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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD17-ANKRD17 (FusionGDB2 ID:4710)

Fusion Gene Summary for ANKRD17-ANKRD17

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD17-ANKRD17
Fusion gene ID: 4710
HgeneTgene
Gene symbol

ANKRD17

ANKRD17

Gene ID

26057

26057

Gene nameankyrin repeat domain 17ankyrin repeat domain 17
SynonymsGTAR|MASK2|NY-BR-16GTAR|MASK2|NY-BR-16
Cytomap

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date2020031320200313
UniProtAcc

O75179

O75179

Ensembl transtripts involved in fusion geneENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
ENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
Fusion gene scores* DoF score14 X 22 X 6=184812 X 18 X 5=1080
# samples 2521
** MAII scorelog2(25/1848*10)=-2.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1080*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD17 [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD17(74115326)-ANKRD17(74098733), # samples:2
ANKRD17(74099493)-ANKRD17(74099383), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD17

GO:0042742

defense response to bacterium

23711367

HgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

HgeneANKRD17

GO:0045087

innate immune response

23711367

HgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

HgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336

TgeneANKRD17

GO:0042742

defense response to bacterium

23711367

TgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

TgeneANKRD17

GO:0045087

innate immune response

23711367

TgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

TgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check buttonFusion gene breakpoints across ANKRD17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKRD17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAF075002ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
ChiTaRS5.0N/AAF075680ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
ChiTaRS5.0N/ABE772112ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
ChiTaRS5.0N/ABE934392ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
ChiTaRS5.0N/ABF196944ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
ChiTaRS5.0N/ABU753672ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
ChiTaRS5.0N/ACV423793ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
ChiTaRS5.0N/ACV423794ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
ChiTaRS5.0N/AEC446457ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
ChiTaRS5.0N/AEC505410ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
ChiTaRS5.0N/AH24553ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+


Top

Fusion Gene ORF analysis for ANKRD17-ANKRD17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000358602ENST00000358602ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000358602ENST00000509867ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000358602ENST00000330838ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000358602ENST00000514252ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000509867ENST00000358602ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000509867ENST00000509867ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000509867ENST00000330838ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000509867ENST00000514252ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000330838ENST00000358602ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000330838ENST00000509867ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000330838ENST00000330838ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000330838ENST00000514252ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000514252ENST00000358602ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000514252ENST00000509867ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000514252ENST00000330838ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000514252ENST00000514252ANKRD17chr4

74098733

-ANKRD17chr4

74115326

-
intron-intronENST00000358602ENST00000358602ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000358602ENST00000509867ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000358602ENST00000330838ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000358602ENST00000514252ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000509867ENST00000358602ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000509867ENST00000509867ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000509867ENST00000330838ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000509867ENST00000514252ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000330838ENST00000358602ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000330838ENST00000509867ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000330838ENST00000330838ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000330838ENST00000514252ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000514252ENST00000358602ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000514252ENST00000509867ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000514252ENST00000330838ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-intronENST00000514252ENST00000514252ANKRD17chr4

73973191

+ANKRD17chr4

74050054

-
intron-3CDSENST00000358602ENST00000358602ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000358602ENST00000509867ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000358602ENST00000330838ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-5UTRENST00000358602ENST00000514252ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000509867ENST00000358602ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000509867ENST00000509867ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000509867ENST00000330838ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-5UTRENST00000509867ENST00000514252ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000330838ENST00000358602ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000330838ENST00000509867ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000330838ENST00000330838ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-5UTRENST00000330838ENST00000514252ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000514252ENST00000358602ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000514252ENST00000509867ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000514252ENST00000330838ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-5UTRENST00000514252ENST00000514252ANKRD17chr4

73968123

+ANKRD17chr4

73985901

-
intron-3CDSENST00000358602ENST00000358602ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000358602ENST00000509867ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000358602ENST00000330838ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-intronENST00000358602ENST00000514252ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000509867ENST00000358602ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000509867ENST00000509867ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000509867ENST00000330838ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-intronENST00000509867ENST00000514252ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000330838ENST00000358602ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000330838ENST00000509867ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000330838ENST00000330838ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-intronENST00000330838ENST00000514252ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000514252ENST00000358602ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000514252ENST00000509867ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-3CDSENST00000514252ENST00000330838ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-intronENST00000514252ENST00000514252ANKRD17chr4

73957698

+ANKRD17chr4

73959835

-
intron-intronENST00000358602ENST00000358602ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000358602ENST00000509867ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000358602ENST00000330838ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000358602ENST00000514252ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000509867ENST00000358602ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000509867ENST00000509867ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000509867ENST00000330838ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000509867ENST00000514252ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000330838ENST00000358602ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000330838ENST00000509867ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000330838ENST00000330838ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000330838ENST00000514252ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000514252ENST00000358602ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000514252ENST00000509867ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000514252ENST00000330838ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000514252ENST00000514252ANKRD17chr4

74115326

+ANKRD17chr4

74098733

+
intron-intronENST00000358602ENST00000358602ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000358602ENST00000509867ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000358602ENST00000330838ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000358602ENST00000514252ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000509867ENST00000358602ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000509867ENST00000509867ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000509867ENST00000330838ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000509867ENST00000514252ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000330838ENST00000358602ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000330838ENST00000509867ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000330838ENST00000330838ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000330838ENST00000514252ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000514252ENST00000358602ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000514252ENST00000509867ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000514252ENST00000330838ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-intronENST00000514252ENST00000514252ANKRD17chr4

74099493

+ANKRD17chr4

74099383

-
intron-3UTRENST00000358602ENST00000358602ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000358602ENST00000509867ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000358602ENST00000330838ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-intronENST00000358602ENST00000514252ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000509867ENST00000358602ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000509867ENST00000509867ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000509867ENST00000330838ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-intronENST00000509867ENST00000514252ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000330838ENST00000358602ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000330838ENST00000509867ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000330838ENST00000330838ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-intronENST00000330838ENST00000514252ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000514252ENST00000358602ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000514252ENST00000509867ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000514252ENST00000330838ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-intronENST00000514252ENST00000514252ANKRD17chr4

73941444

-ANKRD17chr4

73941512

+
intron-3UTRENST00000358602ENST00000358602ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000358602ENST00000509867ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000358602ENST00000330838ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-intronENST00000358602ENST00000514252ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000509867ENST00000358602ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000509867ENST00000509867ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000509867ENST00000330838ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-intronENST00000509867ENST00000514252ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000330838ENST00000358602ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000330838ENST00000509867ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000330838ENST00000330838ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-intronENST00000330838ENST00000514252ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000514252ENST00000358602ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000514252ENST00000509867ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-3UTRENST00000514252ENST00000330838ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-intronENST00000514252ENST00000514252ANKRD17chr4

73941451

-ANKRD17chr4

73941512

+
intron-intronENST00000358602ENST00000358602ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000358602ENST00000509867ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000358602ENST00000330838ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000358602ENST00000514252ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000509867ENST00000358602ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000509867ENST00000509867ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000509867ENST00000330838ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000509867ENST00000514252ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000330838ENST00000358602ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000330838ENST00000509867ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000330838ENST00000330838ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000330838ENST00000514252ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000514252ENST00000358602ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000514252ENST00000509867ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000514252ENST00000330838ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+
intron-intronENST00000514252ENST00000514252ANKRD17chr4

73958018

+ANKRD17chr4

73950965

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKRD17-ANKRD17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD17chr473958017+ANKRD17chr473950965+0.076279230.92372084
ANKRD17chr473958017+ANKRD17chr473950965+0.076279230.92372084

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD17-ANKRD17


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD17

O75179

ANKRD17

O75179

FUNCTION: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.FUNCTION: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANKRD17-ANKRD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKRD17-ANKRD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD17-ANKRD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD17-ANKRD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource