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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LYST-GNG4 (FusionGDB2 ID:50259) |
Fusion Gene Summary for LYST-GNG4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LYST-GNG4 | Fusion gene ID: 50259 | Hgene | Tgene | Gene symbol | LYST | GNG4 | Gene ID | 1130 | 2786 |
| Gene name | lysosomal trafficking regulator | G protein subunit gamma 4 | |
| Synonyms | CHS|CHS1 | - | |
| Cytomap | 1q42.3 | 1q42.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysosomal-trafficking regulatorChediak-Higashi syndrome 1beige homolog | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4guanine nucleotide binding protein (G protein), gamma 4guanine nucleotide binding protein 4 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q99698 | P50150 | |
| Ensembl transtripts involved in fusion gene | ENST00000389794, ENST00000389793, ENST00000536965, ENST00000473037, | ENST00000391854, ENST00000450593, ENST00000366598, ENST00000366597, ENST00000484517, | |
| Fusion gene scores | * DoF score | 14 X 15 X 10=2100 | 5 X 4 X 3=60 |
| # samples | 18 | 5 | |
| ** MAII score | log2(18/2100*10)=-3.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LYST [Title/Abstract] AND GNG4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LYST(235929379)-GNG4(235715537), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | LYST-GNG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. LYST-GNG4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across LYST (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GNG4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-W8-A86G-01A | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
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Fusion Gene ORF analysis for LYST-GNG4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000389794 | ENST00000391854 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| In-frame | ENST00000389794 | ENST00000450593 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| In-frame | ENST00000389794 | ENST00000366598 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| In-frame | ENST00000389794 | ENST00000366597 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 5CDS-5UTR | ENST00000389794 | ENST00000484517 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| Frame-shift | ENST00000389793 | ENST00000391854 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| In-frame | ENST00000389793 | ENST00000450593 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| In-frame | ENST00000389793 | ENST00000366598 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| In-frame | ENST00000389793 | ENST00000366597 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 5CDS-5UTR | ENST00000389793 | ENST00000484517 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 3UTR-3CDS | ENST00000536965 | ENST00000391854 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 3UTR-3CDS | ENST00000536965 | ENST00000450593 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 3UTR-3CDS | ENST00000536965 | ENST00000366598 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 3UTR-3CDS | ENST00000536965 | ENST00000366597 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| 3UTR-5UTR | ENST00000536965 | ENST00000484517 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| intron-3CDS | ENST00000473037 | ENST00000391854 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| intron-3CDS | ENST00000473037 | ENST00000450593 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| intron-3CDS | ENST00000473037 | ENST00000366598 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| intron-3CDS | ENST00000473037 | ENST00000366597 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| intron-5UTR | ENST00000473037 | ENST00000484517 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000389794 | LYST | chr1 | 235929379 | - | ENST00000450593 | GNG4 | chr1 | 235715537 | - | 10847 | 6296 | 175 | 6333 | 2052 |
| ENST00000389794 | LYST | chr1 | 235929379 | - | ENST00000366598 | GNG4 | chr1 | 235715537 | - | 7702 | 6296 | 175 | 6333 | 2052 |
| ENST00000389794 | LYST | chr1 | 235929379 | - | ENST00000366597 | GNG4 | chr1 | 235715537 | - | 7702 | 6296 | 175 | 6333 | 2052 |
| ENST00000389793 | LYST | chr1 | 235929379 | - | ENST00000450593 | GNG4 | chr1 | 235715537 | - | 10847 | 6296 | 175 | 6333 | 2052 |
| ENST00000389793 | LYST | chr1 | 235929379 | - | ENST00000366598 | GNG4 | chr1 | 235715537 | - | 7702 | 6296 | 175 | 6333 | 2052 |
| ENST00000389793 | LYST | chr1 | 235929379 | - | ENST00000366597 | GNG4 | chr1 | 235715537 | - | 7702 | 6296 | 175 | 6333 | 2052 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000389794 | ENST00000450593 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - | 0.000400836 | 0.99959916 |
| ENST00000389794 | ENST00000366598 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - | 0.000429195 | 0.9995708 |
| ENST00000389794 | ENST00000366597 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - | 0.000429195 | 0.9995708 |
| ENST00000389793 | ENST00000450593 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - | 0.000402918 | 0.99959713 |
| ENST00000389793 | ENST00000366598 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - | 0.000432125 | 0.9995679 |
| ENST00000389793 | ENST00000366597 | LYST | chr1 | 235929379 | - | GNG4 | chr1 | 235715537 | - | 0.000432125 | 0.9995679 |
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Fusion Genomic Features for LYST-GNG4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LYST-GNG4 |
| Go to FGviewer for the breakpoints of chr1:235929379-chr1:235715537 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LYST | GNG4 |
| FUNCTION: Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. | FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 31_36 | 2040.3333333333333 | 3802.0 | Compositional bias | Note=Poly-Glu |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 31_36 | 2040.3333333333333 | 3802.0 | Compositional bias | Note=Poly-Glu |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 1582_1626 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 2 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 662_700 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 1 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 1582_1626 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 2 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 662_700 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 2448_2452 | 2040.3333333333333 | 3802.0 | Compositional bias | Note=Poly-Leu |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 2448_2452 | 2040.3333333333333 | 3802.0 | Compositional bias | Note=Poly-Leu |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3009_3115 | 2040.3333333333333 | 3802.0 | Domain | BEACH-type PH |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3120_3422 | 2040.3333333333333 | 3802.0 | Domain | BEACH |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3009_3115 | 2040.3333333333333 | 3802.0 | Domain | BEACH-type PH |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3120_3422 | 2040.3333333333333 | 3802.0 | Domain | BEACH |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3563_3602 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 3 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3614_3653 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 4 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3656_3699 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 5 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3700_3744 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 6 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389793 | - | 21 | 53 | 3749_3788 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 7 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3563_3602 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 3 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3614_3653 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 4 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3656_3699 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 5 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3700_3744 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 6 |
| Hgene | LYST | chr1:235929379 | chr1:235715537 | ENST00000389794 | - | 21 | 53 | 3749_3788 | 2040.3333333333333 | 3802.0 | Repeat | Note=WD 7 |
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Fusion Gene Sequence for LYST-GNG4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000389794_ENST00000450593_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(transcript)=10847nt_BP=6296nt GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTAAAGCTTTGT TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGGTCT CCCAGGCAGCTGCGGACCTCCTGGCCTACTGTGAAGCTCACGTGCGGGAAGATCCTCTCATCATTCCAGTGCCTGCATCAGAAAACCCCT TTCGCGAGAAGAAGTTCTTTTGTACCATTCTCTAACTCCGTGTGTGATGAAAACGCCTCCTTTTCTGACCTTCAAAGTCCCCTGTAGAGA CCATGCATGCTCTAAGCCTTAGGGAGTGAGACCAACACCCATCCCTGCCCAGCCAACAGTGGCCGGGGCTTGTCTTATGTTTCCATCTGT TTTCTTCGTGGCATTCAATTTCATTTTTTTCCTTTTCATTTTCATGTTATTTTCATTATTGGCAAAGAAAATCAAAATGTTTATAGCCAA ATAACAAATGTGCCATGTAAAAGTAAGTCTGGACTTAAGAGTTTAAAATTTTTAAACATCAGTTTCCAAGTTTATATCATATTAATACAT TTCAGTGGATAATTTATTTTAAAAAAAAAACTATGCCTAAATATCCCTTATTTGCAATATTCAGTATCAAATTAGAGCATTTTGACCAAC TGAAACATATAACGTTTTCATCTCCTTTCCTGGAGAAAGCAGCTGCAGAGGTTCTGTATTTCCTGCATTTCCATCATCCTAGTAAAAAGA CAACAACCCACAGGATTGGAATGGTTTTCTTTTGTTTTTTTTTTGTTGTTGTTGTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGC TGGAGTGCAATGGCGTGACCTCAGCTCACTGCGACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA TCATAGGCACGCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTC CTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCGTGGAATGGTTTTCTTAG CATATCCTCCTGGGGCCGTGGCGCCCCGGCTGTGGGCCGTGGTGGATGTCCCTTGTTTCAGTGGTCCTACAAAGGTAGATGGTGGGCGGA CACCGAAGTCAACTTGACTGTAAAAGTACCCCATACCGTTGACGCGCTGTGGCAGACCTGTGGGTGCGGTCTCCCCTCTCCAAATGCCAC CTCTTCCTGCTCCCTCCTCTTTTGGCTCCTACTCAGTAGTTCCATTGTGGGCTGCAGTAATATAAGGACCTGTTCTGGACACAGCACTGG GCCCGCTGGGGTTTTAGTAGGGCAGCCCCTTCCCTGCAGGAGTGAGGCATGGTGACAGCAGTCCCCTATGTGCCCCCAAGTCATCTGAGC ATTGGTGTGCATTAAGGTACTCAATCTTCCAACAATAAATACCATAAGTGCATGTCTGTTTTATTTTATTTATTTATCTTTTTGAGACAG AGTCTTGCTCTGTCGCCCGGGCTGGAATGCAATGGCACAATCTCAGCTCACCGCAACCTCCACTCGCAGGTTCAAGTGATCCTCATGTCT CAGCCTCCCTAGTAGCTGGGATGACAAGCACACGCCAACATGCCTGGCTCATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTCG GCCAGGCTGGTCTCCAACTACTGGCCTCGAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTGCAGGTGTGAGCCAGTGCACCC GGCCGTATGTCTTAGAGTGAGGGGAAACTGAGGCACAAAGCGTTTATGTAGTTTGCCCAAGGTTACACATGGTAAGCAGAAAAACTGGGA TTTGAGGGCAGGCAGCCCGGCCCCAGAGTTCCCTTAGCCCCCTGAACTGTGCTACCTTCCAGGTCTACCTGTTTGCAGGTAGGGAGACCC ACAAACTATCATAACTGCACACCGTGAAGCAAACACCTTTGTTGCAGTAACCCGTGGCACACTTCACTTCCCACATTCTCCAGGAGGAAG CCGTATTCTGGTAGTTTAAGGAAGGTGATTCATGGATGCCCCAAGGAAAGGCTAGACATCGATGAATTAGCTCTTGGATTGTCTAAGATC AACCTGAAGGTCCTACCTAAACCAAACTCATATGATCCCGATGAAAGAGGAGAATACACAGTGGGAGCAGAGCTCTTTGTGTAAGTTTGT TCTATTCTGTTTATTTGGAAACTGCCTCTCTCCCTAGTTCTGAAAGAGACTTGCTGTGTGATAGAGAACAGGCCATTTGTGCCTGAAATG TTCTAACCTGCAAATTGGGTTTAATGGTAATTATCCTGCCTTTCTGTCTGGGAGGAAACAGAGATGCTACATAGATGAAAGCTCTGATTA TCATTTAAAACAAATAAATGTACTAAATGCCGTGGTATAATATAGGGAAGAATGGATGACTTCAAAGAGACCATGGTTCCGTTGGAGGCA TAAAATTGCCTGCAAAGAGGCAAATGTAATTTCCAGACCAATTAATGACTTGCTGCCCTCGTAAATGGATTTAGGACATCTTTGTTCCTT GCTTCTTTTGTTAAAACTCATTCTTAGTTTCATTATCAGCTCACTAATAATACCAGTGTTGTTAAGATGCTCAAACTAGAGCAGAATTGT ATGCTGGATGTGACGCTAGGACCTCAGATCCTTTGATAGTGCAGTTATGACCAGGATCTCTTTATTCTGTGCTTCACGTCAACATCATTA ACCCGATGAAGCGAAGCACAAGTCATAAAGGCACATCAGAGAAGCCGAGAAAGCGGGGCCGTACAGAGAGCATCAAAATCAGGTCAGAAA AATGCTGCTTTCCTCTTCCACCAAACCTTCTCCCTGTTGTTTTTACATGCCCCGTCCCTCCAGATTCAGCCTCCGTTTTGTTCTCTCTCC TTTTCCTTTTCCTCCTCTCTTCCTTACCTTCCCCTGTGAGATGCTTTTCTGTCCTTTTACTGCACCTCTTCCAGACCTATGGCATTTGGG GACGGGTCACCCTTCCTAGAGTGATCCTGAATCCAGCTGCCTCTTCTTTTTTTGTTTTTGTTTTTGTTTTTGAGACAGAGTCTCTTTCTG TCGTCCAGGCTGGAGTGCAGTAGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTTGTGCCTCAACCTCACGA GGAGCTGGGATTGCAGGCGCCCGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACCATGTTGGCCACGCTGGT CTTGAAGCCCAGACCTCAAGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTAGTTCC CTCTTCTTAGATGGAGATTTCTGCACATGAGCTGTGAGATCCACAGACATGTCACTGAGCTCCCCCACTCTGTCAGTGGAAGATGAATGG AATAAAGCCTGCTTGCATTGTGGAGTGCAGCTGTGGGGACAGTTGTCATTTTTGTGTTTTCAGCTTAACTGTCCAGCATCTCCCCTCCCT TCCTACAGCAGGGACATCATGCCTTAGATATAAACTTAGTGGTGTGCAGTACCCACCGTGGAAGCTGAAGAAGGGAAGTATTTCCTGTCT CTCAGGCACACCCCGCTTCCAGCCCCATACCAGTCGGGAAGTGGTCATTGACCTGGGGTGGACTACCTGGACCCTTGCTTGGGGCTATGA GCCTGGAGAATGTGACACAAATGAAGGGATGCTGAGACTCATTTCAAGGAAGCCACCGTGGTCCGGGGTTGGTAGTCATACAGCAAGGCA GGTGGGTAGGGCTGGCAGGCTGCAGGGATGGTGTGTCCACTGGTAGCAATGTCCAGGGATGGCAGCGTCCTGGGAATGTCATTTCTGCTC CACTCCTTGGACTCGCTGAGCTGTCTCCGCCTCCACCTATCTTCCTACAGACCTCCCTTCTAGTTTTCTGTCAATTCTTTGAGCCAGCAA ACTCCATCCAGTACATTCTTTCTTCTTTCATGAAAGAGCTTGAGTTGGATGTAAATATATATGACCTAACAATTCCACCCCTAGGTGTAT ACCCTACAGAAATGTGTACATGTGTTCATCCAGAGACATGCTCTAAATCTTCACAAAAACACTCTCCATAATAACCCCGAACAGGAAAGC ACCCCAATGCCCATGTTGGCTGGATAAGCACATTAGGGTATATTCACACGATGGAATCCCAGACTGCAATGGGAATGAGCTGCAACTCCA CCCCCAACTTGGAGTGTATTCACCAACCCTAGTGTTGAACGAGATAAGGCAAAAATGCACCATAGGATTCCATTTATATAAAGTTTAAAA CCCAGCAAAATTCATCCATGCGGTTGCAAGTAGAGATCAGTCCTAAGAAGACAGTAACCAGAAGCGGGCATGAGGTGGTGCTTCTGGGGT GTTCTGTTTCTTGATCTGGTTGCCGGTTACCTGGGTGCTTTCCGTTTGTGAACATTCTTGGAGCTGTACACTTTTGATCTGGGCACTTTT >In-frame_ENST00000389794_ENST00000450593_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(amino acids)=2052AA_start in transcript=175_stop in transcript=6333 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ -------------------------------------------------------------- >In-frame_ENST00000389794_ENST00000366598_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(transcript)=7702nt_BP=6296nt GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTAAAGCTTTGT TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGGTCT CCCAGGCAGCTGCGGACCTCCTGGCCTACTGTGAAGCTCACGTGCGGGAAGATCCTCTCATCATTCCAGTGCCTGCATCAGAAAACCCCT TTCGCGAGAAGAAGTTCTTTTGTACCATTCTCTAACTCCGTGTGTGATGAAAACGCCTCCTTTTCTGACCTTCAAAGTCCCCTGTAGAGA CCATGCATGCTCTAAGCCTTAGGGAGTGAGACCAACACCCATCCCTGCCCAGCCAACAGTGGCCGGGGCTTGTCTTATGTTTCCATCTGT TTTCTTCGTGGCATTCAATTTCATTTTTTTCCTTTTCATTTTCATGTTATTTTCATTATTGGCAAAGAAAATCAAAATGTTTATAGCCAA ATAACAAATGTGCCATGTAAAAGTAAGTCTGGACTTAAGAGTTTAAAATTTTTAAACATCAGTTTCCAAGTTTATATCATATTAATACAT TTCAGTGGATAATTTATTTTAAAAAAAAAACTATGCCTAAATATCCCTTATTTGCAATATTCAGTATCAAATTAGAGCATTTTGACCAAC TGAAACATATAACGTTTTCATCTCCTTTCCTGGAGAAAGCAGCTGCAGAGGTTCTGTATTTCCTGCATTTCCATCATCCTAGTAAAAAGA CAACAACCCACAGGATTGGAATGGTTTTCTTTTGTTTTTTTTTTGTTGTTGTTGTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGC TGGAGTGCAATGGCGTGACCTCAGCTCACTGCGACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA TCATAGGCACGCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTC CTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCGTGGAATGGTTTTCTTAG CATATCCTCCTGGGGCCGTGGCGCCCCGGCTGTGGGCCGTGGTGGATGTCCCTTGTTTCAGTGGTCCTACAAAGGTAGATGGTGGGCGGA CACCGAAGTCAACTTGACTGTAAAAGTACCCCATACCGTTGACGCGCTGTGGCAGACCTGTGGGTGCGGTCTCCCCTCTCCAAATGCCAC CTCTTCCTGCTCCCTCCTCTTTTGGCTCCTACTCAGTAGTTCCATTGTGGGCTGCAGTAATATAAGGACCTGTTCTGGACACAGCACTGG GCCCGCTGGGGTTTTAGTAGGGCAGCCCCTTCCCTGCAGGAGTGAGGCATGGTGACAGCAGTCCCCTATGTGCCCCCAAGTCATCTGAGC >In-frame_ENST00000389794_ENST00000366598_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(amino acids)=2052AA_start in transcript=175_stop in transcript=6333 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ -------------------------------------------------------------- >In-frame_ENST00000389794_ENST00000366597_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(transcript)=7702nt_BP=6296nt GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTAAAGCTTTGT TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGGTCT CCCAGGCAGCTGCGGACCTCCTGGCCTACTGTGAAGCTCACGTGCGGGAAGATCCTCTCATCATTCCAGTGCCTGCATCAGAAAACCCCT TTCGCGAGAAGAAGTTCTTTTGTACCATTCTCTAACTCCGTGTGTGATGAAAACGCCTCCTTTTCTGACCTTCAAAGTCCCCTGTAGAGA CCATGCATGCTCTAAGCCTTAGGGAGTGAGACCAACACCCATCCCTGCCCAGCCAACAGTGGCCGGGGCTTGTCTTATGTTTCCATCTGT TTTCTTCGTGGCATTCAATTTCATTTTTTTCCTTTTCATTTTCATGTTATTTTCATTATTGGCAAAGAAAATCAAAATGTTTATAGCCAA ATAACAAATGTGCCATGTAAAAGTAAGTCTGGACTTAAGAGTTTAAAATTTTTAAACATCAGTTTCCAAGTTTATATCATATTAATACAT TTCAGTGGATAATTTATTTTAAAAAAAAAACTATGCCTAAATATCCCTTATTTGCAATATTCAGTATCAAATTAGAGCATTTTGACCAAC TGAAACATATAACGTTTTCATCTCCTTTCCTGGAGAAAGCAGCTGCAGAGGTTCTGTATTTCCTGCATTTCCATCATCCTAGTAAAAAGA CAACAACCCACAGGATTGGAATGGTTTTCTTTTGTTTTTTTTTTGTTGTTGTTGTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGC TGGAGTGCAATGGCGTGACCTCAGCTCACTGCGACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA TCATAGGCACGCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTC CTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCGTGGAATGGTTTTCTTAG CATATCCTCCTGGGGCCGTGGCGCCCCGGCTGTGGGCCGTGGTGGATGTCCCTTGTTTCAGTGGTCCTACAAAGGTAGATGGTGGGCGGA CACCGAAGTCAACTTGACTGTAAAAGTACCCCATACCGTTGACGCGCTGTGGCAGACCTGTGGGTGCGGTCTCCCCTCTCCAAATGCCAC CTCTTCCTGCTCCCTCCTCTTTTGGCTCCTACTCAGTAGTTCCATTGTGGGCTGCAGTAATATAAGGACCTGTTCTGGACACAGCACTGG GCCCGCTGGGGTTTTAGTAGGGCAGCCCCTTCCCTGCAGGAGTGAGGCATGGTGACAGCAGTCCCCTATGTGCCCCCAAGTCATCTGAGC >In-frame_ENST00000389794_ENST00000366597_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(amino acids)=2052AA_start in transcript=175_stop in transcript=6333 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ -------------------------------------------------------------- >In-frame_ENST00000389793_ENST00000450593_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(transcript)=10847nt_BP=6296nt GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTGAAGCTTTGT TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGGTCT CCCAGGCAGCTGCGGACCTCCTGGCCTACTGTGAAGCTCACGTGCGGGAAGATCCTCTCATCATTCCAGTGCCTGCATCAGAAAACCCCT TTCGCGAGAAGAAGTTCTTTTGTACCATTCTCTAACTCCGTGTGTGATGAAAACGCCTCCTTTTCTGACCTTCAAAGTCCCCTGTAGAGA CCATGCATGCTCTAAGCCTTAGGGAGTGAGACCAACACCCATCCCTGCCCAGCCAACAGTGGCCGGGGCTTGTCTTATGTTTCCATCTGT TTTCTTCGTGGCATTCAATTTCATTTTTTTCCTTTTCATTTTCATGTTATTTTCATTATTGGCAAAGAAAATCAAAATGTTTATAGCCAA ATAACAAATGTGCCATGTAAAAGTAAGTCTGGACTTAAGAGTTTAAAATTTTTAAACATCAGTTTCCAAGTTTATATCATATTAATACAT TTCAGTGGATAATTTATTTTAAAAAAAAAACTATGCCTAAATATCCCTTATTTGCAATATTCAGTATCAAATTAGAGCATTTTGACCAAC TGAAACATATAACGTTTTCATCTCCTTTCCTGGAGAAAGCAGCTGCAGAGGTTCTGTATTTCCTGCATTTCCATCATCCTAGTAAAAAGA CAACAACCCACAGGATTGGAATGGTTTTCTTTTGTTTTTTTTTTGTTGTTGTTGTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGC TGGAGTGCAATGGCGTGACCTCAGCTCACTGCGACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA TCATAGGCACGCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTC CTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCGTGGAATGGTTTTCTTAG CATATCCTCCTGGGGCCGTGGCGCCCCGGCTGTGGGCCGTGGTGGATGTCCCTTGTTTCAGTGGTCCTACAAAGGTAGATGGTGGGCGGA CACCGAAGTCAACTTGACTGTAAAAGTACCCCATACCGTTGACGCGCTGTGGCAGACCTGTGGGTGCGGTCTCCCCTCTCCAAATGCCAC CTCTTCCTGCTCCCTCCTCTTTTGGCTCCTACTCAGTAGTTCCATTGTGGGCTGCAGTAATATAAGGACCTGTTCTGGACACAGCACTGG GCCCGCTGGGGTTTTAGTAGGGCAGCCCCTTCCCTGCAGGAGTGAGGCATGGTGACAGCAGTCCCCTATGTGCCCCCAAGTCATCTGAGC ATTGGTGTGCATTAAGGTACTCAATCTTCCAACAATAAATACCATAAGTGCATGTCTGTTTTATTTTATTTATTTATCTTTTTGAGACAG AGTCTTGCTCTGTCGCCCGGGCTGGAATGCAATGGCACAATCTCAGCTCACCGCAACCTCCACTCGCAGGTTCAAGTGATCCTCATGTCT CAGCCTCCCTAGTAGCTGGGATGACAAGCACACGCCAACATGCCTGGCTCATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTCG GCCAGGCTGGTCTCCAACTACTGGCCTCGAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTGCAGGTGTGAGCCAGTGCACCC GGCCGTATGTCTTAGAGTGAGGGGAAACTGAGGCACAAAGCGTTTATGTAGTTTGCCCAAGGTTACACATGGTAAGCAGAAAAACTGGGA TTTGAGGGCAGGCAGCCCGGCCCCAGAGTTCCCTTAGCCCCCTGAACTGTGCTACCTTCCAGGTCTACCTGTTTGCAGGTAGGGAGACCC ACAAACTATCATAACTGCACACCGTGAAGCAAACACCTTTGTTGCAGTAACCCGTGGCACACTTCACTTCCCACATTCTCCAGGAGGAAG CCGTATTCTGGTAGTTTAAGGAAGGTGATTCATGGATGCCCCAAGGAAAGGCTAGACATCGATGAATTAGCTCTTGGATTGTCTAAGATC AACCTGAAGGTCCTACCTAAACCAAACTCATATGATCCCGATGAAAGAGGAGAATACACAGTGGGAGCAGAGCTCTTTGTGTAAGTTTGT TCTATTCTGTTTATTTGGAAACTGCCTCTCTCCCTAGTTCTGAAAGAGACTTGCTGTGTGATAGAGAACAGGCCATTTGTGCCTGAAATG TTCTAACCTGCAAATTGGGTTTAATGGTAATTATCCTGCCTTTCTGTCTGGGAGGAAACAGAGATGCTACATAGATGAAAGCTCTGATTA TCATTTAAAACAAATAAATGTACTAAATGCCGTGGTATAATATAGGGAAGAATGGATGACTTCAAAGAGACCATGGTTCCGTTGGAGGCA TAAAATTGCCTGCAAAGAGGCAAATGTAATTTCCAGACCAATTAATGACTTGCTGCCCTCGTAAATGGATTTAGGACATCTTTGTTCCTT GCTTCTTTTGTTAAAACTCATTCTTAGTTTCATTATCAGCTCACTAATAATACCAGTGTTGTTAAGATGCTCAAACTAGAGCAGAATTGT ATGCTGGATGTGACGCTAGGACCTCAGATCCTTTGATAGTGCAGTTATGACCAGGATCTCTTTATTCTGTGCTTCACGTCAACATCATTA ACCCGATGAAGCGAAGCACAAGTCATAAAGGCACATCAGAGAAGCCGAGAAAGCGGGGCCGTACAGAGAGCATCAAAATCAGGTCAGAAA AATGCTGCTTTCCTCTTCCACCAAACCTTCTCCCTGTTGTTTTTACATGCCCCGTCCCTCCAGATTCAGCCTCCGTTTTGTTCTCTCTCC TTTTCCTTTTCCTCCTCTCTTCCTTACCTTCCCCTGTGAGATGCTTTTCTGTCCTTTTACTGCACCTCTTCCAGACCTATGGCATTTGGG GACGGGTCACCCTTCCTAGAGTGATCCTGAATCCAGCTGCCTCTTCTTTTTTTGTTTTTGTTTTTGTTTTTGAGACAGAGTCTCTTTCTG TCGTCCAGGCTGGAGTGCAGTAGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTTGTGCCTCAACCTCACGA GGAGCTGGGATTGCAGGCGCCCGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACCATGTTGGCCACGCTGGT CTTGAAGCCCAGACCTCAAGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTAGTTCC CTCTTCTTAGATGGAGATTTCTGCACATGAGCTGTGAGATCCACAGACATGTCACTGAGCTCCCCCACTCTGTCAGTGGAAGATGAATGG AATAAAGCCTGCTTGCATTGTGGAGTGCAGCTGTGGGGACAGTTGTCATTTTTGTGTTTTCAGCTTAACTGTCCAGCATCTCCCCTCCCT TCCTACAGCAGGGACATCATGCCTTAGATATAAACTTAGTGGTGTGCAGTACCCACCGTGGAAGCTGAAGAAGGGAAGTATTTCCTGTCT CTCAGGCACACCCCGCTTCCAGCCCCATACCAGTCGGGAAGTGGTCATTGACCTGGGGTGGACTACCTGGACCCTTGCTTGGGGCTATGA GCCTGGAGAATGTGACACAAATGAAGGGATGCTGAGACTCATTTCAAGGAAGCCACCGTGGTCCGGGGTTGGTAGTCATACAGCAAGGCA GGTGGGTAGGGCTGGCAGGCTGCAGGGATGGTGTGTCCACTGGTAGCAATGTCCAGGGATGGCAGCGTCCTGGGAATGTCATTTCTGCTC CACTCCTTGGACTCGCTGAGCTGTCTCCGCCTCCACCTATCTTCCTACAGACCTCCCTTCTAGTTTTCTGTCAATTCTTTGAGCCAGCAA ACTCCATCCAGTACATTCTTTCTTCTTTCATGAAAGAGCTTGAGTTGGATGTAAATATATATGACCTAACAATTCCACCCCTAGGTGTAT ACCCTACAGAAATGTGTACATGTGTTCATCCAGAGACATGCTCTAAATCTTCACAAAAACACTCTCCATAATAACCCCGAACAGGAAAGC ACCCCAATGCCCATGTTGGCTGGATAAGCACATTAGGGTATATTCACACGATGGAATCCCAGACTGCAATGGGAATGAGCTGCAACTCCA CCCCCAACTTGGAGTGTATTCACCAACCCTAGTGTTGAACGAGATAAGGCAAAAATGCACCATAGGATTCCATTTATATAAAGTTTAAAA CCCAGCAAAATTCATCCATGCGGTTGCAAGTAGAGATCAGTCCTAAGAAGACAGTAACCAGAAGCGGGCATGAGGTGGTGCTTCTGGGGT GTTCTGTTTCTTGATCTGGTTGCCGGTTACCTGGGTGCTTTCCGTTTGTGAACATTCTTGGAGCTGTACACTTTTGATCTGGGCACTTTT >In-frame_ENST00000389793_ENST00000450593_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(amino acids)=2052AA_start in transcript=175_stop in transcript=6333 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ -------------------------------------------------------------- >In-frame_ENST00000389793_ENST00000366598_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(transcript)=7702nt_BP=6296nt GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTGAAGCTTTGT TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGGTCT CCCAGGCAGCTGCGGACCTCCTGGCCTACTGTGAAGCTCACGTGCGGGAAGATCCTCTCATCATTCCAGTGCCTGCATCAGAAAACCCCT TTCGCGAGAAGAAGTTCTTTTGTACCATTCTCTAACTCCGTGTGTGATGAAAACGCCTCCTTTTCTGACCTTCAAAGTCCCCTGTAGAGA CCATGCATGCTCTAAGCCTTAGGGAGTGAGACCAACACCCATCCCTGCCCAGCCAACAGTGGCCGGGGCTTGTCTTATGTTTCCATCTGT TTTCTTCGTGGCATTCAATTTCATTTTTTTCCTTTTCATTTTCATGTTATTTTCATTATTGGCAAAGAAAATCAAAATGTTTATAGCCAA ATAACAAATGTGCCATGTAAAAGTAAGTCTGGACTTAAGAGTTTAAAATTTTTAAACATCAGTTTCCAAGTTTATATCATATTAATACAT TTCAGTGGATAATTTATTTTAAAAAAAAAACTATGCCTAAATATCCCTTATTTGCAATATTCAGTATCAAATTAGAGCATTTTGACCAAC TGAAACATATAACGTTTTCATCTCCTTTCCTGGAGAAAGCAGCTGCAGAGGTTCTGTATTTCCTGCATTTCCATCATCCTAGTAAAAAGA CAACAACCCACAGGATTGGAATGGTTTTCTTTTGTTTTTTTTTTGTTGTTGTTGTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGC TGGAGTGCAATGGCGTGACCTCAGCTCACTGCGACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA TCATAGGCACGCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTC CTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCGTGGAATGGTTTTCTTAG CATATCCTCCTGGGGCCGTGGCGCCCCGGCTGTGGGCCGTGGTGGATGTCCCTTGTTTCAGTGGTCCTACAAAGGTAGATGGTGGGCGGA CACCGAAGTCAACTTGACTGTAAAAGTACCCCATACCGTTGACGCGCTGTGGCAGACCTGTGGGTGCGGTCTCCCCTCTCCAAATGCCAC CTCTTCCTGCTCCCTCCTCTTTTGGCTCCTACTCAGTAGTTCCATTGTGGGCTGCAGTAATATAAGGACCTGTTCTGGACACAGCACTGG GCCCGCTGGGGTTTTAGTAGGGCAGCCCCTTCCCTGCAGGAGTGAGGCATGGTGACAGCAGTCCCCTATGTGCCCCCAAGTCATCTGAGC >In-frame_ENST00000389793_ENST00000366598_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(amino acids)=2052AA_start in transcript=175_stop in transcript=6333 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ -------------------------------------------------------------- >In-frame_ENST00000389793_ENST00000366597_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(transcript)=7702nt_BP=6296nt GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTGAAGCTTTGT TCTAAGAATATTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAG CACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGA AGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAAT TGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAA GGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATT ACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTACCCATCG CTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCA TAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGA ACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGA CGTTACCTTGAATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCT GAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTT GCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAA AATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTC AAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAA TCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCTTCAAAT GGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCAC TGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCA TCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCA GATCCTATCGGGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCC AGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAAT TAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGA ACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGC TTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGG CAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCAACACCT AAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCC TATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTAT TCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAG CAAATTTTATGCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCT CTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCAC AGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGA CATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAA GTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCA GGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATCAGAACT AGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGA AGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCAT TTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTA TTCAGCAGATTTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGA AGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGG CGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCAC TCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGT ATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGG GTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAGTTCAAG AACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAAT TATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACA AAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGG TTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAA ATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCAT AGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTT TCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATG GCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAA GCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCATTGTTT ATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGA GGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATAT TAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCA AAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCA AGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGC ATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCA TCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATAT GAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAA GATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCAGATGTT TAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCAC ACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTATTGACAATTAT CTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAGGTCT CCCAGGCAGCTGCGGACCTCCTGGCCTACTGTGAAGCTCACGTGCGGGAAGATCCTCTCATCATTCCAGTGCCTGCATCAGAAAACCCCT TTCGCGAGAAGAAGTTCTTTTGTACCATTCTCTAACTCCGTGTGTGATGAAAACGCCTCCTTTTCTGACCTTCAAAGTCCCCTGTAGAGA CCATGCATGCTCTAAGCCTTAGGGAGTGAGACCAACACCCATCCCTGCCCAGCCAACAGTGGCCGGGGCTTGTCTTATGTTTCCATCTGT TTTCTTCGTGGCATTCAATTTCATTTTTTTCCTTTTCATTTTCATGTTATTTTCATTATTGGCAAAGAAAATCAAAATGTTTATAGCCAA ATAACAAATGTGCCATGTAAAAGTAAGTCTGGACTTAAGAGTTTAAAATTTTTAAACATCAGTTTCCAAGTTTATATCATATTAATACAT TTCAGTGGATAATTTATTTTAAAAAAAAAACTATGCCTAAATATCCCTTATTTGCAATATTCAGTATCAAATTAGAGCATTTTGACCAAC TGAAACATATAACGTTTTCATCTCCTTTCCTGGAGAAAGCAGCTGCAGAGGTTCTGTATTTCCTGCATTTCCATCATCCTAGTAAAAAGA CAACAACCCACAGGATTGGAATGGTTTTCTTTTGTTTTTTTTTTGTTGTTGTTGTTGTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGC TGGAGTGCAATGGCGTGACCTCAGCTCACTGCGACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA TCATAGGCACGCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAAAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTC CTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCGTGGAATGGTTTTCTTAG CATATCCTCCTGGGGCCGTGGCGCCCCGGCTGTGGGCCGTGGTGGATGTCCCTTGTTTCAGTGGTCCTACAAAGGTAGATGGTGGGCGGA CACCGAAGTCAACTTGACTGTAAAAGTACCCCATACCGTTGACGCGCTGTGGCAGACCTGTGGGTGCGGTCTCCCCTCTCCAAATGCCAC CTCTTCCTGCTCCCTCCTCTTTTGGCTCCTACTCAGTAGTTCCATTGTGGGCTGCAGTAATATAAGGACCTGTTCTGGACACAGCACTGG GCCCGCTGGGGTTTTAGTAGGGCAGCCCCTTCCCTGCAGGAGTGAGGCATGGTGACAGCAGTCCCCTATGTGCCCCCAAGTCATCTGAGC >In-frame_ENST00000389793_ENST00000366597_TCGA-W8-A86G-01A_LYST_chr1_235929379_-_GNG4_chr1_235715537_length(amino acids)=2052AA_start in transcript=175_stop in transcript=6333 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQE EKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCK FDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISP KIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLN GIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVC HKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALG NYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGER LIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSK YINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDII YMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LYST-GNG4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LYST-GNG4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LYST-GNG4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LYST | C0007965 | Chediak-Higashi Syndrome | 12 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | LYST | C0001916 | Albinism | 3 | GENOMICS_ENGLAND |
| Hgene | LYST | C0242422 | Parkinsonian Disorders | 3 | GENOMICS_ENGLAND |
| Hgene | LYST | C4721453 | Peripheral Nervous System Diseases | 3 | GENOMICS_ENGLAND |
| Hgene | LYST | C0037772 | Spastic Paraplegia | 2 | GENOMICS_ENGLAND |
| Hgene | LYST | C4304022 | Attenuated Chédiak-Higashi syndrome | 1 | ORPHANET |
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