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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAX-RUNX2 (FusionGDB2 ID:51628)

Fusion Gene Summary for MAX-RUNX2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAX-RUNX2
Fusion gene ID: 51628
HgeneTgene
Gene symbol

MAX

RUNX2

Gene ID

4149

860

Gene nameMYC associated factor XRUNX family transcription factor 2
SynonymsbHLHd4AML3|CBF-alpha-1|CBFA1|CCD|CCD1|CLCD|OSF-2|OSF2|PEA2aA|PEBP2aA
Cytomap

14q23.3

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein maxclass D basic helix-loop-helix protein 4runt-related transcription factor 2PEA2-alpha APEBP2-alpha ASL3-3 enhancer factor 1 alpha A subunitSL3/AKV core-binding factor alpha A subunitacute myeloid leukemia 3 proteincore-binding factor, runt domain, alpha subunit 1oncogene AML-3osteoblast
Modification date2020031320200322
UniProtAcc

P61244

.
Ensembl transtripts involved in fusion geneENST00000341653, ENST00000358402, 
ENST00000555932, ENST00000284165, 
ENST00000358664, ENST00000555419, 
ENST00000557277, ENST00000556979, 
ENST00000555667, ENST00000557746, 
ENST00000556443, ENST00000246163, 
ENST00000541979, ENST00000465038, 
ENST00000352853, ENST00000371438, 
ENST00000371436, ENST00000576263, 
ENST00000371432, ENST00000359524, 
ENST00000483243, 
Fusion gene scores* DoF score6 X 4 X 6=1446 X 6 X 4=144
# samples 66
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAX [Title/Abstract] AND RUNX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAX(65560426)-RUNX2(45405684), # samples:3
RUNX2(45399756)-MAX(65544754), # samples:3
Anticipated loss of major functional domain due to fusion event.MAX-RUNX2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
MAX-RUNX2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MAX-RUNX2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
MAX-RUNX2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MAX-RUNX2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
MAX-RUNX2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAX

GO:0000122

negative regulation of transcription by RNA polymerase II

8521822

TgeneRUNX2

GO:0045892

negative regulation of transcription, DNA-templated

11965546

TgeneRUNX2

GO:0045893

positive regulation of transcription, DNA-templated

11965546


check buttonFusion gene breakpoints across MAX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RUNX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-5367-01AMAXchr14

65560426

-RUNX2chr6

45405684

+
ChimerDB4HNSCTCGA-CN-5367MAXchr14

65560426

-RUNX2chr6

45405684

+
ChimerDB4HNSCTCGA-CN-5367-01AMAXchr14

65560426

-RUNX2chr6

45405684

+


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Fusion Gene ORF analysis for MAX-RUNX2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341653ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000341653ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000341653ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358402ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000358402ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555932ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-intronENST00000555932ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000284165ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000284165ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000358664ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000358664ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-3CDSENST00000555419ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
intron-intronENST00000555419ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-3CDSENST00000557277ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5UTR-intronENST00000557277ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556979ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000556979ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000555667ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000555667ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000557746ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000557746ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000556443ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000556443ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000541979MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000465038MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000352853MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000371438MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000371436MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000576263MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000371432MAXchr14

65560426

-RUNX2chr6

45405684

+
Frame-shiftENST00000246163ENST00000359524MAXchr14

65560426

-RUNX2chr6

45405684

+
5CDS-intronENST00000246163ENST00000483243MAXchr14

65560426

-RUNX2chr6

45405684

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAX-RUNX2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAX-RUNX2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAX

P61244

.
FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAX-RUNX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAX-RUNX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAX-RUNX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAX-RUNX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAXC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome8CLINGEN;GENOMICS_ENGLAND
HgeneMAXC0031511Pheochromocytoma4CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMAXC0027708Nephroblastoma1CTD_human
HgeneMAXC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneMAXC1704374Carcinoma of Endocrine Gland1GENOMICS_ENGLAND
HgeneMAXC2930471Bilateral Wilms Tumor1CTD_human
TgeneRUNX2C0008928Cleidocranial Dysplasia21CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRUNX2C0029463Osteosarcoma2CTD_human
TgeneRUNX2C3549874METAPHYSEAL DYSPLASIA WITH MAXILLARY HYPOPLASIA WITH OR WITHOUT BRACHYDACTYLY2GENOMICS_ENGLAND;ORPHANET
TgeneRUNX2C0003872Arthritis, Psoriatic1CTD_human
TgeneRUNX2C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX2C0009171Cocaine Abuse1CTD_human
TgeneRUNX2C0010278Craniosynostosis1GENOMICS_ENGLAND
TgeneRUNX2C0029408Degenerative polyarthritis1CTD_human
TgeneRUNX2C0029410Osteoarthritis of hip1CTD_human
TgeneRUNX2C0038587Substance Withdrawal Syndrome1CTD_human
TgeneRUNX2C0040427Tooth Abnormalities1CTD_human
TgeneRUNX2C0041948Uremia1CTD_human
TgeneRUNX2C0086189Drug Withdrawal Symptoms1CTD_human
TgeneRUNX2C0086743Osteoarthrosis Deformans1CTD_human
TgeneRUNX2C0087169Withdrawal Symptoms1CTD_human
TgeneRUNX2C0236736Cocaine-Related Disorders1CTD_human
TgeneRUNX2C0243057Stomatognathic System Abnormalities1CTD_human
TgeneRUNX2C0376634Craniofacial Abnormalities1CTD_human
TgeneRUNX2C0524730Odontome1CTD_human
TgeneRUNX2C0600427Cocaine Dependence1CTD_human
TgeneRUNX2C0949690Spondylarthritis1CTD_human