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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRC37B-LPP (FusionGDB2 ID:49678)

Fusion Gene Summary for LRRC37B-LPP

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC37B-LPP
Fusion gene ID: 49678
HgeneTgene
Gene symbol

LRRC37B

LPP

Gene ID

114659

4026

Gene nameleucine rich repeat containing 37BLIM domain containing preferred translocation partner in lipoma
SynonymsLRRC37-
Cytomap

17q11.2

3q27.3-q28

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 37BC66 SLIT-like testicular proteinlipoma-preferred partnerLIM proteinlipoma preferred partner
Modification date2020031320200313
UniProtAcc.

Q93052

Ensembl transtripts involved in fusion geneENST00000543378, ENST00000327564, 
ENST00000394713, ENST00000584368, 
ENST00000341671, ENST00000581786, 
ENST00000448637, ENST00000312675, 
ENST00000543006, ENST00000471917, 
Fusion gene scores* DoF score7 X 6 X 4=16825 X 27 X 9=6075
# samples 734
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/6075*10)=-4.1592777572428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC37B [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRC37B(30335151)-LPP(188326949), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRRC37B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LPP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315490LRRC37Bchr17

30335151

+LPPchr3

188326949

+


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Fusion Gene ORF analysis for LRRC37B-LPP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000543378ENST00000448637LRRC37Bchr17

30335151

+LPPchr3

188326949

+
5UTR-3CDSENST00000543378ENST00000312675LRRC37Bchr17

30335151

+LPPchr3

188326949

+
5UTR-3CDSENST00000543378ENST00000543006LRRC37Bchr17

30335151

+LPPchr3

188326949

+
5UTR-3UTRENST00000543378ENST00000471917LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000327564ENST00000448637LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000327564ENST00000312675LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000327564ENST00000543006LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3UTRENST00000327564ENST00000471917LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000394713ENST00000448637LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000394713ENST00000312675LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000394713ENST00000543006LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3UTRENST00000394713ENST00000471917LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000584368ENST00000448637LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000584368ENST00000312675LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000584368ENST00000543006LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3UTRENST00000584368ENST00000471917LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000341671ENST00000448637LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000341671ENST00000312675LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000341671ENST00000543006LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3UTRENST00000341671ENST00000471917LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000581786ENST00000448637LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000581786ENST00000312675LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3CDSENST00000581786ENST00000543006LRRC37Bchr17

30335151

+LPPchr3

188326949

+
intron-3UTRENST00000581786ENST00000471917LRRC37Bchr17

30335151

+LPPchr3

188326949

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LRRC37B-LPP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRRC37Bchr1730335151+LPPchr3188326948+8.47E-141
LRRC37Bchr1730335151+LPPchr3188326948+8.47E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRC37B-LPP


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LPP

Q93052

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LRRC37B-LPP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LRRC37B-LPP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRC37B-LPP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRC37B-LPP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLPPC0087031Juvenile-Onset Still Disease1CTD_human
TgeneLPPC3495559Juvenile arthritis1CTD_human
TgeneLPPC3714758Juvenile psoriatic arthritis1CTD_human
TgeneLPPC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneLPPC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human