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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRC16A-CDKAL1 (FusionGDB2 ID:49630)

Fusion Gene Summary for LRRC16A-CDKAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC16A-CDKAL1
Fusion gene ID: 49630
HgeneTgene
Gene symbol

LRRC16A

CDKAL1

Gene ID

55604

54901

Gene namecapping protein regulator and myosin 1 linker 1CDK5 regulatory subunit associated protein 1 like 1
SynonymsCARMIL|CARMIL1a|LRRC16|LRRC16A|dJ501N12.1|dJ501N12.5-
Cytomap

6p22.2

6p22.3

Type of geneprotein-codingprotein-coding
DescriptionF-actin-uncapping protein LRRC16ACARMIL homologcapping protein regulator and myosin 1 linker protein 1capping protein, Arp2/3 and myosin-I linker homolog 1capping protein, Arp2/3 and myosin-I linker protein 1capping protein, Arp2/3, and Myosin-I Linkthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase
Modification date2020031320200322
UniProtAcc.

Q5VV42

Ensembl transtripts involved in fusion geneENST00000329474, ENST00000377969, 
ENST00000476458, 		ENST00000274695, 
ENST00000378624, ENST00000378610, 
ENST00000476517, 
Fusion gene scores* DoF score7 X 5 X 7=24523 X 22 X 8=4048
# samples 830
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4048*10)=-3.75417488419843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC16A [Title/Abstract] AND CDKAL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRC16A(25557078)-CDKAL1(21198252), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRRC16A

GO:0030335

positive regulation of cell migration

19846667

HgeneLRRC16A

GO:0044351

macropinocytosis

19846667

HgeneLRRC16A

GO:0051639

actin filament network formation

19846667

HgeneLRRC16A

GO:1902745

positive regulation of lamellipodium organization

16054028


check buttonFusion gene breakpoints across LRRC16A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDKAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XJ-A9DX-01ALRRC16Achr6

25557078

-CDKAL1chr6

21198252

+


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Fusion Gene ORF analysis for LRRC16A-CDKAL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000329474ENST00000274695LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
In-frameENST00000329474ENST00000378624LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
In-frameENST00000329474ENST00000378610LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
5CDS-intronENST00000329474ENST00000476517LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-3CDSENST00000377969ENST00000274695LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-3CDSENST00000377969ENST00000378624LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-3CDSENST00000377969ENST00000378610LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-intronENST00000377969ENST00000476517LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-3CDSENST00000476458ENST00000274695LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-3CDSENST00000476458ENST00000378624LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-3CDSENST00000476458ENST00000378610LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+
intron-intronENST00000476458ENST00000476517LRRC16Achr6

25557078

-CDKAL1chr6

21198252

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000329474LRRC16Achr625557078-ENST00000274695CDKAL1chr621198252+4916311036835501060
ENST00000329474LRRC16Achr625557078-ENST00000378624CDKAL1chr621198252+4916311036835501060
ENST00000329474LRRC16Achr625557078-ENST00000378610CDKAL1chr621198252+4916311036835501060

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000329474ENST00000274695LRRC16Achr625557078-CDKAL1chr621198252+0.0007167940.99928325
ENST00000329474ENST00000378624LRRC16Achr625557078-CDKAL1chr621198252+0.0007167940.99928325
ENST00000329474ENST00000378610LRRC16Achr625557078-CDKAL1chr621198252+0.0007167940.99928325

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Fusion Genomic Features for LRRC16A-CDKAL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRC16A-CDKAL1


check button Go to

FGviewer for the breakpoints of chr6:25557078-chr6:21198252

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDKAL1

Q5VV42

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937710_734914.01372.0Coiled coilOntology_term=ECO:0000255
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937245_269914.01372.0RepeatNote=LRR 1
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937275_298914.01372.0RepeatNote=LRR 2
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937304_327914.01372.0RepeatNote=LRR 3
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937336_363914.01372.0RepeatNote=LRR 4
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937391_418914.01372.0RepeatNote=LRR 5
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937423_447914.01372.0RepeatNote=LRR 6
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937481_506914.01372.0RepeatNote=LRR 7
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937543_566914.01372.0RepeatNote=LRR 8
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937570_593914.01372.0RepeatNote=LRR 9
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937654_678914.01372.0RepeatNote=LRR 10
TgeneCDKAL1chr6:25557078chr6:21198252ENST000002746951216431_493433.0580.0DomainTRAM
TgeneCDKAL1chr6:25557078chr6:21198252ENST000003786101014431_493433.0580.0DomainTRAM
TgeneCDKAL1chr6:25557078chr6:21198252ENST000003786241014431_493342.0489.0DomainTRAM
TgeneCDKAL1chr6:25557078chr6:21198252ENST000002746951216556_578433.0580.0TransmembraneHelical
TgeneCDKAL1chr6:25557078chr6:21198252ENST000003786101014556_578433.0580.0TransmembraneHelical
TgeneCDKAL1chr6:25557078chr6:21198252ENST000003786241014556_578342.0489.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112710_7340177.0Coiled coilOntology_term=ECO:0000255
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-29371243_1250914.01372.0Compositional biasNote=Poly-Ser
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-1121243_12500177.0Compositional biasNote=Poly-Ser
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-29371055_1089914.01372.0RegionNecessary for localization at the cell membrane
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937958_1082914.01372.0RegionInhibits capping activity of CAPZA2
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-1121055_10890177.0RegionNecessary for localization at the cell membrane
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112958_10820177.0RegionInhibits capping activity of CAPZA2
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000329474-2937958_981914.01372.0RepeatNote=LRR 11
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112245_2690177.0RepeatNote=LRR 1
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112275_2980177.0RepeatNote=LRR 2
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112304_3270177.0RepeatNote=LRR 3
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112336_3630177.0RepeatNote=LRR 4
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112391_4180177.0RepeatNote=LRR 5
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112423_4470177.0RepeatNote=LRR 6
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112481_5060177.0RepeatNote=LRR 7
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112543_5660177.0RepeatNote=LRR 8
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112570_5930177.0RepeatNote=LRR 9
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112654_6780177.0RepeatNote=LRR 10
HgeneLRRC16Achr6:25557078chr6:21198252ENST00000377969-112958_9810177.0RepeatNote=LRR 11
TgeneCDKAL1chr6:25557078chr6:21198252ENST000002746951216200_431433.0580.0DomainRadical SAM core
TgeneCDKAL1chr6:25557078chr6:21198252ENST00000274695121664_172433.0580.0DomainMTTase N-terminal
TgeneCDKAL1chr6:25557078chr6:21198252ENST000003786101014200_431433.0580.0DomainRadical SAM core
TgeneCDKAL1chr6:25557078chr6:21198252ENST00000378610101464_172433.0580.0DomainMTTase N-terminal
TgeneCDKAL1chr6:25557078chr6:21198252ENST000003786241014200_431342.0489.0DomainRadical SAM core
TgeneCDKAL1chr6:25557078chr6:21198252ENST00000378624101464_172342.0489.0DomainMTTase N-terminal


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Fusion Gene Sequence for LRRC16A-CDKAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000329474_ENST00000274695_TCGA-XJ-A9DX-01A_LRRC16A_chr6_25557078_-_CDKAL1_chr6_21198252_length(transcript)=4916nt_BP=3110nt
TGGGCGGGAGCTACGCCGGCCCAAGCCCCGCCGGGGACCAGCGAGCCGGGAGGAGGAGCAGGCGCCACAGCCGCCCCGCGCCCCGCGCCC
GCTTGTAATCCGGTCCGCTCCTTATTCAGCCGCCGGGAACTGCGAGGAGGCGTCATGTAGCAGCAGCAGCAAATCCGCCTCGCATTTGCA
ACTCTTTTTTTTTTTTTTGGTGGGGCGGGGGGCGCGCGGCAAAATTCTGTCTCCGCCCCCCCTTTTCTTGCCCACTTCCATTTGCAAGCT
GCATCTGCCTCTCTAAAAAAATTGAGGAGTTCGGGGAAGGGCAGGGGGCCATAAATCAGAGTTGGACCTGCAATAACCCCCACACCTACA
GGGCAACCATGACCGAGGAGAGCTCTGACGTTCCCAGGGAGTTGATAGAAAGCATAAAGGATGTTATTGGCAGAAAGATAAAAATTTCAG
TGAAGAAGAAAGTAAAGTTGGAAGTTAAGGGAGACAAAGTTGAAAACAAAGTGCTGGTCCTTACATCATGCCGAGCCTTCCTTGTAACAG
CGCGAATCCCCACCAAGCTCGAGTTAACCTTCAGCTACTTGGAGATTCATGGCGTCGTTTGCAGCAAGTCAGCTCAGATGATTGTGGAAA
CTGAGAAGTGCAGCATTTCCATGAAGATGGCGTCACCCGAGGACGTGAGTGAGGTGCTGGCTCACATAGGCACCTGCCTGAGGAAGATAT
TTCCTGGCCTCTCTCCAGTGAGAATCATGAAAAAAGTCTCCATGGAGCCATCTGAGCGCCTGGCTAGTCTCCAGGCGCTGTGGGACAGCC
AGACCGTGGCTGAGCAGGGCCCCTGTGGTGGATTTTCTCAGATGTATGCCTGTGTTTGTGACTGGCTTGGATTTTCATACAGGGAAGAAG
TACAATGGGATGTGGATACAATTTATCTTACCCAAGACACCAGGGAATTGAATTTACAAGATTTTAGTCATCTTGACCACAGGGACCTAA
TACCTATCATTGCTGCTCTGGAATATAATCAGTGGTTCACAAAACTGTCCTCTAAGGATCTAAAACTGTCCACTGATGTCTGTGAACAGA
TCTTGAGGGTGGTGAGTAGGTCCAATCGACTGGAAGAATTGGTGTTGGAAAATGCTGGACTTAGAACAGATTTTGCACAAAAACTGGCCA
GTGCTCTAGCACATAATCCCAACTCAGGACTCCACACAATTAACCTTGCTGGCAACCCACTGGAGGATAGAGGTGTGTCCTCTTTAAGTA
TTCAATTTGCCAAACTCCCAAAGGGATTAAAGCACTTAAATTTATCTAAAACCTCATTATCACCTAAAGGGGTGAACAGCCTTTCTCAGT
CACTCAGTGCCAATCCATTGACCGCCTCTACCCTTGTCCACCTCGACCTCTCAGGGAACGTCCTTCGTGGAGATGACCTCTCACACATGT
ATAATTTTTTGGCCCAGCCAAATGCCATTGTTCATCTGGATTTATCCAATACAGAATGTTCCCTGGACATGGTCTGTGGAGCTCTTCTCC
GTGGATGCCTTCAATATTTAGCTGTGCTCAACCTCTCCAGAACTGTCTTCTCTCACCGGAAAGGAAAAGAAGTACCTCCATCTTTCAAGC
AATTTTTTAGTAGTTCTCTGGCTTTGATGCACATCAACCTTTCAGGCACAAAACTGTCTCCTGAGCCCTTAAAAGCACTGTTATTGGGCC
TGGCTTGTAATCATAACTTGAAAGGGGTTTCTCTGGATCTCAGCAACTGTGAGCTGAGATCAGGAGGTGCTCAAGTATTAGAAGGTTGCA
TTGCTGAAATACACAACATCACCAGCTTAGACATCTCTGACAATGGTTTAGAATCTGACCTATCTACCTTAATAGTGTGGCTCAGTAAAA
ACAGATCAATACAACACCTGGCGTTAGGCAAAAATTTTAATAATATGAAATCCAAAAATCTGACACCTGTATTGGACAACTTAGTACAGA
TGATTCAAGATGAAGAATCACCTCTGCAGTCCTTGTCCCTGGCTGACTCGAAACTCAAGACTGAGGTCACCATCATCATCAATGCCCTGG
GAAGCAACACCTCCCTGACCAAAGTGGACATTAGCGGCAACGGAATGGGGGACATGGGAGCGAAGATGCTGGCCAAAGCACTGCAGATCA
ACACTAAGCTCAGGACTGTAATATGGGACAAGAACAACATCACTGCACAAGGCTTTCAGGATATAGCTGTTGCTATGGAAAAGAACTACA
CATTAAGATTTATGCCAATTCCTATGTATGATGCTTCTCAAGCCCTAAAAACAAACCCTGAAAAAACAGAAGACGCTCTGCAAAAGATAG
AAAACTACCTGCTACGAAATCACGAGACTAGAAAATACCTTCAAGAGCAGGCCTACCGCCTGCAGCAGGGTATTGTCACCAGCACCACCC
AGCAGATGATTGACAGAATATGTGTGAAAGTACAAGATCATCTCAACTCCTTACGAAATTGTGGGGGAGACGCTATCCAGGAAGATTTAA
AATCAGCAGAGCGGCTCATGCGTGATGCTAAGAACTCTAAAACGTTGTTACCAAATTTATACCATGTTGGTGGTGCATCTTGGGCGGGAG
CCAGTGGCTTACTATCCAGTCCAATTCAGGAGACCCTGGAATCAATGGCTGGAGAAGTTACAAGAGTAGTAGATGAACAACTAAAGGCGT
TGCTTGAGTCCATGGTTGATGCTGCTGAGAATCTTTGTCCCAATGTGATGAAAAAAGCCCACATTCGACAAGACTTGATTCATGCCAGCA
CCGAAAAGATTTCTATTCCACGTACCTTTGTTAAAAATGTCCTGTTGGAGCAGTCTGGAATTGATATCCTTAACAAAATTAGTGAAGTAA
AATTGACAGTGGCCTCGTTCCTGTCTGATAGAATTGTGGATGAAATCCTGGATGCACTCTCACATTGCCATCATAAACTGGCTGACCATT
TCAGCAGACGTGGCAAGACCCTTCCTCAACAAGAATCCTTAGAGATCGAGCTGGCTGAGGAGAAGCCAGTTAAACGTTCCATCATCACAG
TGGAGGAGCTAACAGAGATAGAGCGTTTGGAAGATCTGGATACCTGTATGATTGGTGAAAGACAACAAGTGTTAGTAACAGAAGAATCTT
TTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCGTTCATGGGGAAGATGGTTGAAG
TGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACGCCCTCCATCAGCAAACCGCTAG
CAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGATCCCACACCTCTGCTGCATCTC
AGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGGATGTCCGTGGGCTTGGCTCTGC
TGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAAGAAGAATACATTTCTAATTAAA
ATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCCTCCTTCTCAGCCACTCTTCTTA
ATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCTACCATAGCACATCCTTCAAATT
AAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCTCTAATCTTTAAGTCAGAACCTA
ATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCTTTGTTTTTTTTTTCCAGATGGA
GTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCTCCTGGGTTCAAACGATTCTCCT
GCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTTTCAGTAGAGACGGAGTTTCACC
ATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACT
GCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGTGCTACAAACATTGTATTTTTCA
CAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACGGGGAGAGTCTGCCAGCTAAAGG
ACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCATTTTCTCACATTTTTGATCCATT
GGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGGAGTGCAATGGCACTATCTTGGC
TCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCTACAGGCATATACCACCATGCCC
AACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAGCCTCAAGCAGTCTTCTTGCCTC
AGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTTCTACCTGCCATCATTGGTCTTT

>In-frame_ENST00000329474_ENST00000274695_TCGA-XJ-A9DX-01A_LRRC16A_chr6_25557078_-_CDKAL1_chr6_21198252_length(amino acids)=1060AA_start in transcript=368_stop in transcript=3550
MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEK
CSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW
DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASAL
AHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNF
LAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLAC
NHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQ
DEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLR
FMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSA
ERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEK
ISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEE
LTEIERLEDLDTCMIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKG

--------------------------------------------------------------
>In-frame_ENST00000329474_ENST00000378624_TCGA-XJ-A9DX-01A_LRRC16A_chr6_25557078_-_CDKAL1_chr6_21198252_length(transcript)=4916nt_BP=3110nt
TGGGCGGGAGCTACGCCGGCCCAAGCCCCGCCGGGGACCAGCGAGCCGGGAGGAGGAGCAGGCGCCACAGCCGCCCCGCGCCCCGCGCCC
GCTTGTAATCCGGTCCGCTCCTTATTCAGCCGCCGGGAACTGCGAGGAGGCGTCATGTAGCAGCAGCAGCAAATCCGCCTCGCATTTGCA
ACTCTTTTTTTTTTTTTTGGTGGGGCGGGGGGCGCGCGGCAAAATTCTGTCTCCGCCCCCCCTTTTCTTGCCCACTTCCATTTGCAAGCT
GCATCTGCCTCTCTAAAAAAATTGAGGAGTTCGGGGAAGGGCAGGGGGCCATAAATCAGAGTTGGACCTGCAATAACCCCCACACCTACA
GGGCAACCATGACCGAGGAGAGCTCTGACGTTCCCAGGGAGTTGATAGAAAGCATAAAGGATGTTATTGGCAGAAAGATAAAAATTTCAG
TGAAGAAGAAAGTAAAGTTGGAAGTTAAGGGAGACAAAGTTGAAAACAAAGTGCTGGTCCTTACATCATGCCGAGCCTTCCTTGTAACAG
CGCGAATCCCCACCAAGCTCGAGTTAACCTTCAGCTACTTGGAGATTCATGGCGTCGTTTGCAGCAAGTCAGCTCAGATGATTGTGGAAA
CTGAGAAGTGCAGCATTTCCATGAAGATGGCGTCACCCGAGGACGTGAGTGAGGTGCTGGCTCACATAGGCACCTGCCTGAGGAAGATAT
TTCCTGGCCTCTCTCCAGTGAGAATCATGAAAAAAGTCTCCATGGAGCCATCTGAGCGCCTGGCTAGTCTCCAGGCGCTGTGGGACAGCC
AGACCGTGGCTGAGCAGGGCCCCTGTGGTGGATTTTCTCAGATGTATGCCTGTGTTTGTGACTGGCTTGGATTTTCATACAGGGAAGAAG
TACAATGGGATGTGGATACAATTTATCTTACCCAAGACACCAGGGAATTGAATTTACAAGATTTTAGTCATCTTGACCACAGGGACCTAA
TACCTATCATTGCTGCTCTGGAATATAATCAGTGGTTCACAAAACTGTCCTCTAAGGATCTAAAACTGTCCACTGATGTCTGTGAACAGA
TCTTGAGGGTGGTGAGTAGGTCCAATCGACTGGAAGAATTGGTGTTGGAAAATGCTGGACTTAGAACAGATTTTGCACAAAAACTGGCCA
GTGCTCTAGCACATAATCCCAACTCAGGACTCCACACAATTAACCTTGCTGGCAACCCACTGGAGGATAGAGGTGTGTCCTCTTTAAGTA
TTCAATTTGCCAAACTCCCAAAGGGATTAAAGCACTTAAATTTATCTAAAACCTCATTATCACCTAAAGGGGTGAACAGCCTTTCTCAGT
CACTCAGTGCCAATCCATTGACCGCCTCTACCCTTGTCCACCTCGACCTCTCAGGGAACGTCCTTCGTGGAGATGACCTCTCACACATGT
ATAATTTTTTGGCCCAGCCAAATGCCATTGTTCATCTGGATTTATCCAATACAGAATGTTCCCTGGACATGGTCTGTGGAGCTCTTCTCC
GTGGATGCCTTCAATATTTAGCTGTGCTCAACCTCTCCAGAACTGTCTTCTCTCACCGGAAAGGAAAAGAAGTACCTCCATCTTTCAAGC
AATTTTTTAGTAGTTCTCTGGCTTTGATGCACATCAACCTTTCAGGCACAAAACTGTCTCCTGAGCCCTTAAAAGCACTGTTATTGGGCC
TGGCTTGTAATCATAACTTGAAAGGGGTTTCTCTGGATCTCAGCAACTGTGAGCTGAGATCAGGAGGTGCTCAAGTATTAGAAGGTTGCA
TTGCTGAAATACACAACATCACCAGCTTAGACATCTCTGACAATGGTTTAGAATCTGACCTATCTACCTTAATAGTGTGGCTCAGTAAAA
ACAGATCAATACAACACCTGGCGTTAGGCAAAAATTTTAATAATATGAAATCCAAAAATCTGACACCTGTATTGGACAACTTAGTACAGA
TGATTCAAGATGAAGAATCACCTCTGCAGTCCTTGTCCCTGGCTGACTCGAAACTCAAGACTGAGGTCACCATCATCATCAATGCCCTGG
GAAGCAACACCTCCCTGACCAAAGTGGACATTAGCGGCAACGGAATGGGGGACATGGGAGCGAAGATGCTGGCCAAAGCACTGCAGATCA
ACACTAAGCTCAGGACTGTAATATGGGACAAGAACAACATCACTGCACAAGGCTTTCAGGATATAGCTGTTGCTATGGAAAAGAACTACA
CATTAAGATTTATGCCAATTCCTATGTATGATGCTTCTCAAGCCCTAAAAACAAACCCTGAAAAAACAGAAGACGCTCTGCAAAAGATAG
AAAACTACCTGCTACGAAATCACGAGACTAGAAAATACCTTCAAGAGCAGGCCTACCGCCTGCAGCAGGGTATTGTCACCAGCACCACCC
AGCAGATGATTGACAGAATATGTGTGAAAGTACAAGATCATCTCAACTCCTTACGAAATTGTGGGGGAGACGCTATCCAGGAAGATTTAA
AATCAGCAGAGCGGCTCATGCGTGATGCTAAGAACTCTAAAACGTTGTTACCAAATTTATACCATGTTGGTGGTGCATCTTGGGCGGGAG
CCAGTGGCTTACTATCCAGTCCAATTCAGGAGACCCTGGAATCAATGGCTGGAGAAGTTACAAGAGTAGTAGATGAACAACTAAAGGCGT
TGCTTGAGTCCATGGTTGATGCTGCTGAGAATCTTTGTCCCAATGTGATGAAAAAAGCCCACATTCGACAAGACTTGATTCATGCCAGCA
CCGAAAAGATTTCTATTCCACGTACCTTTGTTAAAAATGTCCTGTTGGAGCAGTCTGGAATTGATATCCTTAACAAAATTAGTGAAGTAA
AATTGACAGTGGCCTCGTTCCTGTCTGATAGAATTGTGGATGAAATCCTGGATGCACTCTCACATTGCCATCATAAACTGGCTGACCATT
TCAGCAGACGTGGCAAGACCCTTCCTCAACAAGAATCCTTAGAGATCGAGCTGGCTGAGGAGAAGCCAGTTAAACGTTCCATCATCACAG
TGGAGGAGCTAACAGAGATAGAGCGTTTGGAAGATCTGGATACCTGTATGATTGGTGAAAGACAACAAGTGTTAGTAACAGAAGAATCTT
TTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCGTTCATGGGGAAGATGGTTGAAG
TGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACGCCCTCCATCAGCAAACCGCTAG
CAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGATCCCACACCTCTGCTGCATCTC
AGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGGATGTCCGTGGGCTTGGCTCTGC
TGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAAGAAGAATACATTTCTAATTAAA
ATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCCTCCTTCTCAGCCACTCTTCTTA
ATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCTACCATAGCACATCCTTCAAATT
AAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCTCTAATCTTTAAGTCAGAACCTA
ATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCTTTGTTTTTTTTTTCCAGATGGA
GTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCTCCTGGGTTCAAACGATTCTCCT
GCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTTTCAGTAGAGACGGAGTTTCACC
ATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACT
GCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGTGCTACAAACATTGTATTTTTCA
CAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACGGGGAGAGTCTGCCAGCTAAAGG
ACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCATTTTCTCACATTTTTGATCCATT
GGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGGAGTGCAATGGCACTATCTTGGC
TCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCTACAGGCATATACCACCATGCCC
AACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAGCCTCAAGCAGTCTTCTTGCCTC
AGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTTCTACCTGCCATCATTGGTCTTT

>In-frame_ENST00000329474_ENST00000378624_TCGA-XJ-A9DX-01A_LRRC16A_chr6_25557078_-_CDKAL1_chr6_21198252_length(amino acids)=1060AA_start in transcript=368_stop in transcript=3550
MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEK
CSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW
DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASAL
AHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNF
LAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLAC
NHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQ
DEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLR
FMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSA
ERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEK
ISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEE
LTEIERLEDLDTCMIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKG

--------------------------------------------------------------
>In-frame_ENST00000329474_ENST00000378610_TCGA-XJ-A9DX-01A_LRRC16A_chr6_25557078_-_CDKAL1_chr6_21198252_length(transcript)=4916nt_BP=3110nt
TGGGCGGGAGCTACGCCGGCCCAAGCCCCGCCGGGGACCAGCGAGCCGGGAGGAGGAGCAGGCGCCACAGCCGCCCCGCGCCCCGCGCCC
GCTTGTAATCCGGTCCGCTCCTTATTCAGCCGCCGGGAACTGCGAGGAGGCGTCATGTAGCAGCAGCAGCAAATCCGCCTCGCATTTGCA
ACTCTTTTTTTTTTTTTTGGTGGGGCGGGGGGCGCGCGGCAAAATTCTGTCTCCGCCCCCCCTTTTCTTGCCCACTTCCATTTGCAAGCT
GCATCTGCCTCTCTAAAAAAATTGAGGAGTTCGGGGAAGGGCAGGGGGCCATAAATCAGAGTTGGACCTGCAATAACCCCCACACCTACA
GGGCAACCATGACCGAGGAGAGCTCTGACGTTCCCAGGGAGTTGATAGAAAGCATAAAGGATGTTATTGGCAGAAAGATAAAAATTTCAG
TGAAGAAGAAAGTAAAGTTGGAAGTTAAGGGAGACAAAGTTGAAAACAAAGTGCTGGTCCTTACATCATGCCGAGCCTTCCTTGTAACAG
CGCGAATCCCCACCAAGCTCGAGTTAACCTTCAGCTACTTGGAGATTCATGGCGTCGTTTGCAGCAAGTCAGCTCAGATGATTGTGGAAA
CTGAGAAGTGCAGCATTTCCATGAAGATGGCGTCACCCGAGGACGTGAGTGAGGTGCTGGCTCACATAGGCACCTGCCTGAGGAAGATAT
TTCCTGGCCTCTCTCCAGTGAGAATCATGAAAAAAGTCTCCATGGAGCCATCTGAGCGCCTGGCTAGTCTCCAGGCGCTGTGGGACAGCC
AGACCGTGGCTGAGCAGGGCCCCTGTGGTGGATTTTCTCAGATGTATGCCTGTGTTTGTGACTGGCTTGGATTTTCATACAGGGAAGAAG
TACAATGGGATGTGGATACAATTTATCTTACCCAAGACACCAGGGAATTGAATTTACAAGATTTTAGTCATCTTGACCACAGGGACCTAA
TACCTATCATTGCTGCTCTGGAATATAATCAGTGGTTCACAAAACTGTCCTCTAAGGATCTAAAACTGTCCACTGATGTCTGTGAACAGA
TCTTGAGGGTGGTGAGTAGGTCCAATCGACTGGAAGAATTGGTGTTGGAAAATGCTGGACTTAGAACAGATTTTGCACAAAAACTGGCCA
GTGCTCTAGCACATAATCCCAACTCAGGACTCCACACAATTAACCTTGCTGGCAACCCACTGGAGGATAGAGGTGTGTCCTCTTTAAGTA
TTCAATTTGCCAAACTCCCAAAGGGATTAAAGCACTTAAATTTATCTAAAACCTCATTATCACCTAAAGGGGTGAACAGCCTTTCTCAGT
CACTCAGTGCCAATCCATTGACCGCCTCTACCCTTGTCCACCTCGACCTCTCAGGGAACGTCCTTCGTGGAGATGACCTCTCACACATGT
ATAATTTTTTGGCCCAGCCAAATGCCATTGTTCATCTGGATTTATCCAATACAGAATGTTCCCTGGACATGGTCTGTGGAGCTCTTCTCC
GTGGATGCCTTCAATATTTAGCTGTGCTCAACCTCTCCAGAACTGTCTTCTCTCACCGGAAAGGAAAAGAAGTACCTCCATCTTTCAAGC
AATTTTTTAGTAGTTCTCTGGCTTTGATGCACATCAACCTTTCAGGCACAAAACTGTCTCCTGAGCCCTTAAAAGCACTGTTATTGGGCC
TGGCTTGTAATCATAACTTGAAAGGGGTTTCTCTGGATCTCAGCAACTGTGAGCTGAGATCAGGAGGTGCTCAAGTATTAGAAGGTTGCA
TTGCTGAAATACACAACATCACCAGCTTAGACATCTCTGACAATGGTTTAGAATCTGACCTATCTACCTTAATAGTGTGGCTCAGTAAAA
ACAGATCAATACAACACCTGGCGTTAGGCAAAAATTTTAATAATATGAAATCCAAAAATCTGACACCTGTATTGGACAACTTAGTACAGA
TGATTCAAGATGAAGAATCACCTCTGCAGTCCTTGTCCCTGGCTGACTCGAAACTCAAGACTGAGGTCACCATCATCATCAATGCCCTGG
GAAGCAACACCTCCCTGACCAAAGTGGACATTAGCGGCAACGGAATGGGGGACATGGGAGCGAAGATGCTGGCCAAAGCACTGCAGATCA
ACACTAAGCTCAGGACTGTAATATGGGACAAGAACAACATCACTGCACAAGGCTTTCAGGATATAGCTGTTGCTATGGAAAAGAACTACA
CATTAAGATTTATGCCAATTCCTATGTATGATGCTTCTCAAGCCCTAAAAACAAACCCTGAAAAAACAGAAGACGCTCTGCAAAAGATAG
AAAACTACCTGCTACGAAATCACGAGACTAGAAAATACCTTCAAGAGCAGGCCTACCGCCTGCAGCAGGGTATTGTCACCAGCACCACCC
AGCAGATGATTGACAGAATATGTGTGAAAGTACAAGATCATCTCAACTCCTTACGAAATTGTGGGGGAGACGCTATCCAGGAAGATTTAA
AATCAGCAGAGCGGCTCATGCGTGATGCTAAGAACTCTAAAACGTTGTTACCAAATTTATACCATGTTGGTGGTGCATCTTGGGCGGGAG
CCAGTGGCTTACTATCCAGTCCAATTCAGGAGACCCTGGAATCAATGGCTGGAGAAGTTACAAGAGTAGTAGATGAACAACTAAAGGCGT
TGCTTGAGTCCATGGTTGATGCTGCTGAGAATCTTTGTCCCAATGTGATGAAAAAAGCCCACATTCGACAAGACTTGATTCATGCCAGCA
CCGAAAAGATTTCTATTCCACGTACCTTTGTTAAAAATGTCCTGTTGGAGCAGTCTGGAATTGATATCCTTAACAAAATTAGTGAAGTAA
AATTGACAGTGGCCTCGTTCCTGTCTGATAGAATTGTGGATGAAATCCTGGATGCACTCTCACATTGCCATCATAAACTGGCTGACCATT
TCAGCAGACGTGGCAAGACCCTTCCTCAACAAGAATCCTTAGAGATCGAGCTGGCTGAGGAGAAGCCAGTTAAACGTTCCATCATCACAG
TGGAGGAGCTAACAGAGATAGAGCGTTTGGAAGATCTGGATACCTGTATGATTGGTGAAAGACAACAAGTGTTAGTAACAGAAGAATCTT
TTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCGTTCATGGGGAAGATGGTTGAAG
TGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACGCCCTCCATCAGCAAACCGCTAG
CAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGATCCCACACCTCTGCTGCATCTC
AGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGGATGTCCGTGGGCTTGGCTCTGC
TGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAAGAAGAATACATTTCTAATTAAA
ATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCCTCCTTCTCAGCCACTCTTCTTA
ATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCTACCATAGCACATCCTTCAAATT
AAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCTCTAATCTTTAAGTCAGAACCTA
ATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCTTTGTTTTTTTTTTCCAGATGGA
GTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCTCCTGGGTTCAAACGATTCTCCT
GCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTTTCAGTAGAGACGGAGTTTCACC
ATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACT
GCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGTGCTACAAACATTGTATTTTTCA
CAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACGGGGAGAGTCTGCCAGCTAAAGG
ACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCATTTTCTCACATTTTTGATCCATT
GGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGGAGTGCAATGGCACTATCTTGGC
TCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCTACAGGCATATACCACCATGCCC
AACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAGCCTCAAGCAGTCTTCTTGCCTC
AGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTTCTACCTGCCATCATTGGTCTTT

>In-frame_ENST00000329474_ENST00000378610_TCGA-XJ-A9DX-01A_LRRC16A_chr6_25557078_-_CDKAL1_chr6_21198252_length(amino acids)=1060AA_start in transcript=368_stop in transcript=3550
MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEK
CSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW
DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASAL
AHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNF
LAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLAC
NHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQ
DEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLR
FMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSA
ERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEK
ISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEE
LTEIERLEDLDTCMIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LRRC16A-CDKAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRC16A-CDKAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRC16A-CDKAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
TgeneCDKAL1C0005910Body Weight2CTD_human
TgeneCDKAL1C0005612Birth Weight1CTD_human
TgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human