Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANK2-ARHGAP31 (FusionGDB2 ID:4461)

Fusion Gene Summary for ANK2-ARHGAP31

Fusion gene summary

Fusion gene information	Fusion gene name: ANK2-ARHGAP31
	Fusion gene ID: 4461
		Hgene	Tgene
	Gene symbol	ANK2	ARHGAP31
	Gene ID	287	57514
	Gene name	ankyrin 2	Rho GTPase activating protein 31
	Synonyms	ANK-2\|CFAP87\|FAP87\|LQT4\|brank-2	AOS1\|CDGAP
	Cytomap	4q25-q26	3q13.32-q13.33
	Type of gene	protein-coding	protein-coding
	Description	ankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrin	rho GTPase-activating protein 31Cdc42 GTPase-activating protein
	Modification date	20200313	20200313
	UniProtAcc	Q01484	Q2M1Z3
	Ensembl transtripts involved in fusion gene	ENST00000506722, ENST00000394537, ENST00000357077, ENST00000264366, ENST00000509550, ENST00000510275, ENST00000504887,	ENST00000264245,
Fusion gene scores	* DoF score	11 X 12 X 4=528	3 X 3 X 3=27
	# samples	15	3
	** MAII score	log2(15/528*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ANK2 [Title/Abstract] AND ARHGAP31 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANK2(114304891)-ARHGAP31(119013220), # samples:1
Anticipated loss of major functional domain due to fusion event.	ANK2-ARHGAP31 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ANK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP31 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DB-A75P-01A	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+

Top

Fusion Gene ORF analysis for ANK2-ARHGAP31

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000506722	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+
intron-3CDS	ENST00000394537	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+
Frame-shift	ENST00000357077	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+
intron-3CDS	ENST00000264366	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+
intron-3CDS	ENST00000509550	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+
intron-3CDS	ENST00000510275	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+
intron-3CDS	ENST00000504887	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000506722

ANK2

chr4

114304891

ENST00000264245

ARHGAP31

chr3

119013220

17368

8051

108

5786

1892

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000506722	ENST00000264245	ANK2	chr4	114304891	-	ARHGAP31	chr3	119013220	+	0.000806311	0.9991937

Top

Fusion Genomic Features for ANK2-ARHGAP31

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ANK2-ARHGAP31

Go to
FGviewer for the breakpoints of chr4:114304891-chr3:119013220
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANK2 Q01484	ARHGAP31 Q2M1Z3
FUNCTION: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250\|UniProtKB:Q8C8R3, ECO:0000269\|PubMed:12571597}.	FUNCTION: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269\|PubMed:12192056, ECO:0000269\|PubMed:16519628}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1158_1304

4714.333333333333

3958.0

Domain

ZU5 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1450_1535

4714.333333333333

3958.0

Domain

Death 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

3569_3653

4714.333333333333

3958.0

Domain

Death 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

968_1156

4714.333333333333

3958.0

Domain

ZU5 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1158_1304

2618.6666666666665

1864.0

Domain

ZU5 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1450_1535

2618.6666666666665

1864.0

Domain

Death 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

3569_3653

2618.6666666666665

1864.0

Domain

Death 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

968_1156

2618.6666666666665

1864.0

Domain

ZU5 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1289_1423

4714.333333333333

3958.0

Region

Note=UPA domain

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1806_1983

4714.333333333333

3958.0

Region

Note=Repeat-rich region

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1289_1423

2618.6666666666665

1864.0

Region

Note=UPA domain

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1806_1983

2618.6666666666665

1864.0

Region

Note=Repeat-rich region

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

129_158

4714.333333333333

3958.0

Repeat

Note=ANK 4

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

162_191

4714.333333333333

3958.0

Repeat

Note=ANK 5

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1806_1817

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1818_1829

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1830_1841

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1842_1853

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1854_1865

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1866_1877

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1878_1889

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1890_1900

4714.333333333333

3958.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1901_1912

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1913_1924

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1925_1935

4714.333333333333

3958.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1936_1947

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

193_220

4714.333333333333

3958.0

Repeat

Note=ANK 6

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1948_1959

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1960_1971

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

1972_1983

4714.333333333333

3958.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

232_261

4714.333333333333

3958.0

Repeat

Note=ANK 7

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

265_294

4714.333333333333

3958.0

Repeat

Note=ANK 8

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

298_327

4714.333333333333

3958.0

Repeat

Note=ANK 9

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

30_62

4714.333333333333

3958.0

Repeat

Note=ANK 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

331_360

4714.333333333333

3958.0

Repeat

Note=ANK 10

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

364_393

4714.333333333333

3958.0

Repeat

Note=ANK 11

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

397_426

4714.333333333333

3958.0

Repeat

Note=ANK 12

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

430_459

4714.333333333333

3958.0

Repeat

Note=ANK 13

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

463_492

4714.333333333333

3958.0

Repeat

Note=ANK 14

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

496_525

4714.333333333333

3958.0

Repeat

Note=ANK 15

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

529_558

4714.333333333333

3958.0

Repeat

Note=ANK 16

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

562_591

4714.333333333333

3958.0

Repeat

Note=ANK 17

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

595_624

4714.333333333333

3958.0

Repeat

Note=ANK 18

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

628_657

4714.333333333333

3958.0

Repeat

Note=ANK 19

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

63_92

4714.333333333333

3958.0

Repeat

Note=ANK 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

661_690

4714.333333333333

3958.0

Repeat

Note=ANK 20

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

694_723

4714.333333333333

3958.0

Repeat

Note=ANK 21

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

727_756

4714.333333333333

3958.0

Repeat

Note=ANK 22

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

760_789

4714.333333333333

3958.0

Repeat

Note=ANK 23

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

793_822

4714.333333333333

3958.0

Repeat

Note=ANK 24

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000357077

96_125

4714.333333333333

3958.0

Repeat

Note=ANK 3

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

129_158

2618.6666666666665

1864.0

Repeat

Note=ANK 4

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

162_191

2618.6666666666665

1864.0

Repeat

Note=ANK 5

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1806_1817

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1818_1829

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1830_1841

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1842_1853

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1854_1865

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1866_1877

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1878_1889

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1890_1900

2618.6666666666665

1864.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1901_1912

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1913_1924

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1925_1935

2618.6666666666665

1864.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1936_1947

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

193_220

2618.6666666666665

1864.0

Repeat

Note=ANK 6

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1948_1959

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1960_1971

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

1972_1983

2618.6666666666665

1864.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

232_261

2618.6666666666665

1864.0

Repeat

Note=ANK 7

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

265_294

2618.6666666666665

1864.0

Repeat

Note=ANK 8

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

298_327

2618.6666666666665

1864.0

Repeat

Note=ANK 9

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

30_62

2618.6666666666665

1864.0

Repeat

Note=ANK 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

331_360

2618.6666666666665

1864.0

Repeat

Note=ANK 10

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

364_393

2618.6666666666665

1864.0

Repeat

Note=ANK 11

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

397_426

2618.6666666666665

1864.0

Repeat

Note=ANK 12

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

430_459

2618.6666666666665

1864.0

Repeat

Note=ANK 13

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

463_492

2618.6666666666665

1864.0

Repeat

Note=ANK 14

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

496_525

2618.6666666666665

1864.0

Repeat

Note=ANK 15

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

529_558

2618.6666666666665

1864.0

Repeat

Note=ANK 16

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

562_591

2618.6666666666665

1864.0

Repeat

Note=ANK 17

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

595_624

2618.6666666666665

1864.0

Repeat

Note=ANK 18

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

628_657

2618.6666666666665

1864.0

Repeat

Note=ANK 19

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

63_92

2618.6666666666665

1864.0

Repeat

Note=ANK 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

661_690

2618.6666666666665

1864.0

Repeat

Note=ANK 20

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

694_723

2618.6666666666665

1864.0

Repeat

Note=ANK 21

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

727_756

2618.6666666666665

1864.0

Repeat

Note=ANK 22

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

760_789

2618.6666666666665

1864.0

Repeat

Note=ANK 23

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

793_822

2618.6666666666665

1864.0

Repeat

Note=ANK 24

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000506722

96_125

2618.6666666666665

1864.0

Repeat

Note=ANK 3

Tgene

ARHGAP31

chr4:114304891

chr3:119013220

ENST00000264245

-1

673_790

33.333333333333336

1445.0

Compositional bias

Note=Pro-rich

Tgene

ARHGAP31

chr4:114304891

chr3:119013220

ENST00000264245

-1

971_974

33.333333333333336

1445.0

Compositional bias

Note=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1158_1304

1873.0

Domain

ZU5 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1450_1535

1873.0

Domain

Death 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

3569_3653

1873.0

Domain

Death 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

968_1156

1873.0

Domain

ZU5 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1158_1304

556.0

Domain

ZU5 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1450_1535

556.0

Domain

Death 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

3569_3653

556.0

Domain

Death 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

968_1156

556.0

Domain

ZU5 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1289_1423

1873.0

Region

Note=UPA domain

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1806_1983

1873.0

Region

Note=Repeat-rich region

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1289_1423

556.0

Region

Note=UPA domain

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1806_1983

556.0

Region

Note=Repeat-rich region

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

129_158

1873.0

Repeat

Note=ANK 4

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

162_191

1873.0

Repeat

Note=ANK 5

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1806_1817

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1818_1829

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1830_1841

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1842_1853

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1854_1865

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1866_1877

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1878_1889

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1890_1900

1873.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1901_1912

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1913_1924

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1925_1935

1873.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1936_1947

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

193_220

1873.0

Repeat

Note=ANK 6

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1948_1959

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1960_1971

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

1972_1983

1873.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

232_261

1873.0

Repeat

Note=ANK 7

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

265_294

1873.0

Repeat

Note=ANK 8

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

298_327

1873.0

Repeat

Note=ANK 9

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

30_62

1873.0

Repeat

Note=ANK 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

331_360

1873.0

Repeat

Note=ANK 10

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

364_393

1873.0

Repeat

Note=ANK 11

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

397_426

1873.0

Repeat

Note=ANK 12

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

430_459

1873.0

Repeat

Note=ANK 13

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

463_492

1873.0

Repeat

Note=ANK 14

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

496_525

1873.0

Repeat

Note=ANK 15

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

529_558

1873.0

Repeat

Note=ANK 16

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

562_591

1873.0

Repeat

Note=ANK 17

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

595_624

1873.0

Repeat

Note=ANK 18

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

628_657

1873.0

Repeat

Note=ANK 19

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

63_92

1873.0

Repeat

Note=ANK 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

661_690

1873.0

Repeat

Note=ANK 20

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

694_723

1873.0

Repeat

Note=ANK 21

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

727_756

1873.0

Repeat

Note=ANK 22

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

760_789

1873.0

Repeat

Note=ANK 23

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

793_822

1873.0

Repeat

Note=ANK 24

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000394537

96_125

1873.0

Repeat

Note=ANK 3

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

129_158

556.0

Repeat

Note=ANK 4

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

162_191

556.0

Repeat

Note=ANK 5

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1806_1817

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1818_1829

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1830_1841

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1842_1853

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1854_1865

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1866_1877

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1878_1889

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1890_1900

556.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1901_1912

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1913_1924

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1925_1935

556.0

Repeat

Note=Repeat A%3B approximate

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1936_1947

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

193_220

556.0

Repeat

Note=ANK 6

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1948_1959

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1960_1971

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

1972_1983

556.0

Repeat

Note=Repeat A

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

232_261

556.0

Repeat

Note=ANK 7

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

265_294

556.0

Repeat

Note=ANK 8

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

298_327

556.0

Repeat

Note=ANK 9

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

30_62

556.0

Repeat

Note=ANK 1

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

331_360

556.0

Repeat

Note=ANK 10

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

364_393

556.0

Repeat

Note=ANK 11

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

397_426

556.0

Repeat

Note=ANK 12

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

430_459

556.0

Repeat

Note=ANK 13

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

463_492

556.0

Repeat

Note=ANK 14

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

496_525

556.0

Repeat

Note=ANK 15

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

529_558

556.0

Repeat

Note=ANK 16

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

562_591

556.0

Repeat

Note=ANK 17

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

595_624

556.0

Repeat

Note=ANK 18

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

628_657

556.0

Repeat

Note=ANK 19

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

63_92

556.0

Repeat

Note=ANK 2

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

661_690

556.0

Repeat

Note=ANK 20

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

694_723

556.0

Repeat

Note=ANK 21

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

727_756

556.0

Repeat

Note=ANK 22

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

760_789

556.0

Repeat

Note=ANK 23

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

793_822

556.0

Repeat

Note=ANK 24

Hgene

ANK2

chr4:114304891

chr3:119013220

ENST00000510275

96_125

556.0

Repeat

Note=ANK 3

Tgene

ARHGAP31

chr4:114304891

chr3:119013220

ENST00000264245

-1

21_216

33.333333333333336

1445.0

Domain

Rho-GAP

Top

Fusion Gene Sequence for ANK2-ARHGAP31

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000506722_ENST00000264245_TCGA-DB-A75P-01A_ANK2_chr4_114304891_-_ARHGAP31_chr3_119013220_length(transcript)=17368nt_BP=8051nt
ACAGTCTGAGGCTGTAATGGGAAAGTCGGTTCCTGGGCTGCTGTCTCATAGACATCAGCTTGCAGGGAAGCTGGGGGCTCTCCGAATTGC
CCTGCTCCGGGGCCCCTCCTGCTGCGTGACTCACAGGCACATTGCAGAGAGAAGCTGCCGCTCCCAGTAAGTAATGAAAAGAGACATGAA
GAATTGGTATTTCAAATGACCACCATGTTGCAAAAGTCTGACAGCAATGCAAGCTTCCTCCGTGCTGCCAGAGCAGGCAACCTGGACAAA
GTTGTGGAATATCTGAAGGGGGGCATAGACATCAATACCTGCAATCAGAATGGACTCAACGCTCTCCATCTGGCTGCCAAGGAAGGCCAC
GTGGGGCTGGTGCAGGAGCTGCTGGGAAGAGGGTCCTCTGTGGATTCTGCCACTAAGAAGGGAAATACCGCTCTTCACATTGCATCTTTG
GCTGGACAAGCAGAAGTTGTCAAAGTTCTTGTTAAGGAAGGAGCCAATATTAATGCACAGTCTCAGAATGGCTTTACTCCTTTATACATG
GCTGCCCAAGAGAATCACATTGATGTTGTAAAATATTTGCTGGAAAATGGAGCTAATCAGAGCACTGCTACAGAGGATGGCTTTACTCCT
CTAGCTGTGGCACTCCAGCAAGGACACAACCAGGCGGTGGCCATCCTCTTGGAGAATGACACCAAAGGGAAAGTGAGGCTGCCAGCTCTG
CATATTGCCGCTAGGAAAGACGACACCAAATCTGCCGCACTTCTGCTTCAGAATGACCACAATGCTGACGTACAATCCAAGATGATGGTG
AATAGGACAACTGAGAGTGGTTTTACCCCTTTGCACATAGCTGCACATTACGGAAATGTCAACGTGGCAACTCTTCTTCTAAACCGGGGA
GCTGCTGTGGACTTCACAGCCAGGAATGGAATCACTCCTCTGCATGTGGCTTCCAAAAGAGGAAATACAAACATGGTGAAGCTCTTACTG
GATCGAGGCGGTCAGATCGATGCCAAAACTAGGGATGGGTTGACACCACTTCACTGTGCTGCACGAAGTGGGCATGACCAAGTGGTGGAA
CTTCTGTTGGAACGGGGTGCCCCCTTGCTGGCAAGGACTAAGAATGGGCTGTCTCCACTACACATGGCTGCCCAGGGAGACCACGTGGAA
TGTGTGAAGCACCTGTTACAGCACAAGGCACCTGTTGATGATGTCACCCTAGACTACCTGACAGCCCTCCACGTTGCTGCGCACTGTGGC
CACTACCGTGTAACCAAACTCCTTTTAGACAAGAGAGCCAATCCGAACGCCAGAGCCCTGAATGGTTTTACTCCACTGCACATTGCCTGC
AAGAAAAACCGCATCAAAGTCATGGAACTGCTGGTGAAATATGGGGCTTCAATCCAAGCTATAACAGAGTCTGGCCTCACACCAATACAT
GTGGCTGCCTTCATGGGCCACTTGAACATTGTCCTCCTTCTGCTGCAGAACGGAGCCTCTCCAGATGTCACTAACATTCGTGGTGAGACG
GCACTACACATGGCAGCCCGAGCCGGGCAGGTGGAAGTGGTCCGATGCCTCCTGAGAAATGGTGCCCTTGTTGATGCCAGAGCCAGGGAG
GAACAGACACCTTTACATATTGCCTCCCGCCTGGGTAAGACAGAAATTGTCCAGCTGCTTCTACAACATATGGCTCATCCAGATGCGGCC
ACTACAAATGGGTACACACCACTGCACATCTCTGCCCGGGAGGGCCAGGTGGATGTGGCATCAGTCCTATTGGAAGCAGGAGCAGCCCAC
TCCTTAGCTACCAAGAAGGGTTTTACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTTCTCTTGCAACGCCGT
GCTGCCGCAGATTCTGCAGGGAAGAACGGCCTTACCCCGCTCCATGTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGCTGTTACTG
GAGAAGGGTGCTTCCCCTCATGCCACTGCCAAGAATGGCTATACTCCGTTACATATTGCTGCCAAGAAGAATCAAATGCAGATAGCTTCC
ACACTCCTGAACTATGGAGCAGAGACAAACATTGTGACAAAGCAAGGAGTAACTCCACTCCATCTGGCCTCGCAGGAGGGGCACACAGAT
ATGGTTACCTTGCTTCTGGATAAGGGAGCCAATATCCACATGTCAACTAAGAGTGGACTCACATCCTTACACCTTGCAGCCCAGGAAGAT
AAAGTGAATGTTGCTGATATTCTCACCAAGCATGGAGCTGATCAGGATGCTCATACAAAGCTTGGTTACACACCTTTAATTGTGGCCTGT
CACTATGGAAATGTGAAAATGGTCAACTTTCTTCTGAAGCAGGGAGCAAATGTTAACGCAAAAACCAAGAACGGCTACACGCCTTTGCAC
CAGGCCGCTCAGCAGGGTCACACGCACATCATCAACGTCCTGCTCCAGCATGGGGCCAAGCCCAACGCCACCACTGCGAATGGCAACACT
GCCTTGGCGATTGCTAAGCGTCTGGGCTACATCTCCGTGGTCGACACCCTGAAGGTTGTGACTGAGGAGGTCACCACCACCACCACAACT
ATTACAGAAAAACACAAACTAAATGTACCTGAGACGATGACTGAGGTTCTTGATGTTTCTGATGAAGAGGGTGATGACACAATGACTGGT
GATGGGGGAGAATACCTTAGGCCTGAGGACCTAAAAGAACTGGGTGATGACTCACTACCCAGCAGTCAGTTCCTGGATGGTATGAATTAC
CTGCGATACAGCTTGGAGGGAGGACGATCTGACAGCCTTCGATCCTTCAGTTCCGACAGGTCTCACACTCTGAGCCATGCCTCCTACCTG
AGGGACAGTGCCGTGATGGATGACTCAGTTGTGATTCCCAGTCACCAGGTGTCAACTCTAGCCAAGGAGGCAGAAAGGAATTCTTATCGC
CTAAGCTGGGGCACTGAGAACTTAGACAACGTGGCTCTTTCTTCTAGTCCTATTCATTCAGGCCGCGCCTCTCCATGTCTTGAACGTGAC
AACAGCAGTTTCCTGGTTAGTTTTATGGTGGATGCCCGAGGTGGTGCTATGCGAGGATGCAGACACAATGGGCTCCGAATCATTATTCCA
CCTCGGAAATGTACTGCTCCAACGCGAGTCACCTGCCGACTGGTCAAGCGCCACAGACTGGCAACAATGCCTCCAATGGTGGAAGGAGAA
GGCCTGGCCAGTCGCCTGATCGAAGTTGGACCTTCTGGTGCTCAGTTCCTTGGTAAACTTCACCTGCCAACGGCTCCTCCCCCACTTAAT
GAGGGAGAAAGTTTGGTCAGCCGCATTCTTCAGCTGGGGCCTCCTGGAACCAAATTCCTTGGGCCTGTGATCGTGGAGATCCCTCACTTT
GCGGCCCTTCGAGGAAAGGAAAGGGAACTGGTGGTCCTGCGCAGTGAGAATGGGGACAGCTGGAAAGAGCATTTCTGTGACTACACTGAA
GATGAATTGAATGAAATTCTTAACGGCATGGATGAAGTACTGGATAGCCCAGAAGACCTAGAAAAGAAACGAATCTGCCGCATCATCACC
CGAGACTTCCCACAGTACTTTGCAGTGGTGTCTCGTATCAAACAGGACAGCAATCTGATTGGCCCAGAAGGAGGTGTACTGAGCAGCACA
GTGGTGCCCCAGGTGCAGGCCGTCTTCCCAGAGGGGGCACTCACCAAGCGGATCCGCGTAGGCCTGCAGGCTCAACCTATGCACAGTGAG
CTGGTTAAGAAGATCCTAGGCAACAAAGCTACCTTCAGCCCTATAGTCACTTTGGAACCTAGAAGAAGAAAATTCCACAAACCAATTACC
ATGACCATTCCTGTCCCCAAAGCTTCAAGTGATGTCATGTTGAATGGTTTTGGGGGAGATGCACCAACCTTAAGATTACTATGCAGCATA
ACAGGTGGAACCACCCCTGCCCAGTGGGAAGATATTACAGGAACTACGCCATTAACATTTGTCAATGAATGTGTTTCCTTTACAACAAAC
GTGTCTGCCAGGTTCTGGCTGATAGATTGTCGACAGATCCAGGAATCCGTTACTTTTGCATCACAAGTATACAGAGAAATTATCTGCGTA
CCTTATATGGCCAAATTTGTAGTGTTTGCCAAATCACATGACCCCATTGAAGCCAGGTTGAGGTGTTTCTGCATGACTGATGATAAAGTG
GATAAGACCCTTGAACAACAAGAAAATTTTGCTGAGGTGGCCAGAAGCAGGGATGTGGAGGTGTTAGAAGGAAAACCCATCTACGTTGAT
TGTTTCGGCAACTTGGTACCATTAACTAAAAGTGGCCAGCATCATATATTCAGTTTTTTTGCCTTCAAAGAAAATAGACTTCCTCTATTT
GTCAAGGTACGCGATACGACTCAGGAACCTTGCGGACGACTATCATTTATGAAGGAGCCAAAATCCACGAGAGGCCTGGTGCATCAAGCT
ATTTGCAACTTAAACATCACTTTGCCGATTTATACAAAGGAATCAGAGTCAGATCAAGAACAGGAGGAAGAGATCGATATGACATCAGAA
AAAAATCCACAGGATGAGCAGGAACGGATCGAGGAAAGGCTGGCTTATATTGCTGATCACCTTGGCTTCAGCTGGACAGAATTAGCAAGA
GAACTGGATTTCACTGAGGAGCAAATTCATCAAATTCGAATTGAAAATCCCAACTCTCTTCAAGACCAGAGTCATGCACTGTTGAAGTAC
TGGCTAGAGAGGGATGGGAAACATGCTACAGATACCAACCTCGTTGAATGTCTCACCAAGATCAACCGAATGGATATTGTTCATCTCATG
GAGACCAACACAGAACCTCTCCAGGAGCGCATCAGTCATAGTTATGCAGAAATTGAACAGACCATTACACTGGATCATAGTGAAGGGTTC
TCGGTACTTCAAGAGGAGTTATGCACTGCACAGCACAAGCAGAAAGAGGAGCAAGCTGTTTCTAAAGAAAGTGAGACCTGCGATCACCCT
CCTATCGTCTCAGAGGAAGACATTTCTGTTGGTTATTCCACTTTTCAGGATGGCGTCCCCAAAACTGAGGGGGACAGCTCAGCAACAGCA
CTCTTTCCCCAAACTCACAAGGAGCAAGTTCAACAGGATTTCTCAGGGAAAATGCAAGACCTGCCTGAAGAGTCATCTCTGGAATATCAG
CAGGAATATTTTGTGACAACTCCAGGAACAGAAACATCAGAGACTCAGAAGGCTATGATAGTACCCAGCTCTCCCAGCAAGACACCTGAG
GAAGTTAGCACCCCTGCAGAGGAGGAGAAGCTGTACCTCCAGACCCCAACATCCAGCGAGCGGGGAGGCTCTCCCATCATACAAGAACCC
GAAGAGCCCTCAGAGCACAGAGAGGAGAGCTCTCCGCGGAAAACCAGCCTCGTAATAGTGGAGTCTGCCGATAACCAGCCTGAGACCTGT
GAAAGACTCGATGAAGATGCAGCTTTTGAAAAGGGAGACGATATGCCTGAAATACCCCCAGAAACAGTCACAGAAGAAGAATACATTGAT
GAGCATGGACACACCGTGGTAAAGAAGGTTACTAGGAAAATCATTAGGCGGTATGTATCCTCTGAAGGCACAGAGAAAGAAGAGATTATG
GTGCAGGGAATGCCACAGGAACCTGTCAACATCGAGGAAGGGGATGGCTATTCCAAAGTTATAAAGCGTGTTGTATTGAAGAGTGACACC
GAGCAGTCAGAGGACAACAATGAGTAAAGCCATCACACAGAAGAGGGCTGTGGTGAAGGACCAGCATGGAAAACGCATTGACTTGGAGCA
CCTGGAGGATGTACCAGAAGCACTAGACCAGGACGACCTCCAGCGCGATCTCCAGCAGCTCCTTCGGCATTTCTGCAAGGAGGACTTGAA
GCAAGAGGCCAAGTGAGGGGCTGCCCAGTTCTCACACCAGAAACCACACATTCACTCAATATGCAGCTTCCTGTTTCAGTAGGGGAGTGA
CCTAACTGGCCTAATTAATGGGATACCCCGACATTTCCACTGTTAGCAAATATACGGCATTTTGCTTTAGTTTTCCCCCATCCTCTTTAA
CTATAAAGCTAATTTGTGACCAAAGATGGCATCCTTCATACTGGATGCTGTATCCAATACTTTGTTGTGTCTGTGCTAACCTGGGAACTG
GCCACCTCCATTGTTCTTTGCTTCTGCACAAGATCCATGAAAATCCATTGATCAGAAGAACTTCACCTGCAGACCTCTTCAAGTGACACT
ATGTAGGAATCCTTCCAAGGAATATCTATGTACAATGTATATAGCTGAAATGCTCAGATGAACAACATATTAAAATTAAAACCACTGCCT
ATTGTAACTACACTGGGCATCAGAATAAAAGGCCTCTAGAAATTGCTGAACAATGGTTAATTAAGATATTGCTAACACAATCGAGTGATA
ATACAGTTTTACTGCAAAAGAAGCACTTCAAACCTATTATGTCCTTAGAACTTCCAGAGTAGCCACTGCTCCCAGTTAAAGGTGGGTCAG
TAGCCTTGCAGAACTGTCCTGAGAAGTTATTGCTGGTGCTGGCCAGCCATGGCTTAGGACTCCAACAGCCACTCTGAGGGAGGGGAGAAG
GGAGCAGAGGCCACGCAGAATGAACCGATGGGGTATTCAGTTGCTGGCAGCTACATTGTGTGGCATTCTAGCATCTTCAGGTCTTTAGAT
CTTGGACAAGTTGGCAGGGTATTTTAAAAGCTATAACTACTGTAGTTTTCCAGTTTTCATTGCTGCTTTAGCAAACCACGCTGTCTTACA
GTGGTACTTTCTTCTGGCCACTGCACTGTAGATAATTCATTGGAAACAAGATTTACCCACTACATAAAAGGTTAAACTCCTTCAGTATGT
TGGAGTGGTTTCTTTTTTTTTTTCTTTCTTTCTTTTTTTTCTTCAGGTTTATATCTTCTCTAATACCTGCATGTGGCGTTTAAAAATCAA
GACCACGGTCAAACCCCTCTTCTAATCACATTAATTGTTTCCATTCTTTTTACCCTGAGTGAGCACTTTTCACTTTCCAGCTAGGTCTGT
TTTTCAGCTTGCAGACAAGATTGAGAAATCCTTGAAAATTTGGTTTTGGTTAAAATTTTTGGTTTATTTATTTGAAATCCACACTCCCTT
GGAAACTCTTAAGTGCATTTGTGCACTTCTGTTTGTTTGTCTCAAAGAAGGGACTGTAACAATCTGAGTAATTTCCATGTCCTCTTCCTT
ATTCCTCTAGTGGTTGAAGCTGTGTAGCATTTTAACATATATATATTCACAAATATATTCATATAAACAGTATACATTTTGAATCAGTCA
TTTGTTAAAGAAAAGTATATTCAATGAAGATGAAATTTAAATAAAAAAGGACAGAGTCTATCCTCCAGGGATTGAACATTTTCCAATTAT
CTGGTCTTTTCCTGTTGTGCAAAAATGACTCATTGCTCCGAATGTCAAAAACAAATGCGACAAACAATGGCACTTCATCATTTAAAGTAA
TGTTGCCAAGAGAAAAAATTTCCTGGGAGGGAGGTTTCCCACAAGCCAAATCTCCTAAGCCTCAAATGCTAGCACTTTTTGGCAGTTGGA
TAGGAAATGAGACATTCTTTGGCAGCCAAAATAAGAGAGGCCGATGGTGAAACTTTTTGAGACACCCTATGGCCTTCTTGTCAAAACCTT
CACTGGAGCTCAAGAAAAGCATTTCTGTTGTGTTATTTGCAGTGCAGATGATGTCTGTGTAACAACATAATGGTTATTCACCTTTTTTTG
ATTTTGATTTTTGCTGTGTTATCAAAAACTTGAATACTGTGAGAAGAAGTGAATTTTCAGTTGACGAATCAGCATCTTGTTCCCATGGTG
ATAACACTAATTGAATATATCTATGAGGGCATGTATTAGTTAATGGAAAAAAAAATACAACACTAACAATACATAGCTGCAATGTGTACA
ATGGCTGATTTAATTAAATAAAATGTACAAGTGTTAAATGTGGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTT
TTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCCCAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCG
TCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAGCTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGA
GCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACACTCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGG
CGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGGCCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCC
ATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTGATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCA
GAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAACAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTT
GGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGATGTTCCATACGTTTTGAAGAGCTGTGCAGAATTTATAGAGACTCACGGC
ATCGTGGATGGAATCTATCGGCTTTCAGGAGTCACCTCAAACATACAACGGCTAAGGCAAGAGTTTGGCTCAGATCAATGTCCAGATCTG
ACAAGGGAAGTGTACCTCCAGGACATCCACTGTGTGGGCTCGCTTTGCAAGCTCTACTTTAGGGAGCTGCCCAACCCCCTCCTGACTTAT
GAGCTCTATGAGAAATTCACGGAGGCAGTGTCGCATTGCCCTGAAGAAGGCCAACTGGCCCGAATCCAAAATGTTATCCAGGAGCTTCCT
CCATCCCACTATAGGACCTTGGAATACCTGATTCGACACCTGGCCCATATCGCCTCCTTCAGCAGCAAGACCAACATGCACGCCCGGAAC
CTGGCCCTGGTGTGGGCGCCAAACCTCCTCAGGTCTAAAGAAATTGAAGCCACTGGTTGCAATGGAGATGCAGCCTTCCTTGCAGTCCGG
GTCCAGCAGGTGGTGATTGAGTTCATATTGAATCATGTAGATCAAATCTTTAACAACGGTGCACCTGGGTCTCTGGAGAATGATGAAAAC
CGGCCCATCATGAAGAGCCTGACCTTGCCAGCCCTCTCCCTGCCCATGAAGCTGGTGAGCCTTGAGGAAGCTCAAGCCCGCAGCCTGGCC
ACTAACCATCCTGCTCGCAAGGAAAGGAGGGAGAACAGCCTGCCTGAGATTGTCCCTCCCATGGGCACCCTCTTCCACACTGTCCTTGAG
TTACCAGACAACAAGCGAAAGCTCTCCAGTAAATCAAAGAAGTGGAAATCAATATTTAACCTGGGACGTTCTGGATCAGACTCCAAATCA
AAACTGAGTAGAAATGGGAGTGTATTTGTGAGAGGACAGAGGCTCTCGGTGGAAAAGGCTACTATCCGACCAGCTAAAAGCATGGACTCA
CTATGTTCAGTGCCTGTAGAAGGAAAAGAAACCAAGGGAAATTTCAATCGAACAGTTACCACCGGTGGATTTTTCATTCCAGCAACAAAG
ATGCACTCCACCGGCACCGGCAGCTCATGTGACCTCACCAAGCAGGAGGGCGAATGGGGCCAGGAGGGGATGCCTCCCGGGGCTGAGGGT
GGCTTTGATGTGAGCAGTGATCGCAGCCATCTCCAGGGCGCTCAGGCCCGGCCCCCACCGGAACAGCTGAAGGTTTTCCGGCCTGTTGAG
GATCCGGAGAGCGAGCAAACAGCCCCAAAGATGTTGGGTATGTTCTACACTTCGAACGACAGCCCTAGCAAATCCGTCTTCACCAGCAGC
CTCTTCCAGATGGAGCCCTCGCCGCGTAACCAGCGCAAGGCGCTGAACATCTCCGAGCCCTTTGCGGTATCTGTGCCGCTCCGCGTGTCC
GCAGTCATCAGCACCAACAGCACGCCGTGCAGAACACCCCCGAAGGAGCTGCAGTCTCTTTCCAGCCTGGAAGAGTTTTCTTTTCATGGA
TCAGAGAGCGGAGGCTGGCCAGAAGAAGAGAAACCGCTGGGAGCTGAGACTTCTGCAGCTTCTGTACCTAAGAAGGCAGGTCTTGAGGAT
GCCAAGGCAGTACCTGAAGCACCGGGGACAGTGGAATGCAGCAAAGGCCTGTCCCAGGAGCCAGGCGCCCACCTGGAGGAGAAGAAAACC
CCAGAAAGCTCCTTGAGCTCTCAACATTTAAATGAATTAGAGAAGAGGCCAAATCCGGAGAAGGTGGTGGAGGAGGGACGAGAGGCTGGT
GAGATGGAGTCCAGCACCCTGCAGGAGAGCCCCAGGGCCAGAGCCGAAGCTGTGCTTCTCCATGAGATGGATGAAGATGATCTGGCCAAT
GCCCTGATCTGGCCTGAGATTCAACAGGAGCTGAAAATCATTGAATCTGAGGAGGAGCTCTCATCGTTGCCACCTCCTGCTCTGAAGACC
AGCCCAATTCAGCCTATTCTCGAGTCGAGTCTGGGGCCCTTTATTCCCTCAGAGCCTCCTGGGAGCTTGCCTTGTGGCTCCTTCCCTGCT
CCAGTCTCCACCCCTCTGGAGGTGTGGACTAGGGATCCAGCCAATCAGAGCACACAGGGGGCTTCCACAGCAGCCAGCAGAGAGAAGCCG
GAACCTGAGCAGGGCCTGCACCCAGACCTCGCCAGCCTGGCTCCTCTGGAAATAGTTCCTTTTGAGAAGGCATCTCCACAAGCAACAGTG
GAAGTAGGAGGCCCAGGCAATCTGTCTCCTCCACTCCCACCTGCTCCTCCCCCTCCAACTCCTCTGGAGGAGTCAACTCCAGTCCTGCTT
TCAAAGGGCGGCCCGGAAAGAGAAGACTCATCCAGGAAATTGAGGACAGATCTCTACATAGACCAGCTGAAGTCCCAAGACAGCCCTGAG
ATCTCTAGCCTCTGTCAGGGAGAGGAGGCAACCCCAAGACACAGTGACAAGCAAAATTCAAAGAATGCTGCTTCTGAGGGGAAAGGCTGT
GGTTTTCCAAGCCCAACCAGGGAGGTTGAGATCGTCTCACAAGAAGAGGAGGATGTAACCCATTCAGTACAGGAGCCTTCAGACTGTGAC
GAAGATGACACTGTGACAGACATTGCCCAGCATGGCCTGGAGATGGTGGAGCCCTGGGAGGAACCCCAGTGGGTGACGAGTCCCCTTCAC
TCTCCCACCCTGAAAGACGCGCACAAGGCCCAGGTACAGGGCCTTCAGGGTCACCAGTTGGAGAAGAGGCTTTCCCACAGGCCCAGCCTT
CGCCAGAGCCATTCTCTAGATAGCAAACCCACGGTTAAAAGCCAGTGGACTCTCGAGGTTCCCTCCTCCAGCAGCTGTGCTAATCTTGAA
ACAGAGAGGAATTCTGACCCTCTTCAGCCCCAGGCACCCAGGAGAGAGATTACTGGATGGGATGAGAAAGCCCTGAGGTCCTTCAGAGAG
TTCTCTGGCCTGAAAGGGGCAGAGGCTCCTCCCAACCAGAAGGGACCAAGTGGTGTGCAACCCAACCCAGCAGAAACCAGCCCCATCAGC
CTAGCAGAGGGAAAGGAGCTAGGGACACACCTGGGGCACAGCAGTCCACAGATTAGGCAAGGTGGTGTTCCTGGGCCAGAGAGCAGCAAG
GAGAGTTCACCCAGCGTGCAGGACAGCACTTCGCCTGGAGAGCACCCCGCAAAGTTACAGCTAAAGAGCACAGAGTGTGGGCCCCCAAAA
GGGAAAAACAGGCCTTCTTCCCTCAACTTGGACCCTGCCATTCCCATTGCTGACCTCTTCTGGTTTGAGAATGTGGCCTCATTTAGTTCA
CCTGGAATGCAGGTCTCTGAGCCAGGAGACCCAAAGGTCACATGGATGACCTCATCTTACTGTAAAGCAGACCCCTGGAGGGTTTACTCC
CAGGACCCCCAGGACCTGGACATTGTTGCTCATGCACTGACAGGCCGCCGTAACTCAGCTCCTGTGAGTGTGTCAGCTGTGAGAACCTCC
TTCATGGTCAAAATGTGCCAGGCCAGGGCGGTCCCAGTCATCCCTCCCAAGATTCAGTACACCCAGATCCCACAGCCCCTGCCCTCTCAG
AGCTCAGGGGAGAATGGGGTTCAGCCTCTGGAGAGGAGCCAGGAGGGACCCAGCTCAACCAGTGGGACCACTCAGAAACCTGCCAAAGAT
GATTCTCCCTCCTCCCTGGAAAGCTCAAAGGAAGAAAAACCAAAGCAAGATCCCGGAGCCATTAAGTCCTCACCAGTGGATGCCACTGCA
CCCTGCATGTGCGAGGGACCTACCCTTTCTCCAGAACCAGGCTCGTCTAACCTGCTCTCCACCCAGGATGCAGTAGTGCAATGCAGAAAG
CGCATGTCAGAGACAGAGCCATCTGGGGACAACCTTCTTTCTTCAAAACTAGAGCGACCATCTGGGGGTTCTAAGCCTTTCCACAGGTCA
AGGCCAGGAAGACCTCAGAGCCTAATCTTATTCAGTCCTCCTTTCCCCATTATGGACCACCTGCCCCCTTCATCCACAGTGACAGATTCC
AAGGTCCTGCTGTCCCCTATCAGAAGTCCCACCCAGACAGTTTCCCCTGGCCTTCTTTGTGGAGAGTTGGCAGAAAACACATGGGTCACA
CCAGAAGGGGTTACACTTAGGAATAAAATGACCATCCCTAAGAATGGCCAGAGACTAGAGACCTCAACCAGCTGTTTTTACCAGCCTCAG
CGGAGATCAGTAATTCTGGATGGAAGAAGTGGGAGGCAAATAGAATGATTTCGGTTCACCTGCTGGTGTCTGAAAAAAACCGTGATTCAT
CTGGAAGTTATTACAGGGCCAGCTTGCCATATTCCAGGCACACGTTATCAAGTTTGGGCCTATTGTGGCCTCTGACTTCTCTTTCTTCAG
CCTTTTGACCACTTATTAATTAGTCCATTTGCTAGAAGAGTGGTCAAGGGAAAAACGAGAGATGAAATTTAGTTAAGTCTATGTGAGCAA
GTGAGAGAAGGTTAGGTAAGGGGAGAGGATGGAATGCTTGCCTCCAATGAACTTTGGAGCTTGTATGTGAGTCAGATTGCTCCCCTATTG
CTATTATCTATTACTCTTGAGAGCTGGCTGTCCTTTGAAAGAAAGAAGTAATGTTCTTTGAAAGAAAGAAAAATCTCTTGCTGTGTCAAA
CCTCAAAATGTTGCTATTGGGGTTAGAAGGCCTCCTCTTTATGCTTTTTAATGCTCTTTCAAACGTGTTCTTTTAGACCAGTTTTCTAAT
AAGCTTTGTAAAATGTACTATCCAAATTAGAAGCGGATTTGGAAATGCAAACTAACGTGCACTTAGATATCCAAGTGGGTGAGCTTAGCC
ACTCTTACCCATGCTCTTTCCCTGGAATCCCTGGAGACCTGTCCAAGATGATTTCCATATACCAGCATAGAAAATCAGAATCAAGAGCAA
ACTCTGAGACTGGCACAATCCAAGAAGATTTCCTGGCTCTGGCTTTTAGTAATTTGGGACTCCAACTGCCACTGTACTGGACTGTAATTT
ATAAATCCAGTAGCTACGCAGGGTGGAGGCTGGGCTGAGGATTACCATAATGAAATGTACTAAATCTTCATTTAGGTATGCAATTGTGAA
GTGAAGGCATCTGCTTTCTTTACAGTATCAGAGTCCAAGAACAGGATGTCACCATAGATAAAAGCCTCATACAAAGGCAGAACTACACTC
CAAATTTAATGTGTTTAAATTGGTGGGGCACCAGCAGAAAATATTCTAGCTCAGCTTTACTCTTCTTCCACACTAGGCTGGGCCCAGCAA
TACAGGAGAGGATGAAGGGAGGAGCTCCAGGAGGCGAGGGAAGAGCCCTAGCAGGGCGGCCATCACAACCACTCACTGAGAGTTGCCCTT
CTTAAAAATGTATTTTATTTTAGCCAGTGGGTCCCTTCCTTTCTCCTTTCCTCTCTACTGCTCAAGAACAGATTTGAGGCCAGGTGCGGT
GCCTCACATCTGTAATCCCAACACTTTGGGAGGCTGAGATGGGTGGATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGC
GAGACCCCATCTCTTAAAAAATAACAGACTTGAGGAACCCCTCTCCCTTCCATAATTCCCCTCATCCACCGCCCACTCCAGGCACTCACT
CAAACTTGCTCTTCAACTCTGTATACAAGCAGAAGCAATAAACCAATCTGATTTTCTTTTCAATTATTTATAACTTTCAATGGTTCTTTC
CTTTCCAGCTGGCGAGAGAAAGGAGAACTAATATACCTGCTGGCAGATTTTTGGTGCTGCCCAAAAAAGGACTTCACAGGGCATCTCTTC
TCAGGTTCAAGCCTGGCTGAATTCTGCCCAGAAGCTCAGTCATTGCAGAAATTTCTCTAAGGGCTGATAGTACCTCTGGGTAGGCGTCAC
AACCAAGGCTGGTTCTGGGCTTAGTGGGGGCTGAGATGAAGTTACCTCCTCCAATGAGAAATTGGGAGCTGATGCCCTGCAACAGATATA
TATTCCTCTCTCTCTCTGTCTCTCTATCTCTCTCCTCCCTCTCCCTCCCTCCCTCCCCGCCAATAAGCCTTACAAACAGTTTTGAAATCT
TGTTCTGTACCTTTTAAGCCAGTGTCTGTGGCGAGGGTGACTGGCAAGTCAGCTGATGAGTTCTGCCTTCTGAGAGCACTGAGTGAGCAA
GGCCTTTCATCAGTGTTTTGGCCTTCTCATTGGGTGAGGAAGACATTGAACCAACAGCCAACGAGATATGAACCTGTAAGAAAAAAGTCC
TAGAATATAGTATTTTTCCCCAGGCCAGCAAAGTGAAGAAATACAGTGGTGACAGATGAGAAAGGCCATGTTCAAGAGATCTGAAAAGTA
CATTCCTGCCTTATCAGAAAATGTGTCAGACAGGTTTTATGTCAGCCTCAGTGCTCCTGCGGTGTCGACGCTCTGATAAGGACCATGTTC
CAGTTAGAATGCGAGGGAGGGAAAGAGCTGCACTTTGCTTCACCATCAGAACTCTGAGCCAAATAATGAATATGTAAACTATTTTATGAT
TATTTTAAATGTTTGTTTGGTAACATTTATAAGATCTATTTTTATTTGGGGATAGACTGAGAAGCCACCATTTACATATTAACAAGTGAC
TTCAGTTCTAAGGGTTGAGATGCCTGTGTGGATTTATAAAATGGTTGCAAGATCTTTTAGACTCTGACATTTATAGCATCACCTTCAGGA
ACACAGTTCTGGGGATGTCATCATGAGACACACTGACAGCTGTGGAGATAGTCCCTACTCTCAGCTTTCCTTGCTAGTCAAGTCCAAAAG
GCCTTAGAAGCTGACTCACCTTCTCAGCCAGAGTCCTGCTGCTCAAGTGTGGACCTCCACTTTGACTCTCACCCAGCCTGCCAGCCATCA
CAAAGGCTTTCATAAACTTCCTGTGGTCTGGGCTAGCCTGGCACTGATGAAATTCCATTCTAAAGAAAGAAAACTCATATTCCTCCCCCC
CACAAATTGTTCCCCCAAATGCTCTGGGATTACCTATTTCACCACTCATTTGAGTCTCCGAAAAATGAACTCCCTGAGAATGGCTGGATG
GGAATCAGATAGTCTGCTTCCATTCAGGAGAGGGACAGAACAGGAGCTGCTGTGTTTAGGAGGATTTACCTGGTGCCCTAGAAAGGGCTA
TGCAATCAAATTCTCAAGGGCTCCTTCAAATCAGCTATCAGTCCTCAAAATGGGGGTTGCTGATGTTAAATGATGGATTTGCAGTGAAAC
GCATGCATGTACTGACGTTTTCTTTCAGCATTAGTGGTTGCTTAAGAAAATAGTAACCTATATTTTCTGCTACACTTGGAATATGAAGAA
ATCTGAACAAGAACCCCATTAAGACACCTAACCTAATCTAAACCCTAAAATTCAAAATATTGTCCAAGTCAAAAGTCTAGACTCTGAGGA
CATTAAAAATGTAAATATCATCATCCTTAGCAAATATTTATTGGGAGCTTAGTAATAGTGCACTGGGTACCTTAGCACTCCCAAATCATT
CAAGAGTCTAGTGAAAAAGGGGGAGGGATGGCAGCAAATAAAACACCCCCATAAACAACCAGGAGCAAGGTTGAGAACCATTAAGTTGCC
AAACAAAAGCAGAAGGGGAAAAAGTGTGGCAACAAGCATCTTTTAATAGGATAGTTGACGGTATTCAAGTGACCTACTGACTCCAAATAA
TCAAATTGAACACAATTGCAAATCCAATAGAACATCCCAGTGAGACACTCGGGTATTTGAGAACTTTGCTTGATTTAGAAAACTGGAAAG
TGGCAACTAGGCTAGAATAGTGGCAACTAGGTTCGGAGGTTTCGTGTGGTCATAATTGGTTTGGTGAAGTGTGAGATCTCTGCAAATGAG
CCAGGTAAGATCAGTATTCCATAGTGCTTGAAAAGGGGATTTTAGAGACTTCTGTCATCACAAAGCAGATTAACTCCTAGTTAATGATGA
AGCAGTAGGCCCAAGATAAACTGTTCAATTCAAGATAAATTGTTCTTGTCAGTGTTTGGCATATGATAATCACATTTGGCTAAAATTGGA
TGGGACAGTCATTTGTCTACACAGGCCTTCCATTCCTGCATGAAGAGATACTGGGGAGCATACAATTATTTTGTCCAGTATTAGAGTGGG
AGAAGTTCTCAGTAAGTCCAGTCCCACCAGGATTTATTTGGGCCACATTCTACCACGGCCAGTCCAATCTGATGACCACATGAATTGGGG
TTAAGTGTTGCTAAGACTATGATTTTAGACATGTCTGGCAGGAAGGTCAGCTCAAAATGTGGCATGACAAAGAATATGTGCTCTACTACC
AAAACCTTTCCTAGCAAAACAAGGCCAGAAGAGGGAGCAAGCATCTTTCCAAGCATGGAGAGGAGGGGGCAATGGTGGAAGGGTGATTGC
CTGAAATCAGTGCCAGTACAGATAGCATAAAATTGGGGGCCACCACAGATTGGCTGGCTACTGTGTAGATCATTTAGTAATCTTGAGGTA
CATTAATAATGCAGAGATTACTTTTCTGTGAGGGTAAGGGGGACGTAGCTAAATATAAGAAGCTTACAAGGTCCATAGCCATGTATTTTA

>In-frame_ENST00000506722_ENST00000264245_TCGA-DB-A75P-01A_ANK2_chr4_114304891_-_ARHGAP31_chr3_119013220_length(amino acids)=1892AA_start in transcript=108_stop in transcript=5786
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE
LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQ
QGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT
ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL
QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG
HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT
PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP
HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD
ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK
RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLE
GGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLV
SFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLV
SRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQY
FAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVP
KASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKF
VVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDT
TQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTE
EQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE
LCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVT
TPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDED
AAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ANK2-ARHGAP31

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	ANK2	chr4:114304891	chr3:119013220	ENST00000357077	-	46	46	966_1125	4714.333333333333	3958.0	SPTBN1
Hgene	ANK2	chr4:114304891	chr3:119013220	ENST00000506722	-	47	47	966_1125	2618.6666666666665	1864.0	SPTBN1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ANK2	chr4:114304891	chr3:119013220	ENST00000394537	-	1	45	966_1125	0	1873.0	SPTBN1
Hgene	ANK2	chr4:114304891	chr3:119013220	ENST00000510275	-	1	14	966_1125	0	556.0	SPTBN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ANK2-ARHGAP31

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ANK2-ARHGAP31

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ANK2	C1970119	CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	ANK2	C1142166	Brugada Syndrome (disorder)	4	CLINGEN
Hgene	ANK2	C0035828	Romano-Ward Syndrome	3	ORPHANET
Hgene	ANK2	C0038454	Cerebrovascular accident	1	CTD_human
Hgene	ANK2	C0751956	Acute Cerebrovascular Accidents	1	CTD_human
Hgene	ANK2	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	ARHGAP31	C4551482	Adams-Oliver syndrome 1	4	CTD_human;GENOMICS_ENGLAND
Tgene	ARHGAP31	C0265268	Adams Oliver syndrome	1	ORPHANET