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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRTOMT-LAMTOR1 (FusionGDB2 ID:49895)

Fusion Gene Summary for LRTOMT-LAMTOR1

check button Fusion gene summary
Fusion gene informationFusion gene name: LRTOMT-LAMTOR1
Fusion gene ID: 49895
HgeneTgene
Gene symbol

LRTOMT

LAMTOR1

Gene ID

220074

55004

Gene nameleucine rich transmembrane and O-methyltransferase domain containinglate endosomal/lysosomal adaptor, MAPK and MTOR activator 1
SynonymsCFAP111|DFNB63|LRRC51C11orf59|PDRO|Ragulator1|p18|p27RF-Rho
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane O-methyltransferaseleucine-rich repeat-containing protein 51leucine rich transmembrane and 0-methyltransferase domain containingragulator complex protein LAMTOR1RhoA activator C11orf59late endosomal/lysosomal adaptor and MAPK and MTOR activator 1lipid raft adaptor protein p18p27Kip1-releasing factor from RhoAp27kip1 releasing factor from RhoAprotein associated with DRMs and
Modification date2020031320200327
UniProtAcc

Q96E66

Q6IAA8

Ensembl transtripts involved in fusion geneENST00000435085, ENST00000307198, 
ENST00000419228, ENST00000447974, 
ENST00000289488, ENST00000539271, 
ENST00000423494, ENST00000539587, 
ENST00000538478, ENST00000324866, 
ENST00000439209, ENST00000541614, 
ENST00000536917, ENST00000440313, 
ENST00000545249, ENST00000535107, 
ENST00000278671, ENST00000538404, 
ENST00000539797, 
Fusion gene scores* DoF score8 X 9 X 3=2162 X 2 X 3=12
# samples 113
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LRTOMT [Title/Abstract] AND LAMTOR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRTOMT(71804747)-LAMTOR1(71810302), # samples:1
LRTOMT(71808899)-LAMTOR1(71808811), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRTOMT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LAMTOR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-50-5066-01ALRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
ChiTaRS5.0N/ABE877022LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-


Top

Fusion Gene ORF analysis for LRTOMT-LAMTOR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000435085ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000435085ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000435085ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000435085ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-5UTRENST00000435085ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000307198ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000307198ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000307198ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000307198ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-5UTRENST00000307198ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000419228ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000419228ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000419228ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000419228ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-5UTRENST00000419228ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000447974ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000447974ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000447974ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000447974ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000447974ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000289488ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000289488ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000289488ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000289488ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000289488ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000539271ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000539271ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000539271ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-3CDSENST00000539271ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5UTR-5UTRENST00000539271ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000423494ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000423494ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000423494ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000423494ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000423494ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000539587ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000539587ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000539587ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000539587ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-5UTRENST00000539587ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000538478ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000538478ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000538478ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000538478ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000538478ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000324866ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000324866ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000324866ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000324866ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000324866ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000439209ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000439209ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000439209ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000439209ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000439209ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000541614ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000541614ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000541614ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000541614ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000541614ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000536917ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000536917ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000536917ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
In-frameENST00000536917ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
5CDS-5UTRENST00000536917ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000440313ENST00000545249LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000440313ENST00000535107LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000440313ENST00000278671LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-3CDSENST00000440313ENST00000538404LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-5UTRENST00000440313ENST00000539797LRTOMTchr11

71804747

+LAMTOR1chr11

71810302

-
intron-intronENST00000435085ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000435085ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000435085ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000435085ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000435085ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000307198ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000307198ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000307198ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000307198ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000307198ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000419228ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000419228ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000419228ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000419228ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000419228ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000447974ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000447974ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000447974ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000447974ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000447974ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000289488ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000289488ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000289488ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000289488ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000289488ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000539271ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000539271ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000539271ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000539271ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000539271ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000423494ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000423494ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000423494ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000423494ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000423494ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000539587ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000539587ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000539587ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000539587ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000539587ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000538478ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000538478ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000538478ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000538478ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000538478ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000324866ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000324866ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000324866ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000324866ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000324866ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000439209ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000439209ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000439209ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000439209ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000439209ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000541614ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000541614ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000541614ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000541614ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000541614ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000536917ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000536917ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000536917ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000536917ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000536917ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000440313ENST00000545249LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000440313ENST00000535107LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000440313ENST00000278671LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-3UTRENST00000440313ENST00000538404LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-
intron-intronENST00000440313ENST00000539797LRTOMTchr11

71808899

+LAMTOR1chr11

71808811

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for LRTOMT-LAMTOR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRTOMT-LAMTOR1


check button Go to

FGviewer for the breakpoints of chr11:71804747-chr11:71810302

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRTOMT

Q96E66

LAMTOR1

Q6IAA8

FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000289488+4649_7196.0193.0RepeatNote=LRR 1
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000324866+4549_7196.0147.0RepeatNote=LRR 1
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000423494+3549_7178.0175.0RepeatNote=LRR 1
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000447974+4649_7196.0159.0RepeatNote=LRR 1
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000536917+2349_7196.0147.0RepeatNote=LRR 1
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000538478+4649_7196.0193.0RepeatNote=LRR 1
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000541614+3549_7196.0159.0RepeatNote=LRR 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000289488+46137_17596.0193.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000324866+45137_17596.0147.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000423494+35137_17578.0175.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000447974+46137_17596.0159.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000536917+23137_17596.0147.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000538478+46137_17596.0193.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000541614+35137_17596.0159.0DomainNote=LRRCT
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000307198+27139_1400292.0RegionS-adenosyl-L-methionine binding
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000419228+49139_1400252.0RegionS-adenosyl-L-methionine binding
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000435085+49139_1400292.0RegionS-adenosyl-L-methionine binding
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000289488+46103_12496.0193.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000289488+4680_10196.0193.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000324866+45103_12496.0147.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000324866+4580_10196.0147.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000423494+35103_12478.0175.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000423494+3580_10178.0175.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000447974+46103_12496.0159.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000447974+4680_10196.0159.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000536917+23103_12496.0147.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000536917+2380_10196.0147.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000538478+46103_12496.0193.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000538478+4680_10196.0193.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000541614+35103_12496.0159.0RepeatNote=LRR 3
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000541614+3580_10196.0159.0RepeatNote=LRR 2
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000307198+2731_510292.0TransmembraneHelical
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000419228+4931_510252.0TransmembraneHelical
HgeneLRTOMTchr11:71804747chr11:71810302ENST00000435085+4931_510292.0TransmembraneHelical


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Fusion Gene Sequence for LRTOMT-LAMTOR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LRTOMT-LAMTOR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLAMTOR1chr11:71804747chr11:71810302ENST0000027867105121_16114.0162.0LAMTOR2 and LAMTOR3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRTOMT-LAMTOR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRTOMT-LAMTOR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRTOMTC1969621DEAFNESS, AUTOSOMAL RECESSIVE 635CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneLRTOMTC0018784Sensorineural Hearing Loss (disorder)1GENOMICS_ENGLAND
HgeneLRTOMTC1384666hearing impairment1GENOMICS_ENGLAND