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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAGI1-JUN (FusionGDB2 ID:50529)

Fusion Gene Summary for MAGI1-JUN

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGI1-JUN
Fusion gene ID: 50529
HgeneTgene
Gene symbol

MAGI1

JUN

Gene ID

154043

3725

Gene nameCNKSR family member 3Jun proto-oncogene, AP-1 transcription factor subunit
SynonymsCNK3|CNK3/IPCEF1|MAGI1AP-1|AP1|c-Jun|cJUN|p39
Cytomap

6q25.2

1p32.1

Type of geneprotein-codingprotein-coding
Descriptionconnector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1transcription factor AP-1Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogeneproto-oncogene c-Junproto-oncogene cJunv-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homolog
Modification date2020032020200313
UniProtAcc

Q96QZ7

P17535

Ensembl transtripts involved in fusion geneENST00000330909, ENST00000402939, 
ENST00000483466, ENST00000497477, 
ENST00000470990, 		ENST00000371222, 
Fusion gene scores* DoF score19 X 13 X 10=24706 X 6 X 2=72
# samples 236
** MAII scorelog2(23/2470*10)=-3.42480527552766
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAGI1 [Title/Abstract] AND JUN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAGI1(65783486)-JUN(59247697), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJUN

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

TgeneJUN

GO:0007265

Ras protein signal transduction

24623306

TgeneJUN

GO:0043392

negative regulation of DNA binding

14645924

TgeneJUN

GO:0043922

negative regulation by host of viral transcription

2833704

TgeneJUN

GO:0043923

positive regulation by host of viral transcription

2833704

TgeneJUN

GO:0045892

negative regulation of transcription, DNA-templated

2833704

TgeneJUN

GO:0045893

positive regulation of transcription, DNA-templated

2833704|9732876|22083952

TgeneJUN

GO:0045944

positive regulation of transcription by RNA polymerase II

2833704|10508860|12490281|19861239

TgeneJUN

GO:0060395

SMAD protein signal transduction

9732876

TgeneJUN

GO:2000144

positive regulation of DNA-templated transcription, initiation

23027619


check buttonFusion gene breakpoints across MAGI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across JUN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE770729MAGI1chr3

65783486

-JUNchr1

59247697

+


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Fusion Gene ORF analysis for MAGI1-JUN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000330909ENST00000371222MAGI1chr3

65783486

-JUNchr1

59247697

+
intron-3UTRENST00000402939ENST00000371222MAGI1chr3

65783486

-JUNchr1

59247697

+
intron-3UTRENST00000483466ENST00000371222MAGI1chr3

65783486

-JUNchr1

59247697

+
intron-3UTRENST00000497477ENST00000371222MAGI1chr3

65783486

-JUNchr1

59247697

+
intron-3UTRENST00000470990ENST00000371222MAGI1chr3

65783486

-JUNchr1

59247697

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAGI1-JUN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAGI1-JUN


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI1

Q96QZ7

JUN

P17535

FUNCTION: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250}.FUNCTION: Transcription factor binding AP-1 sites. {ECO:0000269|PubMed:9989505}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAGI1-JUN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAGI1-JUN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAGI1-JUN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAGI1-JUN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAGI1C0005586Bipolar Disorder2PSYGENET
HgeneMAGI1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneMAGI1C0036341Schizophrenia1PSYGENET
HgeneMAGI1C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET
TgeneJUNC0007102Malignant tumor of colon2CTD_human
TgeneJUNC0007621Neoplastic Cell Transformation2CTD_human
TgeneJUNC0009375Colonic Neoplasms2CTD_human
TgeneJUNC0023903Liver neoplasms2CTD_human
TgeneJUNC0036341Schizophrenia2PSYGENET
TgeneJUNC0345904Malignant neoplasm of liver2CTD_human
TgeneJUNC0005398Cholestasis, Extrahepatic1CTD_human
TgeneJUNC0006142Malignant neoplasm of breast1CTD_human
TgeneJUNC0007786Brain Ischemia1CTD_human
TgeneJUNC0018923Hemangiosarcoma1CTD_human
TgeneJUNC0020538Hypertensive disease1CTD_human
TgeneJUNC0021846Intestinal Polyps1CTD_human
TgeneJUNC0024121Lung Neoplasms1CTD_human
TgeneJUNC0024623Malignant neoplasm of stomach1CTD_human
TgeneJUNC0029463Osteosarcoma1CTD_human
TgeneJUNC0035126Reperfusion Injury1CTD_human
TgeneJUNC0037116Silicosis1CTD_human
TgeneJUNC0038220Status Epilepticus1CTD_human
TgeneJUNC0038356Stomach Neoplasms1CTD_human
TgeneJUNC0086626Minamata Disease1CTD_human
TgeneJUNC0087031Juvenile-Onset Still Disease1CTD_human
TgeneJUNC0242379Malignant neoplasm of lung1CTD_human
TgeneJUNC0270823Petit mal status1CTD_human
TgeneJUNC0274859Inorganic Mercury Poisoning1CTD_human
TgeneJUNC0274860Mercury Poisoning, Organic1CTD_human
TgeneJUNC0311335Grand Mal Status Epilepticus1CTD_human
TgeneJUNC0393734Complex Partial Status Epilepticus1CTD_human
TgeneJUNC0546127Mercury Poisoning, Nervous System1CTD_human
TgeneJUNC0678222Breast Carcinoma1CTD_human
TgeneJUNC0751522Status Epilepticus, Subclinical1CTD_human
TgeneJUNC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneJUNC0751524Simple Partial Status Epilepticus1CTD_human
TgeneJUNC0751855Mercury Encephalopathy1CTD_human
TgeneJUNC0751856Mad Hatter Disease1CTD_human
TgeneJUNC0751857Mercurial Neuroanesthenia1CTD_human
TgeneJUNC0751858Mercury Psychosis1CTD_human
TgeneJUNC0917798Cerebral Ischemia1CTD_human
TgeneJUNC1257931Mammary Neoplasms, Human1CTD_human
TgeneJUNC1458155Mammary Neoplasms1CTD_human
TgeneJUNC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneJUNC2239176Liver carcinoma1CTD_human
TgeneJUNC3495559Juvenile arthritis1CTD_human
TgeneJUNC3714758Juvenile psoriatic arthritis1CTD_human
TgeneJUNC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneJUNC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneJUNC4704874Mammary Carcinoma, Human1CTD_human
TgeneJUNC4721453Peripheral Nervous System Diseases1CTD_human