Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANKRD13C-LRRC40 (FusionGDB2 ID:4702)

Fusion Gene Summary for ANKRD13C-LRRC40

Fusion gene summary

Fusion gene information	Fusion gene name: ANKRD13C-LRRC40
	Fusion gene ID: 4702
		Hgene	Tgene
	Gene symbol	ANKRD13C	LRRC40
	Gene ID	81573	55631
	Gene name	ankyrin repeat domain 13C	leucine rich repeat containing 40
	Synonyms	dJ677H15.3	dJ677H15.1
	Cytomap	1p31.1	1p31.1
	Type of gene	protein-coding	protein-coding
	Description	ankyrin repeat domain-containing protein 13C	leucine-rich repeat-containing protein 40testicular tissue protein Li 109
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H9A6
	Ensembl transtripts involved in fusion gene	ENST00000370944, ENST00000262346, ENST00000464236,	ENST00000370952,
Fusion gene scores	* DoF score	6 X 4 X 6=144	3 X 3 X 3=27
	# samples	6	3
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ANKRD13C [Title/Abstract] AND LRRC40 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANKRD13C(70790536)-LRRC40(70625121), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ANKRD13C	GO:0010869	regulation of receptor biosynthetic process	20959461
Hgene	ANKRD13C	GO:2000209	regulation of anoikis	20959461

Fusion gene breakpoints across ANKRD13C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRRC40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-8576-01A	ANKRD13C	chr1	70790536	-	LRRC40	chr1	70625121	-

Top

Fusion Gene ORF analysis for ANKRD13C-LRRC40

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000370944	ENST00000370952	ANKRD13C	chr1	70790536	-	LRRC40	chr1	70625121	-
intron-3CDS	ENST00000262346	ENST00000370952	ANKRD13C	chr1	70790536	-	LRRC40	chr1	70625121	-
intron-3CDS	ENST00000464236	ENST00000370952	ANKRD13C	chr1	70790536	-	LRRC40	chr1	70625121	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000370944

ANKRD13C

chr1

70790536

ENST00000370952

LRRC40

chr1

70625121

2584

891

296

1588

430

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370944	ENST00000370952	ANKRD13C	chr1	70790536	-	LRRC40	chr1	70625121	-	0.000333736	0.9996662

Top

Fusion Genomic Features for ANKRD13C-LRRC40

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ANKRD13C-LRRC40

Go to
FGviewer for the breakpoints of chr1:70790536-chr1:70625121
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LRRC40 Q9H9A6
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000370944

30_33

192.33333333333334

542.0

Compositional bias

Note=Poly-Ala

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000370944

111_142

192.33333333333334

542.0

Repeat

Note=ANK 1

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000370944

143_172

192.33333333333334

542.0

Repeat

Note=ANK 2

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

400_421

370.3333333333333

603.0

Repeat

Note=LRR 13

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

426_447

370.3333333333333

603.0

Repeat

Note=LRR 14

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

450_472

370.3333333333333

603.0

Repeat

Note=LRR 15

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

473_494

370.3333333333333

603.0

Repeat

Note=LRR 16

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

496_517

370.3333333333333

603.0

Repeat

Note=LRR 17

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

519_540

370.3333333333333

603.0

Repeat

Note=LRR 18

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

543_564

370.3333333333333

603.0

Repeat

Note=LRR 19

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

566_586

370.3333333333333

603.0

Repeat

Note=LRR 20

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000262346

30_33

507.0

Compositional bias

Note=Poly-Ala

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000262346

111_142

507.0

Repeat

Note=ANK 1

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000262346

143_172

507.0

Repeat

Note=ANK 2

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000262346

176_205

507.0

Repeat

Note=ANK 3

Hgene

ANKRD13C

chr1:70790536

chr1:70625121

ENST00000370944

176_205

192.33333333333334

542.0

Repeat

Note=ANK 3

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

106_127

370.3333333333333

603.0

Repeat

Note=LRR 2

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

129_150

370.3333333333333

603.0

Repeat

Note=LRR 3

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

152_173

370.3333333333333

603.0

Repeat

Note=LRR 4

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

175_196

370.3333333333333

603.0

Repeat

Note=LRR 5

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

198_219

370.3333333333333

603.0

Repeat

Note=LRR 6

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

221_242

370.3333333333333

603.0

Repeat

Note=LRR 7

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

244_265

370.3333333333333

603.0

Repeat

Note=LRR 8

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

266_286

370.3333333333333

603.0

Repeat

Note=LRR 9

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

290_311

370.3333333333333

603.0

Repeat

Note=LRR 10

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

313_335

370.3333333333333

603.0

Repeat

Note=LRR 11

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

336_356

370.3333333333333

603.0

Repeat

Note=LRR 12

Tgene

LRRC40

chr1:70790536

chr1:70625121

ENST00000370952

83_104

370.3333333333333

603.0

Repeat

Note=LRR 1

Top

Fusion Gene Sequence for ANKRD13C-LRRC40

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000370944_ENST00000370952_TCGA-D7-8576-01A_ANKRD13C_chr1_70790536_-_LRRC40_chr1_70625121_length(transcript)=2584nt_BP=891nt
GAGCAAGAGGAAGATGGCCGTGCCCTGTTTTTCGGTGTAAGGCAGCGACGGCGGCTGCGACGGCGAGACTGAGATCCTGGTGTCGTGGGC
ACCTGAGTTCTAGCTTCCCCCAGCGAGCGCGCGTCCCTTCGTGCCTAGGCGAGAGCCGGCTCTTCCCCGGGAGATGCGTTTGTCCCAGGC
TCGGGGGCTCAGTGGGAGTTCATGCTGCGCTGGAGGCTCTTGGCCACCGCTCTAATCGCCTTGTGCCGCCGCAGCGCCAGCTCCGTCGCC
AGCGGTGAGCCTCCCGATTCCCCCCCTTGCCCCTGGCGGCGGCGATGACCGGGGAGAAGATCCGCTCACTGCGGAGGGACCACAAGCCCA
GCAAAGAAGAAGGGGACCTGCTGGAGCCCGGGGATGAGGAAGCGGCGGCTGCCCTCGGCGGTACCTTTACCAGAAGCAGGATTGGCAAGG
GCGGCAAAGCTTGTCATAAGATCTTCAGTAACCATCACCACCGGCTACAGCTGAAGGCAGCTCCGGCCTCCTCCAATCCCCCCGGCGCCC
CGGCTCTGCCGCTGCACAATTCCTCCGTGACTGCCAACTCCCAGTCCCCGGCCCTTCTGGCCGGCACCAACCCCGTTGCTGTCGTCGCGG
ATGGAGGCAGTTGCCCCGCACACTACCCGGTGCACGAGTGCGTCTTCAAGGGGGATGTGAGGAGACTCTCCTCTCTCATCCGCACGCACA
ATATCGGGCAGAAAGATAATCACGGAAATACTCCTTTACACCTTGCTGTGATGTTAGGAAATAAAGAATGTGCCCATTTACTTTTGGCTC
ACAATGCTCCAGTCAAGGTGAAAAATGCTCAGGGATGGAGCCCTCTGGCGGAAGCCATCAGCTATGGAGATAGGCAGATGAATGATGGAC
CTAGCCAAAGTGAGTCTGCTACTGAGACTGCCATGACACTACCAAGTGAATCCAGAGTCAATATACATGCCATCATTACATTAAAAATAT
TAGACTATAGTGATAAACAAGCAACTTTGATTCCTGATGAGGTGTTTGATGCAGTAAAAAGCAACATCGTCACTTCTATTAACTTCAGTA
AGAATCAACTATGTGAAATTCCAAAAAGGATGGTAGAACTGAAGGAAATGGTTTCTGATGTCGATCTCAGTTTTAATAAACTTTCCTTTA
TATCCTTGGAGTTATGTGTGCTTCAGAAATTGACTTTTTTAGATCTCAGGAACAATTTTTTAAATTCTTTGCCAGAAGAAATGGAATCAC
TGGTAAGACTGCAAACGATCAATCTTTCCTTTAATAGGTTTAAAATGCTACCTGAAGTTCTATATCGTATCTTCACACTTGAAACAATTC
TGATTAGTAATAATCAGGTTGGATCTGTGGACCCTCAGAAAATGAAGATGATGGAAAATCTGACCACGTTGGACCTTCAAAATAATGACC
TCTTACAAATTCCACCAGAGCTCGGTAATTGTGTAAACTTAAGAACATTACTACTGGATGGAAATCCATTCCGAGTTCCTCGAGCAGCCA
TATTAATGAAAGGAACAGCTGCTATACTTGAATATTTGAGAGACCGAATTCCTACTTAACATGGAGTTGCTTTATAACCCTTGTCATGTA
TTATTAACCCTGGTTAATTCTAAGGAGGATGTAACATTTGTTTTAGTATCATCTTAAAAGGTGATTATTGTAATTGATCTTGTAGTTTCC
CAGTATCACCTACCTGTTGGTATAATTAGCCTGGGCCATATTCACTGCCAGTAAATATTTTTACATTTTTATTTAAGATTTTTGTAAGGT
GTTGTATACATTTGTAATGGTGATAACCACAATGTGTTCATACATTTGTTCTAAATGTTTTGCTTATGATTTATCCTGCTAACTTTCATT
TTCTTATAGCAAGCAGTTTTTTCAAAAATGAATTTTTATTTAATGTGGTTCAGTATTATAATAACAAAGCATTTTTGTAGAACTGGTTTT
TTTTCTCATTTATTTTTGTATTCCATACAATGTGACCAATTGACTTGAATATGACTAGCCAGTTTCTATGTTTTTGTTAGATATAAAATT
AAATCGAATTTTGTTGAATACTGTTCTTTGGCATTTAAAAAATAAGACCTTCTTATCTTGGGCCACATGTCAAAAGAAAAAGGAAACAAA
AATATATTAAAAATAAGACTTTTCATTACCCATGATAGGACTTTTGTGATATGGCTAATCTCAGTACACATTTCAACTTAAAACCTTTTT
ATTTACAGCACCATAATTTTAAAATTTACTTGCAATCTTGGTAAGACTAAACTTGCAGTGTTTTTCTAAAAGGGAATTTGATAGGTAAAC
TTGATTTAATAAAAATTAAATATCATTTTTGTTTACACCAAAATTATCAGAAGTAGGTTGATTAGTCATTATAACACTTACCATATGATT
CTATTAAGAAGTCAATTCAGTAGCATGTATATCAATTTATATAGATAGGTAGATAGCTTTTGGATGATTGAGGCATGCTTATATTATGAA

>In-frame_ENST00000370944_ENST00000370952_TCGA-D7-8576-01A_ANKRD13C_chr1_70790536_-_LRRC40_chr1_70625121_length(amino acids)=430AA_start in transcript=296_stop in transcript=1588
MPLAAAMTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSNPPGAPALPLHNSS
VTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN
AQGWSPLAEAISYGDRQMNDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPK
RMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ANKRD13C-LRRC40

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ANKRD13C-LRRC40

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ANKRD13C-LRRC40

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source