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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANTXR2-CHMP1A (FusionGDB2 ID:5099)

Fusion Gene Summary for ANTXR2-CHMP1A

Fusion gene summary

Fusion gene information	Fusion gene name: ANTXR2-CHMP1A
	Fusion gene ID: 5099
		Hgene	Tgene
	Gene symbol	ANTXR2	CHMP1A
	Gene ID	118429	5119
	Gene name	ANTXR cell adhesion molecule 2	charged multivesicular body protein 1A
	Synonyms	CMG-2\|CMG2\|HFS\|ISH\|JHF	CHMP1\|PCH8\|PCOLN3\|PRSM1\|VPS46-1\|VPS46A
	Cytomap	4q21.21	16q24.3
	Type of gene	protein-coding	protein-coding
	Description	anthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2	charged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1
	Modification date	20200313	20200313
	UniProtAcc	P58335	Q9HD42
	Ensembl transtripts involved in fusion gene	ENST00000403729, ENST00000482406, ENST00000404191, ENST00000346652, ENST00000307333, ENST00000295465,	ENST00000397901, ENST00000253475, ENST00000535997, ENST00000550102, ENST00000547614,
Fusion gene scores	* DoF score	6 X 6 X 4=144	45 X 11 X 21=10395
	# samples	7	48
	** MAII score	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/10395*10)=-4.43671154213721 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANTXR2 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANTXR2(80898775)-CHMP1A(89713739), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CHMP1A	GO:0007076	mitotic chromosome condensation	11559747
Tgene	CHMP1A	GO:0016192	vesicle-mediated transport	11559748
Tgene	CHMP1A	GO:0016458	gene silencing	11559747
Tgene	CHMP1A	GO:0045892	negative regulation of transcription, DNA-templated	11559747

Fusion gene breakpoints across ANTXR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHMP1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-5506-01A	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
ChimerDB4	PRAD	TCGA-EJ-7125-01A	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-

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Fusion Gene ORF analysis for ANTXR2-CHMP1A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000403729	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
Frame-shift	ENST00000403729	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
In-frame	ENST00000403729	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
In-frame	ENST00000403729	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
5CDS-5UTR	ENST00000403729	ENST00000547614	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000482406	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000482406	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000482406	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000482406	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-5UTR	ENST00000482406	ENST00000547614	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
Frame-shift	ENST00000404191	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
In-frame	ENST00000404191	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
Frame-shift	ENST00000404191	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
Frame-shift	ENST00000404191	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
5CDS-5UTR	ENST00000404191	ENST00000547614	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000346652	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000346652	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000346652	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000346652	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-5UTR	ENST00000346652	ENST00000547614	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000307333	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000307333	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000307333	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000307333	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-5UTR	ENST00000307333	ENST00000547614	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000295465	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000295465	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000295465	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-3CDS	ENST00000295465	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-
intron-5UTR	ENST00000295465	ENST00000547614	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403729	ANTXR2	chr4	80898775	-	ENST00000397901	CHMP1A	chr16	89713739	-	3928	1954	526	2292	588
ENST00000403729	ANTXR2	chr4	80898775	-	ENST00000535997	CHMP1A	chr16	89713739	-	3896	1954	526	2292	588
ENST00000403729	ANTXR2	chr4	80898775	-	ENST00000550102	CHMP1A	chr16	89713739	-	2470	1954	526	2292	588
ENST00000404191	ANTXR2	chr4	80898775	-	ENST00000253475	CHMP1A	chr16	89713739	-	3321	1354	157	1692	511

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000403729	ENST00000397901	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-	0.003351509	0.9966485
ENST00000403729	ENST00000535997	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-	0.003556738	0.9964432
ENST00000403729	ENST00000550102	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-	0.006275018	0.993725
ENST00000404191	ENST00000253475	ANTXR2	chr4	80898775	-	CHMP1A	chr16	89713739	-	0.001644341	0.9983557

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Fusion Genomic Features for ANTXR2-CHMP1A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANTXR2-CHMP1A

Go to
FGviewer for the breakpoints of chr4:80898775-chr16:89713739
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANTXR2 P58335	CHMP1A Q9HD42
FUNCTION: Necessary for cellular interactions with laminin and the extracellular matrix. {ECO:0000269\|PubMed:11683410, ECO:0000269\|PubMed:12973667}.	FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269\|PubMed:11559747, ECO:0000269\|PubMed:11559748, ECO:0000269\|PubMed:19129479, ECO:0000269\|PubMed:23045692}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000403729

352_360

476.0

489.0

Compositional bias

Note=Poly-Pro

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000403729

362_366

476.0

489.0

Compositional bias

Note=Poly-Glu

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000403729

44_213

476.0

489.0

Domain

VWFA

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000403729

34_318

476.0

489.0

Topological domain

Extracellular

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000403729

319_341

476.0

489.0

Transmembrane

Helical

Tgene

CHMP1A

chr4:80898775

chr16:89713739

ENST00000397901

102_124

84.0

197.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CHMP1A

chr4:80898775

chr16:89713739

ENST00000397901

185_195

84.0

197.0

Motif

Note=MIT-interacting motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000295465

352_360

323.0

Compositional bias

Note=Poly-Pro

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000295465

362_366

323.0

Compositional bias

Note=Poly-Glu

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000307333

352_360

490.0

Compositional bias

Note=Poly-Pro

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000307333

362_366

490.0

Compositional bias

Note=Poly-Glu

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000346652

352_360

387.0

Compositional bias

Note=Poly-Pro

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000346652

362_366

387.0

Compositional bias

Note=Poly-Glu

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000295465

44_213

323.0

Domain

VWFA

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000307333

44_213

490.0

Domain

VWFA

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000346652

44_213

387.0

Domain

VWFA

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000295465

342_489

323.0

Topological domain

Cytoplasmic

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000295465

34_318

323.0

Topological domain

Extracellular

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000307333

342_489

490.0

Topological domain

Cytoplasmic

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000307333

34_318

490.0

Topological domain

Extracellular

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000346652

342_489

387.0

Topological domain

Cytoplasmic

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000346652

34_318

387.0

Topological domain

Extracellular

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000403729

342_489

476.0

489.0

Topological domain

Cytoplasmic

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000295465

319_341

323.0

Transmembrane

Helical

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000307333

319_341

490.0

Transmembrane

Helical

Hgene

ANTXR2

chr4:80898775

chr16:89713739

ENST00000346652

319_341

387.0

Transmembrane

Helical

Tgene

CHMP1A

chr4:80898775

chr16:89713739

ENST00000397901

5_47

84.0

197.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for ANTXR2-CHMP1A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000403729_ENST00000397901_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(transcript)=3928nt_BP=1954nt
TTTCGGAGTGCGGAGGGAGTTGGGGCCGCCGGAGGAGAAGAGTCTCCACTCCTAGTTTGTTCTGCCGTCGCCGCGTCCCAGGGACCCCTT
GTCCCGAAGCGCACGGCAGCGGGGGGGACTTCAGCCCTCCAGGCGGGGTGGGTTCCAGGTCCGGGTCCGAGGCGGGCGCTGGAGGCTCGG
CCCCAGGCCGGAGAGGAACTCCTTTCGCGAGCTGTCGCCGTGGGCCCGCATTGTCTGCAGGAACTCTCCGGAATCGGGAGGGGGAGGACT
GGATCGCGCTTCCACTGGGATTCGTCAAGAGTTCCGGCGGCAGCTGCGGCGGTGGCGGAGACTCCCTTTGTCCTCTCAGGACCTCCCTCT
CTCCCTCCCTGTCAGCTGGTGGGTCCCGCTGCCGCAGGCGCCGGCGTCTCAGCTGCTCGCCGCCCCCCACCCCAGAGTGCGTGCCGGGTG
ACTCCCGCCACCTTTGCGACCCTCCTGAGCTTAGGGGACTGCGAGCGGGAGGGAGTCTCAGGCCCCCGGCCGCAGGATGGTGGCGGAGCG
GTCCCCGGCCCGCAGCCCCGGGAGCTGGCTGTTCCCCGGGCTGTGGCTGTTGGTGCTCAGCGGTCCCGGGGGGCTGCTGCGCGCCCAGGA
GCAGCCCTCCTGCAGAAGAGCCTTTGATCTCTACTTCGTCCTGGACAAGTCTGGGAGTGTGGCAAATAACTGGATTGAAATTTATAATTT
CGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTTTTCTTCTCAAGCAACTATTATTTTGCCATT
AACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGTAGGAGAGACATATATCCATGAAGGACTAAA
GCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGCTCTGACAGATGGCAAGTTGGACGGTCTGGT
GCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTGTGTTGGTGTCCTTGATTTTGAACAAGCACA
GCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGCTCTTAAAGGAATAATTAATTCTATACTAGC
TCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATTTCAGATTGTCTTAAGTGGAAGAGGATTCAT
GCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAACGAGTGTAAAACCAGTAAGTGTACAGCTTAA
TTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGTGAGCTTTAATGGAGGAAAATCTGTCATTTC
AGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTATTTTGGTGTTACTGCTACTCCTGGGGATCGG
TTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACCACCCGCCCCTGCACCAAAAGAGGAGGAAGA
AGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGGGGTTGGAGGAATTAAAAGAATGGAGGTTCG
TTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGTGGTGAAGATTCCTGAAGAAACAGAGGAACC
CATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTACACCCCAATTAAGGGTCGTCTTGATGCTCT
CTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGATGAGGTGACCAAGAATATGGCCCAGGTGAC
CAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGA
CGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGAT
CGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCA
GGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAA
GGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGG
CCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGA
TTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCA
GCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGG
GCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTG
TCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGC
CTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCA
CCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCT
GTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCC
CTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCT
TGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTG
TGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTC
CTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGA
GTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGT
GGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCT
AGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAA
CAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCC

>In-frame_ENST00000403729_ENST00000397901_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(amino acids)=588AA_start in transcript=526_stop in transcript=2292
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQAT
IILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPV
SVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
RLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDS

--------------------------------------------------------------
>In-frame_ENST00000403729_ENST00000535997_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(transcript)=3896nt_BP=1954nt
TTTCGGAGTGCGGAGGGAGTTGGGGCCGCCGGAGGAGAAGAGTCTCCACTCCTAGTTTGTTCTGCCGTCGCCGCGTCCCAGGGACCCCTT
GTCCCGAAGCGCACGGCAGCGGGGGGGACTTCAGCCCTCCAGGCGGGGTGGGTTCCAGGTCCGGGTCCGAGGCGGGCGCTGGAGGCTCGG
CCCCAGGCCGGAGAGGAACTCCTTTCGCGAGCTGTCGCCGTGGGCCCGCATTGTCTGCAGGAACTCTCCGGAATCGGGAGGGGGAGGACT
GGATCGCGCTTCCACTGGGATTCGTCAAGAGTTCCGGCGGCAGCTGCGGCGGTGGCGGAGACTCCCTTTGTCCTCTCAGGACCTCCCTCT
CTCCCTCCCTGTCAGCTGGTGGGTCCCGCTGCCGCAGGCGCCGGCGTCTCAGCTGCTCGCCGCCCCCCACCCCAGAGTGCGTGCCGGGTG
ACTCCCGCCACCTTTGCGACCCTCCTGAGCTTAGGGGACTGCGAGCGGGAGGGAGTCTCAGGCCCCCGGCCGCAGGATGGTGGCGGAGCG
GTCCCCGGCCCGCAGCCCCGGGAGCTGGCTGTTCCCCGGGCTGTGGCTGTTGGTGCTCAGCGGTCCCGGGGGGCTGCTGCGCGCCCAGGA
GCAGCCCTCCTGCAGAAGAGCCTTTGATCTCTACTTCGTCCTGGACAAGTCTGGGAGTGTGGCAAATAACTGGATTGAAATTTATAATTT
CGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTTTTCTTCTCAAGCAACTATTATTTTGCCATT
AACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGTAGGAGAGACATATATCCATGAAGGACTAAA
GCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGCTCTGACAGATGGCAAGTTGGACGGTCTGGT
GCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTGTGTTGGTGTCCTTGATTTTGAACAAGCACA
GCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGCTCTTAAAGGAATAATTAATTCTATACTAGC
TCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATTTCAGATTGTCTTAAGTGGAAGAGGATTCAT
GCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAACGAGTGTAAAACCAGTAAGTGTACAGCTTAA
TTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGTGAGCTTTAATGGAGGAAAATCTGTCATTTC
AGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTATTTTGGTGTTACTGCTACTCCTGGGGATCGG
TTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACCACCCGCCCCTGCACCAAAAGAGGAGGAAGA
AGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGGGGTTGGAGGAATTAAAAGAATGGAGGTTCG
TTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGTGGTGAAGATTCCTGAAGAAACAGAGGAACC
CATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTACACCCCAATTAAGGGTCGTCTTGATGCTCT
CTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGATGAGGTGACCAAGAATATGGCCCAGGTGAC
CAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGA
CGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGAT
CGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCA
GGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAA
GGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGG
CCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGA
TTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCA
GCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGG
GCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTG
TCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGC
CTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCA
CCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCT
GTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCC
CTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCT
TGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTG
TGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTC
CTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGA
GTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGT
GGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCT
AGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAA
CAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCC

>In-frame_ENST00000403729_ENST00000535997_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(amino acids)=588AA_start in transcript=526_stop in transcript=2292
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQAT
IILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPV
SVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
RLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDS

--------------------------------------------------------------
>In-frame_ENST00000403729_ENST00000550102_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(transcript)=2470nt_BP=1954nt
TTTCGGAGTGCGGAGGGAGTTGGGGCCGCCGGAGGAGAAGAGTCTCCACTCCTAGTTTGTTCTGCCGTCGCCGCGTCCCAGGGACCCCTT
GTCCCGAAGCGCACGGCAGCGGGGGGGACTTCAGCCCTCCAGGCGGGGTGGGTTCCAGGTCCGGGTCCGAGGCGGGCGCTGGAGGCTCGG
CCCCAGGCCGGAGAGGAACTCCTTTCGCGAGCTGTCGCCGTGGGCCCGCATTGTCTGCAGGAACTCTCCGGAATCGGGAGGGGGAGGACT
GGATCGCGCTTCCACTGGGATTCGTCAAGAGTTCCGGCGGCAGCTGCGGCGGTGGCGGAGACTCCCTTTGTCCTCTCAGGACCTCCCTCT
CTCCCTCCCTGTCAGCTGGTGGGTCCCGCTGCCGCAGGCGCCGGCGTCTCAGCTGCTCGCCGCCCCCCACCCCAGAGTGCGTGCCGGGTG
ACTCCCGCCACCTTTGCGACCCTCCTGAGCTTAGGGGACTGCGAGCGGGAGGGAGTCTCAGGCCCCCGGCCGCAGGATGGTGGCGGAGCG
GTCCCCGGCCCGCAGCCCCGGGAGCTGGCTGTTCCCCGGGCTGTGGCTGTTGGTGCTCAGCGGTCCCGGGGGGCTGCTGCGCGCCCAGGA
GCAGCCCTCCTGCAGAAGAGCCTTTGATCTCTACTTCGTCCTGGACAAGTCTGGGAGTGTGGCAAATAACTGGATTGAAATTTATAATTT
CGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTTTTCTTCTCAAGCAACTATTATTTTGCCATT
AACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGTAGGAGAGACATATATCCATGAAGGACTAAA
GCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGCTCTGACAGATGGCAAGTTGGACGGTCTGGT
GCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTGTGTTGGTGTCCTTGATTTTGAACAAGCACA
GCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGCTCTTAAAGGAATAATTAATTCTATACTAGC
TCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATTTCAGATTGTCTTAAGTGGAAGAGGATTCAT
GCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAACGAGTGTAAAACCAGTAAGTGTACAGCTTAA
TTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGTGAGCTTTAATGGAGGAAAATCTGTCATTTC
AGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTATTTTGGTGTTACTGCTACTCCTGGGGATCGG
TTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACCACCCGCCCCTGCACCAAAAGAGGAGGAAGA
AGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGGGGTTGGAGGAATTAAAAGAATGGAGGTTCG
TTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGTGGTGAAGATTCCTGAAGAAACAGAGGAACC
CATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTACACCCCAATTAAGGGTCGTCTTGATGCTCT
CTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGATGAGGTGACCAAGAATATGGCCCAGGTGAC
CAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGA
CGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGAT
CGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCA
GGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAA
GGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGG

>In-frame_ENST00000403729_ENST00000550102_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(amino acids)=588AA_start in transcript=526_stop in transcript=2292
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQAT
IILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPV
SVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
RLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDS

--------------------------------------------------------------
>In-frame_ENST00000404191_ENST00000253475_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(transcript)=3321nt_BP=1354nt
AGTCTTGGGTTTGTGAACCACGCATGGGGGCTGTTTTAGCACAGCTGCTAAAATAGGCCAGGCCTGCAGGACATACGGGTCTGGGAGTGT
GGCAAATAACTGGATTGAAATTTATAATTTCGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTT
TTCTTCTCAAGCAACTATTATTTTGCCATTAACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGT
AGGAGAGACATATATCCATGAAGGACTAAAGCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGC
TCTGACAGATGGCAAGTTGGACGGTCTGGTGCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTG
TGTTGGTGTCCTTGATTTTGAACAAGCACAGCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGC
TCTTAAAGGAATAATTAATTCTATACTAGCTCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATT
TCAGATTGTCTTAAGTGGAAGAGGATTCATGCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAAC
GAGTGTAAAACCAGTAAGTGTACAGCTTAATTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGT
GAGCTTTAATGGAGGAAAATCTGTCATTTCAGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTAT
TTTGGTGTTACTGCTACTCCTGGGGATCGGTTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACC
ACCCGCCCCTGCACCAAAAGAGGAGGAAGAAGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGG
GGTTGGAGGAATTAAAAGAATGGAGGTTCGTTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGT
GGTGAAGATTCCTGAAGAAACAGAGGAACCCATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTA
CACCCCAATTAAGGGTCGTCTTGATGCTCTCTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGA
TGAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGA
CAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCA
GGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTC
TGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGT
GCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCG
GCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGG
TGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCA
GCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACT
CCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTG
CTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGC
CGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACC
GTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGC
TGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCT
GGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTT
CCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGT
TGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCT
TTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAG
AAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTG
CAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTT
TCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTG
AGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTC

>In-frame_ENST00000404191_ENST00000253475_TCGA-EJ-5506-01A_ANTXR2_chr4_80898775_-_CHMP1A_chr16_89713739_length(amino acids)=511AA_start in transcript=157_stop in transcript=1692
MRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISR
SLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTY
TVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKV
VIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTH
QPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANTXR2-CHMP1A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ANTXR2-CHMP1A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ANTXR2-CHMP1A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ANTXR2	C2745948	Hyalinosis, Systemic	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	ANTXR2	C0009917	Contracture	2	CTD_human
Hgene	ANTXR2	C0016045	fibroma	2	CTD_human
Hgene	ANTXR2	C0016048	Fibromatosis	2	CTD_human
Hgene	ANTXR2	C0017567	Gingival Hypertrophy	2	CTD_human
Hgene	ANTXR2	C0038013	Ankylosing spondylitis	2	CTD_human
Hgene	ANTXR2	C0205766	Myxofibroma	2	CTD_human
Hgene	ANTXR2	C0001787	Osteoporosis, Age-Related	1	CTD_human
Hgene	ANTXR2	C0029456	Osteoporosis	1	CTD_human
Hgene	ANTXR2	C0029459	Osteoporosis, Senile	1	CTD_human
Hgene	ANTXR2	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	ANTXR2	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	ANTXR2	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
Hgene	ANTXR2	C4721411	Osteolysis	1	CTD_human
Tgene	CHMP1A	C0266468	Congenital pontocerebellar hypoplasia	1	GENOMICS_ENGLAND
Tgene	CHMP1A	C3554209	Congenital pontocerebellar hypoplasia type 8	1	CTD_human;GENOMICS_ENGLAND;ORPHANET