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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAST2-CARD16 (FusionGDB2 ID:51507) |
Fusion Gene Summary for MAST2-CARD16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAST2-CARD16 | Fusion gene ID: 51507 | Hgene | Tgene | Gene symbol | MAST2 | CARD16 | Gene ID | 23139 | 114769 |
| Gene name | microtubule associated serine/threonine kinase 2 | caspase recruitment domain family member 16 | |
| Synonyms | MAST205|MTSSK | COP|COP1|PSEUDO-ICE | |
| Cytomap | 1p34.1 | 11q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinase | caspase recruitment domain-containing protein 16CARD only domain-containing protein 1CARD only proteinCARD-only protein 1caspase recruitment domain-only protein 1caspase-1 dominant-negative inhibitor pseudo-ICEcaspase-1 inhibitor COPpseudo interleu | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | Q6P0Q8 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000372009, ENST00000361297, ENST00000477968, | ENST00000375706, ENST00000375704, ENST00000525374, | |
| Fusion gene scores | * DoF score | 25 X 15 X 13=4875 | 3 X 2 X 3=18 |
| # samples | 28 | 3 | |
| ** MAII score | log2(28/4875*10)=-4.12190348657937 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAST2 [Title/Abstract] AND CARD16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MAST2(46489652)-CARD16(104915385), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MAST2-CARD16 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. MAST2-CARD16 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CARD16 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway | 11432859 |
| Tgene | CARD16 | GO:0032091 | negative regulation of protein binding | 11432859|11536016 |
| Tgene | CARD16 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 15383541 |
| Tgene | CARD16 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16920334 |
| Tgene | CARD16 | GO:0050713 | negative regulation of interleukin-1 beta secretion | 11432859|11536016|15383541|16920334 |
| Tgene | CARD16 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 11536016 |
| Tgene | CARD16 | GO:0071222 | cellular response to lipopolysaccharide | 15383541 |
| Tgene | CARD16 | GO:0071456 | cellular response to hypoxia | 16920334 |
| Tgene | CARD16 | GO:0071494 | cellular response to UV-C | 16920334 |
| Tgene | CARD16 | GO:0097340 | inhibition of cysteine-type endopeptidase activity | 11432859 |
| Fusion gene breakpoints across MAST2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CARD16 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CV-7235-01A | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
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Fusion Gene ORF analysis for MAST2-CARD16 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000372009 | ENST00000375706 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| Frame-shift | ENST00000372009 | ENST00000375704 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| Frame-shift | ENST00000372009 | ENST00000525374 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| In-frame | ENST00000361297 | ENST00000375706 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| Frame-shift | ENST00000361297 | ENST00000375704 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| Frame-shift | ENST00000361297 | ENST00000525374 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| intron-3CDS | ENST00000477968 | ENST00000375706 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| intron-3CDS | ENST00000477968 | ENST00000375704 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| intron-3CDS | ENST00000477968 | ENST00000525374 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000372009 | MAST2 | chr1 | 46489652 | + | ENST00000375706 | CARD16 | chr11 | 104915385 | - | 2514 | 1853 | 283 | 2439 | 718 |
| ENST00000361297 | MAST2 | chr1 | 46489652 | + | ENST00000375706 | CARD16 | chr11 | 104915385 | - | 2724 | 2063 | 283 | 2649 | 788 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000372009 | ENST00000375706 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - | 0.028481875 | 0.9715181 |
| ENST00000361297 | ENST00000375706 | MAST2 | chr1 | 46489652 | + | CARD16 | chr11 | 104915385 | - | 0.01653324 | 0.9834668 |
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Fusion Genomic Features for MAST2-CARD16 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAST2-CARD16 |
| Go to FGviewer for the breakpoints of chr1:46489652-chr11:104915385 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAST2 | . |
| FUNCTION: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAST2 | chr1:46489652 | chr11:104915385 | ENST00000361297 | + | 15 | 29 | 518_526 | 593.3333333333334 | 1799.0 | Nucleotide binding | ATP |
| Tgene | CARD16 | chr1:46489652 | chr11:104915385 | ENST00000375704 | 0 | 4 | 1_91 | 2.3333333333333335 | 67.0 | Domain | CARD | |
| Tgene | CARD16 | chr1:46489652 | chr11:104915385 | ENST00000375706 | 0 | 3 | 1_91 | 2.3333333333333335 | 198.0 | Domain | CARD | |
| Tgene | CARD16 | chr1:46489652 | chr11:104915385 | ENST00000525374 | 0 | 4 | 1_91 | 2.3333333333333335 | 71.66666666666667 | Domain | CARD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAST2 | chr1:46489652 | chr11:104915385 | ENST00000361297 | + | 15 | 29 | 1104_1192 | 593.3333333333334 | 1799.0 | Domain | PDZ |
| Hgene | MAST2 | chr1:46489652 | chr11:104915385 | ENST00000361297 | + | 15 | 29 | 512_785 | 593.3333333333334 | 1799.0 | Domain | Protein kinase |
| Hgene | MAST2 | chr1:46489652 | chr11:104915385 | ENST00000361297 | + | 15 | 29 | 786_854 | 593.3333333333334 | 1799.0 | Domain | AGC-kinase C-terminal |
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Fusion Gene Sequence for MAST2-CARD16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000372009_ENST00000375706_TCGA-CV-7235-01A_MAST2_chr1_46489652_+_CARD16_chr11_104915385_length(transcript)=2514nt_BP=1853nt TAGGCAGGCGGCTGAGCCGGCGGCGGGTGGCCTGCCCAACGTGTGCTGGGTGGGAGAAGGCGAGGCGTCAGCGATGCTGTCTCTTCCGTG AGGAGCGCAGAGGAGGTCGCGGCGCCGGAGGCCCCAGAAGGCTCGAAGGCGCCGCGGGCTGGGGTCGGTGGCTTAGGGAGCCCGTCCGGC CATGGTGGCCGCGGGTGGTGGTTGGCGCGGCTGCGCTGCGGCCCGGGGCAGTGCGGAGCCGGGACAGTCGCGGCGCTGACGCCCGCGGGC CCCAGCTGCAGATATGAAGCGGAGCCGCTGCCGCGACCGACCGCAGCCGCCGCCGCCCGACCGCCGGGAGGATGGAGTTCAGCGGGCAGC GGAGCTGTCTCAGTCTTTGCCGCCGCGCCGGCGAGCGCCGCCCGGGAGGCAGCGGCTGGAGGAGCGGACGGGCCCCGCGGGGCCCGAGGG CAAGGAGCAGGATGTAGTAACTGGAGTTAGTCCCCTGCTCTTCAGGAAACTCAGTAATCCTGACATATTTTCATCCACTGGAAAAGTTAA ACTTCAGCGACAACTGAGTCAGGATGATTGTAAGTTATGGAGAGGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTC CAGCAGTGTACATAGCAGTGTGGGACAGGTGACTTGGCAGTCGTCAGGAGAAGCATCAAACCTGGTTCGAATGAGAAACCAGTCCCTTGG ACAGTCTGCACCTTCTCTTACTGCTGGCCTGAAGGAGTTGAGCCTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTT GATTGTGACCTCTAGCACATCACCTACACTACCACGGCCACACTCACCACTCCATGGCCACACAGGTAACAGTCCTTTGGACAGCCCCCG GAATTTCTCTCCAAATGCACCTGCTCACTTTTCTTTTGTTCCTGCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTC TTCAGGATATGGAACTAACACTCCTAGCTCCACTGTCTCATCATCATGCTCCTCACAGGAAAAGCTGCATCAGTTGCCTTTCCAGCCTAC AGCTGATGAGCTGCACTTTTTGACGAAGCATTTCAGCACAGAGAGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCG CTCCCGGAGCCTCAGTCCCGGACGATCCCCAGTATCCTTTGACAGTGAAATAATAATGATGAATCATGTTTACAAAGAAAGATTCCCAAA GGCTCATGAGCGCTCAGAGAGCTCAGAAGTGGCTTTTGTGATGCAGCTGGTGAAAAAGCTGATGATTATCATTGCCCGCCCAGCACGTCT CCTGGAATGCCTGGAGTTTGACCCTGAAGAGTTCTACCACCTTTTAGAAGCAGCTGAGGGCCACGCCAAAGAGGGACAAGGGATTAAATG TGACATTCCCCGCTACATCGTTAGCCAGCTGGGCCTCACCCGGGATCCCCTAGAAGAAATGGCCCAGTTGAGCAGCTGTGACAGTCCTGA CACTCCAGAGACAGATGATTCTATTGAGGGCCATGGGGCATCTCTGCCATCTAAAAAGACACCCTCTGAAGAGGACTTCGAGACCATTAA GCTCATCAGCAATGGCGCCTATGGGGCTGTATTTCTGGTGCGGCACAAGTCCACCCGGCAGCGCTTTGCCATGAAGAAGATCAACAAGCA GAACCTGATCCTACGGAACCAGATCCAGCAGGCCTTCGTGGAGCGTGACATACTGACTTTCGCTGAGAACCCCTTTGTGGTCAGCATGTT CTGCTCCTTTGATACCAAGCGCCACTTGTGCATGGTGATGGAGTACGTTGAAGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCA TTCCATGGGTGAAGGTACAATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACCAGGAAGAGATGGAGAAAGTAAAACG TGAAAATGCTACAGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCATCACATA CATTTGTGAAGAAGACAGTTACCTGGCAGAGACGCTGGGACTCTCAGCAGCTCTTCAGGCAGTGCAGGACAACCCAGCTATGCCCACATG CTCAAGCCCAGAAGGCAGAATCAAGCTTTGCTTTCTAGAAGACGCTCAAAGGATATGGAAACAAAAGTTGCAGAGGTGCCATGTTCAGAA TACAATAATAAAGTGGAGTGAAAGATATACTTCAGGCAGTTTTGAAATGCAGTGGCTTTTTCTTAGAACCAATTTTATTGAGCGGTTCTG GAGGAACATACTTCTGCTCCCCTTGCATAAAGGATCTCTATATCCTAGAATCCCAGGTTTAGGTAAAGAGTTGCAAACTGGAACTCATAA >In-frame_ENST00000372009_ENST00000375706_TCGA-CV-7235-01A_MAST2_chr1_46489652_+_CARD16_chr11_104915385_length(amino acids)=718AA_start in transcript=283_stop in transcript=2439 MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQ LSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADEL HFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKAHERSESSEVAFVMQLVKKLMIIIARPARLLECL EFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISN GAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEDKVLKEKRKLFIHSMGE GTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPE -------------------------------------------------------------- >In-frame_ENST00000361297_ENST00000375706_TCGA-CV-7235-01A_MAST2_chr1_46489652_+_CARD16_chr11_104915385_length(transcript)=2724nt_BP=2063nt TAGGCAGGCGGCTGAGCCGGCGGCGGGTGGCCTGCCCAACGTGTGCTGGGTGGGAGAAGGCGAGGCGTCAGCGATGCTGTCTCTTCCGTG AGGAGCGCAGAGGAGGTCGCGGCGCCGGAGGCCCCAGAAGGCTCGAAGGCGCCGCGGGCTGGGGTCGGTGGCTTAGGGAGCCCGTCCGGC CATGGTGGCCGCGGGTGGTGGTTGGCGCGGCTGCGCTGCGGCCCGGGGCAGTGCGGAGCCGGGACAGTCGCGGCGCTGACGCCCGCGGGC CCCAGCTGCAGATATGAAGCGGAGCCGCTGCCGCGACCGACCGCAGCCGCCGCCGCCCGACCGCCGGGAGGATGGAGTTCAGCGGGCAGC GGAGCTGTCTCAGTCTTTGCCGCCGCGCCGGCGAGCGCCGCCCGGGAGGCAGCGGCTGGAGGAGCGGACGGGCCCCGCGGGGCCCGAGGG CAAGGAGCAGGATGTAGTAACTGGAGTTAGTCCCCTGCTCTTCAGGAAACTCAGTAATCCTGACATATTTTCATCCACTGGAAAAGTTAA ACTTCAGCGACAACTGAGTCAGGATGATTGTAAGTTATGGAGAGGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTC CAGCAGTGTACATAGCAGTGTGGGACAGGTGACTTGGCAGTCGTCAGGAGAAGCATCAAACCTGGTTCGAATGAGAAACCAGTCCCTTGG ACAGTCTGCACCTTCTCTTACTGCTGGCCTGAAGGAGTTGAGCCTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTT GATTGTGACCTCTAGCACATCACCTACACTACCACGGCCACACTCACCACTCCATGGCCACACAGGTAACAGTCCTTTGGACAGCCCCCG GAATTTCTCTCCAAATGCACCTGCTCACTTTTCTTTTGTTCCTGCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTC TTCAGGATATGGAACTAACACTCCTAGCTCCACTGTCTCATCATCATGCTCCTCACAGGAAAAGCTGCATCAGTTGCCTTTCCAGCCTAC AGCTGATGAGCTGCACTTTTTGACGAAGCATTTCAGCACAGAGAGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCG CTCCCGGAGCCTCAGTCCCGGACGATCCCCAGTATCCTTTGACAGTGAAATAATAATGATGAATCATGTTTACAAAGAAAGATTCCCAAA GGCCACCGCACAAATGGAAGAGCGACTAGCAGAGTTTATTTCCTCCAACACTCCAGACAGCGTGCTGCCCTTGGCAGATGGAGCCCTGAG CTTTATTCATCATCAGGTGATTGAGATGGCCCGAGACTGCCTGGATAAATCTCGGAGTGGCCTCATTACATCACAATACTTCTACGAACT TCAAGATAATTTGGAGAAACTTTTACAAGATGCTCATGAGCGCTCAGAGAGCTCAGAAGTGGCTTTTGTGATGCAGCTGGTGAAAAAGCT GATGATTATCATTGCCCGCCCAGCACGTCTCCTGGAATGCCTGGAGTTTGACCCTGAAGAGTTCTACCACCTTTTAGAAGCAGCTGAGGG CCACGCCAAAGAGGGACAAGGGATTAAATGTGACATTCCCCGCTACATCGTTAGCCAGCTGGGCCTCACCCGGGATCCCCTAGAAGAAAT GGCCCAGTTGAGCAGCTGTGACAGTCCTGACACTCCAGAGACAGATGATTCTATTGAGGGCCATGGGGCATCTCTGCCATCTAAAAAGAC ACCCTCTGAAGAGGACTTCGAGACCATTAAGCTCATCAGCAATGGCGCCTATGGGGCTGTATTTCTGGTGCGGCACAAGTCCACCCGGCA GCGCTTTGCCATGAAGAAGATCAACAAGCAGAACCTGATCCTACGGAACCAGATCCAGCAGGCCTTCGTGGAGCGTGACATACTGACTTT CGCTGAGAACCCCTTTGTGGTCAGCATGTTCTGCTCCTTTGATACCAAGCGCCACTTGTGCATGGTGATGGAGTACGTTGAAGACAAGGT CCTGAAGGAGAAGAGAAAGCTGTTTATCCATTCCATGGGTGAAGGTACAATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCT GAACCAGGAAGAGATGGAGAAAGTAAAACGTGAAAATGCTACAGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGG GGCACAGGCATGCCAAATTTGCATCACATACATTTGTGAAGAAGACAGTTACCTGGCAGAGACGCTGGGACTCTCAGCAGCTCTTCAGGC AGTGCAGGACAACCCAGCTATGCCCACATGCTCAAGCCCAGAAGGCAGAATCAAGCTTTGCTTTCTAGAAGACGCTCAAAGGATATGGAA ACAAAAGTTGCAGAGGTGCCATGTTCAGAATACAATAATAAAGTGGAGTGAAAGATATACTTCAGGCAGTTTTGAAATGCAGTGGCTTTT TCTTAGAACCAATTTTATTGAGCGGTTCTGGAGGAACATACTTCTGCTCCCCTTGCATAAAGGATCTCTATATCCTAGAATCCCAGGTTT AGGTAAAGAGTTGCAAACTGGAACTCATAAATTATCATAGTCTTCACCCAGTCTGTCTCTTAGAATTTATTTCCCACTGACACAAACAAG >In-frame_ENST00000361297_ENST00000375706_TCGA-CV-7235-01A_MAST2_chr1_46489652_+_CARD16_chr11_104915385_length(amino acids)=788AA_start in transcript=283_stop in transcript=2649 MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQ LSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADEL HFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHH QVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKE GQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAM KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEDKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEE MEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAST2-CARD16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAST2-CARD16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAST2-CARD16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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