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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMTK2-IMMP2L (FusionGDB2 ID:45599)

Fusion Gene Summary for LMTK2-IMMP2L

check button Fusion gene summary
Fusion gene informationFusion gene name: LMTK2-IMMP2L
Fusion gene ID: 45599
HgeneTgene
Gene symbol

LMTK2

IMMP2L

Gene ID

22853

83943

Gene namelemur tyrosine kinase 2inner mitochondrial membrane peptidase subunit 2
SynonymsAATYK2|BREK|KPI-2|KPI2|LMR2|PPP1R100|cprk|hBREKIMMP2L-IT1|IMP2|IMP2-LIKE
Cytomap

7q21.3

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase LMTK2CDK5/p35-regulated kinaseapoptosis-associated tyrosine kinase 2brain-enriched kinasecyclin-dependent kinase 5/p35-regulated kinasekinase/phosphatase/inhibitor 2protein phosphatase 1, regulatory subunit 100serinemitochondrial inner membrane protease subunit 2IMP2 inner mitochondrial membrane peptidase-likeIMP2 inner mitochondrial membrane protease-likeinner mitochondrial membrane peptidase 2 like
Modification date2020031320200313
UniProtAcc

Q8IWU2

Q96T52

Ensembl transtripts involved in fusion geneENST00000297293, ENST00000493372, 
ENST00000405709, ENST00000331762, 
ENST00000452895, ENST00000415362, 
ENST00000447215, ENST00000437687, 
ENST00000489381, ENST00000450877, 
Fusion gene scores* DoF score12 X 9 X 5=54029 X 19 X 14=7714
# samples 1232
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/7714*10)=-4.5913353357414
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMTK2 [Title/Abstract] AND IMMP2L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMTK2(97800986)-IMMP2L(110603621), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMTK2

GO:0006468

protein phosphorylation

12393858

HgeneLMTK2

GO:0018105

peptidyl-serine phosphorylation

16887929

HgeneLMTK2

GO:0018107

peptidyl-threonine phosphorylation

16887929

HgeneLMTK2

GO:0046777

protein autophosphorylation

12393858


check buttonFusion gene breakpoints across LMTK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IMMP2L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-A5MG-01ALMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
ChimerDB4LUSCTCGA-63-A5MGLMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
ChimerDB4LUSCTCGA-63-A5MG-01ALMTK2chr7

97800986

-IMMP2Lchr7

110603621

-


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Fusion Gene ORF analysis for LMTK2-IMMP2L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000297293ENST00000405709LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
In-frameENST00000297293ENST00000331762LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
In-frameENST00000297293ENST00000452895LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
In-frameENST00000297293ENST00000415362LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
In-frameENST00000297293ENST00000447215LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
In-frameENST00000297293ENST00000437687LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
5CDS-5UTRENST00000297293ENST00000489381LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
5CDS-5UTRENST00000297293ENST00000450877LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-3CDSENST00000493372ENST00000405709LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-3CDSENST00000493372ENST00000331762LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-3CDSENST00000493372ENST00000452895LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-3CDSENST00000493372ENST00000415362LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-3CDSENST00000493372ENST00000447215LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-3CDSENST00000493372ENST00000437687LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-5UTRENST00000493372ENST00000489381LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-
intron-5UTRENST00000493372ENST00000450877LMTK2chr7

97800986

+IMMP2Lchr7

110603621

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297293LMTK2chr797800986+ENST00000405709IMMP2Lchr7110603621-192110842931372359
ENST00000297293LMTK2chr797800986+ENST00000331762IMMP2Lchr7110603621-192110842931372359
ENST00000297293LMTK2chr797800986+ENST00000452895IMMP2Lchr7110603621-155910842931372359
ENST00000297293LMTK2chr797800986+ENST00000415362IMMP2Lchr7110603621-137310842931372360
ENST00000297293LMTK2chr797800986+ENST00000447215IMMP2Lchr7110603621-193310842931177294
ENST00000297293LMTK2chr797800986+ENST00000437687IMMP2Lchr7110603621-117810842931177295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297293ENST00000405709LMTK2chr797800986+IMMP2Lchr7110603621-0.0001948970.99980515
ENST00000297293ENST00000331762LMTK2chr797800986+IMMP2Lchr7110603621-0.0001948970.99980515
ENST00000297293ENST00000452895LMTK2chr797800986+IMMP2Lchr7110603621-0.000595930.9994041
ENST00000297293ENST00000415362LMTK2chr797800986+IMMP2Lchr7110603621-0.0011493550.9988506
ENST00000297293ENST00000447215LMTK2chr797800986+IMMP2Lchr7110603621-0.000205540.9997944
ENST00000297293ENST00000437687LMTK2chr797800986+IMMP2Lchr7110603621-0.0015014980.99849856

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Fusion Genomic Features for LMTK2-IMMP2L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LMTK2-IMMP2L


check button Go to

FGviewer for the breakpoints of chr7:97800986-chr7:110603621

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMTK2

Q8IWU2

IMMP2L

Q96T52

FUNCTION: Phosphorylates PPP1C, phosphorylase b and CFTR.FUNCTION: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269|PubMed:15814844}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+714143_151263.66666666666671504.0Nucleotide bindingATP
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+7141_10263.66666666666671504.0Topological domainCytoplasmic
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+71432_42263.66666666666671504.0Topological domainLumenal
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+71411_31263.66666666666671504.0TransmembraneHelical
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+71443_63263.66666666666671504.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+7141451_1454263.66666666666671504.0Compositional biasNote=Poly-Pro
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+714137_407263.66666666666671504.0DomainProtein kinase
HgeneLMTK2chr7:97800986chr7:110603621ENST00000297293+71464_1503263.66666666666671504.0Topological domainCytoplasmic
TgeneIMMP2Lchr7:97800986chr7:110603621ENST000003317623719_3779.66666666666667176.0TransmembraneHelical
TgeneIMMP2Lchr7:97800986chr7:110603621ENST000004057092619_3779.66666666666667176.0TransmembraneHelical
TgeneIMMP2Lchr7:97800986chr7:110603621ENST000004153621519_3779.66666666666667176.0TransmembraneHelical
TgeneIMMP2Lchr7:97800986chr7:110603621ENST000004376871419_3779.66666666666667111.0TransmembraneHelical
TgeneIMMP2Lchr7:97800986chr7:110603621ENST000004472152519_3779.66666666666667111.0TransmembraneHelical
TgeneIMMP2Lchr7:97800986chr7:110603621ENST000004528953719_3779.66666666666667176.0TransmembraneHelical


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Fusion Gene Sequence for LMTK2-IMMP2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000297293_ENST00000405709_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(transcript)=1921nt_BP=1084nt
GCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTGCTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGC
GGGAAGGATGGTGTTTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAACGTGTGCTCGGGAGCAA
CCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGACTGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGC
CCCGGAGCCGCGCCGTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATCGCCGGCA
GTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGT
GCAGTTTAATAATATTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAAGATAATT
TTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAGTCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATA
TTTCACTCCCAGCTCCCTCGCAATTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATACAGGAAA
TTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACTAGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAA
GTGCCAACCCAAAGGAACAAGATACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGTGTTGGAC
AGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGTGACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACA
TGCGGGGGGACTCACAGACCATGCTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCACTTCCTGC
ACAGGTCTCCTAAAAACCCAGAACAGAAGATCATTAAGAGAGTGATTGCTCTTGAAGGAGATATTGTCAGAACCATAGGACACAAAAACC
GGTATGTCAAAGTCCCCCGTGGTCACATCTGGGTTGAAGGTGATCATCATGGACACAGTTTTGACAGTAATTCTTTTGGGCCGGTTTCCC
TAGGACTTCTGCATGCCCATGCCACACATATCCTGTGGCCCCCAGAGCGCTGGCAGAAATTGGAATCTGTTCTTCCTCCAGAGCGCTTAC
CAGTACAGAGAGAAGAGGAATGACTGCATGAATCTACCTGAGTTGCTGGCATTGGGAGGCCAGTTACTGGAAAGGAATGGAAAAAAGAAG
CCTCCAAAAGGGAAAAACTTCTGACAATATGATGCTGTGCGAGAAATATTTACAGCACATTAAAACGATCTGTATTATTAAATAAATAAT
TTTCAAATGTTAAACAGTATTAAATGGCACCTGATTTTGTGTTAAATTTTAGTTCCCTGTTGTTTAATGCCCCCAAAATATGCAGACCTT
TGGGAATATAAAAATATTGCACCCACATGTCTTAATGGGGCTGAATTTCAGATTATTTGTTACATATACTTATTATATTGATTGTTGGGT
TTTGATTTTGGTGCTTGCTGCTGAAATAAATTGAAAATTAATATTCAATAAAAATGATGTATTTGTCACTTGCTGTTAAGGTAGAACAAG
AAGGAACACATATTATACACATAATGATGGGAATTACATTGTGATTTGTACTATCTACAAAGGAGTAACTGCCAGTTAGGAAGAACAGTA

>In-frame_ENST00000297293_ENST00000405709_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(amino acids)=359AA_start in transcript=293_stop in transcript=1372
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFT
PPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHRSPKNPE

--------------------------------------------------------------
>In-frame_ENST00000297293_ENST00000331762_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(transcript)=1921nt_BP=1084nt
GCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTGCTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGC
GGGAAGGATGGTGTTTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAACGTGTGCTCGGGAGCAA
CCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGACTGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGC
CCCGGAGCCGCGCCGTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATCGCCGGCA
GTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGT
GCAGTTTAATAATATTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAAGATAATT
TTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAGTCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATA
TTTCACTCCCAGCTCCCTCGCAATTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATACAGGAAA
TTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACTAGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAA
GTGCCAACCCAAAGGAACAAGATACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGTGTTGGAC
AGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGTGACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACA
TGCGGGGGGACTCACAGACCATGCTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCACTTCCTGC
ACAGGTCTCCTAAAAACCCAGAACAGAAGATCATTAAGAGAGTGATTGCTCTTGAAGGAGATATTGTCAGAACCATAGGACACAAAAACC
GGTATGTCAAAGTCCCCCGTGGTCACATCTGGGTTGAAGGTGATCATCATGGACACAGTTTTGACAGTAATTCTTTTGGGCCGGTTTCCC
TAGGACTTCTGCATGCCCATGCCACACATATCCTGTGGCCCCCAGAGCGCTGGCAGAAATTGGAATCTGTTCTTCCTCCAGAGCGCTTAC
CAGTACAGAGAGAAGAGGAATGACTGCATGAATCTACCTGAGTTGCTGGCATTGGGAGGCCAGTTACTGGAAAGGAATGGAAAAAAGAAG
CCTCCAAAAGGGAAAAACTTCTGACAATATGATGCTGTGCGAGAAATATTTACAGCACATTAAAACGATCTGTATTATTAAATAAATAAT
TTTCAAATGTTAAACAGTATTAAATGGCACCTGATTTTGTGTTAAATTTTAGTTCCCTGTTGTTTAATGCCCCCAAAATATGCAGACCTT
TGGGAATATAAAAATATTGCACCCACATGTCTTAATGGGGCTGAATTTCAGATTATTTGTTACATATACTTATTATATTGATTGTTGGGT
TTTGATTTTGGTGCTTGCTGCTGAAATAAATTGAAAATTAATATTCAATAAAAATGATGTATTTGTCACTTGCTGTTAAGGTAGAACAAG
AAGGAACACATATTATACACATAATGATGGGAATTACATTGTGATTTGTACTATCTACAAAGGAGTAACTGCCAGTTAGGAAGAACAGTA

>In-frame_ENST00000297293_ENST00000331762_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(amino acids)=359AA_start in transcript=293_stop in transcript=1372
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFT
PPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHRSPKNPE

--------------------------------------------------------------
>In-frame_ENST00000297293_ENST00000452895_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(transcript)=1559nt_BP=1084nt
GCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTGCTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGC
GGGAAGGATGGTGTTTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAACGTGTGCTCGGGAGCAA
CCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGACTGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGC
CCCGGAGCCGCGCCGTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATCGCCGGCA
GTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGT
GCAGTTTAATAATATTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAAGATAATT
TTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAGTCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATA
TTTCACTCCCAGCTCCCTCGCAATTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATACAGGAAA
TTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACTAGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAA
GTGCCAACCCAAAGGAACAAGATACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGTGTTGGAC
AGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGTGACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACA
TGCGGGGGGACTCACAGACCATGCTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCACTTCCTGC
ACAGGTCTCCTAAAAACCCAGAACAGAAGATCATTAAGAGAGTGATTGCTCTTGAAGGAGATATTGTCAGAACCATAGGACACAAAAACC
GGTATGTCAAAGTCCCCCGTGGTCACATCTGGGTTGAAGGTGATCATCATGGACACAGTTTTGACAGTAATTCTTTTGGGCCGGTTTCCC
TAGGACTTCTGCATGCCCATGCCACACATATCCTGTGGCCCCCAGAGCGCTGGCAGAAATTGGAATCTGTTCTTCCTCCAGAGCGCTTAC
CAGTACAGAGAGAAGAGGAATGACTGCATGAATCTACCTGAGTTGCTGGCATTGGGAGGCCAGTTACTGGAAAGGAATGGAAAAAAGAAG
CCTCCAAAAGGGAAAAACTTCTGACAATATGATGCTGTGCGAGAAATATTTACAGCACATTAAAACGATCTGTATTATTAAATAAATAAT

>In-frame_ENST00000297293_ENST00000452895_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(amino acids)=359AA_start in transcript=293_stop in transcript=1372
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFT
PPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHRSPKNPE

--------------------------------------------------------------
>In-frame_ENST00000297293_ENST00000415362_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(transcript)=1373nt_BP=1084nt
GCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTGCTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGC
GGGAAGGATGGTGTTTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAACGTGTGCTCGGGAGCAA
CCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGACTGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGC
CCCGGAGCCGCGCCGTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATCGCCGGCA
GTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGT
GCAGTTTAATAATATTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAAGATAATT
TTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAGTCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATA
TTTCACTCCCAGCTCCCTCGCAATTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATACAGGAAA
TTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACTAGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAA
GTGCCAACCCAAAGGAACAAGATACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGTGTTGGAC
AGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGTGACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACA
TGCGGGGGGACTCACAGACCATGCTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCACTTCCTGC
ACAGGTCTCCTAAAAACCCAGAACAGAAGATCATTAAGAGAGTGATTGCTCTTGAAGGAGATATTGTCAGAACCATAGGACACAAAAACC
GGTATGTCAAAGTCCCCCGTGGTCACATCTGGGTTGAAGGTGATCATCATGGACACAGTTTTGACAGTAATTCTTTTGGGCCGGTTTCCC
TAGGACTTCTGCATGCCCATGCCACACATATCCTGTGGCCCCCAGAGCGCTGGCAGAAATTGGAATCTGTTCTTCCTCCAGAGCGCTTAC

>In-frame_ENST00000297293_ENST00000415362_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(amino acids)=360AA_start in transcript=293_stop in transcript=1372
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFT
PPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHRSPKNPE
QKIIKRVIALEGDIVRTIGHKNRYVKVPRGHIWVEGDHHGHSFDSNSFGPVSLGLLHAHATHILWPPERWQKLESVLPPERLPVQREEEX

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>In-frame_ENST00000297293_ENST00000447215_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(transcript)=1933nt_BP=1084nt
GCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTGCTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGC
GGGAAGGATGGTGTTTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAACGTGTGCTCGGGAGCAA
CCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGACTGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGC
CCCGGAGCCGCGCCGTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATCGCCGGCA
GTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGT
GCAGTTTAATAATATTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAAGATAATT
TTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAGTCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATA
TTTCACTCCCAGCTCCCTCGCAATTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATACAGGAAA
TTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACTAGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAA
GTGCCAACCCAAAGGAACAAGATACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGTGTTGGAC
AGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGTGACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACA
TGCGGGGGGACTCACAGACCATGCTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCACTTCCTGC
ACAGGTCTCCTAAAAACCCAGAACAGAAGATCATTAAGAGAGTGATTGCTCTTGAAGGAGATATTGTCAGAGATGGGAGAAAACTGAAAA
GGATATGAAACAGAAACTTCCGAATCAGTGACAAGAATGAAAGCTTTAGATGATAAGATTGTAACAATCAGGTGTTTAAGCAGCCTTTAG
TAATGTCGTATTTATTGTACTTGCTGATAAATCAAGAACAATTGTTGACATTCAGCAAGTAAATACTGTGTGGCATGATGTGTCTCATTG
TGATCGCTTTCTTTAAACAAGTTGTAGCCAGGCCTATACAATGTGGTAGCCAAAATGCTTTGACTACTACATTGAGGAAGTTTTCTGACC
CTGTTTTCTAAAAAAACTTGATCCTAAAGTATTTGTATTAATGATAGTACACATATTAACTAATCTCACTGAAATGAACCTCAGTCAGTT
TTAGAGCAGATTCTAGGCTAGCAGTTCTCACAGCATGGCCAGAGGATCCCAGGGGATCCCCACTGGGGGCCTATGAGATTAAAACTACTT
TCCTAATAATACTAAAGTGTTACTTGCCGTTTTTCACTCTCATTCTCTTGTGAGTGTACAGTGGAATTTTCCAGATATGTAATATTGGAG
TTGATTGAATGCAGGAGCAGATATGAGAATCCAGCTGTTTTCTATTAAGCCAGAAACTAAAAAGATTTGCAAAAATGTAAAAAAAAAAAA
TCATTATTTTTACTATTTATTGTTTGCTTTTGGAAAAGGACTATAATTTTTATTTAAATCGTATTCTTTTTGTTAACATAAGGGTTTATT

>In-frame_ENST00000297293_ENST00000447215_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(amino acids)=294AA_start in transcript=293_stop in transcript=1177
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFT
PPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHRSPKNPE

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>In-frame_ENST00000297293_ENST00000437687_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(transcript)=1178nt_BP=1084nt
GCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTGCTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGC
GGGAAGGATGGTGTTTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAACGTGTGCTCGGGAGCAA
CCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGACTGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGC
CCCGGAGCCGCGCCGTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATCGCCGGCA
GTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGT
GCAGTTTAATAATATTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAAGATAATT
TTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAGTCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATA
TTTCACTCCCAGCTCCCTCGCAATTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATACAGGAAA
TTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACTAGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAA
GTGCCAACCCAAAGGAACAAGATACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGTGTTGGAC
AGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGTGACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACA
TGCGGGGGGACTCACAGACCATGCTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCACTTCCTGC
ACAGGTCTCCTAAAAACCCAGAACAGAAGATCATTAAGAGAGTGATTGCTCTTGAAGGAGATATTGTCAGAGATGGGAGAAAACTGAAAA

>In-frame_ENST00000297293_ENST00000437687_TCGA-63-A5MG-01A_LMTK2_chr7_97800986_+_IMMP2L_chr7_110603621_length(amino acids)=295AA_start in transcript=293_stop in transcript=1177
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFT
PPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD
TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHRSPKNPE

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Fusion Gene PPI Analysis for LMTK2-IMMP2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMTK2-IMMP2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMTK2-IMMP2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMTK2C0033578Prostatic Neoplasms1CTD_human
HgeneLMTK2C0376358Malignant neoplasm of prostate1CTD_human
TgeneIMMP2LC0004352Autistic Disorder1CTD_human
TgeneIMMP2LC0079744Diffuse Large B-Cell Lymphoma1CTD_human