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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPP-POLR2H (FusionGDB2 ID:49331)

Fusion Gene Summary for LPP-POLR2H

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP-POLR2H
Fusion gene ID: 49331
HgeneTgene
Gene symbol

LPP

POLR2H

Gene ID

4026

5437

Gene nameLIM domain containing preferred translocation partner in lipomaRNA polymerase II subunit H
Synonyms-RPABC3|RPB17|RPB8
Cytomap

3q27.3-q28

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerDNA-directed RNA polymerases I, II, and III subunit RPABC3DNA-directed RNA polymerase II subunit HDNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptideRPB8 homologpolymerase (RNA) II (DNA directed) polypeptide Hpolymerase (RNA) II subunit
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000448637, ENST00000312675, 
ENST00000543006, ENST00000471917, 
ENST00000456318, ENST00000438240, 
ENST00000460083, ENST00000430783, 
ENST00000443489, ENST00000452961, 
ENST00000296223, ENST00000429568, 
Fusion gene scores* DoF score41 X 30 X 15=184502 X 2 X 2=8
# samples 522
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LPP [Title/Abstract] AND POLR2H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPP(188590551)-POLR2H(184085964), # samples:1
Anticipated loss of major functional domain due to fusion event.LPP-POLR2H seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
LPP-POLR2H seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LPP-POLR2H seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LPP-POLR2H seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLR2H

GO:0006366

transcription by RNA polymerase II

9852112


check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across POLR2H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1495LPPchr3

188590551

+POLR2Hchr3

184085964

+


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Fusion Gene ORF analysis for LPP-POLR2H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000448637ENST00000456318LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-3CDSENST00000448637ENST00000438240LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000448637ENST00000460083LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000448637ENST00000430783LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000448637ENST00000443489LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000448637ENST00000452961LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000448637ENST00000296223LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000448637ENST00000429568LPPchr3

188590551

+POLR2Hchr3

184085964

+
In-frameENST00000312675ENST00000456318LPPchr3

188590551

+POLR2Hchr3

184085964

+
Frame-shiftENST00000312675ENST00000438240LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000312675ENST00000460083LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000312675ENST00000430783LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000312675ENST00000443489LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000312675ENST00000452961LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000312675ENST00000296223LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000312675ENST00000429568LPPchr3

188590551

+POLR2Hchr3

184085964

+
In-frameENST00000543006ENST00000456318LPPchr3

188590551

+POLR2Hchr3

184085964

+
Frame-shiftENST00000543006ENST00000438240LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000543006ENST00000460083LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000543006ENST00000430783LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000543006ENST00000443489LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000543006ENST00000452961LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000543006ENST00000296223LPPchr3

188590551

+POLR2Hchr3

184085964

+
5CDS-intronENST00000543006ENST00000429568LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-3CDSENST00000471917ENST00000456318LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-3CDSENST00000471917ENST00000438240LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000471917ENST00000460083LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000471917ENST00000430783LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000471917ENST00000443489LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000471917ENST00000452961LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000471917ENST00000296223LPPchr3

188590551

+POLR2Hchr3

184085964

+
intron-intronENST00000471917ENST00000429568LPPchr3

188590551

+POLR2Hchr3

184085964

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312675LPPchr3188590551+ENST00000456318POLR2Hchr3184085964+237419561232084653
ENST00000543006LPPchr3188590551+ENST00000456318POLR2Hchr3184085964+2317189992027672

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312675ENST00000456318LPPchr3188590551+POLR2Hchr3184085964+0.0088136660.9911863
ENST00000543006ENST00000456318LPPchr3188590551+POLR2Hchr3184085964+0.0120783110.98792166

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Fusion Genomic Features for LPP-POLR2H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LPPchr3188590551+POLR2Hchr3184085964+0.344652680.6553473
LPPchr3188590551+POLR2Hchr3184085964+0.344652680.6553473

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPP-POLR2H


check button Go to

FGviewer for the breakpoints of chr3:188590551-chr3:184085964

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188590551chr3:184085964ENST00000312675+101141_370570.0613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188590551chr3:184085964ENST00000543006+101141_370570.0613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188590551chr3:184085964ENST00000312675+1011414_473570.0613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188590551chr3:184085964ENST00000312675+1011474_534570.0613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188590551chr3:184085964ENST00000543006+1011414_473570.0613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188590551chr3:184085964ENST00000543006+1011474_534570.0613.0DomainLIM zinc-binding 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188590551chr3:184085964ENST00000312675+1011535_603570.0613.0DomainLIM zinc-binding 3
HgeneLPPchr3:188590551chr3:184085964ENST00000543006+1011535_603570.0613.0DomainLIM zinc-binding 3
TgenePOLR2Hchr3:188590551chr3:184085964ENST000002962233516_40111.66666666666667151.0RegionNote=Non-specific ssDNA binding
TgenePOLR2Hchr3:188590551chr3:184085964ENST000004563184616_40111.66666666666667151.0RegionNote=Non-specific ssDNA binding


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Fusion Gene Sequence for LPP-POLR2H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000312675_ENST00000456318_TCGA-13-1495_LPP_chr3_188590551_+_POLR2H_chr3_184085964_length(transcript)=2374nt_BP=1956nt
GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA
TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT
GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA
CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA
CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT
CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT
TTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTG
GCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTC
ACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCT
GGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGG
CCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCC
CAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCA
CCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGG
GGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGG
AACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTG
CAGCCAAAGGGTGGCCATTCAGGGCAACTGGGGCCTTCGTCAGTTGCCCCTTCATTCCGCCCAGAGGATGAGCTTGAGCACCTGACCAAA
AAGATGCTGTATGACATGGAAAATCCACCTGCTGACGAATACTTTGGCCGCTGTGCTCGCTGTGGAGAAAACGTAGTTGGGGAAGGTACA
GGATGCACTGCCATGGATCAGGTCTTCCACGTGGATTGTTTTACCTGCATCATCTGCAACAACAAGCTCCGAGGGCAGCCATTCTATGCT
GTGGAAAAGAAAGCATACTGCGAGCCCTGCTACATTAATACTCTGGAGCAGTGCAATGTGTGTTCCAAGCCCATCATGGAGCGGATTCTC
CGAGCCACCGGGAAGGCCTATCATCCTCACTGTTTCACCTGCGTGATGTGCCACCGCAGCCTGGATGGGATCCCATTCACTGTGGATGCT
GGCGGGCTCATTCACTGCATTGAGGACTTCCACAAGAAATTTGCCCCGCGATGTTCTGTGTGCAAGGAGCCTATTATGCCAGCCCCGGGC
CAGGAGGAGACTGTCCGTATTGTGGCTTTGGATCGAGATTTCCATGTTCACTGCTACCGATGCGAGCTCTGCGTACGTGTCCTATGGGGG
CCTGCTCATGAGGCTGCAGGGGGATGCCAACAACCTGCATGGATTCGAGGTGGACTCCAGAGTTTATCTCCTGATGAAGAAGCTAGCCTT
CTGAACCTCGCCTGAAGCCAGCCTCTCTGCCAAGTCACTCAGGTCATGGGCATTGTTCAAGCCTGAGTGGCAGCCGCTCTTGCTCACCTG
TTGAGGAAGGGCTGGCTCACTGTCCACCGTGGCGGCATCTTTAACTGGCCTCCACTCAATGGGAAACTGACTCGCCTGTGAAAGACACAG
TGGGAGAGCTGAAAATGAATCAGAAGCTTTATGTATATGATTTTTAAATTAAACTTTACTTTTTCAGACTGCCCCTCCCCTTTTTGTAAA

>In-frame_ENST00000312675_ENST00000456318_TCGA-13-1495_LPP_chr3_188590551_+_POLR2H_chr3_184085964_length(amino acids)=653AA_start in transcript=123_stop in transcript=2084
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPA
DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHC
FTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCELCVRVLWGPAHEAAGGCQQ

--------------------------------------------------------------
>In-frame_ENST00000543006_ENST00000456318_TCGA-13-1495_LPP_chr3_188590551_+_POLR2H_chr3_184085964_length(transcript)=2317nt_BP=1899nt
GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC
GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG
ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT
TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA
TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC
TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTG
GACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGT
TCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAG
TCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCA
GCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCC
CCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACA
CGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTAT
GAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAA
CGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACA
GATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGGGTGGCCATTCAGGGCAACTGGGGCCTTCGTCAGTTGCCCCTTCATTC
CGCCCAGAGGATGAGCTTGAGCACCTGACCAAAAAGATGCTGTATGACATGGAAAATCCACCTGCTGACGAATACTTTGGCCGCTGTGCT
CGCTGTGGAGAAAACGTAGTTGGGGAAGGTACAGGATGCACTGCCATGGATCAGGTCTTCCACGTGGATTGTTTTACCTGCATCATCTGC
AACAACAAGCTCCGAGGGCAGCCATTCTATGCTGTGGAAAAGAAAGCATACTGCGAGCCCTGCTACATTAATACTCTGGAGCAGTGCAAT
GTGTGTTCCAAGCCCATCATGGAGCGGATTCTCCGAGCCACCGGGAAGGCCTATCATCCTCACTGTTTCACCTGCGTGATGTGCCACCGC
AGCCTGGATGGGATCCCATTCACTGTGGATGCTGGCGGGCTCATTCACTGCATTGAGGACTTCCACAAGAAATTTGCCCCGCGATGTTCT
GTGTGCAAGGAGCCTATTATGCCAGCCCCGGGCCAGGAGGAGACTGTCCGTATTGTGGCTTTGGATCGAGATTTCCATGTTCACTGCTAC
CGATGCGAGCTCTGCGTACGTGTCCTATGGGGGCCTGCTCATGAGGCTGCAGGGGGATGCCAACAACCTGCATGGATTCGAGGTGGACTC
CAGAGTTTATCTCCTGATGAAGAAGCTAGCCTTCTGAACCTCGCCTGAAGCCAGCCTCTCTGCCAAGTCACTCAGGTCATGGGCATTGTT
CAAGCCTGAGTGGCAGCCGCTCTTGCTCACCTGTTGAGGAAGGGCTGGCTCACTGTCCACCGTGGCGGCATCTTTAACTGGCCTCCACTC
AATGGGAAACTGACTCGCCTGTGAAAGACACAGTGGGAGAGCTGAAAATGAATCAGAAGCTTTATGTATATGATTTTTAAATTAAACTTT

>In-frame_ENST00000543006_ENST00000456318_TCGA-13-1495_LPP_chr3_188590551_+_POLR2H_chr3_184085964_length(amino acids)=672AA_start in transcript=9_stop in transcript=2027
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE
DELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCS
KPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LPP-POLR2H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPP-POLR2H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPP-POLR2H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPPC0087031Juvenile-Onset Still Disease1CTD_human
HgeneLPPC3495559Juvenile arthritis1CTD_human
HgeneLPPC3714758Juvenile psoriatic arthritis1CTD_human
HgeneLPPC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneLPPC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human