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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MCTP1-CBLB (FusionGDB2 ID:51983)

Fusion Gene Summary for MCTP1-CBLB

check button Fusion gene summary
Fusion gene informationFusion gene name: MCTP1-CBLB
Fusion gene ID: 51983
HgeneTgene
Gene symbol

MCTP1

CBLB

Gene ID

79772

868

Gene namemultiple C2 and transmembrane domain containing 1Cbl proto-oncogene B
Synonyms-Cbl-b|Nbla00127|RNF56
Cytomap

5q15

3q13.11

Type of geneprotein-codingprotein-coding
Descriptionmultiple C2 and transmembrane domain-containing protein 1multiple C2 domains, transmembrane 1multiple C2-domains with two transmembrane regions 1E3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase
Modification date2020031320200327
UniProtAcc.

Q13191

Ensembl transtripts involved in fusion geneENST00000515393, ENST00000429576, 
ENST00000312216, ENST00000505208, 
ENST00000514040, ENST00000505078, 
ENST00000264122, ENST00000407712, 
ENST00000394027, ENST00000403724, 
ENST00000405772, ENST00000545639, 
Fusion gene scores* DoF score8 X 9 X 4=28813 X 14 X 7=1274
# samples 916
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1274*10)=-2.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCTP1 [Title/Abstract] AND CBLB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMCTP1(94204038)-CBLB(105495386), # samples:3
Anticipated loss of major functional domain due to fusion event.MCTP1-CBLB seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MCTP1-CBLB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MCTP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CBLB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4849-01AMCTP1chr5

94204038

-CBLBchr3

105495386

-
ChimerDB4KIRCTCGA-B0-4849-01AMCTP1chr5

94204038

-CBLBchr3

105495386

-
ChimerDB4KIRCTCGA-B0-4849-01AMCTP1chr5

94204038

-CBLBchr3

105495386

-


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Fusion Gene ORF analysis for MCTP1-CBLB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000515393ENST00000264122MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000515393ENST00000407712MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000515393ENST00000394027MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000515393ENST00000403724MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000515393ENST00000405772MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000515393ENST00000545639MCTP1chr5

94204038

-CBLBchr3

105495386

-
Frame-shiftENST00000429576ENST00000264122MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000429576ENST00000407712MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000429576ENST00000394027MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000429576ENST00000403724MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000429576ENST00000405772MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000429576ENST00000545639MCTP1chr5

94204038

-CBLBchr3

105495386

-
Frame-shiftENST00000312216ENST00000264122MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000312216ENST00000407712MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000312216ENST00000394027MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000312216ENST00000403724MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000312216ENST00000405772MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000312216ENST00000545639MCTP1chr5

94204038

-CBLBchr3

105495386

-
Frame-shiftENST00000505208ENST00000264122MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505208ENST00000407712MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505208ENST00000394027MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505208ENST00000403724MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505208ENST00000405772MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505208ENST00000545639MCTP1chr5

94204038

-CBLBchr3

105495386

-
intron-3CDSENST00000514040ENST00000264122MCTP1chr5

94204038

-CBLBchr3

105495386

-
intron-intronENST00000514040ENST00000407712MCTP1chr5

94204038

-CBLBchr3

105495386

-
intron-intronENST00000514040ENST00000394027MCTP1chr5

94204038

-CBLBchr3

105495386

-
intron-intronENST00000514040ENST00000403724MCTP1chr5

94204038

-CBLBchr3

105495386

-
intron-intronENST00000514040ENST00000405772MCTP1chr5

94204038

-CBLBchr3

105495386

-
intron-intronENST00000514040ENST00000545639MCTP1chr5

94204038

-CBLBchr3

105495386

-
In-frameENST00000505078ENST00000264122MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505078ENST00000407712MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505078ENST00000394027MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505078ENST00000403724MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505078ENST00000405772MCTP1chr5

94204038

-CBLBchr3

105495386

-
5CDS-intronENST00000505078ENST00000545639MCTP1chr5

94204038

-CBLBchr3

105495386

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000505078MCTP1chr594204038-ENST00000264122CBLBchr3105495386-7199116011763689837

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000505078ENST00000264122MCTP1chr594204038-CBLBchr3105495386-0.0005889050.9994111

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Fusion Genomic Features for MCTP1-CBLB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MCTP1-CBLB


check button Go to

FGviewer for the breakpoints of chr5:94204038-chr3:105495386

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBLB

Q13191

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCTP1chr5:94204038chr3:105495386ENST00000312216-1723152_169591.0779.0Compositional biasNote=Ser-rich
HgeneMCTP1chr5:94204038chr3:105495386ENST00000429576-1520152_169545.0693.0Compositional biasNote=Ser-rich
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505078-1016152_169328.0516.0Compositional biasNote=Ser-rich
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505208-1718152_169591.0601.0Compositional biasNote=Ser-rich
HgeneMCTP1chr5:94204038chr3:105495386ENST00000515393-1723152_169812.01000.0Compositional biasNote=Ser-rich
HgeneMCTP1chr5:94204038chr3:105495386ENST00000312216-1723242_360591.0779.0DomainC2 1
HgeneMCTP1chr5:94204038chr3:105495386ENST00000312216-1723452_569591.0779.0DomainC2 2
HgeneMCTP1chr5:94204038chr3:105495386ENST00000429576-1520242_360545.0693.0DomainC2 1
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505208-1718242_360591.0601.0DomainC2 1
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505208-1718452_569591.0601.0DomainC2 2
HgeneMCTP1chr5:94204038chr3:105495386ENST00000515393-1723242_360812.01000.0DomainC2 1
HgeneMCTP1chr5:94204038chr3:105495386ENST00000515393-1723452_569812.01000.0DomainC2 2
HgeneMCTP1chr5:94204038chr3:105495386ENST00000515393-1723603_724812.01000.0DomainC2 3
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219219_232139.66666666666666983.0Calcium bindingOntology_term=ECO:0000255
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215219_232139.66666666666666771.0Calcium bindingOntology_term=ECO:0000255
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219477_925139.66666666666666983.0Compositional biasNote=Pro-rich
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215477_925139.66666666666666771.0Compositional biasNote=Pro-rich
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219931_970139.66666666666666983.0DomainUBA
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215931_970139.66666666666666771.0DomainUBA
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219168_240139.66666666666666983.0RegionNote=EF-hand-like
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219241_343139.66666666666666983.0RegionNote=SH2-like
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219344_372139.66666666666666983.0RegionNote=Linker
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215168_240139.66666666666666771.0RegionNote=EF-hand-like
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215241_343139.66666666666666771.0RegionNote=SH2-like
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215344_372139.66666666666666771.0RegionNote=Linker
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219373_412139.66666666666666983.0Zinc fingerRING-type
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215373_412139.66666666666666771.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCTP1chr5:94204038chr3:105495386ENST00000312216-1723603_724591.0779.0DomainC2 3
HgeneMCTP1chr5:94204038chr3:105495386ENST00000429576-1520452_569545.0693.0DomainC2 2
HgeneMCTP1chr5:94204038chr3:105495386ENST00000429576-1520603_724545.0693.0DomainC2 3
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505078-1016242_360328.0516.0DomainC2 1
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505078-1016452_569328.0516.0DomainC2 2
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505078-1016603_724328.0516.0DomainC2 3
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505208-1718603_724591.0601.0DomainC2 3
HgeneMCTP1chr5:94204038chr3:105495386ENST00000312216-1723811_831591.0779.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000312216-1723914_934591.0779.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000429576-1520811_831545.0693.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000429576-1520914_934545.0693.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505078-1016811_831328.0516.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505078-1016914_934328.0516.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505208-1718811_831591.0601.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000505208-1718914_934591.0601.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000515393-1723811_831812.01000.0TransmembraneHelical
HgeneMCTP1chr5:94204038chr3:105495386ENST00000515393-1723914_934812.01000.0TransmembraneHelical
TgeneCBLBchr5:94204038chr3:105495386ENST0000026412221935_343139.66666666666666983.0DomainCbl-PTB
TgeneCBLBchr5:94204038chr3:105495386ENST0000040372421535_343139.66666666666666771.0DomainCbl-PTB
TgeneCBLBchr5:94204038chr3:105495386ENST0000026412221935_167139.66666666666666983.0RegionNote=4H
TgeneCBLBchr5:94204038chr3:105495386ENST0000040372421535_167139.66666666666666771.0RegionNote=4H


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Fusion Gene Sequence for MCTP1-CBLB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000505078_ENST00000264122_TCGA-B0-4849-01A_MCTP1_chr5_94204038_-_CBLB_chr3_105495386_length(transcript)=7199nt_BP=1160nt
ACACACTCTGCTACATTGAAACTGCTCCCTGAATCTTTTCCTCCGGTAAATTGTGCTTCCTGGGAAACTAAGGGTTTCAGACCCAAAGTT
TACGCCTATCAGACCTACACAGAAAATCGCATCTTTGGAGAGGAATAGTCAGCATCACCTTGATTGAAGGGAGAGACCTCAAGGCCATGG
ATTCCAACGGGTTGAGCGATCCCTACGTGAAGTTCCGGCTTGGGCATCAGAAGTACAAGAGCAAGATTATGCCAAAAACGTTGAATCCTC
AGTGGAGGGAACAATTTGATTTTCACCTTTATGAAGAAAGAGGAGGAGTCATTGATATCACTGCATGGGACAAAGATGCTGGGAAAAGGG
ATGATTTCATTGGCAGGTGCCAGGTCGACCTGTCAGCCCTCAGTAGGGAACAGACGCACAAGCTGGAGTTGCAGCTGGAAGAGGGTGAGG
GACACCTGGTGCTGCTGGTCACTCTGACAGCATCAGCCACAGTCAGCATCTCTGACCTGTCTGTCAACTCCCTGGAGGACCAGAAGGAAC
GAGAGGAGATATTAAAGAGATATAGCCCATTGAGGATATTTCACAACCTGAAAGATGTGGGATTTCTCCAGGTGAAAGTCATCAGAGCGG
AAGGGTTAATGGCTGCCGACGTCACTGGAAAAAGTGACCCATTTTGTGTGGTAGAACTGAACAACGATAGACTGCTAACACATACTGTCT
ACAAAAATCTCAATCCTGAGTGGAATAAAGTCTTCACGTTCAACATTAAAGATATCCATTCAGTTCTTGAAGTGACAGTTTATGATGAAG
ATCGGGATCGAAGTGCTGACTTTCTGGGCAAAGTTGCTATACCATTGCTGTCTATTCAAAATGGTGAACAGAAAGCCTACGTCTTGAAAA
ACAAGCAGCTGACAGGGCCAACAAAGGGGGTCATCTATCTTGAAATAGATGTGATTTTTAATGCTGTGAAAGCCAGCTTACGAACATTAA
TACCCAAAGAACAGAAGTACATTGAAGAGGAAAACAGACTCTCTAAACAGCTGCTACTAAGAAACTTTATCAGAATGAAACGTTGTGTCA
TGGTGCTGGTAAATGCTGCATACTACGTTAATAGTTGCTTTGATTGGGATTCACCCCCAAGGAGTCTCGCTGCTTTTGTGACGAAATCTC
ACAAAACTGTCCCTTATCTTCAGTCACATGCTGGCAGAAATCAAAGCAATCTTTCCCAATGGTCAATTCCAGGGAGATAACTTTCGTATC
ACAAAAGCAGATGCTGCTGAATTCTGGAGAAAGTTTTTTGGAGACAAAACTATCGTACCATGGAAAGTATTCAGACAGTGCCTTCATGAG
GTCCACCAGATTAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTTGCAATGATTACATTTCAGTTTTTGAATTT
GATATTTTTACCAGGCTGTTTCAGCCTTGGGGCTCTATTTTGCGGAATTGGAATTTCTTAGCTGTGACACATCCAGGTTACATGGCATTT
CTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAACCCGGAAGCTATATTTTCCGGTTAAGTTGCACTCGATTGGGA
CAGTGGGCCATTGGCTATGTGACTGGGGATGGGAATATCTTACAGACCATACCTCATAACAAGCCCTTATTTCAAGCCCTGATTGATGGC
AGCAGGGAAGGATTTTATCTTTATCCTGATGGGAGGAGTTATAATCCTGATTTAACTGGATTATGTGAACCTACACCTCATGACCATATA
AAAGTTACACAGGAACAATATGAATTATATTGTGAAATGGGCTCCACTTTTCAGCTCTGTAAGATTTGTGCAGAGAATGACAAAGATGTC
AAGATTGAGCCTTGTGGGCATTTGATGTGCACCTCTTGCCTTACGGCATGGCAGGAGTCGGATGGTCAGGGCTGCCCTTTCTGTCGTTGT
GAAATAAAAGGAACTGAGCCCATAATCGTGGACCCCTTTGATCCAAGAGATGAAGGCTCCAGGTGTTGCAGCATCATTGACCCCTTTGGC
ATGCCGATGCTAGACTTGGACGACGATGATGATCGTGAGGAGTCCTTGATGATGAATCGGTTGGCAAACGTCCGAAAGTGCACTGACAGG
CAGAACTCACCAGTCACATCACCAGGATCCTCTCCCCTTGCCCAGAGAAGAAAGCCACAGCCTGACCCACTCCAGATCCCACATCTAAGC
CTGCCACCCGTGCCTCCTCGCCTGGATCTAATTCAGAAAGGCATAGTTAGATCTCCCTGTGGCAGCCCAACGGGTTCACCAAAGTCTTCT
CCTTGCATGGTGAGAAAACAAGATAAACCACTCCCAGCACCACCTCCTCCCTTAAGAGATCCTCCTCCACCGCCACCTGAAAGACCTCCA
CCAATCCCACCAGACAATAGACTGAGTAGACACATCCATCATGTGGAAAGCGTGCCTTCCAGAGACCCGCCAATGCCTCTTGAAGCATGG
TGCCCTCGGGATGTGTTTGGGACTAATCAGCTTGTGGGATGTCGACTCCTAGGGGAGGGCTCTCCAAAACCTGGAATCACAGCGAGTTCA
AATGTCAATGGAAGGCACAGTAGAGTGGGCTCTGACCCAGTGCTTATGCGGAAACACAGACGCCATGATTTGCCTTTAGAAGGAGCTAAG
GTCTTTTCCAATGGTCACCTTGGAAGTGAAGAATATGATGTTCCTCCCCGGCTTTCTCCTCCTCCTCCAGTTACCACCCTCCTCCCTAGC
ATAAAGTGTACTGGTCCGTTAGCAAATTCTCTTTCAGAGAAAACAAGAGACCCAGTAGAGGAAGATGATGATGAATACAAGATTCCTTCA
TCCCACCCTGTTTCCCTGAATTCACAACCATCTCATTGTCATAATGTAAAACCTCCTGTTCGGTCTTGTGATAATGGTCACTGTATGCTG
AATGGAACACATGGTCCATCTTCAGAGAAGAAATCAAACATCCCTGACTTAAGCATATATTTAAAGGGAGATGTTTTTGATTCAGCCTCT
GATCCCGTGCCATTACCACCTGCCAGGCCTCCAACTCGGGACAATCCAAAGCATGGTTCTTCACTCAACAGGACGCCCTCTGATTATGAT
CTTCTCATCCCTCCATTAGGTGAAGATGCTTTTGATGCCCTCCCTCCATCTCTCCCACCTCCCCCACCTCCTGCAAGGCATAGTCTCATT
GAACATTCAAAACCTCCTGGCTCCAGTAGCCGGCCATCCTCAGGACAGGATCTTTTTCTTCTTCCTTCAGATCCCTTTGTTGATCTAGCA
AGTGGCCAAGTTCCTTTGCCTCCTGCTAGAAGGTTACCAGGTGAAAATGTCAAAACTAACAGAACATCACAGGACTATGATCAGCTTCCT
TCATGTTCAGATGGTTCACAGGCACCAGCCAGACCCCCTAAACCACGACCGCGCAGGACTGCACCAGAAATTCACCACAGAAAACCCCAT
GGGCCTGAGGCGGCATTGGAAAATGTCGATGCAAAAATTGCAAAACTCATGGGAGAGGGTTATGCCTTTGAAGAGGTGAAGAGAGCCTTA
GAGATAGCCCAGAATAATGTCGAAGTTGCCCGGAGCATCCTCCGAGAATTTGCCTTCCCTCCTCCAGTATCCCCACGTCTAAATCTATAG
CAGCCAGAACTGTAGACACCAAAATGGAAAGCAATCGATGTATTCCAAGAGTGTGGAAATAAAGAGAACTGAGATGGAATTCAAGAGAGA
AGTGTCTCCTCCTCGTGTAGCAGCTTGAGAAGAGGCTTGGGAGTGCAGCTTCTCAAAGGAGACCGATGCTTGCTCAGGATGTCGACAGCT
GTGGCTTCCTTGTTTTTGCTAGCCATATTTTTAAATCAGGGTTGAACTGACAAAAATAATTTAAAGACGTTTACTTCCCTTGAACTTTGA
ACCTGTGAAATGCTTTACCTTGTTTACAGTTTGGCAAAGTTGCAGTTTGTTCTTGTTTTTAGTTTAGTTTTGTTTTGGTGTTTTGATACC
TGTACTGTGTTCTTCACAGACCCTTTGTAGCGTGGTCAGGTCTGCTGTAACATTTCCCACCAACTCTCTTGCTGTCCACATCAACAGCTA
AATCATTTATTCATATGGATCTCTACCATCCCCATGCCTTGCCCAGGTCCAGTTCCATTTCTCTCATTCACAAGATGCTTTGAAGGTTCT
GATTTTCAACTGATCAAACTAATGCAAAAAAAAAAAAGTATGTATTCTTCACTACTGAGTTTCTTCTTTGGAAACCATCACTATTGAGAG
ATGGGAAAAACCTGAATGTATAAAGCATTTATTTGTCAATAAACTGCCTTTTGTAAGGGGTTTTCACATAACATAGAGGAGCTTCCCTTT
TTTGTTTAAGTTTTGTAACCTTTAATCCTCCATATTCTCATGTCTGTCATCCCAGGGGTGTCACAACTGTAAAAATCTACAATATTAGAA
AGCAGCTACTACAGATGTGGAAGAGAGAACACTTGTATAAGACAATGCTGTACTGAAGTTATATAACAAGGTCCCCTGATACTTATGCCT
GCATTACTTTGAGGGATGCTGAATGAGAGGACCATCTCCCTGAAATATATTAATAATTTTCAGATAAAATTATGAACATAACATACCTTT
TCTCAAGTGGAATTAGAGTTCATTTCCCATTTAAGTGATTACACTCTATCTCCTAAGAGCTGTGGGAACCAGTTCATATTGCAGTGGAAA
CATTAACTCTTCGTTGCACTGTTGAGTGTCAAGGCTACTGTGGCAATGTTTTTTGCAAAGTTCTCAGTAATTTTCTCTCTGCAATCAAAT
TAGAGTTCATATTTAATTTGCAGATTCTCTCATTCATTGCTCCACACTGCTTTATCAAATCAGGTGAAAGAAATTAATGTAGTTTTGCCT
ATTTTACAAAATGGTGGTTGGTTCTTTAAACACCATGTTATTACTCTTAATAAATCTACAAATATTTATTGAGCATCTATGATATGCTTG
GTGCTGTTAGGCACTGTGTTTTTAAAGCACAAACTCTCAAAAGCTGATTCCAGCGTAATGTTTTATTTTTGTTTTTCTGTGTTTTTTATG
ACAAAGTCTGTCTGATAGACAAAGCCTGGAAGGTTTCCCCCAGGGCTTTAGAATTTAGAATTAGCTGGTTTTCATTTCAAATGGGAAATT
AATGGAGAAATGAGATAAAATCATCTCTGTGTAAATGCTTGAACCCACAGAAAGTTTTCTAAATATGGACTAATTGTGGGTTTGTGCATA
TTTCTGTGTCTCCTCTTTTCACTTCACACCCACCATGATATAAAAAGATGCATCAGAGAGTGAGCCTGCCTTCAGGACCTGAAAGGACAT
GACTGAACATCTAGTAGATCTGGTGGAAATTAATGTTATACAAAAGACACGTAGACTAAGTTGACCCTGGGAGAGGAGTTAATACATTCC
TTTGCAAAGTGACATGTGCCCTTTTTTTGACAGTCTGGCTTTCATGGTATGAGATGAGGACTCACAGGCCTTGGGTAATTTCTGCTTTTG
TATGAATTTTTTCAGATGGTTCTGAGCTGGTTATGTCCCTGGAGGGGAATTTTTCATTTGCCTTAGATGTTCTTCCCATGAGTAGGTACA
TGAGTGAAGTTTCTTACACTTTTAAAATTGCATTGGCAAATTTTCTTTTGCTTTATGAACCCCTGTTTTGTCATTATGATTTTTCACTTG
TTTTAACAGTTTCAGATGTCACCTTGGAATAGCACTGTTTATTTTGGCCTTTTTATGATTGCTGATGATAGGTACAGTCTAAAGGCCAAA
AGTTGCCACTTCATTGTGATAACATTGTTGCAACATTCCTAATATATTAGAGAATGATGTAAAATAAGAATGTTAGAGAACATAGCACAT
TCTCATTCAGTTTATAAACAATATTTGAAAATTTCCAGTGAGAATTAAAAAAGGACTAGTGATGATATAGCAAACCTGGACCTGAAATTT
GGGGGTGGGGGGTGGGGGGATATCTGTTTTGCAGAGAAAATTTACCAGCCTCCAGCAAAATCTCTGCATCTTGTACTCAATAGCAACCAT
TAGTATTGTCATTTAAAAAGAATGAATCAAAAATTCATACGTAATGGAATGAAAAGAGGAAAACTTTCTATTAAACACTGTCAAGAAAGA
CCCATTGCTATCTATCACCTATGAAATTAAACCTAAAAAAATTTTTTTTTATTGTAAAAGCGACTGCTCGTTGATGTCTGGAAGTGATCC
AGACTTTGTTTCACTGTGATCCAAAAAGTTAGACATTCCTTCCATTTCTCAAGATTTGGTAACAATTTTTTTTTAAGTCAGCATTTCATA
TAATACATAAAATTAAGACAAATTAACTTACTGATATGTGGCCAATATCAACCCTTCTCACCCAACCCAAACATGTTCTGGAGATAGAAG
GACTTATCCTCAATTATATTCCAGTAAATTTATCTCCATAATCTGTTTTATCCCCTAATGTATGATATATCTCACCAAATTTTTCTAGAA
TTGAATAAAAGCAGTTTTTGCTTAACTTGAATTTCCTTCCACAAATACAACCTTCAGCTCTTCCCTCTCTGTTTCCCTTTTGCCCACATT
GCAAATAGTCTTCATAATAGAACCCTCACTGCAACTTAAAAGGGTCCCATTTCTTAACTCAGCATTTCATATACCAAGAACACTTGCAAA
GATTTCTTCATAATGTGATTTTTTAATTTTTCAGTTCCAGAAGCATTTCCTACAGTTCGAACGTTATTTTTTCTCTCAGATTTTCAACTT
GAAGCTTTGATTTGCACTGAATTAACTTGGATAAAATTTTAGTTTCTCTCTTCAGCTAACAGATTTGGAAGCAAATTACAGTATACTTGA
ATAATTCAGGTACTACCTGTTGACCTGGAATTTTAGTGATTCTGGGAAAGTTTTCCAGACAAAGACACCAATAGAGTGAAGGGTTTTTTC
CCCAATTACTATTTTATTGTTTTTTAAAATGCCTTTTTAAAACTTGTGTGATGTGGCAAAATAGTCATATGTTCAATTAATTTATATTTT

>In-frame_ENST00000505078_ENST00000264122_TCGA-B0-4849-01A_MCTP1_chr5_94204038_-_CBLB_chr3_105495386_length(amino acids)=837AA_start in transcript=1176_stop in transcript=3689
MSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDI
FTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSR
EGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEI
KGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLP
PVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCP
RDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIK
CTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDP
VPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASG
QVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEI

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Fusion Gene PPI Analysis for MCTP1-CBLB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219891_927139.66666666666666983.0SH3KBP1
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215891_927139.66666666666666771.0SH3KBP1
TgeneCBLBchr5:94204038chr3:105495386ENST00000264122219543_568139.66666666666666983.0VAV1
TgeneCBLBchr5:94204038chr3:105495386ENST00000403724215543_568139.66666666666666771.0VAV1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MCTP1-CBLB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MCTP1-CBLB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCBLBC0014072Experimental Autoimmune Encephalomyelitis1CTD_human
TgeneCBLBC0026769Multiple Sclerosis1CTD_human
TgeneCBLBC0751324Multiple Sclerosis, Acute Fulminating1CTD_human