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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4-HADHA (FusionGDB2 ID:51122)

Fusion Gene Summary for MAP4-HADHA

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4-HADHA
Fusion gene ID: 51122
HgeneTgene
Gene symbol

MAP4

HADHA

Gene ID

4134

3030

Gene namemicrotubule associated protein 4hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Synonyms-ECHA|GBP|HADH|LCEH|LCHAD|MTPA|TP-ALPHA
Cytomap

3p21.31

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4trifunctional enzyme subunit alpha, mitochondrial3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit3-oxoacyl-CoA thiolase78 kDa gastrin-binding proteingastrin-binding proteinhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (
Modification date2020031320200313
UniProtAcc.

P40939

Ensembl transtripts involved in fusion geneENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
ENST00000380649, ENST00000457468, 
ENST00000461025, 
Fusion gene scores* DoF score43 X 31 X 16=213287 X 6 X 7=294
# samples 619
** MAII scorelog2(61/21328*10)=-5.12779563263872
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4 [Title/Abstract] AND HADHA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4(48130263)-HADHA(26462011), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHADHA

GO:0035965

cardiolipin acyl-chain remodeling

23152787


check buttonFusion gene breakpoints across MAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HADHA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1471-01AMAP4chr3

48130263

-HADHAchr2

26462011

-
ChimerDB4OVTCGA-24-1471MAP4chr3

48130262

-HADHAchr2

26462011

-
ChimerDB4OVTCGA-24-1471-01AMAP4chr3

48130263

-HADHAchr2

26462011

-


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Fusion Gene ORF analysis for MAP4-HADHA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000383737ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-5UTRENST00000383737ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-intronENST00000383737ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-3CDSENST00000395734ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-5UTRENST00000395734ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-intronENST00000395734ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-3CDSENST00000426837ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-5UTRENST00000426837ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-intronENST00000426837ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-3CDSENST00000360240ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-5UTRENST00000360240ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-intronENST00000360240ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-3CDSENST00000439356ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-5UTRENST00000439356ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-intronENST00000439356ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-3CDSENST00000264724ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-5UTRENST00000264724ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-intronENST00000264724ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-3CDSENST00000420772ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-5UTRENST00000420772ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-intronENST00000420772ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-3CDSENST00000441748ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-5UTRENST00000441748ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-intronENST00000441748ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-3CDSENST00000462206ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-5UTRENST00000462206ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-intronENST00000462206ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-3CDSENST00000434267ENST00000380649MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-5UTRENST00000434267ENST00000457468MAP4chr3

48130263

-HADHAchr2

26462011

-
intron-intronENST00000434267ENST00000461025MAP4chr3

48130263

-HADHAchr2

26462011

-
5UTR-3CDSENST00000383737ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-5UTRENST00000383737ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-intronENST00000383737ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-3CDSENST00000395734ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-5UTRENST00000395734ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-intronENST00000395734ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-3CDSENST00000426837ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-5UTRENST00000426837ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-intronENST00000426837ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-3CDSENST00000360240ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-5UTRENST00000360240ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-intronENST00000360240ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-3CDSENST00000439356ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-5UTRENST00000439356ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
5UTR-intronENST00000439356ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-3CDSENST00000264724ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-5UTRENST00000264724ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-intronENST00000264724ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-3CDSENST00000420772ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-5UTRENST00000420772ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-intronENST00000420772ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-3CDSENST00000441748ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-5UTRENST00000441748ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-intronENST00000441748ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-3CDSENST00000462206ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-5UTRENST00000462206ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-intronENST00000462206ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-3CDSENST00000434267ENST00000380649MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-5UTRENST00000434267ENST00000457468MAP4chr3

48130262

-HADHAchr2

26462011

-
intron-intronENST00000434267ENST00000461025MAP4chr3

48130262

-HADHAchr2

26462011

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAP4-HADHA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP4-HADHA


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HADHA

P40939

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:1550553, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536). Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity (PubMed:23152787). It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP (PubMed:23152787). Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity (PubMed:23152787). {ECO:0000269|PubMed:1550553, ECO:0000269|PubMed:23152787, ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAP4-HADHA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAP4-HADHA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4-HADHA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHADHAP40939DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneHADHAP40939DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for MAP4-HADHA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4C0043094Weight Gain1CTD_human
TgeneHADHAC3711645Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency9CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneHADHAC1969443Trifunctional Protein Deficiency With Myopathy And Neuropathy3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneHADHAC0019193Hepatitis, Toxic1CTD_human
TgeneHADHAC0029408Degenerative polyarthritis1CTD_human
TgeneHADHAC0086743Osteoarthrosis Deformans1CTD_human
TgeneHADHAC0151744Myocardial Ischemia1CTD_human
TgeneHADHAC0369183Erythrocyte Mean Corpuscular Hemoglobin Test1GENOMICS_ENGLAND
TgeneHADHAC0860207Drug-Induced Liver Disease1CTD_human
TgeneHADHAC1261502Finding of Mean Corpuscular Hemoglobin1GENOMICS_ENGLAND
TgeneHADHAC1262760Hepatitis, Drug-Induced1CTD_human
TgeneHADHAC1455728Acute fatty liver of pregnancy1ORPHANET
TgeneHADHAC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneHADHAC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneHADHAC4279912Chemically-Induced Liver Toxicity1CTD_human