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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD13D-ANKRD13D (FusionGDB2 ID:4705)

Fusion Gene Summary for ANKRD13D-ANKRD13D

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD13D-ANKRD13D
Fusion gene ID: 4705
HgeneTgene
Gene symbol

ANKRD13D

ANKRD13D

Gene ID

338692

338692

Gene nameankyrin repeat domain 13Dankyrin repeat domain 13D
Synonyms--
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 13Dankyrin repeat domain 13 family, member Dankyrin repeat domain-containing protein 13Dankyrin repeat domain 13 family, member D
Modification date2020032020200320
UniProtAcc.

Q6ZTN6

Ensembl transtripts involved in fusion geneENST00000447274, ENST00000511455, 
ENST00000308440, ENST00000514166, 
ENST00000515828, ENST00000504236, 
ENST00000447274, ENST00000511455, 
ENST00000308440, ENST00000514166, 
ENST00000515828, ENST00000504236, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 4 X 2=24
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKRD13D [Title/Abstract] AND ANKRD13D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD13D(67069265)-ANKRD13D(67068436), # samples:1
ANKRD13D(67067359)-ANKRD13D(67057883), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD13D-ANKRD13D seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANKRD13D-ANKRD13D seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD13D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKRD13D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI054238ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
ChiTaRS5.0N/ACN354157ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+


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Fusion Gene ORF analysis for ANKRD13D-ANKRD13D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000447274ENST00000447274ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000447274ENST00000511455ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000447274ENST00000308440ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000447274ENST00000514166ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-5UTRENST00000447274ENST00000515828ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000447274ENST00000504236ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000511455ENST00000447274ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000511455ENST00000511455ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000511455ENST00000308440ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000511455ENST00000514166ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-5UTRENST00000511455ENST00000515828ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000511455ENST00000504236ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000308440ENST00000447274ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000308440ENST00000511455ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000308440ENST00000308440ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000308440ENST00000514166ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-5UTRENST00000308440ENST00000515828ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000308440ENST00000504236ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000514166ENST00000447274ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000514166ENST00000511455ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000514166ENST00000308440ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000514166ENST00000514166ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-5UTRENST00000514166ENST00000515828ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000514166ENST00000504236ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000515828ENST00000447274ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000515828ENST00000511455ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000515828ENST00000308440ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000515828ENST00000514166ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-5UTRENST00000515828ENST00000515828ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
5CDS-intronENST00000515828ENST00000504236ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
intron-intronENST00000504236ENST00000447274ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
intron-intronENST00000504236ENST00000511455ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
intron-intronENST00000504236ENST00000308440ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
intron-intronENST00000504236ENST00000514166ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
intron-5UTRENST00000504236ENST00000515828ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
intron-intronENST00000504236ENST00000504236ANKRD13Dchr11

67069265

-ANKRD13Dchr11

67068436

+
Frame-shiftENST00000447274ENST00000447274ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000447274ENST00000511455ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000447274ENST00000308440ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
In-frameENST00000447274ENST00000514166ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000447274ENST00000515828ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000447274ENST00000504236ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000511455ENST00000447274ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000511455ENST00000511455ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000511455ENST00000308440ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
In-frameENST00000511455ENST00000514166ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000511455ENST00000515828ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000511455ENST00000504236ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000308440ENST00000447274ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000308440ENST00000511455ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000308440ENST00000308440ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
In-frameENST00000308440ENST00000514166ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000308440ENST00000515828ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000308440ENST00000504236ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000514166ENST00000447274ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000514166ENST00000511455ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
Frame-shiftENST00000514166ENST00000308440ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
In-frameENST00000514166ENST00000514166ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000514166ENST00000515828ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
5CDS-intronENST00000514166ENST00000504236ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000515828ENST00000447274ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000515828ENST00000511455ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000515828ENST00000308440ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000515828ENST00000514166ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-intronENST00000515828ENST00000515828ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-intronENST00000515828ENST00000504236ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000504236ENST00000447274ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000504236ENST00000511455ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000504236ENST00000308440ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-3CDSENST00000504236ENST00000514166ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-intronENST00000504236ENST00000515828ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+
intron-intronENST00000504236ENST00000504236ANKRD13Dchr11

67067359

+ANKRD13Dchr11

67057883

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKRD13D-ANKRD13D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD13D-ANKRD13D


check button Go to

FGviewer for the breakpoints of chr11:67067359-chr11:67057883

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKRD13D

Q6ZTN6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440016395_4140519.0DomainUIM 1
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440016441_4600519.0DomainUIM 2
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440016477_4960519.0DomainUIM 3
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440016502_5180519.0DomainUIM 4
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274015395_4140519.0DomainUIM 1
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274015441_4600519.0DomainUIM 2
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274015477_4960519.0DomainUIM 3
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274015502_5180519.0DomainUIM 4
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455015395_4140606.0DomainUIM 1
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455015441_4600606.0DomainUIM 2
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455015477_4960606.0DomainUIM 3
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455015502_5180606.0DomainUIM 4
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166014395_4140519.0DomainUIM 1
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166014441_4600519.0DomainUIM 2
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166014477_4960519.0DomainUIM 3
TgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166014502_5180519.0DomainUIM 4
TgeneANKRD13Dchr11:67067359chr11:67057883ENST0000051582805395_4140256.0DomainUIM 1
TgeneANKRD13Dchr11:67067359chr11:67057883ENST0000051582805441_4600256.0DomainUIM 2
TgeneANKRD13Dchr11:67067359chr11:67057883ENST0000051582805477_4960256.0DomainUIM 3
TgeneANKRD13Dchr11:67067359chr11:67057883ENST0000051582805502_5180256.0DomainUIM 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440+1016395_414227.0519.0DomainUIM 1
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440+1016441_460227.0519.0DomainUIM 2
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440+1016477_496227.0519.0DomainUIM 3
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000308440+1016502_518227.0519.0DomainUIM 4
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274+915395_414227.0519.0DomainUIM 1
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274+915441_460227.0519.0DomainUIM 2
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274+915477_496227.0519.0DomainUIM 3
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000447274+915502_518227.0519.0DomainUIM 4
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455+915395_414314.0606.0DomainUIM 1
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455+915441_460314.0606.0DomainUIM 2
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455+915477_496314.0606.0DomainUIM 3
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000511455+915502_518314.0606.0DomainUIM 4
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166+814395_414227.0519.0DomainUIM 1
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166+814441_460227.0519.0DomainUIM 2
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166+814477_496227.0519.0DomainUIM 3
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000514166+814502_518227.0519.0DomainUIM 4
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000515828+15395_4140256.0DomainUIM 1
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000515828+15441_4600256.0DomainUIM 2
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000515828+15477_4960256.0DomainUIM 3
HgeneANKRD13Dchr11:67067359chr11:67057883ENST00000515828+15502_5180256.0DomainUIM 4


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Fusion Gene Sequence for ANKRD13D-ANKRD13D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKRD13D-ANKRD13D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD13D-ANKRD13D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD13D-ANKRD13D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource