTGAAAAGTAG
CTCTAATCAAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCACTGAACATGGCAATGTGAAGGA
TATCGACAGCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTTATGCAAGAATCTCCCATGCTGA
ACTGAGTGATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACAACCAGAAAGTGGTCATAGACCA
CAGAGAAGTTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATGAAAACAACCATCATTTTCATAT
GAATACTCCCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAAAAAAGTATGTAAGATAAAAAGA
AGAGATTAATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCAGTGGGAAATTACCTCCATTTGT

>In-frame_ENST00000512632_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=10_stop in transcript=1104
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000512820_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1286nt_BP=263nt
GCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTCAGCCCCTGCAGCCCGAGCCGCCCCCCGAGC
CCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATAAAGATTTTCGGACAGGTTTAGAAAATGGAA
TCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGATTGCCTACCCCCATTGCAGGACTGGCACCAA
CCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGTCTAGTCTAGAAAGATCAGCTCACCTGCTCA
ATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGGGGAACAATGACTTAACCATGTGGCTAGGGG
AAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTATGGCTTTGTCAAGATACCCAATTGTGAAAT
CTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCGTTAACATTTCGGGCAAGCTGGTGGATTTTG
TCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTGTTTCAAAACTACTGAAAAGTAGCTCTAATC
AAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCACTGAACATGGCAATGTGAAGGATATCGACA
GCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTTATGCAAGAATCTCCCATGCTGAACTGAGTG
ATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACAACCAGAAAGTGGTCATAGACCACAGAGAAG
TTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATGAAAACAACCATCATTTTCATATGAATACTC
CCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAAAAAAGTATGTAAGATAAAAAGAAGAGATTA
ATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCAGTGGGAAATTACCTCCATTTGTAAACTATG

>In-frame_ENST00000512820_ENST00000226432_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=2_stop in transcript=1096
LRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------
>In-frame_ENST00000512820_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(transcript)=1283nt_BP=263nt
GCTTGAGAGGACGCGGGGCTGCGCAAATGGCTTGTCCCGCTCTCGGTCTGGAAGCTCTTCAGCCCCTGCAGCCCGAGCCGCCCCCCGAGC
CCGCCTTCTCCGAGGCGCAGAAGTGGATTGAGCAAGTAACTGGCAGAAGTTTTGGTGATAAAGATTTTCGGACAGGTTTAGAAAATGGAA
TCCTCCTCTGCGAGTTGCTGAATGCTATAAAGCCAGGACTTGTTAAAAAGATCAATAGATTGCCTACCCCCATTGCAGGACTGGCACCAA
CCAAAGAGGTCTCTGCTGCCATCTGGCCTTTCAGGTTTGGATATGACAATGAAGGGTGGTCTAGTCTAGAAAGATCAGCTCACCTGCTCA
ATGAAACAGGTGCAGATTTCATAACAATTTTGGAGAGTGATGCTTCTAAGCCCTATATGGGGAACAATGACTTAACCATGTGGCTAGGGG
AAAAGTTGGGTTTCTATACAGACTTTGGTCCAAGCACAAGGTATCACACTTGGGGGATTATGGCTTTGTCAAGATACCCAATTGTGAAAT
CTGAGCATCACCTTCTTCCGTCACCAGAGGGCGAGATCGCACCAGCCATCACATTGACCGTTAACATTTCGGGCAAGCTGGTGGATTTTG
TCGTGACACACTTTGGGAACCACGAAGATGACCTCGACAGGAAACTGCAGGCTATTGCTGTTTCAAAACTACTGAAAAGTAGCTCTAATC
AAGTGATATTTCTGGGATATATCACTTCAGCACCTGGCTCCAGAGATTATCTACAGCTCACTGAACATGGCAATGTGAAGGATATCGACA
GCACTGATCATGACAGATGGTGTGAATACATTATGTATCGAGGGCTGATCAGGTTGGGTTATGCAAGAATCTCCCATGCTGAACTGAGTG
ATTCAGAAATTCAGATGGCAAAATTTAGGATCCCTGATGACCCCACTAATTATAGAGACAACCAGAAAGTGGTCATAGACCACAGAGAAG
TTTCTGAGAAAATTCATTTTAATCCCAGATTTGGATCCTACAAAGAAGGACACAATTATGAAAACAACCATCATTTTCATATGAATACTC
CCAAATACTTTTTATGAAACATTTAAAACAAGAAGTTATTGGCTGGGAAAATCTAAGAAAAAAAGTATGTAAGATAAAAAGAAGAGATTA
ATGAAAGTGGGAAAATACACATGAAGAACCTCAACTTAAAAAACACATGGTATCTATGCAGTGGGAAATTACCTCCATTTGTAAACTATG

>In-frame_ENST00000512820_ENST00000513409_TCGA-CU-A5W6-01A_LIMCH1_chr4_41526495_+_CWH43_chr4_49030646_length(amino acids)=364AA_start in transcript=2_stop in transcript=1096
LRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLAPT
KEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKS
EHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDS
TDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LIMCH1-CWH43


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LIMCH1-CWH43


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LIMCH1-CWH43


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIMCH1C0013146Drug abuse1CTD_human
HgeneLIMCH1C0013170Drug habituation1CTD_human
HgeneLIMCH1C0013222Drug Use Disorders1CTD_human
HgeneLIMCH1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneLIMCH1C0038580Substance Dependence1CTD_human
HgeneLIMCH1C0038586Substance Use Disorders1CTD_human
HgeneLIMCH1C0236969Substance-Related Disorders1CTD_human
HgeneLIMCH1C0345967Malignant mesothelioma1CTD_human
HgeneLIMCH1C0740858Substance abuse problem1CTD_human
HgeneLIMCH1C1510472Drug Dependence1CTD_human
HgeneLIMCH1C4316881Prescription Drug Abuse1CTD_human
TgeneCWH43C0024121Lung Neoplasms1CTD_human
TgeneCWH43C0242379Malignant neoplasm of lung1CTD_human