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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD42-RHOD (FusionGDB2 ID:4837)

Fusion Gene Summary for ANKRD42-RHOD

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD42-RHOD
Fusion gene ID: 4837
HgeneTgene
Gene symbol

ANKRD42

RHOD

Gene ID

338699

29984

Gene nameankyrin repeat domain 42ras homolog family member D
SynonymsPPP1R79|SARPARHD|RHOHP1|RHOM|Rho
Cytomap

11q14.1

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 42protein phosphatase 1, regulatory subunit 79several ankyrin repeat proteinrho-related GTP-binding protein RhoDRho-related protein HP1ras homolog Dras homolog gene family, member Aras homolog gene family, member D
Modification date2020031320200313
UniProtAcc.

GRK7

Ensembl transtripts involved in fusion geneENST00000528190, ENST00000393389, 
ENST00000528722, ENST00000260047, 
ENST00000526731, ENST00000531895, 
ENST00000393392, ENST00000533342, 
ENST00000308831, ENST00000533360, 
ENST00000532559, 
Fusion gene scores* DoF score6 X 6 X 3=10810 X 6 X 6=360
# samples 615
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/360*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD42 [Title/Abstract] AND RHOD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD42(82959129)-RHOD(66837896), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RHOD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FZ-01AANKRD42chr11

82959129

+RHODchr11

66837896

+
ChimerDB4BRCATCGA-AN-A0FZ-01AANKRD42chr11

82959129

+RHODchr11

66837896

+
ChimerDB4BRCATCGA-AN-A0FZ-01AANKRD42chr11

82959129

-RHODchr11

66837896

+


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Fusion Gene ORF analysis for ANKRD42-RHOD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000528190ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
3UTR-3UTRENST00000528190ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
3UTR-3UTRENST00000528190ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3CDSENST00000393389ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3UTRENST00000393389ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3UTRENST00000393389ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3CDSENST00000528722ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3UTRENST00000528722ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3UTRENST00000528722ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
In-frameENST00000260047ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
5CDS-3UTRENST00000260047ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
5CDS-3UTRENST00000260047ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3CDSENST00000526731ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3UTRENST00000526731ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
intron-3UTRENST00000526731ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
In-frameENST00000531895ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
5CDS-3UTRENST00000531895ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
5CDS-3UTRENST00000531895ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
3UTR-3CDSENST00000393392ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
3UTR-3UTRENST00000393392ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
3UTR-3UTRENST00000393392ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+
In-frameENST00000533342ENST00000308831ANKRD42chr11

82959129

+RHODchr11

66837896

+
5CDS-3UTRENST00000533342ENST00000533360ANKRD42chr11

82959129

+RHODchr11

66837896

+
5CDS-3UTRENST00000533342ENST00000532559ANKRD42chr11

82959129

+RHODchr11

66837896

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260047ANKRD42chr1182959129+ENST00000308831RHODchr1166837896+297322591502561803
ENST00000531895ANKRD42chr1182959129+ENST00000308831RHODchr1166837896+245417402342042602
ENST00000533342ANKRD42chr1182959129+ENST00000308831RHODchr1166837896+25181804261441471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260047ENST00000308831ANKRD42chr1182959129+RHODchr1166837896+0.0070451280.9929549
ENST00000531895ENST00000308831ANKRD42chr1182959129+RHODchr1166837896+0.007156280.9928437
ENST00000533342ENST00000308831ANKRD42chr1182959129+RHODchr1166837896+0.0017893170.99821067

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Fusion Genomic Features for ANKRD42-RHOD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD42chr1182959129+RHODchr1166837895+1.98E-081
ANKRD42chr1182959129+RHODchr1166837895+1.98E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD42-RHOD


check button Go to

FGviewer for the breakpoints of chr11:82959129-chr11:66837896

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RHOD

GRK7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.553

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHODchr11:82959129chr11:66837896ENST0000030883125129_132110.0211.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+16130_1590199.0RepeatNote=ANK 4
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+16163_1920199.0RepeatNote=ANK 5
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+16200_2320199.0RepeatNote=ANK 6
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+16235_2650199.0RepeatNote=ANK 7
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+1625_600199.0RepeatNote=ANK 1
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+16269_2980199.0RepeatNote=ANK 8
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+16302_3320199.0RepeatNote=ANK 9
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+1664_930199.0RepeatNote=ANK 2
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393389+1697_1260199.0RepeatNote=ANK 3
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+110130_1590390.0RepeatNote=ANK 4
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+110163_1920390.0RepeatNote=ANK 5
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+110200_2320390.0RepeatNote=ANK 6
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+110235_2650390.0RepeatNote=ANK 7
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+11025_600390.0RepeatNote=ANK 1
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+110269_2980390.0RepeatNote=ANK 8
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+110302_3320390.0RepeatNote=ANK 9
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+11064_930390.0RepeatNote=ANK 2
HgeneANKRD42chr11:82959129chr11:66837896ENST00000393392+11097_1260390.0RepeatNote=ANK 3
TgeneRHODchr11:82959129chr11:66837896ENST000003088312546_54110.0211.0MotifEffector region
TgeneRHODchr11:82959129chr11:66837896ENST000003088312524_31110.0211.0Nucleotide bindingGTP
TgeneRHODchr11:82959129chr11:66837896ENST000003088312571_75110.0211.0Nucleotide bindingGTP


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Fusion Gene Sequence for ANKRD42-RHOD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000260047_ENST00000308831_TCGA-AN-A0FZ-01A_ANKRD42_chr11_82959129_+_RHOD_chr11_66837896_length(transcript)=2973nt_BP=2259nt
TGGAGGATAAACGGTCTACACGGCCATTCCGGCGCCGAGTCTAGGGAAAGAGTTAGCGACGACGGGGAAAGAAAATGTGAAGAGAGCGAC
CGCCGCTCCAGGGTCGCTGCAGGAAGCCTAAGTGCAGACGCCGGCTTCTCCCGCAGTGACTTGAGAAGGGTCAGTGAAAACCTCGGCCAC
TGCCGCAGCGTCTCTAGGGAGAGAGTTAGGGGAGATAGTGGCCACAGTCACAGCTGCTCTTGGGAGAGAGTTAGGGGAGACAGCACCTTC
TGCAGCAGCGACGTGAATTTTAGTGAAGTTGGAGGCCACCAAACTACCGACTCCAGGGGAACAGCCAGAGAAGACCGAGGCCTCCGCCTC
AGTGGTCCTTGGGAGGGAGTCAGTGACATTCGGGACCCGCGAACTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTC
AGTGGCTCCTGGGAGGGAGGGAGTGTCGAAGGCGGCCACAGCGTTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCC
AGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGC
TGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGG
GTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCC
AATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGA
GCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACAT
TGGGCAGCACATTCTGGAAGTTTGGAGTGTCTTCATTGGCTGCTCTGGCATGGAGCTGATATCACACACGTAACAACGAGAGGTTGGACA
GCATCTCACATAGCTGCAATCAGGGGTCAGGATGCTTGTGTACAGGCTCTTATAATGAATGGAGCAAATCTGACAGCCCAGGATGACCGG
GGATGCACTCCTTTACATCTTGCTGCAACTCATGGACATTCTTTCACTTTACAAATAATGCTCCGAAGTGGAGATCCCAGTGTGACTGAT
AAGAGAGAATGGAGACCTGTGCATTATGCAGCTTTTCATGGGCGGCTTGGCTGCTTGCAACTTCTTGTTAAATGGGGTTGTAGCATAGAA
GATGTGGACTACAATGGAAACCTTCCAGTTCACTTAGCAGCCATGGAAGGCCACCTTCACTGTTTCAAATTCCTAGTCAGTAGAATGAGC
AGTGCGACGCAAGTTTTAAAAGCTTTCAATGATAATGGAGAAAATGTACTGGATTTGGCCCAGAGGTTCTTCAAGCAGAACATTTTACAG
TTTATCCAGGGGGCTGAGTATGAAGGAAAAGACCTAGAGGATCAGGAAACTTTAGCATTTCCAGGTCATGTGGCTGCCTTTAAGGGTGAT
TTGGGGATGCTTAAGAAATTAGTGGAAGATGGAGTAATCAATATTAATGAGCGTGCTGATAATGGATCAACTCCTATGCATAAAGCTGCT
GGACAAGGCCACATAGAGTGTTTGCAGTGGTTAATTAAAATGGGAGCAGACAGTAATATTACCAACAAAGCAGGGGAGAGACCCAGTGAT
GTGGCAAAGAGGTTTGCCCATTTGGCAGCAGTGAAGCTGTTAGAGGAGCTACAGAAATATGATATAGATGACGAAAATGAAATTGATGAA
AATGATGTGAAATATTTTATAAGACATGGTGTTGAGGGAAGCACTGATGCCAAGGATGATTTATGTCTGAGTGACTTGGATAAAACAGAT
GCCAGAATGAGAGCTTACAAGAAAATTGTAGAATTGAGACACCTCCTGGAAATTGCCGAGAGCAACTATAAACACTTGGGAGGCATAACA
GAAGAAGATTTAAAGCAGAAGAAAGAACAGCTTGAGTCTGAAAAGACCATCAAAGAACTGCAGGGCCAGCTGGAGTATGAACGACTACGT
AGAGAAAAATTAGAATGTCAGCTTGATGAATATCGAGCAGAAGTTGATCAACTCAGGGAAACACTGGAAAAAATTCAAGTCCCAAACTTT
GTGGCTATGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGACAAA
TCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGGTGGCC
TACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTCGCAAC
TTCTGGCGGCGGATTACCCAGGGCTTTTGCGTGGTGACCTGAGCGGCTCGGGGCGTCCCAGCGACGCGGGAAGGGGCAGGGCGCTGACCT
GCTGCTGAGCTGGCTGGGCTGGACCCGGTCCCTAGGCTGTGACCGCCGAACTCCACTGCAACAGACGGGCGCCACCAAAGCCAGGCCCTG
AGGCCTGGGAGTCCTGGACTGAGAAAGGGGGTTCCTGGGCCCACCTGCTCTGTGTAGGGCTCGTCCTGCGGTGCCCGAGAATCACTCGCT
AACCCCTATGCCCGGTCCCGGACCGACATCCTGGAGCCGCCTGTGCAGCCTGATGCCCCCTCGTGGCTGCTCCCAGGGCTGCACCTGCCA
GGACCTAATGTTCTTAGGTCCCTCTGGCCAGAACCCACACCCGGCCCCTTCCCACCTGTCATACTGGTAACTGTAACAAGAAAAACGACA

>In-frame_ENST00000260047_ENST00000308831_TCGA-AN-A0FZ-01A_ANKRD42_chr11_82959129_+_RHOD_chr11_66837896_length(amino acids)=803AA_start in transcript=150_stop in transcript=2561
MRRVSENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGD
RVSDDRSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGE
EGRCRCSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINEL
DVLHKFTPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIM
LRSGDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA
QRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI
TNKAGERPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDENDVKYFIRHGVEGSTDAKDDLCLSDLDKTDARMRAYKKIVELRHLLEIAE
SNYKHLGGITEEDLKQKKEQLESEKTIKELQGQLEYERLRREKLECQLDEYRAEVDQLRETLEKIQVPNFVAMWYPEVNHFCKKVPIIVV

--------------------------------------------------------------
>In-frame_ENST00000531895_ENST00000308831_TCGA-AN-A0FZ-01A_ANKRD42_chr11_82959129_+_RHOD_chr11_66837896_length(transcript)=2454nt_BP=1740nt
GACCGCGGCTACGCAGCCAGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGT
GAAGACGAAGGTTTCCGCTGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGC
CGCTGCAGTGGCTCGTGGGTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGC
GCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGC
ATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCAT
AAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGTGTCTTCATTGGCTGCTCTGGCATGGAGCTGATATCACACACGTA
ACAACGAGAGGTTGGACAGCATCTCACATAGCTGCAATCAGGGGTCAGGATGCTTGTGTACAGGCTCTTATAATGAATGGAGCAAATCTG
ACAGCCCAGGATGACCGGGGATGCACTCCTTTACATCTTGCTGCAACTCATGGACATTCTTTCACTTTACAAATAATGCTCCGAAGTGGA
GTGGATCCCAGTGTGACTGATAAGAGAGAATGGAGACCTGTGCATTATGCAGCTTTTCATGGGCGGCTTGGCTGCTTGCAACTTCTTGTT
AAATGGGGTTGTAGCATAGAAGATGTGGACTACAATGGAAACCTTCCAGTTCACTTAGCAGCCATGGAAGGCCACCTTCACTGTTTCAAA
TTCCTAGTCAGTAGAATGAGCAGTGCGACGCAAGTTTTAAAAGCTTTCAATGATAATGGAGAAAATGTACTGGATTTGGCCCAGAGGTTC
TTCAAGCAGAACATTTTACAGTTTATCCAGGGGGCTGAGTATGAAGGAAAAGACCTAGAGGATCAGGAAACTTTAGCATTTCCAGGTCAT
GTGGCTGCCTTTAAGGGTGATTTGGGGATGCTTAAGAAATTAGTGGAAGATGGAGTAATCAATATTAATGAGCGTGCTGATAATGGATCA
ACTCCTATGCATAAAGCTGCTGGACAAGGCCACATAGAGTGTTTGCAGTGGTTAATTAAAATGGGAGCAGACAGTAATATTACCAACAAA
GCAGGGGAGAGACCCAGTGATGTGGCAAAGAGGTTTGCCCATTTGGCAGCAGTGAAGCTGTTAGAGGAGCTACAGAAATATGATATAGAT
GACGAAAATGAAATTGATGAAAATGATGTGAAATATTTTATAAGACATGGTGTTGAGGGAAGCACTGATGCCAAGGATGATTTATGTCTG
AGTGACTTGGATAAAACAGATGCCAGAATGAGAGCTTACAAGAAAATTGTAGAATTGAGACACCTCCTGGAAATTGCCGAGAGCAACTAT
AAACACTTGGGAGGCATAACAGAAGAAGATTTAAAGCAGAAGAAAGAACAGCTTGAGTCTGAAAAGACCATCAAAGAACTGCAGGGCCAG
CTGGAGTATGAACGACTACGTAGAGAAAAATTAGAATGTCAGCTTGATGAATATCGAGCAGAAGTTGATCAACTCAGGGAAACACTGGAA
AAAATTCAAGTCCCAAACTTTGTGGCTATGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAG
ACTGACCTGTGCAAGGACAAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCG
AGGTCCGTGGGCGCGGTGGCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCC
CTCAGCAGCCGCGGTCGCAACTTCTGGCGGCGGATTACCCAGGGCTTTTGCGTGGTGACCTGAGCGGCTCGGGGCGTCCCAGCGACGCGG
GAAGGGGCAGGGCGCTGACCTGCTGCTGAGCTGGCTGGGCTGGACCCGGTCCCTAGGCTGTGACCGCCGAACTCCACTGCAACAGACGGG
CGCCACCAAAGCCAGGCCCTGAGGCCTGGGAGTCCTGGACTGAGAAAGGGGGTTCCTGGGCCCACCTGCTCTGTGTAGGGCTCGTCCTGC
GGTGCCCGAGAATCACTCGCTAACCCCTATGCCCGGTCCCGGACCGACATCCTGGAGCCGCCTGTGCAGCCTGATGCCCCCTCGTGGCTG
CTCCCAGGGCTGCACCTGCCAGGACCTAATGTTCTTAGGTCCCTCTGGCCAGAACCCACACCCGGCCCCTTCCCACCTGTCATACTGGTA

>In-frame_ENST00000531895_ENST00000308831_TCGA-AN-A0FZ-01A_ANKRD42_chr11_82959129_+_RHOD_chr11_66837896_length(amino acids)=602AA_start in transcript=234_stop in transcript=2042
MDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLH
WLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAA
FHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKD
LEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAV
KLLEELQKYDIDDENEIDENDVKYFIRHGVEGSTDAKDDLCLSDLDKTDARMRAYKKIVELRHLLEIAESNYKHLGGITEEDLKQKKEQL
ESEKTIKELQGQLEYERLRREKLECQLDEYRAEVDQLRETLEKIQVPNFVAMWYPEVNHFCKKVPIIVVGCKTDLCKDKSLVNKLRRNGL

--------------------------------------------------------------
>In-frame_ENST00000533342_ENST00000308831_TCGA-AN-A0FZ-01A_ANKRD42_chr11_82959129_+_RHOD_chr11_66837896_length(transcript)=2518nt_BP=1804nt
CTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCA
GGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCA
TTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGTGTCTTCATTGGCTGCTCTGGC
ATGGAGCTGATATCACACACGTAACAACGAGAGGTTGGACAGCATCTCACATAGCTGCAATCAGGGGTCAGGATGCTTGTGTACAGGCTC
TTATAATGAATGGAGCAAATCTGACAGCCCAGGATGACCGGGGATGCACTCCTTTACATCTTGCTGCAACTCATGGACATTCTTTCACTT
TACAAATAATGCTCCGAAGTGGAGTGGATCCCAGTGTGACTGATAAGAGAGAATGGAGACCTGTGCATTATGCAGCTTTTCATGGGCGGC
TTGGCTGCTTGCAACTTCTTGTTAAATGGGGTTGTAGCATAGAAGATGTGGACTACAATGGAAACCTTCCAGTTCACTTAGCAGCCATGG
AAGGCCACCTTCACTGTTTCAAATTCCTAGTCAGTAGAATGAGCAGTGCGACGCAAGTTTTAAAAGCTTTCAATGATAATGGAGAAAATG
TACTGGATTTGGCCCAGAGGTTCTTCAAGCAGAACATTTTACAGTTTATCCAGGGGGCTGAGTATGAAGGAAAAGACCTAGAGGATCAGG
AAACTTTAGCATTTCCAGGTCATGTGGCTGCCTTTAAGGGTGATTTGGGGATGCTTAAGAAATTAGTGGAAGATGGAGTAATCAATATTA
ATGAGCGTGCTGATAATGGATCAACTCCTATGCATAAAGCTGCTGGACAAGGCCACATAGAGTGTTTGCAGTGGTTAATTAAAATGGGAG
CAGACAGTAATATTACCAACAAAGCAGGGGAGAGACCCAGTGATGTGGCAAAGAGGTTTGCCCATTTGGCAGCAGTGAAGCTGTTAGAGG
AGCTACAGAAATATGATATAGATGACGAAAATGAAATTGATGAAAATGATGTGAAATATTTTATAAGACATGGTGTTGAGGGAAGCACTG
ATGCCAAGGATGATTTATGTCTGAGTGACTTGGATAAAACAGATGCCAGAATGAGAGCTTACAAGAAAATTGTAGAATTGAGACACCTCC
TGGAAATTGCCGAGAGCAACTATAAACACTTGGGAGGCATAACAGAAGAAGATTTAAAGCAGAAGAAAGAACAGCTTGAGTCTGAAAAGT
TGGTGTCCTTTTTAATACATTTATTTTTCTCAAGAAGTATATACAAGAGTGGCCAAGAGTACAAGCTTTGGGCTGGGGCTCTTTGGACTT
GAATCCTGGCTATAGTCTTTTTTGATTTGGGCTACTCATTTAACCTTTTTGTGCCTCAACTATAAACTGGAGATGATAACTTATACTTTC
TAGAGCTGATGACAGGATTAAAGGAATACACACACACACACACACACACACACACACACACACACACTCTATATGTAACTATAACTTTCT
AGATACATACACACATCTGTCTATCTATCTTCAAACAGCAGCCTAGTTCATAAGTATTATTGTTAACATTGTACCATAGAAGGAGAAAAT
GTTTTCATAAGTAATCAATCAGAATTCTAAGACAGCTAGAGGATATGTATATTTTAATATTCTAAATAACCAAAATAAAGTGCTTTGAAT
GGAATGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGACAAATCACT
GGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGGTGGCCTACCT
CGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTCGCAACTTCTG
GCGGCGGATTACCCAGGGCTTTTGCGTGGTGACCTGAGCGGCTCGGGGCGTCCCAGCGACGCGGGAAGGGGCAGGGCGCTGACCTGCTGC
TGAGCTGGCTGGGCTGGACCCGGTCCCTAGGCTGTGACCGCCGAACTCCACTGCAACAGACGGGCGCCACCAAAGCCAGGCCCTGAGGCC
TGGGAGTCCTGGACTGAGAAAGGGGGTTCCTGGGCCCACCTGCTCTGTGTAGGGCTCGTCCTGCGGTGCCCGAGAATCACTCGCTAACCC
CTATGCCCGGTCCCGGACCGACATCCTGGAGCCGCCTGTGCAGCCTGATGCCCCCTCGTGGCTGCTCCCAGGGCTGCACCTGCCAGGACC

>In-frame_ENST00000533342_ENST00000308831_TCGA-AN-A0FZ-01A_ANKRD42_chr11_82959129_+_RHOD_chr11_66837896_length(amino acids)=471AA_start in transcript=26_stop in transcript=1441
MPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHVT
TRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVK
WGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHV
AAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEELQKYDIDD
ENEIDENDVKYFIRHGVEGSTDAKDDLCLSDLDKTDARMRAYKKIVELRHLLEIAESNYKHLGGITEEDLKQKKEQLESEKLVSFLIHLF

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Fusion Gene PPI Analysis for ANKRD42-RHOD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD42-RHOD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD42-RHOD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource