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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD11-ANKRD11 (FusionGDB2 ID:4635)

Fusion Gene Summary for ANKRD11-ANKRD11

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD11-ANKRD11
Fusion gene ID: 4635
HgeneTgene
Gene symbol

ANKRD11

ANKRD11

Gene ID

29123

29123

Gene nameankyrin repeat domain 11ankyrin repeat domain 11
SynonymsANCO-1|ANCO1|LZ16|T13ANCO-1|ANCO1|LZ16|T13
Cytomap

16q24.3

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 11ankyrin repeat-containing cofactor 1nasopharyngeal carcinoma susceptibility proteintruncated ankyrin repeat domain 11 aberrant transcript 1truncated ankyrin repeat domain 11 aberrant transcript 2ankyrin repeat domain-containing protein 11ankyrin repeat-containing cofactor 1nasopharyngeal carcinoma susceptibility proteintruncated ankyrin repeat domain 11 aberrant transcript 1truncated ankyrin repeat domain 11 aberrant transcript 2
Modification date2020031320200313
UniProtAcc

Q6UB99

Q6UB99

Ensembl transtripts involved in fusion geneENST00000378330, ENST00000301030, 
ENST00000563291, ENST00000567736, 
ENST00000378330, ENST00000301030, 
ENST00000563291, ENST00000567736, 
Fusion gene scores* DoF score42 X 20 X 20=1680017 X 18 X 6=1836
# samples 5621
** MAII scorelog2(56/16800*10)=-4.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1836*10)=-3.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD11 [Title/Abstract] AND ANKRD11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD11(89350716)-ANKRD11(89349736), # samples:1
ANKRD11(89350746)-ANKRD11(89349869), # samples:1
ANKRD11(89463642)-ANKRD11(89464326), # samples:1
ANKRD11(89349892)-ANKRD11(89349325), # samples:1
ANKRD11(89384869)-ANKRD11(89384601), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKRD11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA581362ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
ChiTaRS5.0N/ABF084757ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
ChiTaRS5.0N/ABF369488ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
ChiTaRS5.0N/ACB178636ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
ChiTaRS5.0N/ACV342044ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+


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Fusion Gene ORF analysis for ANKRD11-ANKRD11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378330ENST00000378330ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000378330ENST00000301030ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000378330ENST00000563291ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000378330ENST00000567736ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000301030ENST00000378330ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000301030ENST00000301030ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000301030ENST00000563291ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000301030ENST00000567736ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000563291ENST00000378330ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000563291ENST00000301030ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000563291ENST00000563291ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000563291ENST00000567736ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000567736ENST00000378330ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000567736ENST00000301030ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000567736ENST00000563291ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-intronENST00000567736ENST00000567736ANKRD11chr16

89350716

+ANKRD11chr16

89349736

+
intron-3CDSENST00000378330ENST00000378330ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000378330ENST00000301030ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000378330ENST00000563291ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000378330ENST00000567736ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000301030ENST00000378330ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000301030ENST00000301030ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000301030ENST00000563291ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000301030ENST00000567736ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000563291ENST00000378330ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000563291ENST00000301030ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000563291ENST00000563291ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000563291ENST00000567736ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000567736ENST00000378330ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-3CDSENST00000567736ENST00000301030ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000567736ENST00000563291ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000567736ENST00000567736ANKRD11chr16

89350746

+ANKRD11chr16

89349869

+
intron-intronENST00000378330ENST00000378330ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000378330ENST00000301030ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000378330ENST00000563291ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000378330ENST00000567736ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000301030ENST00000378330ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000301030ENST00000301030ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000301030ENST00000563291ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000301030ENST00000567736ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000563291ENST00000378330ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000563291ENST00000301030ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000563291ENST00000563291ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000563291ENST00000567736ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000567736ENST00000378330ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000567736ENST00000301030ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000567736ENST00000563291ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-intronENST00000567736ENST00000567736ANKRD11chr16

89463642

-ANKRD11chr16

89464326

-
intron-3CDSENST00000378330ENST00000378330ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000378330ENST00000301030ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000378330ENST00000563291ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000378330ENST00000567736ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000301030ENST00000378330ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000301030ENST00000301030ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000301030ENST00000563291ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000301030ENST00000567736ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000563291ENST00000378330ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000563291ENST00000301030ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000563291ENST00000563291ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000563291ENST00000567736ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000567736ENST00000378330ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-3CDSENST00000567736ENST00000301030ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000567736ENST00000563291ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000567736ENST00000567736ANKRD11chr16

89349892

+ANKRD11chr16

89349325

+
intron-intronENST00000378330ENST00000378330ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000378330ENST00000301030ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000378330ENST00000563291ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000378330ENST00000567736ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000301030ENST00000378330ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000301030ENST00000301030ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000301030ENST00000563291ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000301030ENST00000567736ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000563291ENST00000378330ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000563291ENST00000301030ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000563291ENST00000563291ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000563291ENST00000567736ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000567736ENST00000378330ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000567736ENST00000301030ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000567736ENST00000563291ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+
intron-intronENST00000567736ENST00000567736ANKRD11chr16

89384869

+ANKRD11chr16

89384601

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKRD11-ANKRD11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD11-ANKRD11


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD11

Q6UB99

ANKRD11

Q6UB99

FUNCTION: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.FUNCTION: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANKRD11-ANKRD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKRD11-ANKRD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD11-ANKRD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD11-ANKRD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKRD11C0220687KBG syndrome13CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneANKRD11C1535926Neurodevelopmental Disorders2CTD_human
HgeneANKRD11C0005944Metabolic Bone Disorder1CTD_human
HgeneANKRD11C0014544Epilepsy1CTD_human
HgeneANKRD11C0029453Osteopenia1CTD_human
HgeneANKRD11C0086237Epilepsy, Cryptogenic1CTD_human
HgeneANKRD11C0236018Aura1CTD_human
HgeneANKRD11C0751111Awakening Epilepsy1CTD_human
HgeneANKRD11C1510586Autism Spectrum Disorders1CTD_human
TgeneANKRD11C0220687KBG syndrome13CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneANKRD11C1535926Neurodevelopmental Disorders2CTD_human
TgeneANKRD11C0005944Metabolic Bone Disorder1CTD_human
TgeneANKRD11C0014544Epilepsy1CTD_human
TgeneANKRD11C0029453Osteopenia1CTD_human
TgeneANKRD11C0086237Epilepsy, Cryptogenic1CTD_human
TgeneANKRD11C0236018Aura1CTD_human
TgeneANKRD11C0751111Awakening Epilepsy1CTD_human
TgeneANKRD11C1510586Autism Spectrum Disorders1CTD_human