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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MCL1-GRIP1 (FusionGDB2 ID:51890) |
Fusion Gene Summary for MCL1-GRIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MCL1-GRIP1 | Fusion gene ID: 51890 | Hgene | Tgene | Gene symbol | MCL1 | GRIP1 | Gene ID | 4170 | 85329 |
| Gene name | MCL1 apoptosis regulator, BCL2 family member | galectin 12 | |
| Synonyms | BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT | GAL12|GRIP1 | |
| Cytomap | 1q21.2 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | induced myeloid leukemia cell differentiation protein Mcl-1BCL2 family apoptosis regulatorMCL1, BCL2 family apoptosis regulatorbcl-2-like protein 3bcl-2-related protein EAT/mcl1myeloid cell leukemia 1myeloid cell leukemia ESmyeloid cell leukemia se | galectin-12galectin-related inhibitor of proliferationlectin, galactoside-binding, soluble, 12testicular secretory protein Li 26 | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | Q07820 | Q9Y3R0 | |
| Ensembl transtripts involved in fusion gene | ENST00000369026, ENST00000464132, ENST00000307940, | ENST00000398016, ENST00000359742, ENST00000286445, ENST00000542021, | |
| Fusion gene scores | * DoF score | 12 X 12 X 5=720 | 25 X 17 X 10=4250 |
| # samples | 14 | 27 | |
| ** MAII score | log2(14/720*10)=-2.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/4250*10)=-3.9764315288616 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MCL1 [Title/Abstract] AND GRIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MCL1(150551319)-GRIP1(66990707), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MCL1-GRIP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MCL1 | GO:0034097 | response to cytokine | 9184696 |
| Hgene | MCL1 | GO:0043066 | negative regulation of apoptotic process | 20041405 |
| Tgene | GRIP1 | GO:0097193 | intrinsic apoptotic signaling pathway | 11435439 |
| Fusion gene breakpoints across MCL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GRIP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-AB2S-01A | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
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Fusion Gene ORF analysis for MCL1-GRIP1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369026 | ENST00000398016 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000369026 | ENST00000359742 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000369026 | ENST00000286445 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| 5CDS-intron | ENST00000369026 | ENST00000542021 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000464132 | ENST00000398016 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000464132 | ENST00000359742 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000464132 | ENST00000286445 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| intron-intron | ENST00000464132 | ENST00000542021 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000307940 | ENST00000398016 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000307940 | ENST00000359742 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000307940 | ENST00000286445 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| 5CDS-intron | ENST00000307940 | ENST00000542021 | MCL1 | chr1 | 150551319 | - | GRIP1 | chr12 | 66990707 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MCL1-GRIP1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MCL1-GRIP1 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCL1 | GRIP1 |
| FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}. | FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MCL1-GRIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MCL1-GRIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MCL1-GRIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MCL1 | Q07820 | DB09401 | Isosorbide | Small molecule | Approved|Investigational | |
| Hgene | MCL1 | Q07820 | DB09401 | Isosorbide | Small molecule | Approved|Investigational |
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Related Diseases for MCL1-GRIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MCL1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Hgene | MCL1 | C0242379 | Malignant neoplasm of lung | 2 | CTD_human |
| Hgene | MCL1 | C0004763 | Barrett Esophagus | 1 | CTD_human |
| Hgene | MCL1 | C0023281 | Leishmaniasis | 1 | CTD_human |
| Hgene | MCL1 | C0026764 | Multiple Myeloma | 1 | CTD_human |
| Hgene | MCL1 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Hgene | MCL1 | C0205944 | Sarcoma, Epithelioid | 1 | CTD_human |
| Hgene | MCL1 | C0205945 | Sarcoma, Spindle Cell | 1 | CTD_human |
| Hgene | MCL1 | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
| Hgene | MCL1 | C1258085 | Barrett Epithelium | 1 | CTD_human |
| Hgene | MCL1 | C1261473 | Sarcoma | 1 | CTD_human |
| Tgene | GRIP1 | C0265233 | Cryptophthalmos syndrome | 3 | GENOMICS_ENGLAND;ORPHANET |
| Tgene | GRIP1 | C4551480 | FRASER SYNDROME 1 | 3 | GENOMICS_ENGLAND |
| Tgene | GRIP1 | C4540040 | FRASER SYNDROME 3 | 2 | GENOMICS_ENGLAND |
| Tgene | GRIP1 | C0015397 | Disorder of eye | 1 | GENOMICS_ENGLAND |
| Tgene | GRIP1 | C0152423 | Congenital small ears | 1 | GENOMICS_ENGLAND |
| Tgene | GRIP1 | C0152427 | Polydactyly | 1 | GENOMICS_ENGLAND |
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