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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKFY1-UBE2G1 (FusionGDB2 ID:4540)

Fusion Gene Summary for ANKFY1-UBE2G1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKFY1-UBE2G1
Fusion gene ID: 4540
HgeneTgene
Gene symbol

ANKFY1

UBE2G1

Gene ID

51479

7326

Gene nameankyrin repeat and FYVE domain containing 1ubiquitin conjugating enzyme E2 G1
SynonymsANKHZN|BTBD23|ZFYVE14E217K|UBC7|UBE2G
Cytomap

17p13.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionrabankyrin-5Rabankyrin-5ankyrin repeat and FYVE domain-containing protein 1ankyrin repeat hooked to zinc finger motifankyrin repeats hooked to a zinc finger motifrank-5ubiquitin-conjugating enzyme E2 G1E2 ubiquitin-conjugating enzyme G1ubiquitin carrier protein G1ubiquitin conjugating enzyme E2G 1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)ub
Modification date2020031320200313
UniProtAcc

Q9P2R3

.
Ensembl transtripts involved in fusion geneENST00000341657, ENST00000570535, 
ENST00000574367, ENST00000573722, 
ENST00000433651, 		ENST00000396981, 
ENST00000572484, 
Fusion gene scores* DoF score8 X 9 X 7=50414 X 8 X 8=896
# samples 1215
** MAII scorelog2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/896*10)=-2.57853623156172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKFY1 [Title/Abstract] AND UBE2G1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKFY1(4167226)-UBE2G1(4210418), # samples:1
ANKFY1(4167227)-UBE2G1(4210418), # samples:1
UBE2G1(4192524)-ANKFY1(4077351), # samples:1
UBE2G1(4269565)-ANKFY1(4145743), # samples:1
UBE2G1(4192525)-ANKFY1(4077351), # samples:1
UBE2G1(4269566)-ANKFY1(4145743), # samples:1
UBE2G1(4269566)-ANKFY1(4100872), # samples:1
UBE2G1(4269566)-ANKFY1(4067467), # samples:1
Anticipated loss of major functional domain due to fusion event.UBE2G1-ANKFY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UBE2G1-ANKFY1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKFY1

GO:0034058

endosomal vesicle fusion

15328530

HgeneANKFY1

GO:0048549

positive regulation of pinocytosis

15328530

TgeneUBE2G1

GO:0070534

protein K63-linked ubiquitination

20061386

TgeneUBE2G1

GO:0070936

protein K48-linked ubiquitination

14593114|20061386


check buttonFusion gene breakpoints across ANKFY1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBE2G1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AU-3779ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
ChimerDB4COADTCGA-AU-3779-01AANKFY1chr17

4167227

-UBE2G1chr17

4210418

-


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Fusion Gene ORF analysis for ANKFY1-UBE2G1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341657ENST00000396981ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
5CDS-5UTRENST00000341657ENST00000572484ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
intron-3CDSENST00000570535ENST00000396981ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
intron-5UTRENST00000570535ENST00000572484ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
In-frameENST00000574367ENST00000396981ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
5CDS-5UTRENST00000574367ENST00000572484ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
intron-3CDSENST00000573722ENST00000396981ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
intron-5UTRENST00000573722ENST00000572484ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
In-frameENST00000433651ENST00000396981ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
5CDS-5UTRENST00000433651ENST00000572484ANKFY1chr17

4167226

-UBE2G1chr17

4210418

-
In-frameENST00000341657ENST00000396981ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
5CDS-5UTRENST00000341657ENST00000572484ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
intron-3CDSENST00000570535ENST00000396981ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
intron-5UTRENST00000570535ENST00000572484ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
In-frameENST00000574367ENST00000396981ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
5CDS-5UTRENST00000574367ENST00000572484ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
intron-3CDSENST00000573722ENST00000396981ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
intron-5UTRENST00000573722ENST00000572484ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
In-frameENST00000433651ENST00000396981ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-
5CDS-5UTRENST00000433651ENST00000572484ANKFY1chr17

4167227

-UBE2G1chr17

4210418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKFY1-UBE2G1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKFY1-UBE2G1


check button Go to

FGviewer for the breakpoints of chr17:4167226-chr17:4210418

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKFY1

Q9P2R3

.
FUNCTION: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-12568_1303.33333333333333351170.0DomainBTB
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-11068_1303.3333333333333335488.0DomainBTB
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-12568_13001212.0DomainBTB
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-12568_1303.33333333333333351171.0DomainBTB
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-12568_1303.33333333333333351170.0DomainBTB
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-11068_1303.3333333333333335488.0DomainBTB
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-12568_13001212.0DomainBTB
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-12568_1303.33333333333333351171.0DomainBTB
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-1251005_10373.33333333333333351170.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-1251043_10723.33333333333333351170.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125217_2473.33333333333333351170.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125255_2843.33333333333333351170.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125288_3173.33333333333333351170.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125322_3623.33333333333333351170.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125366_3963.33333333333333351170.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125490_5193.33333333333333351170.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125542_5723.33333333333333351170.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125588_6173.33333333333333351170.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125621_6503.33333333333333351170.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125654_6833.33333333333333351170.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125687_7163.33333333333333351170.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125724_7533.33333333333333351170.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125769_7983.33333333333333351170.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125802_8323.33333333333333351170.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125836_8653.33333333333333351170.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125870_8993.33333333333333351170.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125905_9343.33333333333333351170.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125938_9673.33333333333333351170.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125971_10013.33333333333333351170.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-1101005_10373.3333333333333335488.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-1101043_10723.3333333333333335488.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110217_2473.3333333333333335488.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110255_2843.3333333333333335488.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110288_3173.3333333333333335488.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110322_3623.3333333333333335488.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110366_3963.3333333333333335488.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110490_5193.3333333333333335488.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110542_5723.3333333333333335488.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110588_6173.3333333333333335488.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110621_6503.3333333333333335488.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110654_6833.3333333333333335488.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110687_7163.3333333333333335488.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110724_7533.3333333333333335488.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110769_7983.3333333333333335488.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110802_8323.3333333333333335488.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110836_8653.3333333333333335488.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110870_8993.3333333333333335488.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110905_9343.3333333333333335488.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110938_9673.3333333333333335488.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110971_10013.3333333333333335488.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-1251005_103701212.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-1251043_107201212.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125217_24701212.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125255_28401212.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125288_31701212.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125322_36201212.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125366_39601212.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125490_51901212.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125542_57201212.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125588_61701212.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125621_65001212.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125654_68301212.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125687_71601212.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125724_75301212.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125769_79801212.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125802_83201212.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125836_86501212.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125870_89901212.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125905_93401212.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125938_96701212.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125971_100101212.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-1251005_10373.33333333333333351171.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-1251043_10723.33333333333333351171.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125217_2473.33333333333333351171.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125255_2843.33333333333333351171.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125288_3173.33333333333333351171.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125322_3623.33333333333333351171.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125366_3963.33333333333333351171.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125490_5193.33333333333333351171.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125542_5723.33333333333333351171.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125588_6173.33333333333333351171.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125621_6503.33333333333333351171.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125654_6833.33333333333333351171.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125687_7163.33333333333333351171.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125724_7533.33333333333333351171.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125769_7983.33333333333333351171.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125802_8323.33333333333333351171.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125836_8653.33333333333333351171.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125870_8993.33333333333333351171.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125905_9343.33333333333333351171.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125938_9673.33333333333333351171.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125971_10013.33333333333333351171.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-1251005_10373.33333333333333351170.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-1251043_10723.33333333333333351170.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125217_2473.33333333333333351170.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125255_2843.33333333333333351170.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125288_3173.33333333333333351170.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125322_3623.33333333333333351170.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125366_3963.33333333333333351170.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125490_5193.33333333333333351170.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125542_5723.33333333333333351170.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125588_6173.33333333333333351170.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125621_6503.33333333333333351170.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125654_6833.33333333333333351170.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125687_7163.33333333333333351170.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125724_7533.33333333333333351170.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125769_7983.33333333333333351170.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125802_8323.33333333333333351170.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125836_8653.33333333333333351170.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125870_8993.33333333333333351170.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125905_9343.33333333333333351170.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125938_9673.33333333333333351170.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125971_10013.33333333333333351170.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-1101005_10373.3333333333333335488.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-1101043_10723.3333333333333335488.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110217_2473.3333333333333335488.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110255_2843.3333333333333335488.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110288_3173.3333333333333335488.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110322_3623.3333333333333335488.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110366_3963.3333333333333335488.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110490_5193.3333333333333335488.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110542_5723.3333333333333335488.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110588_6173.3333333333333335488.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110621_6503.3333333333333335488.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110654_6833.3333333333333335488.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110687_7163.3333333333333335488.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110724_7533.3333333333333335488.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110769_7983.3333333333333335488.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110802_8323.3333333333333335488.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110836_8653.3333333333333335488.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110870_8993.3333333333333335488.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110905_9343.3333333333333335488.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110938_9673.3333333333333335488.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110971_10013.3333333333333335488.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-1251005_103701212.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-1251043_107201212.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125217_24701212.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125255_28401212.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125288_31701212.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125322_36201212.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125366_39601212.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125490_51901212.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125542_57201212.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125588_61701212.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125621_65001212.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125654_68301212.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125687_71601212.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125724_75301212.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125769_79801212.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125802_83201212.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125836_86501212.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125870_89901212.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125905_93401212.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125938_96701212.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125971_100101212.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-1251005_10373.33333333333333351171.0RepeatNote=ANK 20
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-1251043_10723.33333333333333351171.0RepeatNote=ANK 21
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125217_2473.33333333333333351171.0RepeatNote=ANK 1
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125255_2843.33333333333333351171.0RepeatNote=ANK 2
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125288_3173.33333333333333351171.0RepeatNote=ANK 3
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125322_3623.33333333333333351171.0RepeatNote=ANK 4
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125366_3963.33333333333333351171.0RepeatNote=ANK 5
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125490_5193.33333333333333351171.0RepeatNote=ANK 6
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125542_5723.33333333333333351171.0RepeatNote=ANK 7
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125588_6173.33333333333333351171.0RepeatNote=ANK 8
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125621_6503.33333333333333351171.0RepeatNote=ANK 9
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125654_6833.33333333333333351171.0RepeatNote=ANK 10
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125687_7163.33333333333333351171.0RepeatNote=ANK 11
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125724_7533.33333333333333351171.0RepeatNote=ANK 12
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125769_7983.33333333333333351171.0RepeatNote=ANK 13
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125802_8323.33333333333333351171.0RepeatNote=ANK 14
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125836_8653.33333333333333351171.0RepeatNote=ANK 15
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125870_8993.33333333333333351171.0RepeatNote=ANK 16
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125905_9343.33333333333333351171.0RepeatNote=ANK 17
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125938_9673.33333333333333351171.0RepeatNote=ANK 18
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125971_10013.33333333333333351171.0RepeatNote=ANK 19
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-1251104_11643.33333333333333351170.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-1101104_11643.3333333333333335488.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-1251104_116401212.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-1251104_11643.33333333333333351171.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-1251104_11643.33333333333333351170.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-1101104_11643.3333333333333335488.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-1251104_116401212.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-1251104_11643.33333333333333351171.0Zinc fingerFYVE-type
TgeneUBE2G1chr17:4167226chr17:4210418ENST00000396981065_16615.3333333333333341193.3333333333333DomainUBC core
TgeneUBE2G1chr17:4167227chr17:4210418ENST00000396981065_16615.3333333333333341193.3333333333333DomainUBC core


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Fusion Gene Sequence for ANKFY1-UBE2G1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKFY1-UBE2G1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANKFY1chr17:4167226chr17:4210418ENST00000341657-125650_7593.33333333333333351170.0RHOD and RAB5A
HgeneANKFY1chr17:4167226chr17:4210418ENST00000433651-110650_7593.3333333333333335488.0RHOD and RAB5A
HgeneANKFY1chr17:4167226chr17:4210418ENST00000570535-125650_75901212.0RHOD and RAB5A
HgeneANKFY1chr17:4167226chr17:4210418ENST00000574367-125650_7593.33333333333333351171.0RHOD and RAB5A
HgeneANKFY1chr17:4167227chr17:4210418ENST00000341657-125650_7593.33333333333333351170.0RHOD and RAB5A
HgeneANKFY1chr17:4167227chr17:4210418ENST00000433651-110650_7593.3333333333333335488.0RHOD and RAB5A
HgeneANKFY1chr17:4167227chr17:4210418ENST00000570535-125650_75901212.0RHOD and RAB5A
HgeneANKFY1chr17:4167227chr17:4210418ENST00000574367-125650_7593.33333333333333351171.0RHOD and RAB5A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKFY1-UBE2G1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKFY1-UBE2G1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKFY1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneANKFY1C0005695Bladder Neoplasm1CTD_human
HgeneANKFY1C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET