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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD36-HNRNPH1 (FusionGDB2 ID:4818)

Fusion Gene Summary for ANKRD36-HNRNPH1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD36-HNRNPH1
Fusion gene ID: 4818
HgeneTgene
Gene symbol

ANKRD36

HNRNPH1

Gene ID

375248

3187

Gene nameankyrin repeat domain 36heterogeneous nuclear ribonucleoprotein H1
SynonymsUNQ2430HNRPH|HNRPH1|hnRNPH
Cytomap

2q11.2

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 36Aankyrin repeat domain-containing protein 36ankyrin-relatedheterogeneous nuclear ribonucleoprotein Hepididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein H1 (H)
Modification date2020031320200320
UniProtAcc

A6QL64

P31943

Ensembl transtripts involved in fusion geneENST00000461153, ENST00000420699, 
ENST00000357042, 		ENST00000393432, 
ENST00000442819, ENST00000356731, 
ENST00000329433, ENST00000510411, 
ENST00000511300, ENST00000524180, 
Fusion gene scores* DoF score3 X 3 X 2=1813 X 10 X 5=650
# samples 314
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD36 [Title/Abstract] AND HNRNPH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD36(97860654)-HNRNPH1(179045324), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD36-HNRNPH1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHNRNPH1

GO:0043484

regulation of RNA splicing

16946708


check buttonFusion gene breakpoints across ANKRD36 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HNRNPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer13NANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-


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Fusion Gene ORF analysis for ANKRD36-HNRNPH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000461153ENST00000393432ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000461153ENST00000442819ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000461153ENST00000356731ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000461153ENST00000329433ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000461153ENST00000510411ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
5CDS-intronENST00000461153ENST00000511300ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
5CDS-intronENST00000461153ENST00000524180ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000420699ENST00000393432ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000420699ENST00000442819ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000420699ENST00000356731ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000420699ENST00000329433ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
Frame-shiftENST00000420699ENST00000510411ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
5CDS-intronENST00000420699ENST00000511300ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
5CDS-intronENST00000420699ENST00000524180ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-3CDSENST00000357042ENST00000393432ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-3CDSENST00000357042ENST00000442819ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-3CDSENST00000357042ENST00000356731ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-3CDSENST00000357042ENST00000329433ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-3CDSENST00000357042ENST00000510411ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-intronENST00000357042ENST00000511300ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-
intron-intronENST00000357042ENST00000524180ANKRD36chr2

97860654

+HNRNPH1chr5

179045324

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKRD36-HNRNPH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD36-HNRNPH1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD36

A6QL64

HNRNPH1

P31943

FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANKRD36-HNRNPH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKRD36-HNRNPH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD36-HNRNPH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHNRNPH1P31943DB09130CopperSmall moleculeApproved|Investigational
TgeneHNRNPH1P31943DB09130CopperSmall moleculeApproved|Investigational
TgeneHNRNPH1P31943DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for ANKRD36-HNRNPH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHNRNPH1C0033578Prostatic Neoplasms1CTD_human
TgeneHNRNPH1C0376358Malignant neoplasm of prostate1CTD_human
TgeneHNRNPH1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET