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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRP6-LRRC23 (FusionGDB2 ID:49581)

Fusion Gene Summary for LRP6-LRRC23

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP6-LRRC23
Fusion gene ID: 49581
HgeneTgene
Gene symbol

LRP6

LRRC23

Gene ID

4040

10233

Gene nameLDL receptor related protein 6leucine rich repeat containing 23
SynonymsADCAD2|STHAG7LRPB7
Cytomap

12p13.2

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 6LRP-6leucine-rich repeat-containing protein 23leucine-rich protein B7
Modification date2020032920200313
UniProtAcc.

Q53EV4

Ensembl transtripts involved in fusion geneENST00000261349, ENST00000543091, 
ENST00000540415, 		ENST00000433346, 
ENST00000449039, ENST00000007969, 
ENST00000323702, ENST00000443597, 
ENST00000436789, ENST00000429740, 
Fusion gene scores* DoF score13 X 12 X 8=12487 X 7 X 7=343
# samples 1810
** MAII scorelog2(18/1248*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/343*10)=-1.77820857639809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP6 [Title/Abstract] AND LRRC23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRP6(12397196)-LRRC23(7014749), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP6

GO:0014029

neural crest formation

11029007

HgeneLRP6

GO:0014033

neural crest cell differentiation

11029007

HgeneLRP6

GO:0016055

Wnt signaling pathway

11357136

HgeneLRP6

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

HgeneLRP6

GO:0051091

positive regulation of DNA-binding transcription factor activity

14739301

HgeneLRP6

GO:0060070

canonical Wnt signaling pathway

11448771|11742004|12121999|14739301|15271658|15908424|16263759|16543246|17239604|19107203|20059949|20093106|20137080

HgeneLRP6

GO:0071901

negative regulation of protein serine/threonine kinase activity

19107203


check buttonFusion gene breakpoints across LRP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LRRC23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-S6-A8JY-01ALRP6chr12

12397196

-LRRC23chr12

7014749

+
ChimerDB4TGCTTCGA-S6-A8JYLRP6chr12

12397195

-LRRC23chr12

7015572

+
ChimerDB4TGCTTCGA-S6-A8JYLRP6chr12

12397196

-LRRC23chr12

7014749

+
ChimerDB4TGCTTCGA-S6-A8JYLRP6chr12

12397196

-LRRC23chr12

7013796

+
ChimerDB4TGCTTCGA-S6-A8JY-01ALRP6chr12

12397196

-LRRC23chr12

7014749

+


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Fusion Gene ORF analysis for LRP6-LRRC23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261349ENST00000433346LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-3UTRENST00000261349ENST00000449039LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000261349ENST00000007969LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000261349ENST00000323702LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000261349ENST00000443597LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000261349ENST00000436789LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-intronENST00000261349ENST00000429740LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000543091ENST00000433346LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-3UTRENST00000543091ENST00000449039LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000543091ENST00000007969LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000543091ENST00000323702LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000543091ENST00000443597LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-5UTRENST00000543091ENST00000436789LRP6chr12

12397196

-LRRC23chr12

7014749

+
5CDS-intronENST00000543091ENST00000429740LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-5UTRENST00000540415ENST00000433346LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-3UTRENST00000540415ENST00000449039LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-5UTRENST00000540415ENST00000007969LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-5UTRENST00000540415ENST00000323702LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-5UTRENST00000540415ENST00000443597LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-5UTRENST00000540415ENST00000436789LRP6chr12

12397196

-LRRC23chr12

7014749

+
intron-intronENST00000540415ENST00000429740LRP6chr12

12397196

-LRRC23chr12

7014749

+
In-frameENST00000261349ENST00000433346LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000261349ENST00000449039LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000261349ENST00000007969LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000261349ENST00000323702LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000261349ENST00000443597LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000261349ENST00000436789LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000261349ENST00000429740LRP6chr12

12397195

-LRRC23chr12

7015572

+
In-frameENST00000543091ENST00000433346LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000543091ENST00000449039LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000543091ENST00000007969LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000543091ENST00000323702LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000543091ENST00000443597LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000543091ENST00000436789LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-3UTRENST00000543091ENST00000429740LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3CDSENST00000540415ENST00000433346LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3UTRENST00000540415ENST00000449039LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3UTRENST00000540415ENST00000007969LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3UTRENST00000540415ENST00000323702LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3UTRENST00000540415ENST00000443597LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3UTRENST00000540415ENST00000436789LRP6chr12

12397195

-LRRC23chr12

7015572

+
intron-3UTRENST00000540415ENST00000429740LRP6chr12

12397195

-LRRC23chr12

7015572

+
5CDS-intronENST00000261349ENST00000433346LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000261349ENST00000449039LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000261349ENST00000007969LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000261349ENST00000323702LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000261349ENST00000443597LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000261349ENST00000436789LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000261349ENST00000429740LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000433346LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000449039LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000007969LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000323702LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000443597LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000436789LRP6chr12

12397196

-LRRC23chr12

7013796

+
5CDS-intronENST00000543091ENST00000429740LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000433346LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000449039LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000007969LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000323702LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000443597LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000436789LRP6chr12

12397196

-LRRC23chr12

7013796

+
intron-intronENST00000540415ENST00000429740LRP6chr12

12397196

-LRRC23chr12

7013796

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261349LRP6chr1212397195-ENST00000433346LRRC23chr127015572+119952677982301
ENST00000543091LRP6chr1212397195-ENST00000433346LRRC23chr127015572+115648334939301

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261349ENST00000433346LRP6chr1212397195-LRRC23chr127015572+0.0012473420.9987526
ENST00000543091ENST00000433346LRP6chr1212397195-LRRC23chr127015572+0.0010095380.9989905

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Fusion Genomic Features for LRP6-LRRC23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRP6chr1212397195-LRRC23chr127014748+3.57E-060.9999964
LRP6chr1212397195-LRRC23chr127014748+3.57E-060.9999964
LRP6chr1212397195-LRRC23chr127015572+2.88E-060.99999714
LRP6chr1212397195-LRRC23chr127014748+3.57E-060.9999964
LRP6chr1212397195-LRRC23chr127014748+3.57E-060.9999964
LRP6chr1212397195-LRRC23chr127015572+2.88E-060.99999714

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRP6-LRRC23


check button Go to

FGviewer for the breakpoints of chr12:12397195-chr12:7015572

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRC23

Q53EV4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223107_149149.666666666666661614.0RepeatNote=LDL-receptor class B 2
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-22363_106149.666666666666661614.0RepeatNote=LDL-receptor class B 1
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928307_32978.66666666666667404.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227307_32978.66666666666667313.0Coiled coilOntology_term=ECO:0000255
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728307_32978.66666666666667405.0Coiled coilOntology_term=ECO:0000255
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928280_31878.66666666666667404.6666666666667DomainNote=LRRCT
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227280_31878.66666666666667313.0DomainNote=LRRCT
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728280_31878.66666666666667405.0DomainNote=LRRCT
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928114_13478.66666666666667404.6666666666667RepeatNote=LRR 2
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928135_15578.66666666666667404.6666666666667RepeatNote=LRR 3
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928156_17778.66666666666667404.6666666666667RepeatNote=LRR 4
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928180_20078.66666666666667404.6666666666667RepeatNote=LRR 5
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928201_22278.66666666666667404.6666666666667RepeatNote=LRR 6
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928223_24478.66666666666667404.6666666666667RepeatNote=LRR 7
TgeneLRRC23chr12:12397195chr12:7015572ENST0000000796928246_26778.66666666666667404.6666666666667RepeatNote=LRR 8
TgeneLRRC23chr12:12397195chr12:7015572ENST000000079692892_11378.66666666666667404.6666666666667RepeatNote=LRR 1
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227114_13478.66666666666667313.0RepeatNote=LRR 2
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227135_15578.66666666666667313.0RepeatNote=LRR 3
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227156_17778.66666666666667313.0RepeatNote=LRR 4
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227180_20078.66666666666667313.0RepeatNote=LRR 5
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227201_22278.66666666666667313.0RepeatNote=LRR 6
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227223_24478.66666666666667313.0RepeatNote=LRR 7
TgeneLRRC23chr12:12397195chr12:7015572ENST0000032370227246_26778.66666666666667313.0RepeatNote=LRR 8
TgeneLRRC23chr12:12397195chr12:7015572ENST000003237022792_11378.66666666666667313.0RepeatNote=LRR 1
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728114_13478.66666666666667405.0RepeatNote=LRR 2
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728135_15578.66666666666667405.0RepeatNote=LRR 3
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728156_17778.66666666666667405.0RepeatNote=LRR 4
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728180_20078.66666666666667405.0RepeatNote=LRR 5
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728201_22278.66666666666667405.0RepeatNote=LRR 6
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728223_24478.66666666666667405.0RepeatNote=LRR 7
TgeneLRRC23chr12:12397195chr12:7015572ENST0000044359728246_26778.66666666666667405.0RepeatNote=LRR 8
TgeneLRRC23chr12:12397195chr12:7015572ENST000004435972892_11378.66666666666667405.0RepeatNote=LRR 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231203_1244149.666666666666661614.0DomainNote=EGF-like 4
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231248_1286149.666666666666661614.0DomainLDL-receptor class A 1
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231287_1323149.666666666666661614.0DomainLDL-receptor class A 2
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231325_1361149.666666666666661614.0DomainLDL-receptor class A 3
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223282_324149.666666666666661614.0DomainNote=EGF-like 1
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223588_628149.666666666666661614.0DomainNote=EGF-like 2
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223889_930149.666666666666661614.0DomainNote=EGF-like 3
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231487_1493149.666666666666661614.0MotifNote=PPPSP motif A
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231527_1534149.666666666666661614.0MotifNote=PPPSP motif B
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231568_1575149.666666666666661614.0MotifNote=PPPSP motif C
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231588_1593149.666666666666661614.0MotifNote=PPPSP motif D
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231603_1610149.666666666666661614.0MotifNote=PPPSP motif E
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-22320_275149.666666666666661614.0RegionNote=Beta-propeller 1
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223328_589149.666666666666661614.0RegionNote=Beta-propeller 2
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223631_890149.666666666666661614.0RegionNote=Beta-propeller 3
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223933_1202149.666666666666661614.0RegionNote=Beta-propeller 4
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231026_1068149.666666666666661614.0RepeatNote=LDL-receptor class B 17
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231069_1113149.666666666666661614.0RepeatNote=LDL-receptor class B 18
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231114_1156149.666666666666661614.0RepeatNote=LDL-receptor class B 19
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231157_1198149.666666666666661614.0RepeatNote=LDL-receptor class B 20
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223150_193149.666666666666661614.0RepeatNote=LDL-receptor class B 3
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223194_236149.666666666666661614.0RepeatNote=LDL-receptor class B 4
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223237_276149.666666666666661614.0RepeatNote=LDL-receptor class B 5
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223372_414149.666666666666661614.0RepeatNote=LDL-receptor class B 6
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223415_457149.666666666666661614.0RepeatNote=LDL-receptor class B 7
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223458_501149.666666666666661614.0RepeatNote=LDL-receptor class B 8
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223502_542149.666666666666661614.0RepeatNote=LDL-receptor class B 9
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223543_584149.666666666666661614.0RepeatNote=LDL-receptor class B 10
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223674_716149.666666666666661614.0RepeatNote=LDL-receptor class B 11
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223717_759149.666666666666661614.0RepeatNote=LDL-receptor class B 12
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223760_802149.666666666666661614.0RepeatNote=LDL-receptor class B 13
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223803_842149.666666666666661614.0RepeatNote=LDL-receptor class B 14
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223843_885149.666666666666661614.0RepeatNote=LDL-receptor class B 15
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-223977_1025149.666666666666661614.0RepeatNote=LDL-receptor class B 16
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231394_1613149.666666666666661614.0Topological domainCytoplasmic
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-22320_1370149.666666666666661614.0Topological domainExtracellular
HgeneLRP6chr12:12397195chr12:7015572ENST00000261349-2231371_1393149.666666666666661614.0TransmembraneHelical


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Fusion Gene Sequence for LRP6-LRRC23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000261349_ENST00000433346_TCGA-S6-A8JY_LRP6_chr12_12397195_-_LRRC23_chr12_7015572_length(transcript)=1199nt_BP=526nt
GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC
TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG
ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA
TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT
TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG
ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGGACCTGACAGACA
TCTACTTGCTGCGCTCCTACATCCATCTGCGCTATGTGGATATTTCTGAGAACCACCTGACAGACCTGTCTCCACTCAACTACCTCACCC
ACCTGCTCTGGCTCAAGGCTGATGGCAATCGGCTGCGAAGTGCCCAGATGAATGAACTGCCCTACCTGCAGATTGCTAGTTTTGCTTATA
ACCAGATTACTGACACTGAAGGCATCTCTCATCCTCGTCTTGAAACCCTGAATCTCAAAGGGAACAGCATCCACATGGTGACAGGTCTGG
ACCCCGAGAAGTTGATCAGCCTGCACACAGTGGAGCTTCGGGGGAACCAGCTGGAAAGCACCCTGGGAATCAATCTTCCTAAGCTGAAGA
ACCTCTACCTGGTAGCTCACTGGGTCAGAGGGTGGTGCAGGGAAGAGGGCACTGTCCTGGGGGTCAGGATGCCTGCTTTCTAGTAGGCTC
AGCTACTAACTTCATCATTATGATAATAACTGGTATTATTATCAAGACCATAGTTGGTTCCAGATGCTGTGGAGATACACAGCCACCTAG
CAGGGCTGATAATATATAATGTGTGGATAATACAGAGATAATTTACCTTGATACAGGTAGTAGCAAAATGGACCATAATTGAGGTACAAA

>In-frame_ENST00000261349_ENST00000433346_TCGA-S6-A8JY_LRP6_chr12_12397195_-_LRRC23_chr12_7015572_length(amino acids)=301AA_start in transcript=77_stop in transcript=982
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGDLTDIYLLRSYIHLRYVDISENHLTDLSPL
NYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGINL

--------------------------------------------------------------
>In-frame_ENST00000543091_ENST00000433346_TCGA-S6-A8JY_LRP6_chr12_12397195_-_LRRC23_chr12_7015572_length(transcript)=1156nt_BP=483nt
TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC
GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG
CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA
ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT
GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA
ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGGACCTGACAGACATCTACTTGCTGCGCTCCTACATCCATCTGCGCTATGTGGATAT
TTCTGAGAACCACCTGACAGACCTGTCTCCACTCAACTACCTCACCCACCTGCTCTGGCTCAAGGCTGATGGCAATCGGCTGCGAAGTGC
CCAGATGAATGAACTGCCCTACCTGCAGATTGCTAGTTTTGCTTATAACCAGATTACTGACACTGAAGGCATCTCTCATCCTCGTCTTGA
AACCCTGAATCTCAAAGGGAACAGCATCCACATGGTGACAGGTCTGGACCCCGAGAAGTTGATCAGCCTGCACACAGTGGAGCTTCGGGG
GAACCAGCTGGAAAGCACCCTGGGAATCAATCTTCCTAAGCTGAAGAACCTCTACCTGGTAGCTCACTGGGTCAGAGGGTGGTGCAGGGA
AGAGGGCACTGTCCTGGGGGTCAGGATGCCTGCTTTCTAGTAGGCTCAGCTACTAACTTCATCATTATGATAATAACTGGTATTATTATC
AAGACCATAGTTGGTTCCAGATGCTGTGGAGATACACAGCCACCTAGCAGGGCTGATAATATATAATGTGTGGATAATACAGAGATAATT

>In-frame_ENST00000543091_ENST00000433346_TCGA-S6-A8JY_LRP6_chr12_12397195_-_LRRC23_chr12_7015572_length(amino acids)=301AA_start in transcript=34_stop in transcript=939
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGDLTDIYLLRSYIHLRYVDISENHLTDLSPL
NYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGINL

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Fusion Gene PPI Analysis for LRP6-LRRC23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRP6-LRRC23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRP6-LRRC23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRP6C1970440CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2 (disorder)2CTD_human;UNIPROT
HgeneLRP6C0020608Hypodontia1ORPHANET
HgeneLRP6C3539878Triple Negative Breast Neoplasms1CTD_human
HgeneLRP6C4082304Oligodontia1ORPHANET
HgeneLRP6C4083050Tooth agenesis1GENOMICS_ENGLAND
HgeneLRP6C4225231TOOTH AGENESIS, SELECTIVE, 71CTD_human;UNIPROT