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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAN1A2-CD101 (FusionGDB2 ID:50808)

Fusion Gene Summary for MAN1A2-CD101

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN1A2-CD101
Fusion gene ID: 50808
HgeneTgene
Gene symbol

MAN1A2

CD101

Gene ID

10905

9398

Gene namemannosidase alpha class 1A member 2CD101 molecule
SynonymsMAN1BEWI-101|IGSF2|V7
Cytomap

1p12

1p13.1

Type of geneprotein-codingprotein-coding
Descriptionmannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IBimmunoglobulin superfamily member 2cell surface glycoprotein V7glu-Trp-Ile EWI motif-containing protein 101leukocyte surface protein
Modification date2020031320200313
UniProtAcc

O60476

Q93033

Ensembl transtripts involved in fusion geneENST00000356554, ENST00000482811, 
ENST00000256652, ENST00000369470, 
ENST00000467588, 
Fusion gene scores* DoF score12 X 11 X 7=9242 X 3 X 3=18
# samples 215
** MAII scorelog2(21/924*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAN1A2 [Title/Abstract] AND CD101 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAN1A2(118009049)-CD101(117576482), # samples:3
MAN1A2(118045592)-CD101(117576482), # samples:3
Anticipated loss of major functional domain due to fusion event.MAN1A2-CD101 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MAN1A2-CD101 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAN1A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CD101 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5D7-01AMAN1A2chr1

118009049

+CD101chr1

117576482

+
ChimerDB4OVTCGA-13-1512-01AMAN1A2chr1

118045592

+CD101chr1

117576482

+
ChimerDB4BRCATCGA-OL-A5D7MAN1A2chr1

118009049

+CD101chr1

117576481

+
ChimerDB4BRCATCGA-OL-A5D7MAN1A2chr1

118009049

+CD101chr1

117576481

+
ChimerDB4OVTCGA-13-1512MAN1A2chr1

118045592

+CD101chr1

117576481

+
ChimerDB4BRCATCGA-OL-A5D7-01AMAN1A2chr1

118009049

+CD101chr1

117576482

+
ChimerDB4OVTCGA-13-1512-01AMAN1A2chr1

118045592

+CD101chr1

117576482

+
ChimerDB4OVTCGA-13-1512-01AMAN1A2chr1

118045592

-CD101chr1

117576482

+
ChimerDB4BRCATCGA-OL-A5D7-01AMAN1A2chr1

118009049

-CD101chr1

117576482

+


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Fusion Gene ORF analysis for MAN1A2-CD101

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356554ENST00000256652MAN1A2chr1

118009049

+CD101chr1

117576482

+
Frame-shiftENST00000356554ENST00000369470MAN1A2chr1

118009049

+CD101chr1

117576482

+
5CDS-3UTRENST00000356554ENST00000467588MAN1A2chr1

118009049

+CD101chr1

117576482

+
intron-3CDSENST00000482811ENST00000256652MAN1A2chr1

118009049

+CD101chr1

117576482

+
intron-3CDSENST00000482811ENST00000369470MAN1A2chr1

118009049

+CD101chr1

117576482

+
intron-3UTRENST00000482811ENST00000467588MAN1A2chr1

118009049

+CD101chr1

117576482

+
Frame-shiftENST00000356554ENST00000256652MAN1A2chr1

118045592

+CD101chr1

117576482

+
Frame-shiftENST00000356554ENST00000369470MAN1A2chr1

118045592

+CD101chr1

117576482

+
5CDS-3UTRENST00000356554ENST00000467588MAN1A2chr1

118045592

+CD101chr1

117576482

+
intron-3CDSENST00000482811ENST00000256652MAN1A2chr1

118045592

+CD101chr1

117576482

+
intron-3CDSENST00000482811ENST00000369470MAN1A2chr1

118045592

+CD101chr1

117576482

+
intron-3UTRENST00000482811ENST00000467588MAN1A2chr1

118045592

+CD101chr1

117576482

+
Frame-shiftENST00000356554ENST00000256652MAN1A2chr1

118009049

+CD101chr1

117576481

+
Frame-shiftENST00000356554ENST00000369470MAN1A2chr1

118009049

+CD101chr1

117576481

+
5CDS-3UTRENST00000356554ENST00000467588MAN1A2chr1

118009049

+CD101chr1

117576481

+
intron-3CDSENST00000482811ENST00000256652MAN1A2chr1

118009049

+CD101chr1

117576481

+
intron-3CDSENST00000482811ENST00000369470MAN1A2chr1

118009049

+CD101chr1

117576481

+
intron-3UTRENST00000482811ENST00000467588MAN1A2chr1

118009049

+CD101chr1

117576481

+
Frame-shiftENST00000356554ENST00000256652MAN1A2chr1

118045592

+CD101chr1

117576481

+
Frame-shiftENST00000356554ENST00000369470MAN1A2chr1

118045592

+CD101chr1

117576481

+
5CDS-3UTRENST00000356554ENST00000467588MAN1A2chr1

118045592

+CD101chr1

117576481

+
intron-3CDSENST00000482811ENST00000256652MAN1A2chr1

118045592

+CD101chr1

117576481

+
intron-3CDSENST00000482811ENST00000369470MAN1A2chr1

118045592

+CD101chr1

117576481

+
intron-3UTRENST00000482811ENST00000467588MAN1A2chr1

118045592

+CD101chr1

117576481

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAN1A2-CD101


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAN1A2-CD101


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN1A2

O60476

CD101

Q93033

FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).FUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAN1A2-CD101


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAN1A2-CD101


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAN1A2-CD101


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAN1A2-CD101


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource