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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD6-ZDHHC14 (FusionGDB2 ID:4888)

Fusion Gene Summary for ANKRD6-ZDHHC14

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD6-ZDHHC14
Fusion gene ID: 4888
HgeneTgene
Gene symbol

ANKRD6

ZDHHC14

Gene ID

22881

79683

Gene nameankyrin repeat domain 6zinc finger DHHC-type palmitoyltransferase 14
Synonyms-NEW1CP
Cytomap

6q15

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 6diego homologdiversinepididymis secretory sperm binding proteinprobable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger DHHC-type containing 14zinc finger, DHHC domain containing 14
Modification date2020031320200313
UniProtAcc

Q9Y2G4

.
Ensembl transtripts involved in fusion geneENST00000369408, ENST00000520886, 
ENST00000339746, ENST00000447838, 
ENST00000522441, ENST00000485637, 
ENST00000520793, 		ENST00000414563, 
ENST00000359775, ENST00000341375, 
Fusion gene scores* DoF score6 X 5 X 5=15011 X 12 X 9=1188
# samples 716
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1188*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD6 [Title/Abstract] AND ZDHHC14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD6(90276815)-ZDHHC14(158049381), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD6-ZDHHC14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZDHHC14

GO:0018345

protein palmitoylation

23034182


check buttonFusion gene breakpoints across ANKRD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZDHHC14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5304-01AANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
ChimerDB4LGGTCGA-E1-5304ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
ChimerDB4LGGTCGA-E1-5304ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
ChimerDB4LGGTCGA-E1-5304-01AANKRD6chr6

90276815

-ZDHHC14chr6

158049381

+


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Fusion Gene ORF analysis for ANKRD6-ZDHHC14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369408ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000369408ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
5CDS-3UTRENST00000369408ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
intron-3CDSENST00000520886ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
intron-3CDSENST00000520886ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
intron-3UTRENST00000520886ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000339746ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000339746ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
5CDS-3UTRENST00000339746ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000447838ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000447838ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
5CDS-3UTRENST00000447838ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000522441ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000522441ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
5CDS-3UTRENST00000522441ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000485637ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000485637ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
5CDS-3UTRENST00000485637ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000520793ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000520793ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
5CDS-3UTRENST00000520793ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049381

+
Frame-shiftENST00000369408ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000369408ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
5CDS-3UTRENST00000369408ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
intron-3CDSENST00000520886ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
intron-3CDSENST00000520886ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
intron-3UTRENST00000520886ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000339746ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000339746ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
5CDS-3UTRENST00000339746ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000447838ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000447838ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
5CDS-3UTRENST00000447838ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000522441ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000522441ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
5CDS-3UTRENST00000522441ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000485637ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000485637ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
5CDS-3UTRENST00000485637ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000520793ENST00000414563ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
Frame-shiftENST00000520793ENST00000359775ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+
5CDS-3UTRENST00000520793ENST00000341375ANKRD6chr6

90276815

+ZDHHC14chr6

158049380

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKRD6-ZDHHC14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD6chr690276815+ZDHHC14chr6158049380+0.106751960.8932481
ANKRD6chr690276815+ZDHHC14chr6158049380+0.106751960.8932481
ANKRD6chr690276815+ZDHHC14chr6158049380+0.106751960.8932481
ANKRD6chr690276815+ZDHHC14chr6158049380+0.106751960.8932481

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD6-ZDHHC14


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD6

Q9Y2G4

.
FUNCTION: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANKRD6-ZDHHC14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKRD6-ZDHHC14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD6-ZDHHC14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD6-ZDHHC14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource