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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRC45-GNB1 (FusionGDB2 ID:49698)

Fusion Gene Summary for LRRC45-GNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC45-GNB1
Fusion gene ID: 49698
HgeneTgene
Gene symbol

LRRC45

GNB1

Gene ID

201255

2782

Gene nameleucine rich repeat containing 45G protein subunit beta 1
Synonyms-MRD42
Cytomap

17q25.3

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 45guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1
Modification date2020031320200321
UniProtAcc.

Q9BYB4

Ensembl transtripts involved in fusion geneENST00000306688, ENST00000583383, 
ENST00000378609, ENST00000472614, 
Fusion gene scores* DoF score2 X 2 X 2=839 X 29 X 13=14703
# samples 248
** MAII scorelog2(2/8*10)=1.32192809488736log2(48/14703*10)=-4.93693233652239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC45 [Title/Abstract] AND GNB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRC45(79987061)-GNB1(1749314), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRRC45 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GNB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-6778-01ALRRC45chr17

79987061

+GNB1chr1

1749314

-
ChimerDB4LUADTCGA-44-6778-01ALRRC45chr17

79987061

+GNB1chr1

1749314

-
ChimerDB4LUADTCGA-44-6778-01ALRRC45chr17

79987061

-GNB1chr1

1749314

-


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Fusion Gene ORF analysis for LRRC45-GNB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000306688ENST00000378609LRRC45chr17

79987061

+GNB1chr1

1749314

-
5CDS-intronENST00000306688ENST00000472614LRRC45chr17

79987061

+GNB1chr1

1749314

-
intron-3CDSENST00000583383ENST00000378609LRRC45chr17

79987061

+GNB1chr1

1749314

-
intron-intronENST00000583383ENST00000472614LRRC45chr17

79987061

+GNB1chr1

1749314

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306688LRRC45chr1779987061+ENST00000378609GNB1chr11749314-448217433002708802

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306688ENST00000378609LRRC45chr1779987061+GNB1chr11749314-0.0046769810.995323

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Fusion Genomic Features for LRRC45-GNB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRC45-GNB1


check button Go to

FGviewer for the breakpoints of chr17:79987061-chr1:1749314

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GNB1

Q9BYB4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+1317115_136467.0671.0RepeatNote=LRR 3
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+1317145_166467.0671.0RepeatNote=LRR 4
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+1317173_194467.0671.0RepeatNote=LRR 5
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+1317201_212467.0671.0RepeatNote=LRR 6
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+131758_80467.0671.0RepeatNote=LRR 1
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+131787_107467.0671.0RepeatNote=LRR 2
TgeneGNB1chr17:79987061chr1:1749314ENST00000378609212141_17019.0872.3333333333334RepeatNote=WD 3
TgeneGNB1chr17:79987061chr1:1749314ENST00000378609212182_21219.0872.3333333333334RepeatNote=WD 4
TgeneGNB1chr17:79987061chr1:1749314ENST00000378609212224_25419.0872.3333333333334RepeatNote=WD 5
TgeneGNB1chr17:79987061chr1:1749314ENST00000378609212268_29819.0872.3333333333334RepeatNote=WD 6
TgeneGNB1chr17:79987061chr1:1749314ENST00000378609212310_34019.0872.3333333333334RepeatNote=WD 7
TgeneGNB1chr17:79987061chr1:1749314ENST0000037860921253_8319.0872.3333333333334RepeatNote=WD 1
TgeneGNB1chr17:79987061chr1:1749314ENST0000037860921295_12519.0872.3333333333334RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRC45chr17:79987061chr1:1749314ENST00000306688+1317252_645467.0671.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for LRRC45-GNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000306688_ENST00000378609_TCGA-44-6778-01A_LRRC45_chr17_79987061_+_GNB1_chr1_1749314_length(transcript)=4482nt_BP=1743nt
CTTGTTCTTCCTGGATACTGAGGCCCCGACGCGGCTGTCGCGAGGGCGGGGGTCGGGGCTGCAGGCGGGGCAGGGCTGGGTGGGGGCGCG
CGACGCACCTGCCTGCTTCCTGCACGGGTGGTCCCCAAGCACTGCGGGGCCCCAGCCCAAAGCGGACCTTGACTACCGCCCAGCCCCGCG
CTCCCAGGACCTCCCGCCCGCGGAGCCCACTCGGATTGCTCTCCGCCCGGGTCGGCGGAGGCCCCGTCTCCTGTACCCGGCGCTGGGACT
GCTCCGCACCGCGCGGCTCCCTTTCAGCAGCTGCGGGAGCATGCGGAGGAGGCCCTGCCGGCCCCGCGGGTCATGGAGGAGTTCCGGCGC
TCCTACAGCCGCCTGTGCAGGGAGAGTGGGGCCGAGCCCCAGGAGGCTGTCCTGCAGCAGCTGCACCAGCTTCCCAGGGGCCGGCTGGAC
CTGGCCACGCAAAGCCTGACGGTGGAGACCTGCAGGGCCCTGGGCAAGCTGCTGCCGAGGGAGACGCTGTGCACGGAGCTGGTCCTGAGT
GACTGCATGCTCAGCGAGGAAGGGGCCACACTGCTGCTCCGAGGCCTGTGTGCCAACACCGTGCTGCGCTTTCTGGACTTAAAGGGCAAC
AACCTTCGGGCTGCAGGGGCCGAGGCTCTGGGAAAACTCCTCCAACAGAACAAGTCCATTCAGAGCCTCACGCTGGAGTGGAACAGCCTG
GGCACGTGGGACGATGCCTTCGCCACCTTCTGCGGGGGCCTGGCGGCCAACGGCGCCCTGCAGCGGCTGGACCTCCGCAACAACCAGATC
AGTCACAAGGGCGCGGAGGAGCTGGCCCTAGCCCTGAAGGGCAACACCACCCTCCAGCAGCTGGACCTGCGCTGGAATAACGTTGGCCTC
CTGGGGGGCCGGGCCCTCATGAACTGTCTCCCCAGCAACAGAACCCTGTGGAGACTGGACCTGGCTGGGAACAACATCCCTGGAGACGTC
CTCAGAGCCGTGGAGCAAGCCATGGGCCACAGCCAGGACCGGCTCACCACCTTCCAGGAGAACCAAGCCCGCACTCACGTCCTCAGCAAG
GAGGTCCAGCACCTCCGGGAGGAGAAGTCCAAGCAGTTCCTCGACTTGATGGAGACTATTGATAAGCAGCGAGAAGAGATGGCCAAGAGC
AGCAGGGCGTCGGCAGCCCGTGTAGGGCAGCTTCAGGAAGCCCTGAATGAGAGGCACTCCATCATCAACGCTCTCAAGGCCAAGCTGCAG
ATGACAGAGGCCGCCCTGGCTCTGTCGGAGCAGAAGGCCCAGGACCTGGGGGAGCTCCTGGCCACAGCGGAGCAGGAGCAGCTGAGCCTG
TCACAGAGGCAGGCCAAGGAGCTCAAGCTGGAGCAGCAGGAAGCTGCAGAGCGGGAGTCTAAACTCCTCAGAGACTTGTCTGCTGCCAAT
GAAAAGAACCTGCTTCTGCAAAACCAGGTAGACGAGTTGGAGCGGAAGTTCAGGTGTCAGCAGGAGCAGCTGTTCCAGACCAGGCAGGAG
ATGACCAGCATGTCAGCTGAGCTGAAGATGCGGGCCATCCAGGCCGAGGAGCGCCTGGACATGGAGAAGAGAAGATGCAGACAGAGCCTG
GAGGACTCCGAAAGCCTGCGCATCAAGGAGGTGGAGCATATGACCCGTCACCTGGAGGAGAGTGAGAAGGCCATGCAGGAGCGGGTGCAG
AGGCTGGAGGCGGCGCGGCTGTCCCTGGAGGAGGACGCCAGGAAAGCATGTGCAGATGCAACTCTCTCTCAGATCACAAACAACATCGAC
CCAGTGGGAAGAATCCAAATGCGCACGAGGAGGACACTGCGGGGGCACCTGGCCAAGATCTACGCCATGCACTGGGGCACAGACTCCAGG
CTTCTCGTCAGTGCCTCGCAGGATGGTAAACTTATCATCTGGGACAGCTACACCACCAACAAGGTCCACGCCATCCCTCTGCGCTCCTCC
TGGGTCATGACCTGTGCATATGCCCCTTCTGGGAACTATGTGGCCTGCGGTGGCCTGGATAACATTTGCTCCATTTACAATCTGAAAACT
CGTGAGGGGAACGTGCGCGTGAGTCGTGAGCTGGCAGGACACACAGGTTACCTGTCCTGCTGCCGATTCCTGGATGACAATCAGATCGTC
ACCAGCTCTGGAGACACCACGTGTGCCCTGTGGGACATCGAGACCGGCCAGCAGACGACCACGTTTACCGGACACACTGGAGATGTCATG
AGCCTTTCTCTTGCTCCTGACACCAGACTGTTCGTCTCTGGTGCTTGTGATGCTTCAGCCAAACTCTGGGATGTGCGAGAAGGCATGTGC
CGGCAGACCTTCACTGGCCACGAGTCTGACATCAATGCCATTTGCTTCTTTCCAAATGGCAATGCATTTGCCACTGGCTCAGACGACGCC
ACCTGCAGGCTGTTTGACCTTCGTGCTGACCAGGAGCTCATGACTTACTCCCATGACAACATCATCTGCGGGATCACCTCTGTCTCCTTC
TCCAAGAGCGGGCGCCTCCTCCTTGCTGGGTACGACGACTTCAACTGCAACGTCTGGGATGCACTCAAAGCCGACCGGGCAGGTGTCTTG
GCTGGGCATGACAACCGCGTCAGCTGCCTGGGCGTGACTGACGATGGCATGGCTGTGGCGACAGGGTCCTGGGATAGCTTCCTCAAGATC
TGGAACTAACGCCAGTAGCATGTGGATGCCATGGAGACTGGAAGACCATTCCAACTTGGACGCGTTACCATGAGAGCATATCCTATCCAA
CCGTACTAACGTGGACACCCTACACCTCCCCTCAGAACTTCAAAAGGGCAAGATCTTTTTTCCTTCACTTATTGCTGAAACCAAGAGCAC
AATTCCCATTGAGAGAAAGATCTCTGTGCTGTAAACTAAAACAAATTGTGCATTCCTTCCGGGGCCATCGTCTTTGTTTTCTTTTTTGTC
TTGAATGAATTTTAAAAGGAAATATATAATAAAAATGTTAACCAGAAGGTAAACTTGAGTGTAATTGTCAGACAGACACACTTTTCCACC
AGTGTATTTGAATTTTAGACCAGTGACCCTGTTTTGTGGCATTCATGCAAAACATGCTGAGGGCTTTGTTCATCTGGTCATCGTGTCCAA
ATTTCAGTCATGTTTGTAGCAAGATTTTGGAAGCATTCATATTTCCTTTTTAAAATGTATTCCTTTGTGTTCAACAGTTAATCAAAACCA
GAGAGTCTAGGGCAGCCTCTCTGATGTTGTCAATGATGTAAATTCAGTCCCTGGTTTTTAATTTTCTGTCTGATGTCACAGATCATTGTT
GCACACAAACGTGGCATAGAAAAGAACATGTTCAGAAGCCATGGGGCCAAGCACATGCGGGGACGGTCTCAAATGCGTGATCAGAGAATC
CTTCACCTTTGCTGAAAAGTGAGCTCAGATCCAGCACCATGTTCCTCCTGACCCATCCTGTCTATCTTCTCAGTTGAGTTTTTAATCTCA
CTTTGGGTTTCCTTGTGAAGTTGGAGGGAAGTTTATAATAGCCTAACACTACCCCACCCCCAACTAGGAGGAACCTCTGTTTTCAAGAGA
GATGCCTGTCCTGTGCTTGGATAGTCAGTCAATTATTTGTGTATGAAACAATGTACAAATCAATGTTTTGAAAATAATGATCTCAGACTT
TCTAAGTTAAATTTTAAAAATTTTGATTGTTTGCCATATTGGGTGGGTTTACTCTTAGAATCGCATGCTGTAGAAATGCTCAAAAGTGCA
TATGGGACTCAGTCCTTAGGTGTTCTTTTTCTTTTAAGAAATAACCTCTTACAGTTGTAACCATTGCGGCTCTGTCCACTTCTCGTTGCT
GCTCTGTGGCACATATCGGAAGCAGTACAGCGCGCGGCTCTACACGCTTGGGTAGCGGGATAAGTCACTGTTTTCTTTATTTCTTTAAAA
AAAAAAAAGTTCTGTTGCAAACGACTGCTGTTGGATTCTGAGGGTGGGGAGGGAGAGAGAGGGAGGGAGAGGGAGTGAAGAGCCTGCCCT
CCTATATGGATTCTTCAGGGCCCTCCACATCTGAGGTGGCTCATTCCCATCACACACAGATTGTCCTGGTGTTCATTTCAAGGCCAGTGT
TCAGCAGCAGCGTTTGGAAAGCAGGTTCTGTGGGACCCCCCGCCCCGCCCCCCGCACTCCTTCATAGCAGCAGTAGTGGCTTCTCCATCC
TGTTTTCTGCAACATTCTATACAAAACTGTGCTGTGACCTTGCGGTAGGCCTGGATCTGGCAAAGAGAATACAAATGAAACCCCTTCTTT
CTCTTTCCGTCCAACAACTCTGTAGAGCTCTCTGCACCCTTACCCCTTTCCACCTTTTGTATTTAATTTTAAAGTCAGTGTACTGCAAGG

>In-frame_ENST00000306688_ENST00000378609_TCGA-44-6778-01A_LRRC45_chr17_79987061_+_GNB1_chr1_1749314_length(amino acids)=802AA_start in transcript=300_stop in transcript=2708
MREHAEEALPAPRVMEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGAT
LLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELAL
ALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKS
KQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKL
EQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKE
VEHMTRHLEESEKAMQERVQRLEAARLSLEEDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK
LIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL
WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD

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Fusion Gene PPI Analysis for LRRC45-GNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRC45-GNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRC45-GNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGNB1C4310774MENTAL RETARDATION, AUTOSOMAL DOMINANT 425CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneGNB1C0003469Anxiety Disorders1CTD_human
TgeneGNB1C0011573Endogenous depression1CTD_human
TgeneGNB1C0011581Depressive disorder1CTD_human
TgeneGNB1C0025193Melancholia1CTD_human
TgeneGNB1C0036572Seizures1GENOMICS_ENGLAND
TgeneGNB1C0041696Unipolar Depression1CTD_human
TgeneGNB1C0086133Depressive Syndrome1CTD_human
TgeneGNB1C0282126Depression, Neurotic1CTD_human
TgeneGNB1C0376280Anxiety States, Neurotic1CTD_human
TgeneGNB1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgeneGNB1C0557874Global developmental delay1GENOMICS_ENGLAND
TgeneGNB1C1279420Anxiety neurosis (finding)1CTD_human
TgeneGNB1C3714756Intellectual Disability1GENOMICS_ENGLAND