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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAPK9-S100A6 (FusionGDB2 ID:51325)

Fusion Gene Summary for MAPK9-S100A6

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK9-S100A6
Fusion gene ID: 51325
HgeneTgene
Gene symbol

MAPK9

S100A6

Gene ID

5601

6277

Gene namemitogen-activated protein kinase 9S100 calcium binding protein A6
SynonymsJNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK2A9|5B10|CABP|CACY|PRA|S10A6
Cytomap

5q35.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 9Jun kinaseMAP kinase 9MAPK 9c-Jun N-terminal kinase 2c-Jun kinase 2stress-activated protein kinase 1astress-activated protein kinase JNK2protein S100-A6MLN 4calcyclingrowth factor-inducible protein 2A9prolactin receptor-associated protein
Modification date2020032720200313
UniProtAcc

P45984

.
Ensembl transtripts involved in fusion geneENST00000452135, ENST00000393360, 
ENST00000455781, ENST00000343111, 
ENST00000347470, ENST00000397072, 
ENST00000425491, ENST00000539014, 
ENST00000524170, 		ENST00000496817, 
ENST00000368719, ENST00000368720, 
Fusion gene scores* DoF score9 X 10 X 6=5406 X 6 X 2=72
# samples 106
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK9 [Title/Abstract] AND S100A6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAPK9(179660683)-S100A6(153507760), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK9

GO:0007254

JNK cascade

8654373

HgeneMAPK9

GO:0018105

peptidyl-serine phosphorylation

21856198


check buttonFusion gene breakpoints across MAPK9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across S100A6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI963166MAPK9chr5

179660683

+S100A6chr1

153507760

+


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Fusion Gene ORF analysis for MAPK9-S100A6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000452135ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000452135ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000452135ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000393360ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000393360ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000393360ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000455781ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000455781ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000455781ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000343111ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000343111ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000343111ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000347470ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000347470ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000347470ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000397072ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000397072ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000397072ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000425491ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000425491ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000425491ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000539014ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000539014ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000539014ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000524170ENST00000496817MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000524170ENST00000368719MAPK9chr5

179660683

+S100A6chr1

153507760

+
intron-3CDSENST00000524170ENST00000368720MAPK9chr5

179660683

+S100A6chr1

153507760

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAPK9-S100A6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAPK9-S100A6


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK9

P45984

.
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9WTU6, ECO:0000269|PubMed:22441692}.; FUNCTION: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAPK9-S100A6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAPK9-S100A6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAPK9-S100A6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAPK9P45984DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneMAPK9P45984DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneMAPK9P45984DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneMAPK9P45984DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for MAPK9-S100A6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK9C0035126Reperfusion Injury2CTD_human
HgeneMAPK9C0005398Cholestasis, Extrahepatic1CTD_human
HgeneMAPK9C0020429Hyperalgesia1CTD_human
HgeneMAPK9C0022116Ischemia1CTD_human
HgeneMAPK9C0027627Neoplasm Metastasis1CTD_human
HgeneMAPK9C0032927Precancerous Conditions1CTD_human
HgeneMAPK9C0040997Trigeminal Neuralgia1CTD_human
HgeneMAPK9C0282313Condition, Preneoplastic1CTD_human
HgeneMAPK9C0393786Trigeminal Neuralgia, Idiopathic1CTD_human
HgeneMAPK9C0393787Secondary Trigeminal Neuralgia1CTD_human
HgeneMAPK9C0458247Allodynia1CTD_human
HgeneMAPK9C0751211Hyperalgesia, Primary1CTD_human
HgeneMAPK9C0751212Hyperalgesia, Secondary1CTD_human
HgeneMAPK9C0751213Tactile Allodynia1CTD_human
HgeneMAPK9C0751214Hyperalgesia, Thermal1CTD_human
HgeneMAPK9C2936719Mechanical Allodynia1CTD_human
TgeneS100A6C0002152Alloxan Diabetes1CTD_human
TgeneS100A6C0007097Carcinoma1CTD_human
TgeneS100A6C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneS100A6C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneS100A6C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneS100A6C0024667Animal Mammary Neoplasms1CTD_human
TgeneS100A6C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneS100A6C0025149Medulloblastoma1CTD_human
TgeneS100A6C0038433Streptozotocin Diabetes1CTD_human
TgeneS100A6C0205696Anaplastic carcinoma1CTD_human
TgeneS100A6C0205697Carcinoma, Spindle-Cell1CTD_human
TgeneS100A6C0205698Undifferentiated carcinoma1CTD_human
TgeneS100A6C0205699Carcinomatosis1CTD_human
TgeneS100A6C0205833Medullomyoblastoma1CTD_human
TgeneS100A6C0265110Cerebral Vasospasm1CTD_human
TgeneS100A6C0278510Childhood Medulloblastoma1CTD_human
TgeneS100A6C0278876Adult Medulloblastoma1CTD_human
TgeneS100A6C0751291Desmoplastic Medulloblastoma1CTD_human
TgeneS100A6C0751895Vasospasm, Intracranial1CTD_human
TgeneS100A6C1257925Mammary Carcinoma, Animal1CTD_human
TgeneS100A6C1275668Melanotic medulloblastoma1CTD_human