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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4-CCDC85B (FusionGDB2 ID:51109)

Fusion Gene Summary for MAP4-CCDC85B

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4-CCDC85B
Fusion gene ID: 51109
HgeneTgene
Gene symbol

MAP4

CCDC85B

Gene ID

4134

11007

Gene namemicrotubule associated protein 4coiled-coil domain containing 85B
Synonyms-DIPA
Cytomap

3p21.31

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4coiled-coil domain-containing protein 85Bdelta-interacting protein Ahepatitis delta antigen-interacting protein A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
ENST00000312579, 
Fusion gene scores* DoF score43 X 31 X 16=213281 X 1 X 1=1
# samples 611
** MAII scorelog2(61/21328*10)=-5.12779563263872
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MAP4 [Title/Abstract] AND CCDC85B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4(48040128)-CCDC85B(65658328), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP4-CCDC85B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MAP4-CCDC85B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCDC85B

GO:0030308

negative regulation of cell growth

17873903

TgeneCCDC85B

GO:0045892

negative regulation of transcription, DNA-templated

17014843


check buttonFusion gene breakpoints across MAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCDC85B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1467-01AMAP4chr3

48040128

-CCDC85Bchr11

65658328

+
ChimerDB4OVTCGA-24-1467-01AMAP4chr3

48040128

-CCDC85Bchr11

65658328

+


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Fusion Gene ORF analysis for MAP4-CCDC85B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000383737ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000395734ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000426837ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000360240ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000439356ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000264724ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000420772ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000441748ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000462206ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
In-frameENST00000434267ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000434267MAP4chr348040128-ENST00000312579CCDC85Bchr1165658328+1098321328855175

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000434267ENST00000312579MAP4chr348040128-CCDC85Bchr1165658328+0.043393580.95660645

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Fusion Genomic Features for MAP4-CCDC85B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP4-CCDC85B


check button Go to

FGviewer for the breakpoints of chr3:48040128-chr11:65658328

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC85Bchr3:48040128chr11:65658328ENST0000031257901118_1470203.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC85Bchr3:48040128chr11:65658328ENST000003125790143_900203.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219248_54574.333333333333331153.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218248_54574.333333333333331136.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24248_54574.33333333333333100.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24248_54574.33333333333333100.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-2191023_105374.333333333333331153.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-2191054_108574.333333333333331153.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219248_26174.333333333333331153.0RepeatNote=1
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219262_27574.333333333333331153.0RepeatNote=2
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219276_28974.333333333333331153.0RepeatNote=3
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219290_30374.333333333333331153.0RepeatNote=4
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219304_31774.333333333333331153.0RepeatNote=5
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219318_33174.333333333333331153.0RepeatNote=6
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219332_34574.333333333333331153.0RepeatNote=7
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219346_35174.333333333333331153.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219352_37774.333333333333331153.0RepeatNote=26 residues 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219378_40374.333333333333331153.0RepeatNote=26 residues 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219408_42174.333333333333331153.0RepeatNote=9
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219422_43374.333333333333331153.0RepeatNote=10
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219434_44774.333333333333331153.0RepeatNote=11
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219448_46174.333333333333331153.0RepeatNote=12
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219462_47574.333333333333331153.0RepeatNote=13
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219476_48974.333333333333331153.0RepeatNote=14
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219490_50374.333333333333331153.0RepeatNote=15
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219504_51774.333333333333331153.0RepeatNote=16
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219532_54574.333333333333331153.0RepeatNote=17
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219923_95374.333333333333331153.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000360240-219992_102274.333333333333331153.0RepeatNote=Tau/MAP 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-2181023_105374.333333333333331136.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-2181054_108574.333333333333331136.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218248_26174.333333333333331136.0RepeatNote=1
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218262_27574.333333333333331136.0RepeatNote=2
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218276_28974.333333333333331136.0RepeatNote=3
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218290_30374.333333333333331136.0RepeatNote=4
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218304_31774.333333333333331136.0RepeatNote=5
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218318_33174.333333333333331136.0RepeatNote=6
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218332_34574.333333333333331136.0RepeatNote=7
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218346_35174.333333333333331136.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218352_37774.333333333333331136.0RepeatNote=26 residues 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218378_40374.333333333333331136.0RepeatNote=26 residues 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218408_42174.333333333333331136.0RepeatNote=9
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218422_43374.333333333333331136.0RepeatNote=10
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218434_44774.333333333333331136.0RepeatNote=11
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218448_46174.333333333333331136.0RepeatNote=12
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218462_47574.333333333333331136.0RepeatNote=13
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218476_48974.333333333333331136.0RepeatNote=14
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218490_50374.333333333333331136.0RepeatNote=15
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218504_51774.333333333333331136.0RepeatNote=16
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218532_54574.333333333333331136.0RepeatNote=17
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218923_95374.333333333333331136.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000395734-218992_102274.333333333333331136.0RepeatNote=Tau/MAP 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-241023_105374.33333333333333100.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-241054_108574.33333333333333100.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24248_26174.33333333333333100.0RepeatNote=1
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24262_27574.33333333333333100.0RepeatNote=2
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24276_28974.33333333333333100.0RepeatNote=3
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24290_30374.33333333333333100.0RepeatNote=4
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24304_31774.33333333333333100.0RepeatNote=5
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24318_33174.33333333333333100.0RepeatNote=6
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24332_34574.33333333333333100.0RepeatNote=7
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24346_35174.33333333333333100.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24352_37774.33333333333333100.0RepeatNote=26 residues 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24378_40374.33333333333333100.0RepeatNote=26 residues 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24408_42174.33333333333333100.0RepeatNote=9
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24422_43374.33333333333333100.0RepeatNote=10
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24434_44774.33333333333333100.0RepeatNote=11
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24448_46174.33333333333333100.0RepeatNote=12
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24462_47574.33333333333333100.0RepeatNote=13
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24476_48974.33333333333333100.0RepeatNote=14
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24490_50374.33333333333333100.0RepeatNote=15
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24504_51774.33333333333333100.0RepeatNote=16
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24532_54574.33333333333333100.0RepeatNote=17
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24923_95374.33333333333333100.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000434267-24992_102274.33333333333333100.0RepeatNote=Tau/MAP 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-241023_105374.33333333333333100.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-241054_108574.33333333333333100.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24248_26174.33333333333333100.0RepeatNote=1
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24262_27574.33333333333333100.0RepeatNote=2
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24276_28974.33333333333333100.0RepeatNote=3
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24290_30374.33333333333333100.0RepeatNote=4
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24304_31774.33333333333333100.0RepeatNote=5
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24318_33174.33333333333333100.0RepeatNote=6
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24332_34574.33333333333333100.0RepeatNote=7
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24346_35174.33333333333333100.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24352_37774.33333333333333100.0RepeatNote=26 residues 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24378_40374.33333333333333100.0RepeatNote=26 residues 2
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24408_42174.33333333333333100.0RepeatNote=9
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24422_43374.33333333333333100.0RepeatNote=10
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24434_44774.33333333333333100.0RepeatNote=11
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24448_46174.33333333333333100.0RepeatNote=12
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24462_47574.33333333333333100.0RepeatNote=13
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24476_48974.33333333333333100.0RepeatNote=14
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24490_50374.33333333333333100.0RepeatNote=15
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24504_51774.33333333333333100.0RepeatNote=16
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24532_54574.33333333333333100.0RepeatNote=17
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24923_95374.33333333333333100.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48040128chr11:65658328ENST00000439356-24992_102274.33333333333333100.0RepeatNote=Tau/MAP 2


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Fusion Gene Sequence for MAP4-CCDC85B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000434267_ENST00000312579_TCGA-24-1467-01A_MAP4_chr3_48040128_-_CCDC85B_chr11_65658328_length(transcript)=1098nt_BP=321nt
GGACAGAAATGTTGAAGGCAGGTGCCTGATCCAAAATGCATTTAGTCAGGACTGAACACAAGCTGCCTGGATAGTTCCTGCAGTTGCAGT
GGTGCAGAATGGCTGACCTCAGTCTTGCAGATGCATTAACAGAACCATCTCCAGACATTGAGGGAGAGATAAAGCGGGACTTCATTGCCA
CACTAGAGGCAGAGGCCTTTGATGATGTTGTGGGAGAAACTGTTGGAAAAACAGACTATATTCCTCTCCTGGATGTTGATGAGAAAACCG
GGAACTCAGAGTCAAAGAAGAAACCGTGCTCAGAAACTAGCCAGATTGAAGGCGGCGCCTGCGGCGGGAGGAGGCGGCGCGCCTGGCGGC
ACTGGTGCAGCGCGGCCGCCTCATGCAGGAGGTGAATCGGCAGCTGCAGGGCCACCTGGGCGAGATCCGCGAGCTCAAGCAGCTCAACCG
GCGTCTGCAGGCAGAGAACCGTGAGCTGCGCGACCTCTGCTGCTTCCTGGACTCGGAGCGCCAGCGCGGGCGGCGCGCCGCACGCCAGTG
GCAGCTCTTCGGGACCCAAGCATCCCGGGCCGTGCGCGAGGACCTGGGCGGCTGTTGGCAGAAGCTGGCCGAGCTGGAGGGCCGCCAGGA
GGAGCTGCTGCGGGAGAACCTAGCGCTTAAGGAGCTCTGCCTGGCGCTGGGCGAAGAATGGGGCCCCCGCGGCGGCCCCAGCGGCGCCGG
GGGATCAGGAGCCGGGCCAGCACCCGAGCTTGCCTTGCCCCCGTGCGGGCCCCGCGACCTAGGCGATGGAAGCTCCAGCACTGGCAGCGT
GGGCAGTCCGGATCAGTTGCCCCTGGCCTGTTCCCCCGATGATTGAAGGCACTGCTTCCTCCACGCCGACGCCCGCCCGGATTGCTCCCC
GAGCCCCGGGACCGCTGTGGACCTCGGGACCTGGACGCCGTCCTGGCTGCGCAGGAGGGGCCGCTGGCATGGACTAAGAAATCCTGACAC
CAAGAAGGGCCCCTCGCTCTTGCTGGCAGGGCAGCAGGGGGACTGAAGGCTGGAGCGGAGGGACTTGCTGGGGGTTGGATTGGGGGTAAT

>In-frame_ENST00000434267_ENST00000312579_TCGA-24-1467-01A_MAP4_chr3_48040128_-_CCDC85B_chr11_65658328_length(amino acids)=175AA_start in transcript=328_stop in transcript=855
MRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP4-CCDC85B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4-CCDC85B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP4-CCDC85B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4C0043094Weight Gain1CTD_human