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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LTBP3-CERS3 (FusionGDB2 ID:50035)

Fusion Gene Summary for LTBP3-CERS3

check button Fusion gene summary
Fusion gene informationFusion gene name: LTBP3-CERS3
Fusion gene ID: 50035
HgeneTgene
Gene symbol

LTBP3

CERS3

Gene ID

4054

204219

Gene namelatent transforming growth factor beta binding protein 3ceramide synthase 3
SynonymsDASS|GPHYSD3|LTBP-3|LTBP2|STHAG6|pp6425ARCI9|LASS3
Cytomap

11q13.1

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionlatent-transforming growth factor beta-binding protein 3latent TGF beta binding protein 3ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
Modification date2020032220200313
UniProtAcc.

Q8IU89

Ensembl transtripts involved in fusion geneENST00000322147, ENST00000301873, 
ENST00000530785, ENST00000529189, 
ENST00000532932, ENST00000536982, 
ENST00000284382, ENST00000538112, 
ENST00000394113, ENST00000560944, 
Fusion gene scores* DoF score9 X 12 X 4=4328 X 7 X 7=392
# samples 1211
** MAII scorelog2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LTBP3 [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLTBP3(65321172)-CERS3(100943070), # samples:2
Anticipated loss of major functional domain due to fusion event.LTBP3-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LTBP3-CERS3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LTBP3-CERS3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCERS3

GO:0046513

ceramide biosynthetic process

17977534|22038835


check buttonFusion gene breakpoints across LTBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6873-01ALTBP3chr11

65321172

-CERS3chr15

100943070

-
ChimerDB4HNSCTCGA-BA-6873-01ALTBP3chr11

65321172

-CERS3chr15

100943070

-


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Fusion Gene ORF analysis for LTBP3-CERS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000322147ENST00000284382LTBP3chr11

65321172

-CERS3chr15

100943070

-
Frame-shiftENST00000322147ENST00000538112LTBP3chr11

65321172

-CERS3chr15

100943070

-
Frame-shiftENST00000322147ENST00000394113LTBP3chr11

65321172

-CERS3chr15

100943070

-
5CDS-5UTRENST00000322147ENST00000560944LTBP3chr11

65321172

-CERS3chr15

100943070

-
In-frameENST00000301873ENST00000284382LTBP3chr11

65321172

-CERS3chr15

100943070

-
Frame-shiftENST00000301873ENST00000538112LTBP3chr11

65321172

-CERS3chr15

100943070

-
Frame-shiftENST00000301873ENST00000394113LTBP3chr11

65321172

-CERS3chr15

100943070

-
5CDS-5UTRENST00000301873ENST00000560944LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000530785ENST00000284382LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000530785ENST00000538112LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000530785ENST00000394113LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-5UTRENST00000530785ENST00000560944LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000529189ENST00000284382LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000529189ENST00000538112LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000529189ENST00000394113LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-5UTRENST00000529189ENST00000560944LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000532932ENST00000284382LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000532932ENST00000538112LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000532932ENST00000394113LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-5UTRENST00000532932ENST00000560944LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000536982ENST00000284382LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000536982ENST00000538112LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-3CDSENST00000536982ENST00000394113LTBP3chr11

65321172

-CERS3chr15

100943070

-
intron-5UTRENST00000536982ENST00000560944LTBP3chr11

65321172

-CERS3chr15

100943070

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000322147LTBP3chr1165321172-ENST00000284382CERS3chr15100943070-333586401016338
ENST00000301873LTBP3chr1165321172-ENST00000284382CERS3chr15100943070-36041133381285415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000322147ENST00000284382LTBP3chr1165321172-CERS3chr15100943070-0.099600250.9003998
ENST00000301873ENST00000284382LTBP3chr1165321172-CERS3chr15100943070-0.102076250.8979237

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Fusion Genomic Features for LTBP3-CERS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LTBP3-CERS3


check button Go to

FGviewer for the breakpoints of chr11:65321172-chr15:100943070

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CERS3

Q8IU89

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:22038835, ECO:0000269|PubMed:23754960, ECO:0000269|PubMed:26887952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-3283_167288.01304.0Compositional biasNote=Gly-rich
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-3273_167288.01257.0Compositional biasNote=Gly-rich
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328109_141288.01304.0DomainEGF-like 1
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327109_141288.01257.0DomainEGF-like 1
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113346_355333.0384.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328578_894288.01304.0Compositional biasNote=Cys-rich
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327578_894288.01257.0Compositional biasNote=Cys-rich
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-3281036_1076288.01304.0DomainEGF-like 11%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-3281082_1122288.01304.0DomainEGF-like 12%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-3281136_1186288.01304.0DomainTB 4
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-3281254_1298288.01304.0DomainEGF-like 13%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328277_331288.01304.0DomainTB 1
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328355_395288.01304.0DomainEGF-like 2%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328403_455288.01304.0DomainTB 2
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328574_615288.01304.0DomainEGF-like 3
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328616_659288.01304.0DomainEGF-like 4%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328660_702288.01304.0DomainEGF-like 5%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328744_784288.01304.0DomainEGF-like 6%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328785_825288.01304.0DomainEGF-like 7%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328826_865288.01304.0DomainEGF-like 8%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328866_908288.01304.0DomainEGF-like 9%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328917_971288.01304.0DomainTB 3
HgeneLTBP3chr11:65321172chr15:100943070ENST00000301873-328993_1035288.01304.0DomainEGF-like 10%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-3271036_1076288.01257.0DomainEGF-like 11%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-3271082_1122288.01257.0DomainEGF-like 12%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-3271136_1186288.01257.0DomainTB 4
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-3271254_1298288.01257.0DomainEGF-like 13%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327277_331288.01257.0DomainTB 1
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327355_395288.01257.0DomainEGF-like 2%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327403_455288.01257.0DomainTB 2
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327574_615288.01257.0DomainEGF-like 3
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327616_659288.01257.0DomainEGF-like 4%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327660_702288.01257.0DomainEGF-like 5%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327744_784288.01257.0DomainEGF-like 6%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327785_825288.01257.0DomainEGF-like 7%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327826_865288.01257.0DomainEGF-like 8%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327866_908288.01257.0DomainEGF-like 9%3B calcium-binding
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327917_971288.01257.0DomainTB 3
HgeneLTBP3chr11:65321172chr15:100943070ENST00000322147-327993_1035288.01257.0DomainEGF-like 10%3B calcium-binding
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113130_331333.0384.0DomainTLC
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214130_331333.0384.0DomainTLC
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113130_331333.0384.0DomainTLC
TgeneCERS3chr11:65321172chr15:100943070ENST00000284382111366_127333.0384.0RegionHomeobox-like
TgeneCERS3chr11:65321172chr15:100943070ENST00000394113121466_127333.0384.0RegionHomeobox-like
TgeneCERS3chr11:65321172chr15:100943070ENST00000538112111366_127333.0384.0RegionHomeobox-like
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113139_159333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113174_194333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113205_225333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113264_284333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000002843821113298_318333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST00000284382111332_52333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214139_159333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214174_194333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214205_225333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214264_284333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000003941131214298_318333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST00000394113121432_52333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113139_159333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113174_194333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113205_225333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113264_284333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST000005381121113298_318333.0384.0TransmembraneHelical
TgeneCERS3chr11:65321172chr15:100943070ENST00000538112111332_52333.0384.0TransmembraneHelical


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Fusion Gene Sequence for LTBP3-CERS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000322147_ENST00000284382_TCGA-BA-6873-01A_LTBP3_chr11_65321172_-_CERS3_chr15_100943070_length(transcript)=3335nt_BP=864nt
ATGCCCGGGCCCCGAGGGGCTGCTGGCGGCCTGGCCCCTGAGATGCGCGGGGCGGGGGCGGCGGGGCTGCTGGCGCTGCTGCTGCTGCTG
CTGCTGCTGCTGCTGGGCCTGGGCGGCAGGGTCGAGGGGGGGCCGGCCGGCGAGCGGGGCGCAGGCGGGGGCGGGGCGCTGGCCCGCGAG
CGCTTCAAGGTGGTCTTTGCGCCGGTGATCTGCAAGCGGACCTGTCTCAAGGGCCAGTGTCGGGACAGTTGTCAGCAGGGCTCCAACATG
ACGCTCATCGGAGAGAACGGCCACAGCACAGACACGCTCACGGGCTCCGGCTTCCGCGTGGTGGTGTGCCCTCTCCCCTGCATGAATGGC
GGCCAGTGCTCCTCGCGAAACCAGTGCCTGTGTCCCCCGGACTTCACTGGGCGCTTCTGCCAGGTGCCCGCAGGAGGAGCCGGTGGGGGT
ACCGGCGGCTCAGGCCCCGGCCTGAGCAGGACAGGGGCCCTGTCCACAGGGGCGCTGCCGCCCCTGGCTCCGGAGGGCGACTCTGTGGCC
AGCAAGCACGCCATCTACGCCGTCCAGGTGATCGCTGACCCTCCTGGGCCCGGGGAGGGGCCTCCTGCCCAGCACGCAGCCTTCCTGGTG
CCCCTAGGCCCGGGACAGATCTCAGCAGAAGTGCAGGCCCCGCCCCCCGTGGTGAATGTGCGCGTCCATCACCCGCCCGAGGCCTCAGTC
CAGGTGCACCGCATTGAGAGCTCGAACGCCGAGAGCGCAGCCCCCTCCCAGCACCTGCTGCCGCACCCCAAGCCCTCGCACCCCCGGCCG
CCCACCCAGAAGCCCCTGGGCCGCTGCTTTCAGGACACTCTGCCCAAGCAGCCGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTAT
GAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTC
ATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCC
AGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTA
ACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCA
CAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTT
GCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATG
AGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGG
TGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCA
TCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTT
AAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTA
GCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCC
TGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTAC
CTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGC
ATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAG
TGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAG
GGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTG
CGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGG
CCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTT
CATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGC
AGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTA
AACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTG
TATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGT
ATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAA
CGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATC
TCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTT
CATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGG
CTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCTATCAATATTGTAACAGTAATGACTACAATAAAGCCAAAAGTCCA

>In-frame_ENST00000322147_ENST00000284382_TCGA-BA-6873-01A_LTBP3_chr11_65321172_-_CERS3_chr15_100943070_length(amino acids)=338AA_start in transcript=0_stop in transcript=1016
MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNM
TLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRP

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>In-frame_ENST00000301873_ENST00000284382_TCGA-BA-6873-01A_LTBP3_chr11_65321172_-_CERS3_chr15_100943070_length(transcript)=3604nt_BP=1133nt
CTTGCTCCGGCCTCCTCGCTCCTGCCTGAGTTCGGGGCCTGGTCTGGGCTTCGTCCTGGGGCTGGGAAGTTTCTGCGCTCCCCGCTGTCC
AGTCTGCATCTCCGCGCCTCCCGCCGGGCCCCCGCGGTCCCCTCCCGCCCGCTTCCCCCGCTGCCCTCCCTCGCTGCCCCCTACCCTCTC
CCGGGGCTCCCGGCCCTCTACTCCCTTCGGGCGCGGGCCCCTCGCCCCGCCCGGGCGCGCCCCCCCTCCCCCGGGTCCTGCGGCCCCGGA
TGCCCGGGCCCCGAGGGGCTGCTGGCGGCCTGGCCCCTGAGATGCGCGGGGCGGGGGCGGCGGGGCTGCTGGCGCTGCTGCTGCTGCTGC
TGCTGCTGCTGCTGGGCCTGGGCGGCAGGGTCGAGGGGGGGCCGGCCGGCGAGCGGGGCGCAGGCGGGGGCGGGGCGCTGGCCCGCGAGC
GCTTCAAGGTGGTCTTTGCGCCGGTGATCTGCAAGCGGACCTGTCTCAAGGGCCAGTGTCGGGACAGTTGTCAGCAGGGCTCCAACATGA
CGCTCATCGGAGAGAACGGCCACAGCACAGACACGCTCACGGGCTCCGGCTTCCGCGTGGTGGTGTGCCCTCTCCCCTGCATGAATGGCG
GCCAGTGCTCCTCGCGAAACCAGTGCCTGTGTCCCCCGGACTTCACTGGGCGCTTCTGCCAGGTGCCCGCAGGAGGAGCCGGTGGGGGTA
CCGGCGGCTCAGGCCCCGGCCTGAGCAGGACAGGGGCCCTGTCCACAGGGGCGCTGCCGCCCCTGGCTCCGGAGGGCGACTCTGTGGCCA
GCAAGCACGCCATCTACGCCGTCCAGGTGATCGCTGACCCTCCTGGGCCCGGGGAGGGGCCTCCTGCCCAGCACGCAGCCTTCCTGGTGC
CCCTAGGCCCGGGACAGATCTCAGCAGAAGTGCAGGCCCCGCCCCCCGTGGTGAATGTGCGCGTCCATCACCCGCCCGAGGCCTCAGTCC
AGGTGCACCGCATTGAGAGCTCGAACGCCGAGAGCGCAGCCCCCTCCCAGCACCTGCTGCCGCACCCCAAGCCCTCGCACCCCCGGCCGC
CCACCCAGAAGCCCCTGGGCCGCTGCTTTCAGGACACTCTGCCCAAGCAGCCGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATG
AAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCA
TTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCA
GGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAA
CTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCAC
AGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTG
CCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGA
GTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGT
GGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCAT
CGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTA
AAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAG
CTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCT
GTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACC
TGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCA
TGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGT
GAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGG
GATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGC
GGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGC
CAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTC
ATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCA
GGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAA
ACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGT
ATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTA
TAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAAC
GGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCT
CCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTC
ATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGC
TCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCTATCAATATTGTAACAGTAATGACTACAATAAAGCCAAAAGTCCAG

>In-frame_ENST00000301873_ENST00000284382_TCGA-BA-6873-01A_LTBP3_chr11_65321172_-_CERS3_chr15_100943070_length(amino acids)=415AA_start in transcript=38_stop in transcript=1285
MVWASSWGWEVSALPAVQSASPRLPPGPRGPLPPASPAALPRCPLPSPGAPGPLLPSGAGPSPRPGAPPLPRVLRPRMPGPRGAAGGLAP
EMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTL
TGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIAD
PPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDT

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Fusion Gene PPI Analysis for LTBP3-CERS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LTBP3-CERS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LTBP3-CERS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLTBP3C0002452Amelogenesis Imperfecta2CTD_human;GENOMICS_ENGLAND
HgeneLTBP3C0018273Growth Disorders2CTD_human
HgeneLTBP3C0020608Hypodontia2CTD_human
HgeneLTBP3C0029408Degenerative polyarthritis2CTD_human
HgeneLTBP3C0029464Osteosclerosis2CTD_human
HgeneLTBP3C0086743Osteoarthrosis Deformans2CTD_human
HgeneLTBP3C0376634Craniofacial Abnormalities2CTD_human
HgeneLTBP3C0399352Developmental absence of tooth2CTD_human
HgeneLTBP3C1832594Verloes Bourguignon syndrome2GENOMICS_ENGLAND;ORPHANET
HgeneLTBP3C3489529Tooth Agenesis, Familial2CTD_human
HgeneLTBP3C0005940Bone Diseases1CTD_human
HgeneLTBP3C0022821Kyphosis deformity of spine1CTD_human
HgeneLTBP3C0026267Mitral Valve Prolapse Syndrome1CTD_human
HgeneLTBP3C0029410Osteoarthritis of hip1CTD_human
HgeneLTBP3C0265287Acromicric Dysplasia1ORPHANET
HgeneLTBP3C0432228Brachyolmia1CTD_human
HgeneLTBP3C3489726Geleophysic dysplasia1ORPHANET
HgeneLTBP3C4540511GELEOPHYSIC DYSPLASIA 31GENOMICS_ENGLAND;UNIPROT
TgeneCERS3C3554349ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 92CTD_human;GENOMICS_ENGLAND
TgeneCERS3C0079154Congenital Nonbullous Ichthyosiform Erythroderma1ORPHANET
TgeneCERS3C2750787Weill-Marchesani-Like Syndrome1ORPHANET