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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRC59-NUP107 (FusionGDB2 ID:49736)

Fusion Gene Summary for LRRC59-NUP107

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC59-NUP107
Fusion gene ID: 49736
HgeneTgene
Gene symbol

LRRC59

NUP107

Gene ID

55379

57122

Gene nameleucine rich repeat containing 59nucleoporin 107
SynonymsPRO1855|p34NPHS11|NUP84|ODG6|ODG6; GAMOS7
Cytomap

17q21.33

12q15

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 59ribosome-binding protein p34nuclear pore complex protein Nup107nucleoporin 107kDa
Modification date2020031320200313
UniProtAcc

Q96AG4

P57740

Ensembl transtripts involved in fusion geneENST00000225972, ENST00000576448, 
ENST00000229179, ENST00000378905, 
ENST00000539906, ENST00000401003, 
Fusion gene scores* DoF score5 X 4 X 2=4027 X 22 X 9=5346
# samples 637
** MAII scorelog2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(37/5346*10)=-3.85286266172677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRC59 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRC59(48469759)-NUP107(69135593), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUP107

GO:0006406

mRNA export from nucleus

11684705


check buttonFusion gene breakpoints across LRRC59 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUP107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A0A7-01ALRRC59chr17

48469759

-NUP107chr12

69135593

+
ChimerDB4BRCATCGA-A8-A0A7LRRC59chr17

48469758

-NUP107chr12

69135592

+
ChimerDB4BRCATCGA-A8-A0A7-01ALRRC59chr17

48469759

-NUP107chr12

69135593

+
ChimerDB4BRCATCGA-A8-A0A7-01ALRRC59chr17

48469759

-NUP107chr12

69135593

+
ChimerDB4BRCATCGA-A8-A0A7-01ALRRC59chr17

48469758

-NUP107chr12

69135592

+


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Fusion Gene ORF analysis for LRRC59-NUP107

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000225972ENST00000229179LRRC59chr17

48469759

-NUP107chr12

69135593

+
In-frameENST00000225972ENST00000378905LRRC59chr17

48469759

-NUP107chr12

69135593

+
In-frameENST00000225972ENST00000539906LRRC59chr17

48469759

-NUP107chr12

69135593

+
5CDS-intronENST00000225972ENST00000401003LRRC59chr17

48469759

-NUP107chr12

69135593

+
intron-3CDSENST00000576448ENST00000229179LRRC59chr17

48469759

-NUP107chr12

69135593

+
intron-3CDSENST00000576448ENST00000378905LRRC59chr17

48469759

-NUP107chr12

69135593

+
intron-3CDSENST00000576448ENST00000539906LRRC59chr17

48469759

-NUP107chr12

69135593

+
intron-intronENST00000576448ENST00000401003LRRC59chr17

48469759

-NUP107chr12

69135593

+
In-frameENST00000225972ENST00000229179LRRC59chr17

48469758

-NUP107chr12

69135592

+
In-frameENST00000225972ENST00000378905LRRC59chr17

48469758

-NUP107chr12

69135592

+
In-frameENST00000225972ENST00000539906LRRC59chr17

48469758

-NUP107chr12

69135592

+
5CDS-intronENST00000225972ENST00000401003LRRC59chr17

48469758

-NUP107chr12

69135592

+
intron-3CDSENST00000576448ENST00000229179LRRC59chr17

48469758

-NUP107chr12

69135592

+
intron-3CDSENST00000576448ENST00000378905LRRC59chr17

48469758

-NUP107chr12

69135592

+
intron-3CDSENST00000576448ENST00000539906LRRC59chr17

48469758

-NUP107chr12

69135592

+
intron-intronENST00000576448ENST00000401003LRRC59chr17

48469758

-NUP107chr12

69135592

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000225972LRRC59chr1748469759-ENST00000229179NUP107chr1269135593+1484665164940258
ENST00000225972LRRC59chr1748469759-ENST00000378905NUP107chr1269135593+1162665164940258
ENST00000225972LRRC59chr1748469759-ENST00000539906NUP107chr1269135593+1010665164940258
ENST00000225972LRRC59chr1748469758-ENST00000229179NUP107chr1269135592+1484665164940258
ENST00000225972LRRC59chr1748469758-ENST00000378905NUP107chr1269135592+1162665164940258
ENST00000225972LRRC59chr1748469758-ENST00000539906NUP107chr1269135592+1010665164940258

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225972ENST00000229179LRRC59chr1748469759-NUP107chr1269135593+0.0014382480.9985618
ENST00000225972ENST00000378905LRRC59chr1748469759-NUP107chr1269135593+0.0022637470.9977362
ENST00000225972ENST00000539906LRRC59chr1748469759-NUP107chr1269135593+0.0016671150.9983329
ENST00000225972ENST00000229179LRRC59chr1748469758-NUP107chr1269135592+0.0014382480.9985618
ENST00000225972ENST00000378905LRRC59chr1748469758-NUP107chr1269135592+0.0022637470.9977362
ENST00000225972ENST00000539906LRRC59chr1748469758-NUP107chr1269135592+0.0016671150.9983329

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Fusion Genomic Features for LRRC59-NUP107


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRRC59chr1748469758-NUP107chr1269135592+5.63E-091
LRRC59chr1748469758-NUP107chr1269135592+5.63E-091
LRRC59chr1748469758-NUP107chr1269135592+5.63E-091
LRRC59chr1748469758-NUP107chr1269135592+5.63E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRC59-NUP107


check button Go to

FGviewer for the breakpoints of chr17:48469759-chr12:69135593

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRC59

Q96AG4

NUP107

P57740

FUNCTION: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}.FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-47109_128143.0308.0RepeatNote=LRR 5
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-4710_31143.0308.0RepeatNote=LRR 1
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-4740_62143.0308.0RepeatNote=LRR 2
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-4763_84143.0308.0RepeatNote=LRR 3
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-4786_107143.0308.0RepeatNote=LRR 4
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-47109_128143.0308.0RepeatNote=LRR 5
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-4710_31143.0308.0RepeatNote=LRR 1
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-4740_62143.0308.0RepeatNote=LRR 2
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-4763_84143.0308.0RepeatNote=LRR 3
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-4786_107143.0308.0RepeatNote=LRR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-47148_216143.0308.0Coiled coilOntology_term=ECO:0000255
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-47148_216143.0308.0Coiled coilOntology_term=ECO:0000255
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-47248_256143.0308.0Compositional biasNote=Poly-Leu
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-47248_256143.0308.0Compositional biasNote=Poly-Leu
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-471_244143.0308.0Topological domainCytoplasmic
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-47266_307143.0308.0Topological domainLumenal
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-471_244143.0308.0Topological domainCytoplasmic
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-47266_307143.0308.0Topological domainLumenal
HgeneLRRC59chr17:48469758chr12:69135592ENST00000225972-47245_265143.0308.0TransmembraneHelical
HgeneLRRC59chr17:48469759chr12:69135593ENST00000225972-47245_265143.0308.0TransmembraneHelical


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Fusion Gene Sequence for LRRC59-NUP107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000225972_ENST00000229179_TCGA-A8-A0A7-01A_LRRC59_chr17_48469759_-_NUP107_chr12_69135593_length(transcript)=1484nt_BP=665nt
ATCTCAGTGGTCGCGGAAGGTGACGTGGACACGGAAGTGGTCGTCGTCGCGGCACCGGTGGGAGCTAGGCGCGAGGCTCGGAGTGCGGCC
AGCGGGCGGAGGCGGTCTCGCATCGGCGGCGACGGAGGGCTCAGGCGTCGTCGTTTGGGTGGGGGGCCGCTGAACTGACAAGCGACATTT
CAGCTCCTTTCACCCGCCGGAACCCCGGAGCCGGGGCCCGCTCAGCCGGCGTTACCATGACCAAGGCCGGTAGCAAGGGCGGGAACCTCC
GCGACAAGCTGGACGGCAACGAACTGGACCTGAGCCTCAGCGACCTGAATGAGGTCCCGGTGAAGGAGCTGGCTGCCCTTCCAAAGGCCA
CCATCCTGGATCTGTCTTGTAATAAACTGACTACTCTACCGTCGGATTTCTGTGGCCTCACACACCTGGTGAAGCTAGACCTGAGTAAGA
ACAAGCTGCAGCAGCTGCCAGCAGACTTTGGCCGTCTGGTCAACCTCCAGCACCTGGATCTCCTCAACAACAAGCTGGTCACCTTGCCTG
TCAGCTTTGCTCAGCTCAAGAACCTGAAGTGGTTGGACCTGAAGGATAACCCCCTGGATCCTGTCCTGGCCAAGGTGGCAGGTGACTGCT
TGGATGAGAAGCAGTGTAAGCAGTGTGCAAACAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTT
GTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCT
CTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAG
ACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAAT
AAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTG
ACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTC
CAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCA
TAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAA
GAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAG

>In-frame_ENST00000225972_ENST00000229179_TCGA-A8-A0A7-01A_LRRC59_chr17_48469759_-_NUP107_chr12_69135593_length(amino acids)=258AA_start in transcript=164_stop in transcript=940
MTSDISAPFTRRNPGAGARSAGVTMTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK
LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKDAKEDHERTHQMV

--------------------------------------------------------------
>In-frame_ENST00000225972_ENST00000378905_TCGA-A8-A0A7-01A_LRRC59_chr17_48469759_-_NUP107_chr12_69135593_length(transcript)=1162nt_BP=665nt
ATCTCAGTGGTCGCGGAAGGTGACGTGGACACGGAAGTGGTCGTCGTCGCGGCACCGGTGGGAGCTAGGCGCGAGGCTCGGAGTGCGGCC
AGCGGGCGGAGGCGGTCTCGCATCGGCGGCGACGGAGGGCTCAGGCGTCGTCGTTTGGGTGGGGGGCCGCTGAACTGACAAGCGACATTT
CAGCTCCTTTCACCCGCCGGAACCCCGGAGCCGGGGCCCGCTCAGCCGGCGTTACCATGACCAAGGCCGGTAGCAAGGGCGGGAACCTCC
GCGACAAGCTGGACGGCAACGAACTGGACCTGAGCCTCAGCGACCTGAATGAGGTCCCGGTGAAGGAGCTGGCTGCCCTTCCAAAGGCCA
CCATCCTGGATCTGTCTTGTAATAAACTGACTACTCTACCGTCGGATTTCTGTGGCCTCACACACCTGGTGAAGCTAGACCTGAGTAAGA
ACAAGCTGCAGCAGCTGCCAGCAGACTTTGGCCGTCTGGTCAACCTCCAGCACCTGGATCTCCTCAACAACAAGCTGGTCACCTTGCCTG
TCAGCTTTGCTCAGCTCAAGAACCTGAAGTGGTTGGACCTGAAGGATAACCCCCTGGATCCTGTCCTGGCCAAGGTGGCAGGTGACTGCT
TGGATGAGAAGCAGTGTAAGCAGTGTGCAAACAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTT
GTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCT
CTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAG
ACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAAT
AAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTG

>In-frame_ENST00000225972_ENST00000378905_TCGA-A8-A0A7-01A_LRRC59_chr17_48469759_-_NUP107_chr12_69135593_length(amino acids)=258AA_start in transcript=164_stop in transcript=940
MTSDISAPFTRRNPGAGARSAGVTMTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK
LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKDAKEDHERTHQMV

--------------------------------------------------------------
>In-frame_ENST00000225972_ENST00000539906_TCGA-A8-A0A7-01A_LRRC59_chr17_48469759_-_NUP107_chr12_69135593_length(transcript)=1010nt_BP=665nt
ATCTCAGTGGTCGCGGAAGGTGACGTGGACACGGAAGTGGTCGTCGTCGCGGCACCGGTGGGAGCTAGGCGCGAGGCTCGGAGTGCGGCC
AGCGGGCGGAGGCGGTCTCGCATCGGCGGCGACGGAGGGCTCAGGCGTCGTCGTTTGGGTGGGGGGCCGCTGAACTGACAAGCGACATTT
CAGCTCCTTTCACCCGCCGGAACCCCGGAGCCGGGGCCCGCTCAGCCGGCGTTACCATGACCAAGGCCGGTAGCAAGGGCGGGAACCTCC
GCGACAAGCTGGACGGCAACGAACTGGACCTGAGCCTCAGCGACCTGAATGAGGTCCCGGTGAAGGAGCTGGCTGCCCTTCCAAAGGCCA
CCATCCTGGATCTGTCTTGTAATAAACTGACTACTCTACCGTCGGATTTCTGTGGCCTCACACACCTGGTGAAGCTAGACCTGAGTAAGA
ACAAGCTGCAGCAGCTGCCAGCAGACTTTGGCCGTCTGGTCAACCTCCAGCACCTGGATCTCCTCAACAACAAGCTGGTCACCTTGCCTG
TCAGCTTTGCTCAGCTCAAGAACCTGAAGTGGTTGGACCTGAAGGATAACCCCCTGGATCCTGTCCTGGCCAAGGTGGCAGGTGACTGCT
TGGATGAGAAGCAGTGTAAGCAGTGTGCAAACAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTT
GTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCT
CTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAG
ACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAAT

>In-frame_ENST00000225972_ENST00000539906_TCGA-A8-A0A7-01A_LRRC59_chr17_48469759_-_NUP107_chr12_69135593_length(amino acids)=258AA_start in transcript=164_stop in transcript=940
MTSDISAPFTRRNPGAGARSAGVTMTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK
LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKDAKEDHERTHQMV

--------------------------------------------------------------
>In-frame_ENST00000225972_ENST00000229179_TCGA-A8-A0A7_LRRC59_chr17_48469758_-_NUP107_chr12_69135592_length(transcript)=1484nt_BP=665nt
ATCTCAGTGGTCGCGGAAGGTGACGTGGACACGGAAGTGGTCGTCGTCGCGGCACCGGTGGGAGCTAGGCGCGAGGCTCGGAGTGCGGCC
AGCGGGCGGAGGCGGTCTCGCATCGGCGGCGACGGAGGGCTCAGGCGTCGTCGTTTGGGTGGGGGGCCGCTGAACTGACAAGCGACATTT
CAGCTCCTTTCACCCGCCGGAACCCCGGAGCCGGGGCCCGCTCAGCCGGCGTTACCATGACCAAGGCCGGTAGCAAGGGCGGGAACCTCC
GCGACAAGCTGGACGGCAACGAACTGGACCTGAGCCTCAGCGACCTGAATGAGGTCCCGGTGAAGGAGCTGGCTGCCCTTCCAAAGGCCA
CCATCCTGGATCTGTCTTGTAATAAACTGACTACTCTACCGTCGGATTTCTGTGGCCTCACACACCTGGTGAAGCTAGACCTGAGTAAGA
ACAAGCTGCAGCAGCTGCCAGCAGACTTTGGCCGTCTGGTCAACCTCCAGCACCTGGATCTCCTCAACAACAAGCTGGTCACCTTGCCTG
TCAGCTTTGCTCAGCTCAAGAACCTGAAGTGGTTGGACCTGAAGGATAACCCCCTGGATCCTGTCCTGGCCAAGGTGGCAGGTGACTGCT
TGGATGAGAAGCAGTGTAAGCAGTGTGCAAACAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTT
GTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCT
CTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAG
ACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAAT
AAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTG
ACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTC
CAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCA
TAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAA
GAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAG

>In-frame_ENST00000225972_ENST00000229179_TCGA-A8-A0A7_LRRC59_chr17_48469758_-_NUP107_chr12_69135592_length(amino acids)=258AA_start in transcript=164_stop in transcript=940
MTSDISAPFTRRNPGAGARSAGVTMTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK
LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKDAKEDHERTHQMV

--------------------------------------------------------------
>In-frame_ENST00000225972_ENST00000378905_TCGA-A8-A0A7_LRRC59_chr17_48469758_-_NUP107_chr12_69135592_length(transcript)=1162nt_BP=665nt
ATCTCAGTGGTCGCGGAAGGTGACGTGGACACGGAAGTGGTCGTCGTCGCGGCACCGGTGGGAGCTAGGCGCGAGGCTCGGAGTGCGGCC
AGCGGGCGGAGGCGGTCTCGCATCGGCGGCGACGGAGGGCTCAGGCGTCGTCGTTTGGGTGGGGGGCCGCTGAACTGACAAGCGACATTT
CAGCTCCTTTCACCCGCCGGAACCCCGGAGCCGGGGCCCGCTCAGCCGGCGTTACCATGACCAAGGCCGGTAGCAAGGGCGGGAACCTCC
GCGACAAGCTGGACGGCAACGAACTGGACCTGAGCCTCAGCGACCTGAATGAGGTCCCGGTGAAGGAGCTGGCTGCCCTTCCAAAGGCCA
CCATCCTGGATCTGTCTTGTAATAAACTGACTACTCTACCGTCGGATTTCTGTGGCCTCACACACCTGGTGAAGCTAGACCTGAGTAAGA
ACAAGCTGCAGCAGCTGCCAGCAGACTTTGGCCGTCTGGTCAACCTCCAGCACCTGGATCTCCTCAACAACAAGCTGGTCACCTTGCCTG
TCAGCTTTGCTCAGCTCAAGAACCTGAAGTGGTTGGACCTGAAGGATAACCCCCTGGATCCTGTCCTGGCCAAGGTGGCAGGTGACTGCT
TGGATGAGAAGCAGTGTAAGCAGTGTGCAAACAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTT
GTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCT
CTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAG
ACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAAT
AAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTG

>In-frame_ENST00000225972_ENST00000378905_TCGA-A8-A0A7_LRRC59_chr17_48469758_-_NUP107_chr12_69135592_length(amino acids)=258AA_start in transcript=164_stop in transcript=940
MTSDISAPFTRRNPGAGARSAGVTMTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK
LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKDAKEDHERTHQMV

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>In-frame_ENST00000225972_ENST00000539906_TCGA-A8-A0A7_LRRC59_chr17_48469758_-_NUP107_chr12_69135592_length(transcript)=1010nt_BP=665nt
ATCTCAGTGGTCGCGGAAGGTGACGTGGACACGGAAGTGGTCGTCGTCGCGGCACCGGTGGGAGCTAGGCGCGAGGCTCGGAGTGCGGCC
AGCGGGCGGAGGCGGTCTCGCATCGGCGGCGACGGAGGGCTCAGGCGTCGTCGTTTGGGTGGGGGGCCGCTGAACTGACAAGCGACATTT
CAGCTCCTTTCACCCGCCGGAACCCCGGAGCCGGGGCCCGCTCAGCCGGCGTTACCATGACCAAGGCCGGTAGCAAGGGCGGGAACCTCC
GCGACAAGCTGGACGGCAACGAACTGGACCTGAGCCTCAGCGACCTGAATGAGGTCCCGGTGAAGGAGCTGGCTGCCCTTCCAAAGGCCA
CCATCCTGGATCTGTCTTGTAATAAACTGACTACTCTACCGTCGGATTTCTGTGGCCTCACACACCTGGTGAAGCTAGACCTGAGTAAGA
ACAAGCTGCAGCAGCTGCCAGCAGACTTTGGCCGTCTGGTCAACCTCCAGCACCTGGATCTCCTCAACAACAAGCTGGTCACCTTGCCTG
TCAGCTTTGCTCAGCTCAAGAACCTGAAGTGGTTGGACCTGAAGGATAACCCCCTGGATCCTGTCCTGGCCAAGGTGGCAGGTGACTGCT
TGGATGAGAAGCAGTGTAAGCAGTGTGCAAACAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTT
GTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCT
CTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAG
ACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAAT

>In-frame_ENST00000225972_ENST00000539906_TCGA-A8-A0A7_LRRC59_chr17_48469758_-_NUP107_chr12_69135592_length(amino acids)=258AA_start in transcript=164_stop in transcript=940
MTSDISAPFTRRNPGAGARSAGVTMTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK
LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKDAKEDHERTHQMV

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Fusion Gene PPI Analysis for LRRC59-NUP107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRC59-NUP107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRC59-NUP107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRRC59C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneLRRC59C0017636Glioblastoma1CTD_human
HgeneLRRC59C0024232Lymphatic Metastasis1CTD_human
HgeneLRRC59C0334588Giant Cell Glioblastoma1CTD_human
HgeneLRRC59C0919267ovarian neoplasm1CTD_human
HgeneLRRC59C1140680Malignant neoplasm of ovary1CTD_human
HgeneLRRC59C1621958Glioblastoma Multiforme1CTD_human
HgeneLRRC59C2239176Liver carcinoma1CTD_human
TgeneNUP107C4225228NEPHROTIC SYNDROME, TYPE 112CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNUP107C0018051Gonadal Dysgenesis1GENOMICS_ENGLAND
TgeneNUP107C0685837Pure Gonadal Dysgenesis, 46, XX1ORPHANET
TgeneNUP107C0795949Galloway Mowat syndrome1ORPHANET
TgeneNUP107C0949595Gonadal Dysgenesis, 46,XX1ORPHANET
TgeneNUP107C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
TgeneNUP107C4748084OVARIAN DYSGENESIS 61UNIPROT