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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAN1A2-LPXN (FusionGDB2 ID:50809)

Fusion Gene Summary for MAN1A2-LPXN

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN1A2-LPXN
Fusion gene ID: 50809
HgeneTgene
Gene symbol

MAN1A2

LPXN

Gene ID

10905

9404

Gene namemannosidase alpha class 1A member 2leupaxin
SynonymsMAN1BLDPL
Cytomap

1p12

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionmannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IBleupaxin
Modification date2020031320200313
UniProtAcc

O60476

O60711

Ensembl transtripts involved in fusion geneENST00000356554, ENST00000482811, 
ENST00000395074, ENST00000528954, 
ENST00000528489, 
Fusion gene scores* DoF score12 X 11 X 7=9247 X 6 X 5=210
# samples 216
** MAII scorelog2(21/924*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAN1A2 [Title/Abstract] AND LPXN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAN1A2(118045592)-LPXN(58322413), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLPXN

GO:0007162

negative regulation of cell adhesion

20543562

TgeneLPXN

GO:0050859

negative regulation of B cell receptor signaling pathway

17640867


check buttonFusion gene breakpoints across MAN1A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LPXN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5717-01AMAN1A2chr1

118045592

+LPXNchr11

58322413

-


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Fusion Gene ORF analysis for MAN1A2-LPXN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356554ENST00000395074MAN1A2chr1

118045592

+LPXNchr11

58322413

-
In-frameENST00000356554ENST00000528954MAN1A2chr1

118045592

+LPXNchr11

58322413

-
In-frameENST00000356554ENST00000528489MAN1A2chr1

118045592

+LPXNchr11

58322413

-
intron-3CDSENST00000482811ENST00000395074MAN1A2chr1

118045592

+LPXNchr11

58322413

-
intron-3CDSENST00000482811ENST00000528954MAN1A2chr1

118045592

+LPXNchr11

58322413

-
intron-3CDSENST00000482811ENST00000528489MAN1A2chr1

118045592

+LPXNchr11

58322413

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356554MAN1A2chr1118045592+ENST00000395074LPXNchr1158322413-405425287353470911
ENST00000356554MAN1A2chr1118045592+ENST00000528954LPXNchr1158322413-405425287353470911
ENST00000356554MAN1A2chr1118045592+ENST00000528489LPXNchr1158322413-388625287353470911

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356554ENST00000395074MAN1A2chr1118045592+LPXNchr1158322413-0.0009065170.99909353
ENST00000356554ENST00000528954MAN1A2chr1118045592+LPXNchr1158322413-0.0009065170.99909353
ENST00000356554ENST00000528489MAN1A2chr1118045592+LPXNchr1158322413-0.0010361850.99896383

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Fusion Genomic Features for MAN1A2-LPXN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAN1A2-LPXN


check button Go to

FGviewer for the breakpoints of chr1:118045592-chr11:58322413

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN1A2

O60476

LPXN

O60711

FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN1A2chr1:118045592chr11:58322413ENST00000356554+12132_36597.6666666666666642.0Topological domainCytoplasmic
HgeneMAN1A2chr1:118045592chr11:58322413ENST00000356554+121337_57597.6666666666666642.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneLPXNchr1:118045592chr11:58322413ENST0000039507429150_20872.66666666666667387.0DomainLIM zinc-binding 1
TgeneLPXNchr1:118045592chr11:58322413ENST0000039507429209_26772.66666666666667387.0DomainLIM zinc-binding 2
TgeneLPXNchr1:118045592chr11:58322413ENST0000039507429268_32672.66666666666667387.0DomainLIM zinc-binding 3
TgeneLPXNchr1:118045592chr11:58322413ENST0000039507429327_38672.66666666666667387.0DomainLIM zinc-binding 4
TgeneLPXNchr1:118045592chr11:58322413ENST0000052895429150_20877.66666666666667392.0DomainLIM zinc-binding 1
TgeneLPXNchr1:118045592chr11:58322413ENST0000052895429209_26777.66666666666667392.0DomainLIM zinc-binding 2
TgeneLPXNchr1:118045592chr11:58322413ENST0000052895429268_32677.66666666666667392.0DomainLIM zinc-binding 3
TgeneLPXNchr1:118045592chr11:58322413ENST0000052895429327_38677.66666666666667392.0DomainLIM zinc-binding 4
TgeneLPXNchr1:118045592chr11:58322413ENST000003950742970_8272.66666666666667387.0MotifNote=LD motif 2
TgeneLPXNchr1:118045592chr11:58322413ENST000003950742992_10372.66666666666667387.0MotifNote=LD motif 3
TgeneLPXNchr1:118045592chr11:58322413ENST000005289542992_10377.66666666666667392.0MotifNote=LD motif 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN1A2chr1:118045592chr11:58322413ENST00000356554+121358_641597.6666666666666642.0Topological domainLumenal
TgeneLPXNchr1:118045592chr11:58322413ENST00000395074293_1572.66666666666667387.0MotifNote=LD motif 1
TgeneLPXNchr1:118045592chr11:58322413ENST00000528954293_1577.66666666666667392.0MotifNote=LD motif 1
TgeneLPXNchr1:118045592chr11:58322413ENST000005289542970_8277.66666666666667392.0MotifNote=LD motif 2


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Fusion Gene Sequence for MAN1A2-LPXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356554_ENST00000395074_TCGA-CG-5717-01A_MAN1A2_chr1_118045592_+_LPXN_chr11_58322413_length(transcript)=4054nt_BP=2528nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTGGAGTAGGGCGAAACTGGGGCTGG
GCATCTGCAGGTAGCAGCATTCTGGCTGAATTTGGTACACTACATATGGAGTTCATCCACCTCAGCTACTTGACAGGGGACCTGACTTAC
TACAAAAAGGTTATGCACATTCGGAAACTACTTCAGAAAATGGATCGTCCAAATGGTCTTTATCCAAATTATTTGAACCCCAGAACAGGG
CGCTGGGGTCAGTATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACA
GACCATGAGGCAAGAAAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATT
GGAGAATGGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCC
AGAGCAGATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTA
GGTCCTGAATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATT
GAAACCTATTGGTACCTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGC
CGAGTTAATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAA
ACATTAAATGAAGCCCAAGAGCCAAAGGAATCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGCTCACCTG
ACTGAGATGCAGGCCAAGGTTGCAGTGAGAGCAGATGCTGGCAAGAAGCACTTACCAGACAAGCAGGATCACAAGGCCTCCCTGGACTCA
ATGCTTGGGGGTCTGGAGCAGGAATTGCAGGACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACCGATTGCT
GGGAAGGTGATCCATGCTCTAGGGCAATCATGGCATCCTGAGCATTTTGTCTGTACTCATTGCAAAGAAGAGATTGGCTCCAGTCCCTTC
TTTGAGCGGAGTGGCTTGGCCTACTGCCCCAACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCATCCTGGAT
AAAGTGCTGACAGCAATGAACCAGACCTGGCACCCAGAGCACTTCTTCTGCTCTCACTGCGGAGAGGTGTTTGGTGCAGAAGGCTTTCAT
GAGAAGGACAAGAAGCCATATTGCCGAAAGGATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTTGGAAAAC
TACCTTTCAGCCATGGACACTGTCTGGCACCCAGAGTGCTTTGTTTGTGGGGACTGCTTCACCAGTTTTTCTACTGGCTCCTTCTTTGAA
CTGGATGGACGTCCATTCTGTGAGCTCCATTACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGGCCGTTGT
ATCAGTGCCATGGGGTACAAGTTCCATCCTGAGCACTTTGTGTGTGCTTTCTGCCTGACACAGTTGTCGAAGGGCATTTTCAGGGAGCAG
AATGACAAGACCTATTGTCAACCTTGCTTCAATAAGCTCTTCCCACTGTAATGCCAACTGATCCATAGCCTCTTCAGATTCCTTATAAAA
TTTAAACCAAGAGAGGAGAGGAAAGGGTAAATTTTCTGTTACTGACCTTCTGCTTAATAGTCTTATAGAAAAAGGAAAGGTGATGAGCAA
ATAAAGGAACTTCTAGACTTTACATGACTAGGCTGATAATCTTATTTTTTAGGCTTCTATACAGTTAATTCTATAAATTCTCTTTCTCCC
TCTCTTCTCCAATCAAGCACTTGGAGTTAGATCTAGGTCCTTCTATCTCGTCCCTCTACAGATGTATTTTCCACTTGCATAATTCATGCC
AACACTGGTTTTCTTAGGTTTCTCCATTTTCACCTCTAGTGATGGCCCTACTCATATCTTCTCTAATTTGGTCCTGATACTTGTTTCTTT
TCACGTTTTCCCATTTCCCTGTGGCTCACTGTCTTACAATCACTGCTGTGGAATCATGATACCACTTTTAGCTCTTTGCATCTTCCTTCA
GTGTATTTTTGTTTTTCAAGAGGAAGTAGATTTTAACTGGACAACTTTGAGTACTGACATCATTGATAAATAAACTGGCTTGTGGTTTCA

>In-frame_ENST00000356554_ENST00000395074_TCGA-CG-5717-01A_MAN1A2_chr1_118045592_+_LPXN_chr11_58322413_length(amino acids)=911AA_start in transcript=735_stop in transcript=3470
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVM
HIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKN
GHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWY
LWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLNEAQEPKESPPPSKTSAAAQLDELMAHLTEMQA
KVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSG
LAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAM
DTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTY

--------------------------------------------------------------
>In-frame_ENST00000356554_ENST00000528954_TCGA-CG-5717-01A_MAN1A2_chr1_118045592_+_LPXN_chr11_58322413_length(transcript)=4054nt_BP=2528nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTGGAGTAGGGCGAAACTGGGGCTGG
GCATCTGCAGGTAGCAGCATTCTGGCTGAATTTGGTACACTACATATGGAGTTCATCCACCTCAGCTACTTGACAGGGGACCTGACTTAC
TACAAAAAGGTTATGCACATTCGGAAACTACTTCAGAAAATGGATCGTCCAAATGGTCTTTATCCAAATTATTTGAACCCCAGAACAGGG
CGCTGGGGTCAGTATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACA
GACCATGAGGCAAGAAAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATT
GGAGAATGGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCC
AGAGCAGATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTA
GGTCCTGAATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATT
GAAACCTATTGGTACCTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGC
CGAGTTAATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAA
ACATTAAATGAAGCCCAAGAGCCAAAGGAATCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGCTCACCTG
ACTGAGATGCAGGCCAAGGTTGCAGTGAGAGCAGATGCTGGCAAGAAGCACTTACCAGACAAGCAGGATCACAAGGCCTCCCTGGACTCA
ATGCTTGGGGGTCTGGAGCAGGAATTGCAGGACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACCGATTGCT
GGGAAGGTGATCCATGCTCTAGGGCAATCATGGCATCCTGAGCATTTTGTCTGTACTCATTGCAAAGAAGAGATTGGCTCCAGTCCCTTC
TTTGAGCGGAGTGGCTTGGCCTACTGCCCCAACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCATCCTGGAT
AAAGTGCTGACAGCAATGAACCAGACCTGGCACCCAGAGCACTTCTTCTGCTCTCACTGCGGAGAGGTGTTTGGTGCAGAAGGCTTTCAT
GAGAAGGACAAGAAGCCATATTGCCGAAAGGATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTTGGAAAAC
TACCTTTCAGCCATGGACACTGTCTGGCACCCAGAGTGCTTTGTTTGTGGGGACTGCTTCACCAGTTTTTCTACTGGCTCCTTCTTTGAA
CTGGATGGACGTCCATTCTGTGAGCTCCATTACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGGCCGTTGT
ATCAGTGCCATGGGGTACAAGTTCCATCCTGAGCACTTTGTGTGTGCTTTCTGCCTGACACAGTTGTCGAAGGGCATTTTCAGGGAGCAG
AATGACAAGACCTATTGTCAACCTTGCTTCAATAAGCTCTTCCCACTGTAATGCCAACTGATCCATAGCCTCTTCAGATTCCTTATAAAA
TTTAAACCAAGAGAGGAGAGGAAAGGGTAAATTTTCTGTTACTGACCTTCTGCTTAATAGTCTTATAGAAAAAGGAAAGGTGATGAGCAA
ATAAAGGAACTTCTAGACTTTACATGACTAGGCTGATAATCTTATTTTTTAGGCTTCTATACAGTTAATTCTATAAATTCTCTTTCTCCC
TCTCTTCTCCAATCAAGCACTTGGAGTTAGATCTAGGTCCTTCTATCTCGTCCCTCTACAGATGTATTTTCCACTTGCATAATTCATGCC
AACACTGGTTTTCTTAGGTTTCTCCATTTTCACCTCTAGTGATGGCCCTACTCATATCTTCTCTAATTTGGTCCTGATACTTGTTTCTTT
TCACGTTTTCCCATTTCCCTGTGGCTCACTGTCTTACAATCACTGCTGTGGAATCATGATACCACTTTTAGCTCTTTGCATCTTCCTTCA
GTGTATTTTTGTTTTTCAAGAGGAAGTAGATTTTAACTGGACAACTTTGAGTACTGACATCATTGATAAATAAACTGGCTTGTGGTTTCA

>In-frame_ENST00000356554_ENST00000528954_TCGA-CG-5717-01A_MAN1A2_chr1_118045592_+_LPXN_chr11_58322413_length(amino acids)=911AA_start in transcript=735_stop in transcript=3470
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVM
HIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKN
GHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWY
LWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLNEAQEPKESPPPSKTSAAAQLDELMAHLTEMQA
KVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSG
LAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAM
DTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTY

--------------------------------------------------------------
>In-frame_ENST00000356554_ENST00000528489_TCGA-CG-5717-01A_MAN1A2_chr1_118045592_+_LPXN_chr11_58322413_length(transcript)=3886nt_BP=2528nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTGGAGTAGGGCGAAACTGGGGCTGG
GCATCTGCAGGTAGCAGCATTCTGGCTGAATTTGGTACACTACATATGGAGTTCATCCACCTCAGCTACTTGACAGGGGACCTGACTTAC
TACAAAAAGGTTATGCACATTCGGAAACTACTTCAGAAAATGGATCGTCCAAATGGTCTTTATCCAAATTATTTGAACCCCAGAACAGGG
CGCTGGGGTCAGTATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACA
GACCATGAGGCAAGAAAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATT
GGAGAATGGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCC
AGAGCAGATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTA
GGTCCTGAATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATT
GAAACCTATTGGTACCTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGC
CGAGTTAATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAA
ACATTAAATGAAGCCCAAGAGCCAAAGGAATCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGCTCACCTG
ACTGAGATGCAGGCCAAGGTTGCAGTGAGAGCAGATGCTGGCAAGAAGCACTTACCAGACAAGCAGGATCACAAGGCCTCCCTGGACTCA
ATGCTTGGGGGTCTGGAGCAGGAATTGCAGGACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACCGATTGCT
GGGAAGGTGATCCATGCTCTAGGGCAATCATGGCATCCTGAGCATTTTGTCTGTACTCATTGCAAAGAAGAGATTGGCTCCAGTCCCTTC
TTTGAGCGGAGTGGCTTGGCCTACTGCCCCAACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCATCCTGGAT
AAAGTGCTGACAGCAATGAACCAGACCTGGCACCCAGAGCACTTCTTCTGCTCTCACTGCGGAGAGGTGTTTGGTGCAGAAGGCTTTCAT
GAGAAGGACAAGAAGCCATATTGCCGAAAGGATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTTGGAAAAC
TACCTTTCAGCCATGGACACTGTCTGGCACCCAGAGTGCTTTGTTTGTGGGGACTGCTTCACCAGTTTTTCTACTGGCTCCTTCTTTGAA
CTGGATGGACGTCCATTCTGTGAGCTCCATTACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGGCCGTTGT
ATCAGTGCCATGGGGTACAAGTTCCATCCTGAGCACTTTGTGTGTGCTTTCTGCCTGACACAGTTGTCGAAGGGCATTTTCAGGGAGCAG
AATGACAAGACCTATTGTCAACCTTGCTTCAATAAGCTCTTCCCACTGTAATGCCAACTGATCCATAGCCTCTTCAGATTCCTTATAAAA
TTTAAACCAAGAGAGGAGAGGAAAGGGTAAATTTTCTGTTACTGACCTTCTGCTTAATAGTCTTATAGAAAAAGGAAAGGTGATGAGCAA
ATAAAGGAACTTCTAGACTTTACATGACTAGGCTGATAATCTTATTTTTTAGGCTTCTATACAGTTAATTCTATAAATTCTCTTTCTCCC
TCTCTTCTCCAATCAAGCACTTGGAGTTAGATCTAGGTCCTTCTATCTCGTCCCTCTACAGATGTATTTTCCACTTGCATAATTCATGCC
AACACTGGTTTTCTTAGGTTTCTCCATTTTCACCTCTAGTGATGGCCCTACTCATATCTTCTCTAATTTGGTCCTGATACTTGTTTCTTT

>In-frame_ENST00000356554_ENST00000528489_TCGA-CG-5717-01A_MAN1A2_chr1_118045592_+_LPXN_chr11_58322413_length(amino acids)=911AA_start in transcript=735_stop in transcript=3470
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVM
HIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKN
GHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWY
LWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLNEAQEPKESPPPSKTSAAAQLDELMAHLTEMQA
KVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSG
LAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAM
DTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTY

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Fusion Gene PPI Analysis for MAN1A2-LPXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAN1A2-LPXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAN1A2-LPXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLPXNC0023893Liver Cirrhosis, Experimental1CTD_human