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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LYST-ARID4B (FusionGDB2 ID:50254)

Fusion Gene Summary for LYST-ARID4B

check button Fusion gene summary
Fusion gene informationFusion gene name: LYST-ARID4B
Fusion gene ID: 50254
HgeneTgene
Gene symbol

LYST

ARID4B

Gene ID

1130

51742

Gene namelysosomal trafficking regulatorAT-rich interaction domain 4B
SynonymsCHS|CHS1BCAA|BRCAA1|RBBP1L1|RBP1L1|SAP180
Cytomap

1q42.3

1q42.3

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-trafficking regulatorChediak-Higashi syndrome 1beige homologAT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1bre
Modification date2020031320200320
UniProtAcc

Q99698

Q4LE39

Ensembl transtripts involved in fusion geneENST00000389794, ENST00000389793, 
ENST00000536965, ENST00000473037, 
ENST00000366603, ENST00000264183, 
ENST00000349213, ENST00000494543, 
Fusion gene scores* DoF score14 X 15 X 10=210012 X 11 X 8=1056
# samples 1814
** MAII scorelog2(18/2100*10)=-3.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1056*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYST [Title/Abstract] AND ARID4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYST(235918778)-ARID4B(235331967), # samples:1
Anticipated loss of major functional domain due to fusion event.LYST-ARID4B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LYST-ARID4B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LYST-ARID4B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LYST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARID4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-93-A4JQ-01ALYSTchr1

235918778

-ARID4Bchr1

235331967

-


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Fusion Gene ORF analysis for LYST-ARID4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389794ENST00000366603LYSTchr1

235918778

-ARID4Bchr1

235331967

-
Frame-shiftENST00000389794ENST00000264183LYSTchr1

235918778

-ARID4Bchr1

235331967

-
In-frameENST00000389794ENST00000349213LYSTchr1

235918778

-ARID4Bchr1

235331967

-
5CDS-intronENST00000389794ENST00000494543LYSTchr1

235918778

-ARID4Bchr1

235331967

-
In-frameENST00000389793ENST00000366603LYSTchr1

235918778

-ARID4Bchr1

235331967

-
Frame-shiftENST00000389793ENST00000264183LYSTchr1

235918778

-ARID4Bchr1

235331967

-
In-frameENST00000389793ENST00000349213LYSTchr1

235918778

-ARID4Bchr1

235331967

-
5CDS-intronENST00000389793ENST00000494543LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-3CDSENST00000536965ENST00000366603LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-3CDSENST00000536965ENST00000264183LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-3CDSENST00000536965ENST00000349213LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-intronENST00000536965ENST00000494543LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-3CDSENST00000473037ENST00000366603LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-3CDSENST00000473037ENST00000264183LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-3CDSENST00000473037ENST00000349213LYSTchr1

235918778

-ARID4Bchr1

235331967

-
intron-intronENST00000473037ENST00000494543LYSTchr1

235918778

-ARID4Bchr1

235331967

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389794LYSTchr1235918778-ENST00000366603ARID4Bchr1235331967-9162740417574792434
ENST00000389794LYSTchr1235918778-ENST00000349213ARID4Bchr1235331967-9162740417574792434
ENST00000389793LYSTchr1235918778-ENST00000366603ARID4Bchr1235331967-9162740417574792434
ENST00000389793LYSTchr1235918778-ENST00000349213ARID4Bchr1235331967-9162740417574792434

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389794ENST00000366603LYSTchr1235918778-ARID4Bchr1235331967-0.0001637980.9998362
ENST00000389794ENST00000349213LYSTchr1235918778-ARID4Bchr1235331967-0.0001637980.9998362
ENST00000389793ENST00000366603LYSTchr1235918778-ARID4Bchr1235331967-0.000165070.9998349
ENST00000389793ENST00000349213LYSTchr1235918778-ARID4Bchr1235331967-0.000165070.9998349

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Fusion Genomic Features for LYST-ARID4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LYST-ARID4B


check button Go to

FGviewer for the breakpoints of chr1:235918778-chr1:235331967

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYST

Q99698

ARID4B

Q4LE39

FUNCTION: Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.FUNCTION: Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-255331_362409.66666666666653802.0Compositional biasNote=Poly-Glu
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-255331_362409.66666666666653802.0Compositional biasNote=Poly-Glu
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25531582_16262409.66666666666653802.0RepeatNote=WD 2
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-2553662_7002409.66666666666653802.0RepeatNote=WD 1
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25531582_16262409.66666666666653802.0RepeatNote=WD 2
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-2553662_7002409.66666666666653802.0RepeatNote=WD 1
TgeneARID4Bchr1:235918778chr1:235331967ENST0000034921321231231_12701184.33333333333331227.0Coiled coilOntology_term=ECO:0000255
TgeneARID4Bchr1:235918778chr1:235331967ENST0000026418322241271_13031270.33333333333331313.0Compositional biasNote=Ser-rich
TgeneARID4Bchr1:235918778chr1:235331967ENST0000034921321231271_13031184.33333333333331227.0Compositional biasNote=Ser-rich
TgeneARID4Bchr1:235918778chr1:235331967ENST0000036660322241271_13031270.33333333333331313.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25532448_24522409.66666666666653802.0Compositional biasNote=Poly-Leu
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25532448_24522409.66666666666653802.0Compositional biasNote=Poly-Leu
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533009_31152409.66666666666653802.0DomainBEACH-type PH
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533120_34222409.66666666666653802.0DomainBEACH
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533009_31152409.66666666666653802.0DomainBEACH-type PH
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533120_34222409.66666666666653802.0DomainBEACH
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533563_36022409.66666666666653802.0RepeatNote=WD 3
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533614_36532409.66666666666653802.0RepeatNote=WD 4
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533656_36992409.66666666666653802.0RepeatNote=WD 5
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533700_37442409.66666666666653802.0RepeatNote=WD 6
HgeneLYSTchr1:235918778chr1:235331967ENST00000389793-25533749_37882409.66666666666653802.0RepeatNote=WD 7
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533563_36022409.66666666666653802.0RepeatNote=WD 3
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533614_36532409.66666666666653802.0RepeatNote=WD 4
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533656_36992409.66666666666653802.0RepeatNote=WD 5
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533700_37442409.66666666666653802.0RepeatNote=WD 6
HgeneLYSTchr1:235918778chr1:235331967ENST00000389794-25533749_37882409.66666666666653802.0RepeatNote=WD 7
TgeneARID4Bchr1:235918778chr1:235331967ENST0000026418322241231_12701270.33333333333331313.0Coiled coilOntology_term=ECO:0000255
TgeneARID4Bchr1:235918778chr1:235331967ENST000002641832224728_7541270.33333333333331313.0Coiled coilOntology_term=ECO:0000255
TgeneARID4Bchr1:235918778chr1:235331967ENST000003492132123728_7541184.33333333333331227.0Coiled coilOntology_term=ECO:0000255
TgeneARID4Bchr1:235918778chr1:235331967ENST0000036660322241231_12701270.33333333333331313.0Coiled coilOntology_term=ECO:0000255
TgeneARID4Bchr1:235918778chr1:235331967ENST000003666032224728_7541270.33333333333331313.0Coiled coilOntology_term=ECO:0000255
TgeneARID4Bchr1:235918778chr1:235331967ENST0000026418322241095_11011270.33333333333331313.0Compositional biasNote=Poly-Ser
TgeneARID4Bchr1:235918778chr1:235331967ENST000002641832224154_1591270.33333333333331313.0Compositional biasNote=Poly-Ser
TgeneARID4Bchr1:235918778chr1:235331967ENST000002641832224268_5671270.33333333333331313.0Compositional biasNote=Glu-rich
TgeneARID4Bchr1:235918778chr1:235331967ENST0000034921321231095_11011184.33333333333331227.0Compositional biasNote=Poly-Ser
TgeneARID4Bchr1:235918778chr1:235331967ENST000003492132123154_1591184.33333333333331227.0Compositional biasNote=Poly-Ser
TgeneARID4Bchr1:235918778chr1:235331967ENST000003492132123268_5671184.33333333333331227.0Compositional biasNote=Glu-rich
TgeneARID4Bchr1:235918778chr1:235331967ENST0000036660322241095_11011270.33333333333331313.0Compositional biasNote=Poly-Ser
TgeneARID4Bchr1:235918778chr1:235331967ENST000003666032224154_1591270.33333333333331313.0Compositional biasNote=Poly-Ser
TgeneARID4Bchr1:235918778chr1:235331967ENST000003666032224268_5671270.33333333333331313.0Compositional biasNote=Glu-rich
TgeneARID4Bchr1:235918778chr1:235331967ENST000002641832224306_3981270.33333333333331313.0DomainARID
TgeneARID4Bchr1:235918778chr1:235331967ENST000003492132123306_3981184.33333333333331227.0DomainARID
TgeneARID4Bchr1:235918778chr1:235331967ENST000003666032224306_3981270.33333333333331313.0DomainARID
TgeneARID4Bchr1:235918778chr1:235331967ENST0000026418322241130_11371270.33333333333331313.0RegionNote=Antigenic epitope
TgeneARID4Bchr1:235918778chr1:235331967ENST000002641832224465_4731270.33333333333331313.0RegionNote=Antigenic epitope
TgeneARID4Bchr1:235918778chr1:235331967ENST0000034921321231130_11371184.33333333333331227.0RegionNote=Antigenic epitope
TgeneARID4Bchr1:235918778chr1:235331967ENST000003492132123465_4731184.33333333333331227.0RegionNote=Antigenic epitope
TgeneARID4Bchr1:235918778chr1:235331967ENST0000036660322241130_11371270.33333333333331313.0RegionNote=Antigenic epitope
TgeneARID4Bchr1:235918778chr1:235331967ENST000003666032224465_4731270.33333333333331313.0RegionNote=Antigenic epitope


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Fusion Gene Sequence for LYST-ARID4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000389794_ENST00000366603_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(transcript)=9162nt_BP=7404nt
GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTAAAGCTTTGT
TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG
CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA
AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT
TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA
GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT
ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG
CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA
TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA
ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC
TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA
CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT
GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT
GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA
AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC
AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA
TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT
GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC
TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA
TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA
TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA
GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC
AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT
TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA
ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC
TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG
CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT
AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC
TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT
TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT
AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG
CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT
CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC
AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA
CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA
GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA
GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT
AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA
AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT
TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT
GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA
TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA
AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG
CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC
TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT
ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG
GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG
AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT
TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA
AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG
TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG
TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA
ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT
AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT
TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG
GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA
GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT
ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA
GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT
TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC
AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA
AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA
AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC
ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA
TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT
GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA
GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT
TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC
ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT
CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGATGG
CAAGATCTTTCAGGAGAAAGTGCGGTCAATCATGTACCTGAGGCATTCCAGCAGTGGAGGAAGGTCCCTTATGAGCCCTGGATTTATGGT
AATAAGCCCATCTGGTTTTACTGCTTCACCATATGAAGGAGAGAATTCCTCTAATATTATTCCACAACAGATGGCCGCCCATATGCTGCG
TTCTAGAAGCCTACCAGCATTCCCTACTTCTTCACTACTAACGCAATCACAAAAACTGACTGGAAGTTTGGGTTGTAGTATCGACAGGTT
ACAAAATATTGCAGATACTTATGTTGCCACCCAATCAAAGAAACAAAATTCTTTGGGGAGTTCCGACACACTGAAAAAAGGCAAAGAGGA
CGCATTCATCAGTAGCTGTGAGTCTGCAAAAACTGTTTGTGAAATGGAAGCTGTCCTCTCAGCCCAGGTCTCTGTCAGTGATGTCCCAAA
GGGAGTGCTGGGATTTCCAGTGGTCAAAGCAGATCATAAACAGTTGGGAGCAGAACCCAGGTCAGAAGATGACAGTCCTGGGGATGAGTC
CTGCCCACGCCGACCTGATTACCTAAAGGGATTGGCCTCCTTCCAGCGAAGCCACAGCACTATTGCAAGCCTTGGGCTAGCTTTTCCTTC
ACAGAACGGATCTGCAGCTGTTGGCCGTTGGCCAAGTCTTGTTGATAGAAACACTGATGATTGGGAAAACTTTGCCTATTCTCTTGGTTA
TGAGCCAAATTACAACCGAACTGCAAGTGCTCACAGTGTAACTGAAGACTGTTTGGTACCTATATGCTGTGGATTATATGAACTCCTAAG
TGGGGTTCTTCTTATCCTGCCTGATGTTTTGCTTGAAGATGTGATGGACAAGCTTATTCAAGCAGATACACTTTTGGTCCTCGTTAACCA
CCCATCACCAGCTATACAACAAGGTGTTATTAAACTATTAGATGCATATTTTGCTAGAGCATCTAAGGAACAAAAAGATAAATTTCTGAA
GAATCGTGGATTTTCCTTGCTAGCCAACCAGTTGTATCTTCATCGAGGAACTCAAGAATTGTTAGAATGCTTCATCGAAATGTTCTTTGG
TCGACATATTGGCCTTGATGAAGAGTGCTGCTACATCCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAACAGCTGCTGTTATGTTAA
CTTTAGCTGAACCGTCAATGTCCAGCGCATCACAAAATGGAATGTCAGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCACTTTGCAC
TTAATGGCTGTTGAGGGCCACTTTTTTTTTATACTGCACAGTGGCACAAAAAAATATCAGACAAGCACTATTTTATATTTAAAAATTGTT
TCTTGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGAAAAAGTACAATGAACTGCTTTTCCTCAAGCAATAATTGTTTCCAA
CTTGTCTGGGAATTGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGGAGGCTTTTCACTGCCTGTAGAGACAATACAGTAAG
CATAGTTAAGGGGTGGGTCAGAACATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTTGTTAAAGCTGGAACATTTGATATTT
TTCCATTTATTTATGAAAAAATATGAACCTATTTTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTTAGGGTGGCTTTAATT
GTATAAGTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAACAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGATTCTCT
TTAAAAAAGACTGAACATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCAGTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTA
CTGTACTTTGCCATTTTTCTATAAATCAGTATTTTTTTTTAATTTTGATATACATTGTGTGAAAAAAGAAAATGGCTAATAAACTGTATT
AAATCTTAAACAATGTATAAAGATTGTACTTAGCCAGTTCAAAGTGTATATTTATTCATAATGAATTATAACAGTTATATTTTTGTGTTT
TCTTGTAAATGTTTCTTTTCCCTTAAATACAGATAATTCATTTGTATTGCTTATTTTATTATGAGCTACAACAAAAGGACTTCAGGAACA
AGTAATGTATTAGTATGGTTCAAGATTGTTGATAGGAACTGTCTCAAAAGGATGGTGGTTATTTTAAATATAAATAGCTAATGGGGGTGG
TAGGCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATGCAAAATTGTTTTCACTTGTATTGACTTTATGTTGTATGATTCCAA
TCTCTGTTCTGTTTGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTATATTGTGGATGTGTTCATTCAAGCTATTTAATATC
TGGCACTGTTAATACACAGTACTTTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTGTACTTTTTTTGGATGGGGCTGGCAT
GTTTTCTTTGTTTCCTGGCAATACGACGTGGGAATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCCTTTACATTCAACTTT
TCTAAGAAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTAACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTACAGGA
CTGTAAAGATTTGTTGACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAAAGCTATAAAGTATATATTAGGATCTGCAAACAATGAA

>In-frame_ENST00000389794_ENST00000366603_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(amino acids)=2434AA_start in transcript=175_stop in transcript=7479
MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE
EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN
KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK
FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA
LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL
QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD
VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP
KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ
KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN
GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL
FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC
HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA
TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG
NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN
LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS
SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR
ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER
LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ
RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK
YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT
IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII
YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ
LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSSSGGRSLMSPGF
MVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK
EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAF
PSQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV
NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRHIGLDEECCYILILLFTFIQFHNSCCY

--------------------------------------------------------------
>In-frame_ENST00000389794_ENST00000349213_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(transcript)=9162nt_BP=7404nt
GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTAAAGCTTTGT
TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG
CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA
AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT
TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA
GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT
ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG
CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA
TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA
ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC
TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA
CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT
GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT
GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA
AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC
AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA
TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT
GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC
TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA
TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA
TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA
GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC
AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT
TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA
ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC
TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG
CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT
AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC
TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT
TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT
AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG
CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT
CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC
AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA
CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA
GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA
GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT
AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA
AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT
TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT
GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA
TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA
AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG
CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC
TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT
ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG
GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG
AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT
TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA
AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG
TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG
TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA
ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT
AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT
TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG
GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA
GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT
ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA
GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT
TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC
AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA
AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA
AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC
ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA
TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT
GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA
GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT
TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC
ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT
CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGATGG
CAAGATCTTTCAGGAGAAAGTGCGGTCAATCATGTACCTGAGGCATTCCAGCAGTGGAGGAAGGTCCCTTATGAGCCCTGGATTTATGGT
AATAAGCCCATCTGGTTTTACTGCTTCACCATATGAAGGAGAGAATTCCTCTAATATTATTCCACAACAGATGGCCGCCCATATGCTGCG
TTCTAGAAGCCTACCAGCATTCCCTACTTCTTCACTACTAACGCAATCACAAAAACTGACTGGAAGTTTGGGTTGTAGTATCGACAGGTT
ACAAAATATTGCAGATACTTATGTTGCCACCCAATCAAAGAAACAAAATTCTTTGGGGAGTTCCGACACACTGAAAAAAGGCAAAGAGGA
CGCATTCATCAGTAGCTGTGAGTCTGCAAAAACTGTTTGTGAAATGGAAGCTGTCCTCTCAGCCCAGGTCTCTGTCAGTGATGTCCCAAA
GGGAGTGCTGGGATTTCCAGTGGTCAAAGCAGATCATAAACAGTTGGGAGCAGAACCCAGGTCAGAAGATGACAGTCCTGGGGATGAGTC
CTGCCCACGCCGACCTGATTACCTAAAGGGATTGGCCTCCTTCCAGCGAAGCCACAGCACTATTGCAAGCCTTGGGCTAGCTTTTCCTTC
ACAGAACGGATCTGCAGCTGTTGGCCGTTGGCCAAGTCTTGTTGATAGAAACACTGATGATTGGGAAAACTTTGCCTATTCTCTTGGTTA
TGAGCCAAATTACAACCGAACTGCAAGTGCTCACAGTGTAACTGAAGACTGTTTGGTACCTATATGCTGTGGATTATATGAACTCCTAAG
TGGGGTTCTTCTTATCCTGCCTGATGTTTTGCTTGAAGATGTGATGGACAAGCTTATTCAAGCAGATACACTTTTGGTCCTCGTTAACCA
CCCATCACCAGCTATACAACAAGGTGTTATTAAACTATTAGATGCATATTTTGCTAGAGCATCTAAGGAACAAAAAGATAAATTTCTGAA
GAATCGTGGATTTTCCTTGCTAGCCAACCAGTTGTATCTTCATCGAGGAACTCAAGAATTGTTAGAATGCTTCATCGAAATGTTCTTTGG
TCGACATATTGGCCTTGATGAAGAGTGCTGCTACATCCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAACAGCTGCTGTTATGTTAA
CTTTAGCTGAACCGTCAATGTCCAGCGCATCACAAAATGGAATGTCAGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCACTTTGCAC
TTAATGGCTGTTGAGGGCCACTTTTTTTTTATACTGCACAGTGGCACAAAAAAATATCAGACAAGCACTATTTTATATTTAAAAATTGTT
TCTTGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGAAAAAGTACAATGAACTGCTTTTCCTCAAGCAATAATTGTTTCCAA
CTTGTCTGGGAATTGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGGAGGCTTTTCACTGCCTGTAGAGACAATACAGTAAG
CATAGTTAAGGGGTGGGTCAGAACATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTTGTTAAAGCTGGAACATTTGATATTT
TTCCATTTATTTATGAAAAAATATGAACCTATTTTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTTAGGGTGGCTTTAATT
GTATAAGTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAACAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGATTCTCT
TTAAAAAAGACTGAACATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCAGTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTA
CTGTACTTTGCCATTTTTCTATAAATCAGTATTTTTTTTTAATTTTGATATACATTGTGTGAAAAAAGAAAATGGCTAATAAACTGTATT
AAATCTTAAACAATGTATAAAGATTGTACTTAGCCAGTTCAAAGTGTATATTTATTCATAATGAATTATAACAGTTATATTTTTGTGTTT
TCTTGTAAATGTTTCTTTTCCCTTAAATACAGATAATTCATTTGTATTGCTTATTTTATTATGAGCTACAACAAAAGGACTTCAGGAACA
AGTAATGTATTAGTATGGTTCAAGATTGTTGATAGGAACTGTCTCAAAAGGATGGTGGTTATTTTAAATATAAATAGCTAATGGGGGTGG
TAGGCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATGCAAAATTGTTTTCACTTGTATTGACTTTATGTTGTATGATTCCAA
TCTCTGTTCTGTTTGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTATATTGTGGATGTGTTCATTCAAGCTATTTAATATC
TGGCACTGTTAATACACAGTACTTTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTGTACTTTTTTTGGATGGGGCTGGCAT
GTTTTCTTTGTTTCCTGGCAATACGACGTGGGAATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCCTTTACATTCAACTTT
TCTAAGAAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTAACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTACAGGA
CTGTAAAGATTTGTTGACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAAAGCTATAAAGTATATATTAGGATCTGCAAACAATGAA

>In-frame_ENST00000389794_ENST00000349213_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(amino acids)=2434AA_start in transcript=175_stop in transcript=7479
MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE
EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN
KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK
FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA
LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL
QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD
VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP
KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ
KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN
GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL
FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC
HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA
TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG
NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN
LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS
SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR
ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER
LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ
RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK
YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT
IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII
YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ
LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSSSGGRSLMSPGF
MVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK
EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAF
PSQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV
NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRHIGLDEECCYILILLFTFIQFHNSCCY

--------------------------------------------------------------
>In-frame_ENST00000389793_ENST00000366603_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(transcript)=9162nt_BP=7404nt
GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTGAAGCTTTGT
TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG
CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA
AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT
TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA
GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT
ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG
CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA
TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA
ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC
TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA
CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT
GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT
GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA
AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC
AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA
TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT
GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC
TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA
TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA
TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA
GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC
AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT
TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA
ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC
TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG
CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT
AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC
TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT
TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT
AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG
CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT
CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC
AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA
CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA
GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA
GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT
AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA
AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT
TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT
GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA
TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA
AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG
CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC
TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT
ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG
GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG
AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT
TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA
AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG
TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG
TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA
ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT
AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT
TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG
GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA
GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT
ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA
GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT
TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC
AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA
AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA
AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC
ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA
TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT
GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA
GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT
TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC
ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT
CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGATGG
CAAGATCTTTCAGGAGAAAGTGCGGTCAATCATGTACCTGAGGCATTCCAGCAGTGGAGGAAGGTCCCTTATGAGCCCTGGATTTATGGT
AATAAGCCCATCTGGTTTTACTGCTTCACCATATGAAGGAGAGAATTCCTCTAATATTATTCCACAACAGATGGCCGCCCATATGCTGCG
TTCTAGAAGCCTACCAGCATTCCCTACTTCTTCACTACTAACGCAATCACAAAAACTGACTGGAAGTTTGGGTTGTAGTATCGACAGGTT
ACAAAATATTGCAGATACTTATGTTGCCACCCAATCAAAGAAACAAAATTCTTTGGGGAGTTCCGACACACTGAAAAAAGGCAAAGAGGA
CGCATTCATCAGTAGCTGTGAGTCTGCAAAAACTGTTTGTGAAATGGAAGCTGTCCTCTCAGCCCAGGTCTCTGTCAGTGATGTCCCAAA
GGGAGTGCTGGGATTTCCAGTGGTCAAAGCAGATCATAAACAGTTGGGAGCAGAACCCAGGTCAGAAGATGACAGTCCTGGGGATGAGTC
CTGCCCACGCCGACCTGATTACCTAAAGGGATTGGCCTCCTTCCAGCGAAGCCACAGCACTATTGCAAGCCTTGGGCTAGCTTTTCCTTC
ACAGAACGGATCTGCAGCTGTTGGCCGTTGGCCAAGTCTTGTTGATAGAAACACTGATGATTGGGAAAACTTTGCCTATTCTCTTGGTTA
TGAGCCAAATTACAACCGAACTGCAAGTGCTCACAGTGTAACTGAAGACTGTTTGGTACCTATATGCTGTGGATTATATGAACTCCTAAG
TGGGGTTCTTCTTATCCTGCCTGATGTTTTGCTTGAAGATGTGATGGACAAGCTTATTCAAGCAGATACACTTTTGGTCCTCGTTAACCA
CCCATCACCAGCTATACAACAAGGTGTTATTAAACTATTAGATGCATATTTTGCTAGAGCATCTAAGGAACAAAAAGATAAATTTCTGAA
GAATCGTGGATTTTCCTTGCTAGCCAACCAGTTGTATCTTCATCGAGGAACTCAAGAATTGTTAGAATGCTTCATCGAAATGTTCTTTGG
TCGACATATTGGCCTTGATGAAGAGTGCTGCTACATCCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAACAGCTGCTGTTATGTTAA
CTTTAGCTGAACCGTCAATGTCCAGCGCATCACAAAATGGAATGTCAGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCACTTTGCAC
TTAATGGCTGTTGAGGGCCACTTTTTTTTTATACTGCACAGTGGCACAAAAAAATATCAGACAAGCACTATTTTATATTTAAAAATTGTT
TCTTGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGAAAAAGTACAATGAACTGCTTTTCCTCAAGCAATAATTGTTTCCAA
CTTGTCTGGGAATTGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGGAGGCTTTTCACTGCCTGTAGAGACAATACAGTAAG
CATAGTTAAGGGGTGGGTCAGAACATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTTGTTAAAGCTGGAACATTTGATATTT
TTCCATTTATTTATGAAAAAATATGAACCTATTTTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTTAGGGTGGCTTTAATT
GTATAAGTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAACAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGATTCTCT
TTAAAAAAGACTGAACATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCAGTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTA
CTGTACTTTGCCATTTTTCTATAAATCAGTATTTTTTTTTAATTTTGATATACATTGTGTGAAAAAAGAAAATGGCTAATAAACTGTATT
AAATCTTAAACAATGTATAAAGATTGTACTTAGCCAGTTCAAAGTGTATATTTATTCATAATGAATTATAACAGTTATATTTTTGTGTTT
TCTTGTAAATGTTTCTTTTCCCTTAAATACAGATAATTCATTTGTATTGCTTATTTTATTATGAGCTACAACAAAAGGACTTCAGGAACA
AGTAATGTATTAGTATGGTTCAAGATTGTTGATAGGAACTGTCTCAAAAGGATGGTGGTTATTTTAAATATAAATAGCTAATGGGGGTGG
TAGGCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATGCAAAATTGTTTTCACTTGTATTGACTTTATGTTGTATGATTCCAA
TCTCTGTTCTGTTTGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTATATTGTGGATGTGTTCATTCAAGCTATTTAATATC
TGGCACTGTTAATACACAGTACTTTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTGTACTTTTTTTGGATGGGGCTGGCAT
GTTTTCTTTGTTTCCTGGCAATACGACGTGGGAATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCCTTTACATTCAACTTT
TCTAAGAAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTAACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTACAGGA
CTGTAAAGATTTGTTGACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAAAGCTATAAAGTATATATTAGGATCTGCAAACAATGAA

>In-frame_ENST00000389793_ENST00000366603_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(amino acids)=2434AA_start in transcript=175_stop in transcript=7479
MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE
EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN
KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK
FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA
LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL
QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD
VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP
KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ
KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN
GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL
FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC
HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA
TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG
NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN
LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS
SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR
ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER
LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ
RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK
YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT
IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII
YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ
LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSSSGGRSLMSPGF
MVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK
EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAF
PSQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV
NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRHIGLDEECCYILILLFTFIQFHNSCCY

--------------------------------------------------------------
>In-frame_ENST00000389793_ENST00000349213_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(transcript)=9162nt_BP=7404nt
GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTGAAGCTTTGT
TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG
CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA
AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT
TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA
GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT
ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG
CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA
TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA
ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC
TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA
CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT
GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT
GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA
AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC
AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA
TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT
GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC
TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA
TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA
TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA
GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC
AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT
TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA
ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC
TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG
CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT
AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC
TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT
TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT
AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG
CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT
CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC
AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA
CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA
GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA
GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT
AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA
AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT
TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT
GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA
TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA
AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG
CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC
TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT
ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG
GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG
AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT
TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA
AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG
TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG
TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA
ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT
AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT
TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG
GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA
GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT
ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA
GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT
TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC
AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA
AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA
AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC
ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA
TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT
GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA
GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT
TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC
ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT
CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGATGG
CAAGATCTTTCAGGAGAAAGTGCGGTCAATCATGTACCTGAGGCATTCCAGCAGTGGAGGAAGGTCCCTTATGAGCCCTGGATTTATGGT
AATAAGCCCATCTGGTTTTACTGCTTCACCATATGAAGGAGAGAATTCCTCTAATATTATTCCACAACAGATGGCCGCCCATATGCTGCG
TTCTAGAAGCCTACCAGCATTCCCTACTTCTTCACTACTAACGCAATCACAAAAACTGACTGGAAGTTTGGGTTGTAGTATCGACAGGTT
ACAAAATATTGCAGATACTTATGTTGCCACCCAATCAAAGAAACAAAATTCTTTGGGGAGTTCCGACACACTGAAAAAAGGCAAAGAGGA
CGCATTCATCAGTAGCTGTGAGTCTGCAAAAACTGTTTGTGAAATGGAAGCTGTCCTCTCAGCCCAGGTCTCTGTCAGTGATGTCCCAAA
GGGAGTGCTGGGATTTCCAGTGGTCAAAGCAGATCATAAACAGTTGGGAGCAGAACCCAGGTCAGAAGATGACAGTCCTGGGGATGAGTC
CTGCCCACGCCGACCTGATTACCTAAAGGGATTGGCCTCCTTCCAGCGAAGCCACAGCACTATTGCAAGCCTTGGGCTAGCTTTTCCTTC
ACAGAACGGATCTGCAGCTGTTGGCCGTTGGCCAAGTCTTGTTGATAGAAACACTGATGATTGGGAAAACTTTGCCTATTCTCTTGGTTA
TGAGCCAAATTACAACCGAACTGCAAGTGCTCACAGTGTAACTGAAGACTGTTTGGTACCTATATGCTGTGGATTATATGAACTCCTAAG
TGGGGTTCTTCTTATCCTGCCTGATGTTTTGCTTGAAGATGTGATGGACAAGCTTATTCAAGCAGATACACTTTTGGTCCTCGTTAACCA
CCCATCACCAGCTATACAACAAGGTGTTATTAAACTATTAGATGCATATTTTGCTAGAGCATCTAAGGAACAAAAAGATAAATTTCTGAA
GAATCGTGGATTTTCCTTGCTAGCCAACCAGTTGTATCTTCATCGAGGAACTCAAGAATTGTTAGAATGCTTCATCGAAATGTTCTTTGG
TCGACATATTGGCCTTGATGAAGAGTGCTGCTACATCCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAACAGCTGCTGTTATGTTAA
CTTTAGCTGAACCGTCAATGTCCAGCGCATCACAAAATGGAATGTCAGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCACTTTGCAC
TTAATGGCTGTTGAGGGCCACTTTTTTTTTATACTGCACAGTGGCACAAAAAAATATCAGACAAGCACTATTTTATATTTAAAAATTGTT
TCTTGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGAAAAAGTACAATGAACTGCTTTTCCTCAAGCAATAATTGTTTCCAA
CTTGTCTGGGAATTGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGGAGGCTTTTCACTGCCTGTAGAGACAATACAGTAAG
CATAGTTAAGGGGTGGGTCAGAACATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTTGTTAAAGCTGGAACATTTGATATTT
TTCCATTTATTTATGAAAAAATATGAACCTATTTTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTTAGGGTGGCTTTAATT
GTATAAGTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAACAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGATTCTCT
TTAAAAAAGACTGAACATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCAGTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTA
CTGTACTTTGCCATTTTTCTATAAATCAGTATTTTTTTTTAATTTTGATATACATTGTGTGAAAAAAGAAAATGGCTAATAAACTGTATT
AAATCTTAAACAATGTATAAAGATTGTACTTAGCCAGTTCAAAGTGTATATTTATTCATAATGAATTATAACAGTTATATTTTTGTGTTT
TCTTGTAAATGTTTCTTTTCCCTTAAATACAGATAATTCATTTGTATTGCTTATTTTATTATGAGCTACAACAAAAGGACTTCAGGAACA
AGTAATGTATTAGTATGGTTCAAGATTGTTGATAGGAACTGTCTCAAAAGGATGGTGGTTATTTTAAATATAAATAGCTAATGGGGGTGG
TAGGCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATGCAAAATTGTTTTCACTTGTATTGACTTTATGTTGTATGATTCCAA
TCTCTGTTCTGTTTGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTATATTGTGGATGTGTTCATTCAAGCTATTTAATATC
TGGCACTGTTAATACACAGTACTTTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTGTACTTTTTTTGGATGGGGCTGGCAT
GTTTTCTTTGTTTCCTGGCAATACGACGTGGGAATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCCTTTACATTCAACTTT
TCTAAGAAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTAACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTACAGGA
CTGTAAAGATTTGTTGACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAAAGCTATAAAGTATATATTAGGATCTGCAAACAATGAA

>In-frame_ENST00000389793_ENST00000349213_TCGA-93-A4JQ-01A_LYST_chr1_235918778_-_ARID4B_chr1_235331967_length(amino acids)=2434AA_start in transcript=175_stop in transcript=7479
MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE
EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN
KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK
FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA
LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL
QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD
VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP
KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ
KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN
GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL
FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC
HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA
TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG
NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN
LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS
SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR
ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER
LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ
RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK
YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT
IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII
YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ
LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSSSGGRSLMSPGF
MVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK
EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAF
PSQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV
NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRHIGLDEECCYILILLFTFIQFHNSCCY

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Fusion Gene PPI Analysis for LYST-ARID4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LYST-ARID4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LYST-ARID4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLYSTC0007965Chediak-Higashi Syndrome12CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLYSTC0001916Albinism3GENOMICS_ENGLAND
HgeneLYSTC0242422Parkinsonian Disorders3GENOMICS_ENGLAND
HgeneLYSTC4721453Peripheral Nervous System Diseases3GENOMICS_ENGLAND
HgeneLYSTC0037772Spastic Paraplegia2GENOMICS_ENGLAND
HgeneLYSTC4304022Attenuated Chédiak-Higashi syndrome1ORPHANET
TgeneARID4BC0010606Adenoid Cystic Carcinoma1CTD_human