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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LRP1-ATP5B (FusionGDB2 ID:49455) |
Fusion Gene Summary for LRP1-ATP5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1-ATP5B | Fusion gene ID: 49455 | Hgene | Tgene | Gene symbol | LRP1 | ATP5B | Gene ID | 10438 | 506 |
| Gene name | C1D nuclear receptor corepressor | ATP synthase F1 subunit beta | |
| Synonyms | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | ATP5B|ATPMB|ATPSB|HEL-S-271 | |
| Cytomap | 2p14 | 12q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | ATP synthase subunit beta, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideepididymis secretory protein Li 271mitochondrial ATP synthase beta subunitmitochondrial ATP synthetase, beta subunit | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q07954 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000553277, ENST00000243077, ENST00000338962, ENST00000554174, ENST00000553446, | ENST00000262030, ENST00000552919, ENST00000550162, | |
| Fusion gene scores | * DoF score | 23 X 27 X 12=7452 | 9 X 10 X 4=360 |
| # samples | 26 | 11 | |
| ** MAII score | log2(26/7452*10)=-4.84104414591318 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRP1 [Title/Abstract] AND ATP5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LRP1(57550703)-ATP5B(57037371), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATP5B | GO:0042776 | mitochondrial ATP synthesis coupled proton transport | 12110673 |
| Fusion gene breakpoints across LRP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ATP5B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 179N | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
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Fusion Gene ORF analysis for LRP1-ATP5B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000553277 | ENST00000262030 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000553277 | ENST00000552919 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-intron | ENST00000553277 | ENST00000550162 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| In-frame | ENST00000243077 | ENST00000262030 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| In-frame | ENST00000243077 | ENST00000552919 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| 5CDS-intron | ENST00000243077 | ENST00000550162 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000338962 | ENST00000262030 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000338962 | ENST00000552919 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-intron | ENST00000338962 | ENST00000550162 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000554174 | ENST00000262030 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000554174 | ENST00000552919 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-intron | ENST00000554174 | ENST00000550162 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000553446 | ENST00000262030 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-3CDS | ENST00000553446 | ENST00000552919 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| intron-intron | ENST00000553446 | ENST00000550162 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000243077 | LRP1 | chr12 | 57550703 | + | ENST00000262030 | ATP5B | chr12 | 57037371 | - | 3158 | 2027 | 442 | 3009 | 855 |
| ENST00000243077 | LRP1 | chr12 | 57550703 | + | ENST00000552919 | ATP5B | chr12 | 57037371 | - | 3096 | 2027 | 442 | 2976 | 844 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000243077 | ENST00000262030 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - | 0.00296043 | 0.9970395 |
| ENST00000243077 | ENST00000552919 | LRP1 | chr12 | 57550703 | + | ATP5B | chr12 | 57037371 | - | 0.003755385 | 0.9962446 |
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Fusion Genomic Features for LRP1-ATP5B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LRP1-ATP5B |
| Go to FGviewer for the breakpoints of chr12:57550703-chr12:57037371 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1 | . |
| FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178}.; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 111_149 | 520.3333333333334 | 4545.0 | Domain | EGF-like 1 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 150_189 | 520.3333333333334 | 4545.0 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 25_66 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 1 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 474_520 | 520.3333333333334 | 4545.0 | Domain | EGF-like 3 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 70_110 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 2 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 292_334 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 335_378 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 379_422 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 3 |
| Tgene | ATP5B | chr12:57550703 | chr12:57037371 | ENST00000262030 | 3 | 10 | 207_214 | 202.33333333333334 | 530.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1013_1053 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 7 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1060_1099 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 8 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1102_1142 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 9 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1143_1182 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 10 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1183_1222 | 520.3333333333334 | 4545.0 | Domain | EGF-like 5 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1223_1262 | 520.3333333333334 | 4545.0 | Domain | EGF-like 6 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1536_1579 | 520.3333333333334 | 4545.0 | Domain | EGF-like 7 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1846_1887 | 520.3333333333334 | 4545.0 | Domain | EGF-like 8 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2155_2195 | 520.3333333333334 | 4545.0 | Domain | EGF-like 9 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2478_2518 | 520.3333333333334 | 4545.0 | Domain | EGF-like 10 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2522_2563 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 11 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2564_2602 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 12 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2603_2641 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 13 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2642_2690 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 14 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2694_2732 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 15 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2732_2771 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 16 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2772_2814 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 17 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2816_2855 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 18 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2856_2899 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 19 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2902_2940 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 20 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2941_2981 | 520.3333333333334 | 4545.0 | Domain | EGF-like 11 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2982_3022 | 520.3333333333334 | 4545.0 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3290_3331 | 520.3333333333334 | 4545.0 | Domain | EGF-like 13 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3332_3371 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 21 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3372_3410 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 22 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3411_3450 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 23 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3451_3491 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 24 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3492_3533 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 25 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3534_3572 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 26 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3573_3611 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 27 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3611_3649 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 28 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3652_3692 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 29 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3693_3733 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 30 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3739_3778 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 31 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3781_3823 | 520.3333333333334 | 4545.0 | Domain | EGF-like 14 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3824_3861 | 520.3333333333334 | 4545.0 | Domain | EGF-like 15 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4147_4183 | 520.3333333333334 | 4545.0 | Domain | EGF-like 16 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4196_4232 | 520.3333333333334 | 4545.0 | Domain | EGF-like 17 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4232_4268 | 520.3333333333334 | 4545.0 | Domain | EGF-like 18 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4268_4304 | 520.3333333333334 | 4545.0 | Domain | EGF-like 19 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4304_4340 | 520.3333333333334 | 4545.0 | Domain | EGF-like 20 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4340_4375 | 520.3333333333334 | 4545.0 | Domain | EGF-like 21 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4373_4409 | 520.3333333333334 | 4545.0 | Domain | EGF-like 22 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 803_843 | 520.3333333333334 | 4545.0 | Domain | EGF-like 4 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 852_892 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 3 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 893_933 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 4 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 934_973 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 5 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 974_1013 | 520.3333333333334 | 4545.0 | Domain | LDL-receptor class A 6 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3940_3943 | 520.3333333333334 | 4545.0 | Motif | Recognition site for proteolytical processing |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4502_4507 | 520.3333333333334 | 4545.0 | Motif | Note=NPXY motif |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1309_1355 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1356_1398 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1399_1445 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1446_1490 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1491_1531 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1627_1669 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1670_1713 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1714_1753 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1754_1798 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1934_1976 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 1977_2019 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 18 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2020_2063 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2064_2107 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2253_2294 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 21 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2295_2343 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 22 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2344_2388 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 23 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2389_2431 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 24 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 2432_2473 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 25 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3069_3113 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 26 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3114_3156 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 27 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3157_3200 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 28 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3201_3243 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 29 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3244_3284 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 30 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3912_3954 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 31 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 3970_4012 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 32 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4013_4056 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 33 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4057_4101 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 34 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 571_613 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 614_659 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 660_710 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 711_754 | 520.3333333333334 | 4545.0 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 20_4419 | 520.3333333333334 | 4545.0 | Topological domain | Extracellular |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4420_4444 | 520.3333333333334 | 4545.0 | Transmembrane | Helical |
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Fusion Gene Sequence for LRP1-ATP5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000243077_ENST00000262030_179N_LRP1_chr12_57550703_+_ATP5B_chr12_57037371_length(transcript)=3158nt_BP=2027nt CAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGCTCCCCT ACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCTGTGAGC TTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGT CAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAG GAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCT TGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAA GACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGA CGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTG TGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTG CTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGG CAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTG TGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAA CTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTT CAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAA GGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACGTGGAACAGATGGCCATCGACTGGCTGACAGGCAACTTCTA CTTTGTGGATGACATCGATGATAGGATCTTTGTCTGCAACAGAAATGGGGACACATGTGTCACATTGCTAGACCTGGAACTCTACAACCC CAAGGGCATTGCCCTGGACCCTGCCATGGGGAAGGTGTTTTTCACTGACTATGGGCAGATCCCAAAGGTGGAACGCTGTGACATGGATGG GCAGAACCGCACCAAGCTCGTCGACAGCAAGATTGTGTTTCCTCATGGCATCACGCTGGACCTGGTCAGCCGCCTTGTCTACTGGGCAGA TGCCTATCTGGACTATATTGAAGTGGTGGACTATGAGGGCAAGGGCCGCCAGACCATCATCCAGGGCATCCTGATTGAGCACCTGTACGG CCTGACTGTGTTTGAGAATTATCTCTATGCCACCAACTCGGACAATGCCAATGCCCAGCAGAAGACGAGTGTGATCCGTGTGAACCGCTT TAACAGCACCGAGTACCAGGTTGTCACCCGGGTGGACAAGGGTGGTGCCCTCCACATCTACCACCAGAGGCGTCAGCCCCGAGTGAGGAG CCATGCCTGTGAAAACGACCAGTATGGGAAGCCGGGTGGCTGCTCTGACATCTGCCTGCTGGCCAACAGCCACAAGGCGCGGACCTGCCG CTGCCGTTCCGGCTTCAGCCTGGGCAGTGACGGGAAGTCATGCAAGAGGCTTTTTGGTGGTGCTGGAGTTGGCAAGACTGTACTGATCAT GGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATA CCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTAGCGCTGGTATATGGTCAAATGAATGAACCACCTGG TGCTCGTGCCCGGGTAGCTCTGACTGGGCTGACTGTGGCTGAATACTTCAGAGACCAAGAAGGTCAAGATGTACTGCTATTTATTGATAA CATCTTTCGCTTCACCCAGGCTGGTTCAGAGGTGTCTGCATTATTGGGCCGAATCCCTTCTGCTGTGGGCTATCAGCCTACCCTGGCCAC TGACATGGGTACTATGCAGGAAAGAATTACCACTACCAAGAAGGGATCTATCACCTCTGTACAGGCTATCTATGTGCCTGCTGATGACTT GACTGACCCTGCCCCTGCTACTACGTTTGCCCATTTGGATGCTACCACTGTACTGTCGCGTGCCATTGCTGAGCTGGGCATCTATCCAGC TGTGGATCCTCTAGACTCCACCTCTCGTATCATGGATCCCAACATTGTTGGCAGTGAGCATTACGATGTTGCCCGTGGGGTGCAAAAGAT CCTGCAGGACTACAAATCCCTCCAGGATATCATTGCCATCCTGGGTATGGATGAACTTTCTGAGGAAGACAAGTTGACCGTGTCCCGTGC ACGGAAAATACAGCGTTTCTTGTCTCAGCCATTCCAGGTTGCTGAGGTCTTCACAGGTCATATGGGGAAGCTGGTACCCCTGAAGGAGAC CATCAAAGGATTCCAGCAGATTTTGGCAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGT GGCAAAAGCTGATAAGCTGGCTGAAGAGCATTCATCGTGAGGGGTCTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAG CTTCATTTTTCTGTGTAGGCTGCACAAGAGCCTTGATTGAAGATATATTCTTTCTGAACAGTATTTAAGGTTTCCAATAAAATGTACACC >In-frame_ENST00000243077_ENST00000262030_179N_LRP1_chr12_57550703_+_ATP5B_chr12_57037371_length(amino acids)=855AA_start in transcript=442_stop in transcript=3009 MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKRLFGGAGVGKTV LIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLF IDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGI YPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPL -------------------------------------------------------------- >In-frame_ENST00000243077_ENST00000552919_179N_LRP1_chr12_57550703_+_ATP5B_chr12_57037371_length(transcript)=3096nt_BP=2027nt CAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGCTCCCCT ACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCTGTGAGC TTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGT CAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAG GAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCT TGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAA GACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGA CGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTG TGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTG CTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGG CAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTG TGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAA CTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTT CAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAA GGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACGTGGAACAGATGGCCATCGACTGGCTGACAGGCAACTTCTA CTTTGTGGATGACATCGATGATAGGATCTTTGTCTGCAACAGAAATGGGGACACATGTGTCACATTGCTAGACCTGGAACTCTACAACCC CAAGGGCATTGCCCTGGACCCTGCCATGGGGAAGGTGTTTTTCACTGACTATGGGCAGATCCCAAAGGTGGAACGCTGTGACATGGATGG GCAGAACCGCACCAAGCTCGTCGACAGCAAGATTGTGTTTCCTCATGGCATCACGCTGGACCTGGTCAGCCGCCTTGTCTACTGGGCAGA TGCCTATCTGGACTATATTGAAGTGGTGGACTATGAGGGCAAGGGCCGCCAGACCATCATCCAGGGCATCCTGATTGAGCACCTGTACGG CCTGACTGTGTTTGAGAATTATCTCTATGCCACCAACTCGGACAATGCCAATGCCCAGCAGAAGACGAGTGTGATCCGTGTGAACCGCTT TAACAGCACCGAGTACCAGGTTGTCACCCGGGTGGACAAGGGTGGTGCCCTCCACATCTACCACCAGAGGCGTCAGCCCCGAGTGAGGAG CCATGCCTGTGAAAACGACCAGTATGGGAAGCCGGGTGGCTGCTCTGACATCTGCCTGCTGGCCAACAGCCACAAGGCGCGGACCTGCCG CTGCCGTTCCGGCTTCAGCCTGGGCAGTGACGGGAAGTCATGCAAGAGGCTTTTTGGTGGTGCTGGAGTTGGCAAGACTGTACTGATCAT GGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATA CCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTAGCGCTGGTATATGGTCAAATGAATGAACCACCTGG TGCTCGTGCCCGGGTAGCTCTGACTGGGCTGACTGTGGCTGAATACTTCAGAGACCAAGAAGGTCAAGATGTACTGCTATTTATTGATGT GTCTGCATTATTGGGCCGAATCCCTTCTGCTGTGGGCTATCAGCCTACCCTGGCCACTGACATGGGTACTATGCAGGAAAGAATTACCAC TACCAAGAAGGGATCTATCACCTCTGTACAGGCTATCTATGTGCCTGCTGATGACTTGACTGACCCTGCCCCTGCTACTACGTTTGCCCA TTTGGATGCTACCACTGTACTGTCGCGTGCCATTGCTGAGCTGGGCATCTATCCAGCTGTGGATCCTCTAGACTCCACCTCTCGTATCAT GGATCCCAACATTGTTGGCAGTGAGCATTACGATGTTGCCCGTGGGGTGCAAAAGATCCTGCAGGACTACAAATCCCTCCAGGATATCAT TGCCATCCTGGGTATGGATGAACTTTCTGAGGAAGACAAGTTGACCGTGTCCCGTGCACGGAAAATACAGCGTTTCTTGTCTCAGCCATT CCAGGTTGCTGAGGTCTTCACAGGTCATATGGGGAAGCTGGTACCCCTGAAGGAGACCATCAAAGGATTCCAGCAGATTTTGGCAGGTGA ATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGAAGAGCATTC ATCGTGAGGGGTCTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTTTCTGTGTAGGCTGCACAAGAGCCT >In-frame_ENST00000243077_ENST00000552919_179N_LRP1_chr12_57550703_+_ATP5B_chr12_57037371_length(amino acids)=844AA_start in transcript=442_stop in transcript=2976 MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKRLFGGAGVGKTV LIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLF IDVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTS RIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQIL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LRP1-ATP5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LRP1 | chr12:57550703 | chr12:57037371 | ENST00000243077 | + | 10 | 89 | 4445_4544 | 520.3333333333334 | 4545.0 | MAFB |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LRP1-ATP5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Biotech | Approved | |
| Hgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Biotech | Approved | |
| Hgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Biotech | Approved | |
| Hgene | LRP1 | Q07954 | DB13152 | Coagulation Factor IX Human | Biotech | Approved | |
| Hgene | LRP1 | Q07954 | DB13152 | Coagulation Factor IX Human | Biotech | Approved | |
| Hgene | LRP1 | Q07954 | DB13152 | Coagulation Factor IX Human | Biotech | Approved | |
| Hgene | LRP1 | Q07954 | DB13999 | Moroctocog alfa | Modulator | Biotech | Approved |
| Hgene | LRP1 | Q07954 | DB13999 | Moroctocog alfa | Modulator | Biotech | Approved |
| Hgene | LRP1 | Q07954 | DB13999 | Moroctocog alfa | Modulator | Biotech | Approved |
| Hgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Modulator | Biotech | Approved|Investigational |
| Hgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Modulator | Biotech | Approved|Investigational |
| Hgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Modulator | Biotech | Approved|Investigational |
| Hgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Biotech | Approved|Investigational | |
| Hgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Biotech | Approved|Investigational | |
| Hgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Biotech | Approved|Investigational | |
| Hgene | LRP1 | Q07954 | DB13998 | Lonoctocog alfa | Modulator | Biotech | Approved|Investigational |
| Hgene | LRP1 | Q07954 | DB13998 | Lonoctocog alfa | Modulator | Biotech | Approved|Investigational |
| Hgene | LRP1 | Q07954 | DB13998 | Lonoctocog alfa | Modulator | Biotech | Approved|Investigational |
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Related Diseases for LRP1-ATP5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRP1 | C0007852 | Cervical Migraine Syndrome | 1 | CTD_human |
| Hgene | LRP1 | C0018984 | Hemicrania migraine | 1 | CTD_human |
| Hgene | LRP1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | LRP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | LRP1 | C0149931 | Migraine Disorders | 1 | CTD_human |
| Hgene | LRP1 | C0263428 | Burnett Schwartz Berberian syndrome | 1 | CTD_human;UNIPROT |
| Hgene | LRP1 | C0263429 | Atrophoderma vermiculatum | 1 | ORPHANET |
| Hgene | LRP1 | C0270858 | Abdominal Migraine | 1 | CTD_human |
| Hgene | LRP1 | C0338480 | Common Migraine | 1 | CTD_human |
| Hgene | LRP1 | C0338489 | Status Migrainosus | 1 | CTD_human |
| Hgene | LRP1 | C0343057 | Keratosis pilaris decalvans | 1 | ORPHANET |
| Hgene | LRP1 | C0521664 | Acute Confusional Migraine | 1 | CTD_human |
| Hgene | LRP1 | C0700438 | Sick Headaches | 1 | CTD_human |
| Hgene | LRP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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