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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANO6-BRD2 (FusionGDB2 ID:5003)

Fusion Gene Summary for ANO6-BRD2

Fusion gene summary

Fusion gene information	Fusion gene name: ANO6-BRD2
	Fusion gene ID: 5003
		Hgene	Tgene
	Gene symbol	ANO6	BRD2
	Gene ID	196527	6046
	Gene name	anoctamin 6	bromodomain containing 2
	Synonyms	BDPLT7\|SCTS\|TMEM16F	BRD2-IT1\|D6S113E\|FSH\|FSRG1\|NAT\|O27.1.1\|RING3\|RNF3
	Cytomap	12q12	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	anoctamin-6SCAN channelsmall-conductance calcium-activated nonselective cation channeltransmembrane protein 16F	bromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 protein
	Modification date	20200313	20200313
	UniProtAcc	Q4KMQ2	P25440
	Ensembl transtripts involved in fusion gene	ENST00000426898, ENST00000425752, ENST00000423947, ENST00000435642, ENST00000320560, ENST00000441606,	ENST00000374825, ENST00000496118, ENST00000580234, ENST00000374831, ENST00000395289, ENST00000443797, ENST00000395287, ENST00000449085, ENST00000438194, ENST00000466744, ENST00000383108, ENST00000547895, ENST00000549843, ENST00000442863, ENST00000552513, ENST00000442219, ENST00000498329, ENST00000488549, ENST00000425201, ENST00000399529, ENST00000399528, ENST00000550142, ENST00000548837, ENST00000399527, ENST00000549236, ENST00000482105, ENST00000414731, ENST00000449118, ENST00000550598, ENST00000479973, ENST00000546777, ENST00000450320, ENST00000547286, ENST00000552587, ENST00000549126, ENST00000553146, ENST00000448067, ENST00000436979, ENST00000466208,
Fusion gene scores	* DoF score	8 X 8 X 6=384	10 X 15 X 3=450
	# samples	10	16
	** MAII score	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/450*10)=-1.49185309632967 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANO6 [Title/Abstract] AND BRD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANO6(45805709)-BRD2(32945942), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ANO6	GO:0006812	cation transport	22946059
Tgene	BRD2	GO:0006357	regulation of transcription by RNA polymerase II	18406326

Fusion gene breakpoints across ANO6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE836582	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-

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Fusion Gene ORF analysis for ANO6-BRD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000426898	ENST00000374825	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000496118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000580234	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000374831	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000395289	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000443797	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000395287	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000449085	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000438194	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000466744	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000383108	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000547895	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000549843	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000442863	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000552513	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000442219	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000498329	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000488549	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000425201	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000399529	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000399528	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000550142	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000548837	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000399527	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000549236	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000482105	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000414731	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000449118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000550598	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000479973	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000546777	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000450320	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000547286	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000552587	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000549126	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000553146	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000448067	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000436979	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000426898	ENST00000466208	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-3CDS	ENST00000425752	ENST00000374825	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000496118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000580234	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000374831	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000395289	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000443797	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000395287	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000449085	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000438194	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000466744	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000383108	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000547895	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000549843	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000442863	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000552513	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000442219	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000498329	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000488549	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000425201	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000399529	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000399528	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000550142	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000548837	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000399527	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000549236	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000482105	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000414731	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000449118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000550598	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000479973	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000546777	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000450320	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000547286	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000552587	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000549126	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000553146	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000448067	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000436979	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000425752	ENST00000466208	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-3CDS	ENST00000423947	ENST00000374825	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000496118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000580234	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000374831	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000395289	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000443797	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000395287	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000449085	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000438194	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000466744	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000383108	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000547895	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000549843	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000442863	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000552513	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000442219	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000498329	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000488549	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000425201	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000399529	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000399528	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000550142	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000548837	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000399527	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000549236	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000482105	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000414731	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000449118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000550598	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000479973	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000546777	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000450320	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000547286	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000552587	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000549126	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000553146	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000448067	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000436979	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000423947	ENST00000466208	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-3CDS	ENST00000435642	ENST00000374825	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000496118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000580234	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000374831	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000395289	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000443797	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000395287	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000449085	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000438194	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000466744	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000383108	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000547895	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000549843	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000442863	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000552513	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000442219	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000498329	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000488549	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000425201	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000399529	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000399528	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000550142	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000548837	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000399527	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000549236	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000482105	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000414731	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000449118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000550598	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000479973	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000546777	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000450320	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000547286	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000552587	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000549126	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000553146	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000448067	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000436979	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000435642	ENST00000466208	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-3CDS	ENST00000320560	ENST00000374825	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000496118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000580234	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000374831	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000395289	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000443797	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000395287	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000449085	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000438194	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000466744	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000383108	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000547895	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000549843	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000442863	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000552513	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000442219	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000498329	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000488549	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000425201	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000399529	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000399528	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000550142	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000548837	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000399527	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000549236	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000482105	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000414731	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000449118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000550598	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000479973	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000546777	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000450320	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000547286	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000552587	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000549126	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000553146	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000448067	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000436979	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000320560	ENST00000466208	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-3CDS	ENST00000441606	ENST00000374825	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000496118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000580234	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000374831	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000395289	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000443797	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000395287	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000449085	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000438194	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000466744	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000383108	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000547895	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000549843	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000442863	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000552513	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000442219	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000498329	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000488549	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000425201	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000399529	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000399528	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000550142	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000548837	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000399527	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000549236	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000482105	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000414731	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000449118	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000550598	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000479973	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000546777	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000450320	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000547286	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000552587	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000549126	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000553146	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000448067	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000436979	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-
intron-intron	ENST00000441606	ENST00000466208	ANO6	chr12	45805709	+	BRD2	chr6	32945942	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ANO6-BRD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANO6-BRD2

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANO6 Q4KMQ2	BRD2 P25440
FUNCTION: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO:0000250\|UniProtKB:Q6P9J9, ECO:0000269\|PubMed:20056604, ECO:0000269\|PubMed:21107324, ECO:0000269\|PubMed:21908539, ECO:0000269\|PubMed:22006324, ECO:0000269\|PubMed:22946059}.	FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269\|PubMed:18406326}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ANO6-BRD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANO6-BRD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ANO6-BRD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ANO6-BRD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ANO6	C0796149	Scott Syndrome	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	ANO6	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	ANO6	C0038013	Ankylosing spondylitis	1	CTD_human
Tgene	BRD2	C0017636	Glioblastoma	1	CTD_human
Tgene	BRD2	C0025149	Medulloblastoma	1	CTD_human
Tgene	BRD2	C0205833	Medullomyoblastoma	1	CTD_human
Tgene	BRD2	C0278510	Childhood Medulloblastoma	1	CTD_human
Tgene	BRD2	C0278876	Adult Medulloblastoma	1	CTD_human
Tgene	BRD2	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	BRD2	C0751291	Desmoplastic Medulloblastoma	1	CTD_human
Tgene	BRD2	C1275668	Melanotic medulloblastoma	1	CTD_human
Tgene	BRD2	C1621958	Glioblastoma Multiforme	1	CTD_human;UNIPROT