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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANLN-DGKB (FusionGDB2 ID:4937)

Fusion Gene Summary for ANLN-DGKB

check button Fusion gene summary
Fusion gene informationFusion gene name: ANLN-DGKB
Fusion gene ID: 4937
HgeneTgene
Gene symbol

ANLN

DGKB

Gene ID

54443

1607

Gene nameanillin actin binding proteindiacylglycerol kinase beta
SynonymsFSGS8|Scraps|scraDAGK2|DGK|DGK-BETA
Cytomap

7p14.2

7p21.2

Type of geneprotein-codingprotein-coding
Descriptionanillindiacylglycerol kinase beta90 kDa diacylglycerol kinaseDAG kinase betadiacylglycerol kinase, beta 90kDadiglyceride kinase beta
Modification date2020031320200313
UniProtAcc.

Q9Y6T7

Ensembl transtripts involved in fusion geneENST00000265748, ENST00000396068, 
ENST00000495714, 		ENST00000399322, 
ENST00000258767, ENST00000403951, 
ENST00000402815, ENST00000407950, 
ENST00000444700, ENST00000406247, 
ENST00000403963, 
Fusion gene scores* DoF score6 X 8 X 7=33619 X 16 X 9=2736
# samples 1019
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2736*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANLN [Title/Abstract] AND DGKB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANLN(36436028)-DGKB(14517850), # samples:3
Anticipated loss of major functional domain due to fusion event.ANLN-DGKB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANLN-DGKB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANLN

GO:0000281

mitotic cytokinesis

10931866

TgeneDGKB

GO:0046486

glycerolipid metabolic process

22627129

TgeneDGKB

GO:0046834

lipid phosphorylation

22627129


check buttonFusion gene breakpoints across ANLN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DGKB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-QQ-A5VA-01AANLNchr7

36436028

+DGKBchr7

14517850

-
ChimerDB4SARCTCGA-QQ-A5VAANLNchr7

36436028

+DGKBchr7

14517850

-
ChimerDB4SARCTCGA-QQ-A5VA-01AANLNchr7

36436028

-DGKBchr7

14517850

-


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Fusion Gene ORF analysis for ANLN-DGKB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265748ENST00000399322ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000265748ENST00000258767ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000265748ENST00000403951ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000265748ENST00000402815ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000265748ENST00000407950ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000265748ENST00000444700ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000265748ENST00000406247ANLNchr7

36436028

+DGKBchr7

14517850

-
5CDS-5UTRENST00000265748ENST00000403963ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000399322ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000258767ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000403951ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000402815ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000407950ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000444700ANLNchr7

36436028

+DGKBchr7

14517850

-
Frame-shiftENST00000396068ENST00000406247ANLNchr7

36436028

+DGKBchr7

14517850

-
5CDS-5UTRENST00000396068ENST00000403963ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000399322ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000258767ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000403951ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000402815ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000407950ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000444700ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-3CDSENST00000495714ENST00000406247ANLNchr7

36436028

+DGKBchr7

14517850

-
intron-5UTRENST00000495714ENST00000403963ANLNchr7

36436028

+DGKBchr7

14517850

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANLN-DGKB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANLN-DGKB


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DGKB

Q9Y6T7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANLN-DGKB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANLN-DGKB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANLN-DGKB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANLN-DGKB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANLNC4014993FOCAL SEGMENTAL GLOMERULOSCLEROSIS 82GENOMICS_ENGLAND;UNIPROT
HgeneANLNC0032460Polycystic Ovary Syndrome1CTD_human
HgeneANLNC1136382Sclerocystic Ovaries1CTD_human
HgeneANLNC1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneANLNC2239176Liver carcinoma1CTD_human
TgeneDGKBC0004238Atrial Fibrillation2CTD_human
TgeneDGKBC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneDGKBC2585653Persistent atrial fibrillation2CTD_human
TgeneDGKBC3468561familial atrial fibrillation2CTD_human
TgeneDGKBC0005586Bipolar Disorder1PSYGENET
TgeneDGKBC0011570Mental Depression1PSYGENET
TgeneDGKBC0011581Depressive disorder1PSYGENET