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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MADD-MADD (FusionGDB2 ID:50440)

Fusion Gene Summary for MADD-MADD

Fusion gene summary

Fusion gene information	Fusion gene name: MADD-MADD
	Fusion gene ID: 50440
		Hgene	Tgene
	Gene symbol	MADD	MADD
	Gene ID	8567	8567
	Gene name	MAP kinase activating death domain	MAP kinase activating death domain
	Synonyms	DENN\|IG20\|RAB3GEP	DENN\|IG20\|RAB3GEP
	Cytomap	11p11.2	11p11.2
	Type of gene	protein-coding	protein-coding
	Description	MAP kinase-activating death domain proteinRab3 GDP/GTP exchange factordifferentially expressed in normal and neoplastic cellsinsulinoma glucagonoma clone 20	MAP kinase-activating death domain proteinRab3 GDP/GTP exchange factordifferentially expressed in normal and neoplastic cellsinsulinoma glucagonoma clone 20
	Modification date	20200313	20200313
	UniProtAcc	Q8WXG6	Q8WXG6
	Ensembl transtripts involved in fusion gene	ENST00000342922, ENST00000402799, ENST00000311027, ENST00000406482, ENST00000407859, ENST00000349238, ENST00000395344, ENST00000395336, ENST00000402192, ENST00000405573, ENST00000489415,	ENST00000342922, ENST00000402799, ENST00000311027, ENST00000406482, ENST00000407859, ENST00000349238, ENST00000395344, ENST00000395336, ENST00000402192, ENST00000405573, ENST00000489415,
Fusion gene scores	* DoF score	6 X 7 X 4=168	5 X 6 X 3=90
	# samples	7	6
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MADD [Title/Abstract] AND MADD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MADD(47311797)-MADD(47331117), # samples:1 MADD(47336811)-MADD(47345220), # samples:1
Anticipated loss of major functional domain due to fusion event.	MADD-MADD seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. MADD-MADD seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MADD-MADD seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. MADD-MADD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MADD	GO:0032483	regulation of Rab protein signal transduction	20937701
Hgene	MADD	GO:2001236	regulation of extrinsic apoptotic signaling pathway	11577081
Tgene	MADD	GO:0032483	regulation of Rab protein signal transduction	20937701
Tgene	MADD	GO:2001236	regulation of extrinsic apoptotic signaling pathway	11577081

Fusion gene breakpoints across MADD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MADD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AW363427	MADD	chr11	47311797	-	MADD	chr11	47331117	+
ChiTaRS5.0	N/A	BE799184	MADD	chr11	47336811	-	MADD	chr11	47345220	+

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Fusion Gene ORF analysis for MADD-MADD

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000342922	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000342922	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000342922	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402799	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000402799	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000311027	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000311027	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000406482	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000406482	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000407859	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000407859	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000349238	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000349238	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395344	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000395344	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000395336	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000395336	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
Frame-shift	ENST00000402192	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
5CDS-intron	ENST00000402192	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000405573	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-intron	ENST00000405573	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000342922	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000402799	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000311027	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000406482	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000407859	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000349238	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000395344	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000395336	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000402192	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-3CDS	ENST00000489415	ENST00000405573	MADD	chr11	47311797	-	MADD	chr11	47331117	+
intron-intron	ENST00000489415	ENST00000489415	MADD	chr11	47311797	-	MADD	chr11	47331117	+
In-frame	ENST00000342922	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000342922	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000342922	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402799	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000402799	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000311027	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000311027	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000406482	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000406482	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000407859	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000407859	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000349238	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000349238	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395344	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000395344	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000395336	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000395336	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000402192	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000402192	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
In-frame	ENST00000405573	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
5CDS-intron	ENST00000405573	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000342922	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000402799	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000311027	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000406482	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000407859	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000349238	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000395344	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000395336	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000402192	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-3CDS	ENST00000489415	ENST00000405573	MADD	chr11	47336811	-	MADD	chr11	47345220	+
intron-intron	ENST00000489415	ENST00000489415	MADD	chr11	47336811	-	MADD	chr11	47345220	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MADD-MADD

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MADD-MADD

Go to
FGviewer for the breakpoints of chr11:47336811-chr11:47345220
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MADD Q8WXG6	MADD Q8WXG6
FUNCTION: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. {ECO:0000269\|PubMed:11577081, ECO:0000269\|PubMed:14716293, ECO:0000269\|PubMed:14735464, ECO:0000269\|PubMed:15007167, ECO:0000269\|PubMed:20937701, ECO:0000269\|PubMed:9115275}.	FUNCTION: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. {ECO:0000269\|PubMed:11577081, ECO:0000269\|PubMed:14716293, ECO:0000269\|PubMed:14735464, ECO:0000269\|PubMed:15007167, ECO:0000269\|PubMed:20937701, ECO:0000269\|PubMed:9115275}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

1157_1250

1648.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

1157_1250

1589.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

1157_1250

1609.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

1157_1250

1877.6666666666667

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

1157_1250

1542.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

1157_1250

1588.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

1157_1250

1546.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

1157_1250

1783.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

1157_1250

1566.0

Compositional bias

Ser-rich

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

1340_1415

1648.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

14_268

1648.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

289_429

1648.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

431_565

1648.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

1340_1415

1589.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

14_268

1589.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

289_429

1589.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

431_565

1589.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

1340_1415

1609.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

14_268

1609.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

289_429

1609.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

431_565

1609.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

1340_1415

1877.6666666666667

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

14_268

1877.6666666666667

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

289_429

1877.6666666666667

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

431_565

1877.6666666666667

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

1340_1415

1542.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

14_268

1542.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

289_429

1542.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

431_565

1542.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

1340_1415

1588.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

14_268

1588.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

289_429

1588.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

431_565

1588.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

1340_1415

1546.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

14_268

1546.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

289_429

1546.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

431_565

1546.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

1340_1415

1783.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

14_268

1783.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

289_429

1783.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

431_565

1783.0

Domain

dDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

1340_1415

1566.0

Domain

Death

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

14_268

1566.0

Domain

uDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

289_429

1566.0

Domain

cDENN

Hgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

431_565

1566.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

1157_1250

1459.0

1648.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

1157_1250

1400.0

1589.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

1157_1250

1420.0

1609.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

1157_1250

1459.0

1877.6666666666667

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

1157_1250

1353.0

1542.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

1157_1250

1399.0

1588.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

1157_1250

1357.0

1546.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

1157_1250

1357.0

1783.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

1157_1250

1377.0

1566.0

Compositional bias

Ser-rich

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

1340_1415

1459.0

1648.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

14_268

1459.0

1648.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

289_429

1459.0

1648.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000311027

431_565

1459.0

1648.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

1340_1415

1400.0

1589.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

14_268

1400.0

1589.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

289_429

1400.0

1589.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000342922

431_565

1400.0

1589.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

1340_1415

1420.0

1609.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

14_268

1420.0

1609.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

289_429

1420.0

1609.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000349238

431_565

1420.0

1609.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

1340_1415

1459.0

1877.6666666666667

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

14_268

1459.0

1877.6666666666667

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

289_429

1459.0

1877.6666666666667

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395336

431_565

1459.0

1877.6666666666667

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

1340_1415

1353.0

1542.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

14_268

1353.0

1542.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

289_429

1353.0

1542.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000395344

431_565

1353.0

1542.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

1340_1415

1399.0

1588.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

14_268

1399.0

1588.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

289_429

1399.0

1588.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402192

431_565

1399.0

1588.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

1340_1415

1357.0

1546.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

14_268

1357.0

1546.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

289_429

1357.0

1546.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000402799

431_565

1357.0

1546.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

1340_1415

1357.0

1783.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

14_268

1357.0

1783.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

289_429

1357.0

1783.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000406482

431_565

1357.0

1783.0

Domain

dDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

1340_1415

1377.0

1566.0

Domain

Death

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

14_268

1377.0

1566.0

Domain

uDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

289_429

1377.0

1566.0

Domain

cDENN

Tgene

MADD

chr11:47336811

chr11:47345220

ENST00000407859

431_565

1377.0

1566.0

Domain

dDENN

Top

Fusion Gene Sequence for MADD-MADD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MADD-MADD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MADD-MADD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MADD-MADD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source