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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBTD1-SYBU (FusionGDB2 ID:51790)

Fusion Gene Summary for MBTD1-SYBU

check button Fusion gene summary
Fusion gene informationFusion gene name: MBTD1-SYBU
Fusion gene ID: 51790
HgeneTgene
Gene symbol

MBTD1

SYBU

Gene ID

54799

55638

Gene namembt domain containing 1syntabulin
SynonymsSA49P01GOLSYN|OCSYN|SNPHL
Cytomap

17q21.33

8q23.2

Type of geneprotein-codingprotein-coding
DescriptionMBT domain-containing protein 1syntabulinGOLSYN A proteinGOLSYN B proteinGOLSYN C proteinGolgi-localized proteingolgi-localized syntaphilin-related proteinimplicated in syntaxin trafficking in neuronsmicrotubule-associated proteinsyntabulin (syntaxin-interacting)syntaxin-1-bin
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000586178, ENST00000415868, 
ENST00000376381, ENST00000593259, 
ENST00000533895, ENST00000424158, 
ENST00000532779, ENST00000399066, 
ENST00000446070, ENST00000528331, 
ENST00000276646, ENST00000528647, 
ENST00000440310, ENST00000433638, 
ENST00000408908, ENST00000408889, 
ENST00000422135, ENST00000419099, 
ENST00000533065, ENST00000533171, 
ENST00000529175, ENST00000529690, 
ENST00000527707, 
Fusion gene scores* DoF score13 X 12 X 11=17167 X 5 X 4=140
# samples 178
** MAII scorelog2(17/1716*10)=-3.33544290136184
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBTD1 [Title/Abstract] AND SYBU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBTD1(49284249)-SYBU(110631268), # samples:3
Anticipated loss of major functional domain due to fusion event.MBTD1-SYBU seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MBTD1-SYBU seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MBTD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SYBU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IC-01AMBTD1chr17

49284249

-SYBUchr8

110631268

-
ChimerDB4PRADTCGA-KK-A8ICMBTD1chr17

49284249

-SYBUchr8

110631268

-
ChimerDB4PRADTCGA-KK-A8IC-01AMBTD1chr17

49284249

-SYBUchr8

110631268

-


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Fusion Gene ORF analysis for MBTD1-SYBU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000586178ENST00000533895MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000586178ENST00000424158MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000586178ENST00000532779MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000586178ENST00000399066MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000586178ENST00000446070MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000528331MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000276646MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000528647MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000440310MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000433638MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000408908MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000408889MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000422135MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000419099MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000533065MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000586178ENST00000533171MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000586178ENST00000529175MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000586178ENST00000529690MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000586178ENST00000527707MBTD1chr17

49284249

-SYBUchr8

110631268

-
In-frameENST00000415868ENST00000533895MBTD1chr17

49284249

-SYBUchr8

110631268

-
In-frameENST00000415868ENST00000424158MBTD1chr17

49284249

-SYBUchr8

110631268

-
In-frameENST00000415868ENST00000532779MBTD1chr17

49284249

-SYBUchr8

110631268

-
In-frameENST00000415868ENST00000399066MBTD1chr17

49284249

-SYBUchr8

110631268

-
In-frameENST00000415868ENST00000446070MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000528331MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000276646MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000528647MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000440310MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000433638MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000408908MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000408889MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000422135MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000419099MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000533065MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000415868ENST00000533171MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000415868ENST00000529175MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000415868ENST00000529690MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000415868ENST00000527707MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000376381ENST00000533895MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000376381ENST00000424158MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000376381ENST00000532779MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000376381ENST00000399066MBTD1chr17

49284249

-SYBUchr8

110631268

-
Frame-shiftENST00000376381ENST00000446070MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000528331MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000276646MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000528647MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000440310MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000433638MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000408908MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000408889MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000422135MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000419099MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000533065MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-5UTRENST00000376381ENST00000533171MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000376381ENST00000529175MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000376381ENST00000529690MBTD1chr17

49284249

-SYBUchr8

110631268

-
5CDS-intronENST00000376381ENST00000527707MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-3CDSENST00000593259ENST00000533895MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-3CDSENST00000593259ENST00000424158MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-3CDSENST00000593259ENST00000532779MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-3CDSENST00000593259ENST00000399066MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-3CDSENST00000593259ENST00000446070MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000528331MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000276646MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000528647MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000440310MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000433638MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000408908MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000408889MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000422135MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000419099MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000533065MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-5UTRENST00000593259ENST00000533171MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-intronENST00000593259ENST00000529175MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-intronENST00000593259ENST00000529690MBTD1chr17

49284249

-SYBUchr8

110631268

-
intron-intronENST00000593259ENST00000527707MBTD1chr17

49284249

-SYBUchr8

110631268

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415868MBTD1chr1749284249-ENST00000533895SYBUchr8110631268-3358667632429788
ENST00000415868MBTD1chr1749284249-ENST00000424158SYBUchr8110631268-3160667632429788
ENST00000415868MBTD1chr1749284249-ENST00000532779SYBUchr8110631268-3160667632429788
ENST00000415868MBTD1chr1749284249-ENST00000399066SYBUchr8110631268-3154667632429788
ENST00000415868MBTD1chr1749284249-ENST00000446070SYBUchr8110631268-3154667632429788

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415868ENST00000533895MBTD1chr1749284249-SYBUchr8110631268-0.000800680.99919933
ENST00000415868ENST00000424158MBTD1chr1749284249-SYBUchr8110631268-0.0011187030.9988813
ENST00000415868ENST00000532779MBTD1chr1749284249-SYBUchr8110631268-0.0011187030.9988813
ENST00000415868ENST00000399066MBTD1chr1749284249-SYBUchr8110631268-0.001198970.998801
ENST00000415868ENST00000446070MBTD1chr1749284249-SYBUchr8110631268-0.001198970.998801

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Fusion Genomic Features for MBTD1-SYBU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MBTD1-SYBU


check button Go to

FGviewer for the breakpoints of chr17:49284249-chr8:110631268

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBTD1chr17:49284249chr8:110631268ENST00000376381-71545_80201.33333333333334390.0Zinc fingerFCS-type
HgeneMBTD1chr17:49284249chr8:110631268ENST00000415868-51545_80201.33333333333334629.0Zinc fingerFCS-type
HgeneMBTD1chr17:49284249chr8:110631268ENST00000586178-71745_80201.33333333333334629.0Zinc fingerFCS-type
TgeneSYBUchr17:49284249chr8:110631268ENST0000027664617271_35376.33333333333333664.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000039906606271_35373.33333333333333661.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000040888906271_3530545.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000040890828271_35376.33333333333333664.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000041909928271_35375.33333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000042213528271_35376.33333333333333664.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000042415839271_35381.33333333333333669.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000043363839271_35376.33333333333333664.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000044031028271_35376.33333333333333664.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000044607028271_35375.33333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000052833106271_3530545.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000052864728271_35375.33333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000053277906271_3538.333333333333334596.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000053306506271_3530545.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000053317128271_35376.33333333333333664.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST0000053389539271_35375.33333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneSYBUchr17:49284249chr8:110631268ENST000004088890642_2410545.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000005283310642_2410545.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000005327790642_2418.333333333333334596.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000005330650642_2410545.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST0000027664617606_62676.33333333333333664.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000039906606606_62673.33333333333333661.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000040888906606_6260545.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000040890828606_62676.33333333333333664.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000041909928606_62675.33333333333333663.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000042213528606_62676.33333333333333664.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000042415839606_62681.33333333333333669.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000043363839606_62676.33333333333333664.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000044031028606_62676.33333333333333664.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000044607028606_62675.33333333333333663.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000052833106606_6260545.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000052864728606_62675.33333333333333663.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000053277906606_6268.333333333333334596.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000053306506606_6260545.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000053317128606_62676.33333333333333664.0TransmembraneHelical
TgeneSYBUchr17:49284249chr8:110631268ENST0000053389539606_62675.33333333333333663.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBTD1chr17:49284249chr8:110631268ENST00000376381-715141_245201.33333333333334390.0RepeatNote=MBT 1
HgeneMBTD1chr17:49284249chr8:110631268ENST00000376381-715253_350201.33333333333334390.0RepeatNote=MBT 2
HgeneMBTD1chr17:49284249chr8:110631268ENST00000376381-715351_456201.33333333333334390.0RepeatNote=MBT 3
HgeneMBTD1chr17:49284249chr8:110631268ENST00000376381-715464_560201.33333333333334390.0RepeatNote=MBT 4
HgeneMBTD1chr17:49284249chr8:110631268ENST00000415868-515141_245201.33333333333334629.0RepeatNote=MBT 1
HgeneMBTD1chr17:49284249chr8:110631268ENST00000415868-515253_350201.33333333333334629.0RepeatNote=MBT 2
HgeneMBTD1chr17:49284249chr8:110631268ENST00000415868-515351_456201.33333333333334629.0RepeatNote=MBT 3
HgeneMBTD1chr17:49284249chr8:110631268ENST00000415868-515464_560201.33333333333334629.0RepeatNote=MBT 4
HgeneMBTD1chr17:49284249chr8:110631268ENST00000586178-717141_245201.33333333333334629.0RepeatNote=MBT 1
HgeneMBTD1chr17:49284249chr8:110631268ENST00000586178-717253_350201.33333333333334629.0RepeatNote=MBT 2
HgeneMBTD1chr17:49284249chr8:110631268ENST00000586178-717351_456201.33333333333334629.0RepeatNote=MBT 3
HgeneMBTD1chr17:49284249chr8:110631268ENST00000586178-717464_560201.33333333333334629.0RepeatNote=MBT 4
TgeneSYBUchr17:49284249chr8:110631268ENST000002766461742_24176.33333333333333664.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000003990660642_24173.33333333333333661.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004089082842_24176.33333333333333664.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004190992842_24175.33333333333333663.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004221352842_24176.33333333333333664.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004241583942_24181.33333333333333669.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004336383942_24176.33333333333333664.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004403102842_24176.33333333333333664.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000004460702842_24175.33333333333333663.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000005286472842_24175.33333333333333663.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000005331712842_24176.33333333333333664.0Compositional biasNote=Ser-rich
TgeneSYBUchr17:49284249chr8:110631268ENST000005338953942_24175.33333333333333663.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for MBTD1-SYBU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000415868_ENST00000533895_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(transcript)=3358nt_BP=667nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCA
GATGCTGGAAACAGCCCCATTGGCTTTTGCCCTGGAAGTGATGAAGGCTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGA
AGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGTAGTGAAGCTGATTTTAGCTCCTCGAGCAGCACA
GGCAGCATTTCCGCTCCTGAGGTCCATATGTCGACTGCGGGAAGCAAGCGGTCTTCTTCTTCACGCAATCGAGGTCCTCATGGGCGGAGT
AATGGAGCTTCGTCACACAAGCCTGGCAGCAGCCCATCATCCCCGCGGGAAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGC
CCTGTCAATATCCATCCCAGTTATGCACCTTCTTCCCCAAGCAGTAGCAACTCAGGCTCCTACAAAGGAAGCGACTGTAGCCCCATCATG
AGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCCCCAAACCCAGAGCAGTATTTGACTCCACTGCAGCAGAAA
GAGGTGACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAAGTGAAATCGTGGAGCTTAAGTCC
CAGCTGGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGTCACCGGGTAGAGGCCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATT
AAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAAACATC
CAAAACAAGAAGCTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGACTTTCCATGT
GATTCCCCAGAGAAGAGCTTAACCCTCAACCCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTCACGGGGGAAGGG
GCTGACAGGGAGCTACTGGTAGGAGATAGCATAGCCAACAGCACAGATTTGTTCGATGAGATAGTGACAGCCACCACCACAGAATCTGGT
GACCTGGAGCTTGTGCATTCCACCCCTGGGGCTAACGTCCTGGAGCTGCTGCCCATAGTCATGGGTCAGGAGGAGGGCAGTGTGGTGGTG
GAGCGAGCCGTTCAGACCGACGTGGTGCCCTACAGCCCAGCCATCTCAGAGCTCATTCAGAGTGTGCTGCAGAAGCTCCAGGACCCCTGT
CCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCCTCTCTGCCTTAGTGGTTGATTTAACT
CCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCCCTACGCCAATGTGGATGCAGAAGTTCATGCAAACCGCCTCATG
AGAGAGCTGGATTTTGCAGCCTGCGTGGAAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGC
AGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGAT
CCTGTGTATAACATCGGGGCCTTGCTCAGGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCGTATCAAAACCTAA
ATAGAAGTTGTTGTTACCGTGTGCCAATGTGTCCCATGTGGGTTGTGCCAGGTAGAGAAACAGGAAGTCAATCATCTGTGACAGTCTCTA
TTCTGTCGTTTTGCTCCTTGGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCAT
GGAGACCTGGTTCCAGTAAATGTCCCACCAGTGGGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTTATC
CTAGTGGTTCAGGAAGAGAAAACGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCCTTGCTTTGCTTTTTGCCG
TTTTAAAATGTGTAATTGTTCCAGCATTCCAATGGTCTTGTGCATAGCAGGGGACTGTAACCAAAAATAAACATGTATTTGTGTAATTGG
TTTGAAGAAGTCTTGAATAGCTCTTTACTGTCTTACTTGGGGTTGATAAGATTTGAGTGTTTGCAATTTTTTACTAAATGTAGCTCCAAA
GTCTTAAATGGCTTGTTTGTTCTTAAACTGTTAATTGATGAAACTGTGCATAAGTTTACAATGTACTAACTTATTTTGCTTATTATATAT
AGTGTTTTATTGGAAATTGTAACCACACACTTCAGCATGATGAAAATAAAGATTAGTGTTTCCATTTAAATAAATGTTTTATCCTCCCAT
AAAATAATAATTATTTCTGTGATTTTACTTCTATGTATAAGAAAGACAATGAATAGCAGATCTTACATCTTTATCAATAGGGGGTCTGTA
AAAATTGAATTAAATTAGGAAGAGGGAAAAAGAGTTAGTTATTAAAGAAAATGAAGATTTCCTACCCTTACTTAAAAAGCATCATTTCTG

>In-frame_ENST00000415868_ENST00000533895_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(amino acids)=788AA_start in transcript=63_stop in transcript=2429
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLADDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSE
ADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSY
KGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQL
ALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLS
LEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQS
VLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLAR

--------------------------------------------------------------
>In-frame_ENST00000415868_ENST00000424158_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(transcript)=3160nt_BP=667nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCA
GATGCTGGAAACAGCCCCATTGGCTTTTGCCCTGGAAGTGATGAAGGCTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGA
AGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGTAGTGAAGCTGATTTTAGCTCCTCGAGCAGCACA
GGCAGCATTTCCGCTCCTGAGGTCCATATGTCGACTGCGGGAAGCAAGCGGTCTTCTTCTTCACGCAATCGAGGTCCTCATGGGCGGAGT
AATGGAGCTTCGTCACACAAGCCTGGCAGCAGCCCATCATCCCCGCGGGAAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGC
CCTGTCAATATCCATCCCAGTTATGCACCTTCTTCCCCAAGCAGTAGCAACTCAGGCTCCTACAAAGGAAGCGACTGTAGCCCCATCATG
AGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCCCCAAACCCAGAGCAGTATTTGACTCCACTGCAGCAGAAA
GAGGTGACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAAGTGAAATCGTGGAGCTTAAGTCC
CAGCTGGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGTCACCGGGTAGAGGCCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATT
AAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAAACATC
CAAAACAAGAAGCTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGACTTTCCATGT
GATTCCCCAGAGAAGAGCTTAACCCTCAACCCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTCACGGGGGAAGGG
GCTGACAGGGAGCTACTGGTAGGAGATAGCATAGCCAACAGCACAGATTTGTTCGATGAGATAGTGACAGCCACCACCACAGAATCTGGT
GACCTGGAGCTTGTGCATTCCACCCCTGGGGCTAACGTCCTGGAGCTGCTGCCCATAGTCATGGGTCAGGAGGAGGGCAGTGTGGTGGTG
GAGCGAGCCGTTCAGACCGACGTGGTGCCCTACAGCCCAGCCATCTCAGAGCTCATTCAGAGTGTGCTGCAGAAGCTCCAGGACCCCTGT
CCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCCTCTCTGCCTTAGTGGTTGATTTAACT
CCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCCCTACGCCAATGTGGATGCAGAAGTTCATGCAAACCGCCTCATG
AGAGAGCTGGATTTTGCAGCCTGCGTGGAAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGC
AGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGAT
CCTGTGTATAACATCGGGGCCTTGCTCAGGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCGTATCAAAACCTAA
ATAGAAGTTGTTGTTACCGTGTGCCAATGTGTCCCATGTGGGTTGTGCCAGGTAGAGAAACAGGAAGTCAATCATCTGTGACAGTCTCTA
TTCTGTCGTTTTGCTCCTTGGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCAT
GGAGACCTGGTTCCAGTAAATGTCCCACCAGTGGGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTTATC
CTAGTGGTTCAGGAAGAGAAAACGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCCTTGCTTTGCTTTTTGCCG
TTTTAAAATGTGTAATTGTTCCAGCATTCCAATGGTCTTGTGCATAGCAGGGGACTGTAACCAAAAATAAACATGTATTTGTGTAATTGG
TTTGAAGAAGTCTTGAATAGCTCTTTACTGTCTTACTTGGGGTTGATAAGATTTGAGTGTTTGCAATTTTTTACTAAATGTAGCTCCAAA
GTCTTAAATGGCTTGTTTGTTCTTAAACTGTTAATTGATGAAACTGTGCATAAGTTTACAATGTACTAACTTATTTTGCTTATTATATAT
AGTGTTTTATTGGAAATTGTAACCACACACTTCAGCATGATGAAAATAAAGATTAGTGTTTCCATTTAAATAAATGTTTTATCCTCCCAT

>In-frame_ENST00000415868_ENST00000424158_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(amino acids)=788AA_start in transcript=63_stop in transcript=2429
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLADDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSE
ADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSY
KGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQL
ALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLS
LEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQS
VLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLAR

--------------------------------------------------------------
>In-frame_ENST00000415868_ENST00000532779_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(transcript)=3160nt_BP=667nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCA
GATGCTGGAAACAGCCCCATTGGCTTTTGCCCTGGAAGTGATGAAGGCTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGA
AGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGTAGTGAAGCTGATTTTAGCTCCTCGAGCAGCACA
GGCAGCATTTCCGCTCCTGAGGTCCATATGTCGACTGCGGGAAGCAAGCGGTCTTCTTCTTCACGCAATCGAGGTCCTCATGGGCGGAGT
AATGGAGCTTCGTCACACAAGCCTGGCAGCAGCCCATCATCCCCGCGGGAAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGC
CCTGTCAATATCCATCCCAGTTATGCACCTTCTTCCCCAAGCAGTAGCAACTCAGGCTCCTACAAAGGAAGCGACTGTAGCCCCATCATG
AGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCCCCAAACCCAGAGCAGTATTTGACTCCACTGCAGCAGAAA
GAGGTGACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAAGTGAAATCGTGGAGCTTAAGTCC
CAGCTGGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGTCACCGGGTAGAGGCCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATT
AAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAAACATC
CAAAACAAGAAGCTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGACTTTCCATGT
GATTCCCCAGAGAAGAGCTTAACCCTCAACCCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTCACGGGGGAAGGG
GCTGACAGGGAGCTACTGGTAGGAGATAGCATAGCCAACAGCACAGATTTGTTCGATGAGATAGTGACAGCCACCACCACAGAATCTGGT
GACCTGGAGCTTGTGCATTCCACCCCTGGGGCTAACGTCCTGGAGCTGCTGCCCATAGTCATGGGTCAGGAGGAGGGCAGTGTGGTGGTG
GAGCGAGCCGTTCAGACCGACGTGGTGCCCTACAGCCCAGCCATCTCAGAGCTCATTCAGAGTGTGCTGCAGAAGCTCCAGGACCCCTGT
CCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCCTCTCTGCCTTAGTGGTTGATTTAACT
CCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCCCTACGCCAATGTGGATGCAGAAGTTCATGCAAACCGCCTCATG
AGAGAGCTGGATTTTGCAGCCTGCGTGGAAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGC
AGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGAT
CCTGTGTATAACATCGGGGCCTTGCTCAGGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCGTATCAAAACCTAA
ATAGAAGTTGTTGTTACCGTGTGCCAATGTGTCCCATGTGGGTTGTGCCAGGTAGAGAAACAGGAAGTCAATCATCTGTGACAGTCTCTA
TTCTGTCGTTTTGCTCCTTGGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCAT
GGAGACCTGGTTCCAGTAAATGTCCCACCAGTGGGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTTATC
CTAGTGGTTCAGGAAGAGAAAACGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCCTTGCTTTGCTTTTTGCCG
TTTTAAAATGTGTAATTGTTCCAGCATTCCAATGGTCTTGTGCATAGCAGGGGACTGTAACCAAAAATAAACATGTATTTGTGTAATTGG
TTTGAAGAAGTCTTGAATAGCTCTTTACTGTCTTACTTGGGGTTGATAAGATTTGAGTGTTTGCAATTTTTTACTAAATGTAGCTCCAAA
GTCTTAAATGGCTTGTTTGTTCTTAAACTGTTAATTGATGAAACTGTGCATAAGTTTACAATGTACTAACTTATTTTGCTTATTATATAT
AGTGTTTTATTGGAAATTGTAACCACACACTTCAGCATGATGAAAATAAAGATTAGTGTTTCCATTTAAATAAATGTTTTATCCTCCCAT

>In-frame_ENST00000415868_ENST00000532779_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(amino acids)=788AA_start in transcript=63_stop in transcript=2429
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLADDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSE
ADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSY
KGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQL
ALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLS
LEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQS
VLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLAR

--------------------------------------------------------------
>In-frame_ENST00000415868_ENST00000399066_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(transcript)=3154nt_BP=667nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCA
GATGCTGGAAACAGCCCCATTGGCTTTTGCCCTGGAAGTGATGAAGGCTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGA
AGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGTAGTGAAGCTGATTTTAGCTCCTCGAGCAGCACA
GGCAGCATTTCCGCTCCTGAGGTCCATATGTCGACTGCGGGAAGCAAGCGGTCTTCTTCTTCACGCAATCGAGGTCCTCATGGGCGGAGT
AATGGAGCTTCGTCACACAAGCCTGGCAGCAGCCCATCATCCCCGCGGGAAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGC
CCTGTCAATATCCATCCCAGTTATGCACCTTCTTCCCCAAGCAGTAGCAACTCAGGCTCCTACAAAGGAAGCGACTGTAGCCCCATCATG
AGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCCCCAAACCCAGAGCAGTATTTGACTCCACTGCAGCAGAAA
GAGGTGACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAAGTGAAATCGTGGAGCTTAAGTCC
CAGCTGGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGTCACCGGGTAGAGGCCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATT
AAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAAACATC
CAAAACAAGAAGCTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGACTTTCCATGT
GATTCCCCAGAGAAGAGCTTAACCCTCAACCCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTCACGGGGGAAGGG
GCTGACAGGGAGCTACTGGTAGGAGATAGCATAGCCAACAGCACAGATTTGTTCGATGAGATAGTGACAGCCACCACCACAGAATCTGGT
GACCTGGAGCTTGTGCATTCCACCCCTGGGGCTAACGTCCTGGAGCTGCTGCCCATAGTCATGGGTCAGGAGGAGGGCAGTGTGGTGGTG
GAGCGAGCCGTTCAGACCGACGTGGTGCCCTACAGCCCAGCCATCTCAGAGCTCATTCAGAGTGTGCTGCAGAAGCTCCAGGACCCCTGT
CCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCCTCTCTGCCTTAGTGGTTGATTTAACT
CCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCCCTACGCCAATGTGGATGCAGAAGTTCATGCAAACCGCCTCATG
AGAGAGCTGGATTTTGCAGCCTGCGTGGAAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGC
AGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGAT
CCTGTGTATAACATCGGGGCCTTGCTCAGGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCGTATCAAAACCTAA
ATAGAAGTTGTTGTTACCGTGTGCCAATGTGTCCCATGTGGGTTGTGCCAGGTAGAGAAACAGGAAGTCAATCATCTGTGACAGTCTCTA
TTCTGTCGTTTTGCTCCTTGGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCAT
GGAGACCTGGTTCCAGTAAATGTCCCACCAGTGGGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTTATC
CTAGTGGTTCAGGAAGAGAAAACGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCCTTGCTTTGCTTTTTGCCG
TTTTAAAATGTGTAATTGTTCCAGCATTCCAATGGTCTTGTGCATAGCAGGGGACTGTAACCAAAAATAAACATGTATTTGTGTAATTGG
TTTGAAGAAGTCTTGAATAGCTCTTTACTGTCTTACTTGGGGTTGATAAGATTTGAGTGTTTGCAATTTTTTACTAAATGTAGCTCCAAA
GTCTTAAATGGCTTGTTTGTTCTTAAACTGTTAATTGATGAAACTGTGCATAAGTTTACAATGTACTAACTTATTTTGCTTATTATATAT
AGTGTTTTATTGGAAATTGTAACCACACACTTCAGCATGATGAAAATAAAGATTAGTGTTTCCATTTAAATAAATGTTTTATCCTCCCAT

>In-frame_ENST00000415868_ENST00000399066_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(amino acids)=788AA_start in transcript=63_stop in transcript=2429
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLADDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSE
ADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSY
KGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQL
ALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLS
LEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQS
VLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLAR

--------------------------------------------------------------
>In-frame_ENST00000415868_ENST00000446070_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(transcript)=3154nt_BP=667nt
TCTCTTACTTCAAAGACTGAACATTCTTCACGATCTGAAAGGAAAAGAAGAGATTCTTTCGGGATGTTTGACGGTTATGATAGCTGCAGT
GAGGACACAAGCAGCAGCTCCAGCTCCGAAGAGAGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGG
CAAGTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTTGGCGTCCGAGATGCTTTTTACTCTAAA
ACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGAAGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCT
CCAACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCTCAGTATCAAGCTACCTTGCAAAATCAA
GCAAAGACAAAAGCAGCAGTCTCCATGGAAGGTTTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGT
TTTAAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTTCCCAATACAGACTGCAGCCTACCTACC
AAAGTCTTCTGGATTGCTGGAATTGTAAAATTAGCAGATGACACAGGCTGTCCTAGCAGCCAGTCAGTGTCTCCTGTGAAGACACCCTCA
GATGCTGGAAACAGCCCCATTGGCTTTTGCCCTGGAAGTGATGAAGGCTTCACCAGAAAGAAATGCACGATTGGAATGGTTGGTGAAGGA
AGCATTCAGTCCTCTCGATATAAGAAGGAATCAAAGTCAGGCCTTGTGAAACCAGGTAGTGAAGCTGATTTTAGCTCCTCGAGCAGCACA
GGCAGCATTTCCGCTCCTGAGGTCCATATGTCGACTGCGGGAAGCAAGCGGTCTTCTTCTTCACGCAATCGAGGTCCTCATGGGCGGAGT
AATGGAGCTTCGTCACACAAGCCTGGCAGCAGCCCATCATCCCCGCGGGAAAAGGACCTTCTGTCCATGCTGTGCAGGAATCAGCTGAGC
CCTGTCAATATCCATCCCAGTTATGCACCTTCTTCCCCAAGCAGTAGCAACTCAGGCTCCTACAAAGGAAGCGACTGTAGCCCCATCATG
AGGCGTTCTGGAAGGTACATGTCTTGCGGTGAAAATCATGGTGTCAGACCCCCAAACCCAGAGCAGTATTTGACTCCACTGCAGCAGAAA
GAGGTGACAGTGAGACACCTCAAAACCAAGCTGAAGGAATCTGAGCGCCGACTCCATGAAAGGGAAAGTGAAATCGTGGAGCTTAAGTCC
CAGCTGGCCCGCATGCGAGAGGACTGGATTGAGGAGGAGTGTCACCGGGTAGAGGCCCAGTTGGCACTCAAAGAAGCCAGGAAAGAGATT
AAACAGCTCAAACAGGTCATCGAAACCATGCGGAGCAGCTTGGCTGATAAAGATAAAGGCATTCAGAAATATTTTGTGGACATAAACATC
CAAAACAAGAAGCTGGAGTCTCTCCTTCAGAGCATGGAGATGGCACACAGTGGCTCTCTGAGGGACGAACTGTGCCTAGACTTTCCATGT
GATTCCCCAGAGAAGAGCTTAACCCTCAACCCCCCTCTTGACACAATGGCAGATGGGTTATCTCTGGAAGAGCAGGTCACGGGGGAAGGG
GCTGACAGGGAGCTACTGGTAGGAGATAGCATAGCCAACAGCACAGATTTGTTCGATGAGATAGTGACAGCCACCACCACAGAATCTGGT
GACCTGGAGCTTGTGCATTCCACCCCTGGGGCTAACGTCCTGGAGCTGCTGCCCATAGTCATGGGTCAGGAGGAGGGCAGTGTGGTGGTG
GAGCGAGCCGTTCAGACCGACGTGGTGCCCTACAGCCCAGCCATCTCAGAGCTCATTCAGAGTGTGCTGCAGAAGCTCCAGGACCCCTGT
CCCTCGAGCTTGGCGTCCCCTGATGAGTCTGAACCAGACTCGATGGAGAGCTTCCCAGAGTCCCTCTCTGCCTTAGTGGTTGATTTAACT
CCAAGAAATCCAAACTCAGCCATCCTTTTGTCTCCCGTGGAGACCCCCTACGCCAATGTGGATGCAGAAGTTCATGCAAACCGCCTCATG
AGAGAGCTGGATTTTGCAGCCTGCGTGGAAGAGAGGTTGGATGGTGTCATCCCACTGGCTCGCGGGGGCGTCGTGAGGCAGTACTGGAGC
AGCAGCTTCCTGGTGGATCTCCTGGCTGTGGCTGCCCCCGTGGTCCCCACGGTTCTGTGGGCATTCAGTACTCAGAGAGGGGGAACGGAT
CCTGTGTATAACATCGGGGCCTTGCTCAGGGGCTGTTGCGTGGTTGCCCTGCATTCGCTCCGCCGCACCGCCTTCCGTATCAAAACCTAA
ATAGAAGTTGTTGTTACCGTGTGCCAATGTGTCCCATGTGGGTTGTGCCAGGTAGAGAAACAGGAAGTCAATCATCTGTGACAGTCTCTA
TTCTGTCGTTTTGCTCCTTGGTATTTGATTTGCACTATATTTAGTTGAAGCCTGTTCACTGTTTAAAACCGGAGGTATCTTCAAAGGCAT
GGAGACCTGGTTCCAGTAAATGTCCCACCAGTGGGGTATAGAAAGCATGCTCATGACCCTGCCGTGTCGTCTGAGGTACCCGTTCTTATC
CTAGTGGTTCAGGAAGAGAAAACGCAGTTTGCACTTTCAAGACAGCTTCTCTAAGGCTGGCATGTTATCTCCTTGCTTTGCTTTTTGCCG
TTTTAAAATGTGTAATTGTTCCAGCATTCCAATGGTCTTGTGCATAGCAGGGGACTGTAACCAAAAATAAACATGTATTTGTGTAATTGG
TTTGAAGAAGTCTTGAATAGCTCTTTACTGTCTTACTTGGGGTTGATAAGATTTGAGTGTTTGCAATTTTTTACTAAATGTAGCTCCAAA
GTCTTAAATGGCTTGTTTGTTCTTAAACTGTTAATTGATGAAACTGTGCATAAGTTTACAATGTACTAACTTATTTTGCTTATTATATAT
AGTGTTTTATTGGAAATTGTAACCACACACTTCAGCATGATGAAAATAAAGATTAGTGTTTCCATTTAAATAAATGTTTTATCCTCCCAT

>In-frame_ENST00000415868_ENST00000446070_TCGA-KK-A8IC-01A_MBTD1_chr17_49284249_-_SYBU_chr8_110631268_length(amino acids)=788AA_start in transcript=63_stop in transcript=2429
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKAS
ILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLADDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSE
ADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSY
KGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQL
ALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLS
LEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQS
VLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLAR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MBTD1-SYBU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBTD1-SYBU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBTD1-SYBU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource